Published in J Hepatol on September 01, 1999
Molecular mediators of hepatic steatosis and liver injury. J Clin Invest (2004) 9.40
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology (2010) 5.35
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J Hepatol (2010) 2.09
The role of mitochondria in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol (2011) 2.02
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J Biol Chem (2009) 1.82
From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol (2013) 1.75
Nonalcoholic fatty liver disease and mitochondrial dysfunction. World J Gastroenterol (2008) 1.73
High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo. Biochem J (2009) 1.63
Pathogenesis and management issues for non-alcoholic fatty liver disease. World J Gastroenterol (2007) 1.59
Hepatocellular ballooning in NASH. J Hepatol (2010) 1.48
Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model. Am J Physiol Gastrointest Liver Physiol (2011) 1.41
Liver diseases and metabolic syndrome. J Gastroenterol (2008) 1.33
Autophagy in nonalcoholic steatohepatitis. Expert Rev Gastroenterol Hepatol (2011) 1.32
Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction. Am J Clin Nutr (2011) 1.29
The Bioenergetic Health Index: a new concept in mitochondrial translational research. Clin Sci (Lond) (2014) 1.25
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan. Hum Genet (2013) 1.24
Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion. Alcohol Clin Exp Res (2002) 1.23
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology (2014) 1.19
Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. Semin Liver Dis (2009) 1.08
Mechanisms and clinical implications of hepatocyte lipoapoptosis. Clin Lipidol (2010) 1.07
High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia. J Cell Mol Med (2010) 1.05
Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet. PLoS One (2011) 1.04
Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease. World J Gastroenterol (2014) 0.99
Mitochondrial morphology in metabolic diseases. Antioxid Redox Signal (2012) 0.98
Hypoxia inducible factor-1alpha accumulation in steatotic liver preservation: role of nitric oxide. World J Gastroenterol (2010) 0.97
Mitochondria and redox signaling in steatohepatitis. Antioxid Redox Signal (2011) 0.96
Beneficial Effects of Fermented Green Tea Extract in a Rat Model of Non-alcoholic Steatohepatitis. J Clin Biochem Nutr (2009) 0.96
Non-alcoholic fatty liver disease: an emerging pathological spectrum. Virchows Arch (2003) 0.93
Hepatic Steatosis as a Marker of Metabolic Dysfunction. Nutrients (2015) 0.92
Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. Am J Pathol (2004) 0.91
Perspectives on: SGP symposium on mitochondrial physiology and medicine: what comes first, misshape or dysfunction? The view from metabolic excess. J Gen Physiol (2012) 0.90
Studies on oxidative stress in liver diseases: important future trends in liver research. Med Mol Morphol (2006) 0.89
Fructose-rich diet leads to reduced aerobic capacity and to liver injury in rats. Lipids Health Dis (2012) 0.88
Binge alcohol-induced microvesicular liver steatosis and injury are associated with down-regulation of hepatic Hdac 1, 7, 9, 10, 11 and up-regulation of Hdac 3. Alcohol Clin Exp Res (2012) 0.88
Autophagy modulation as a potential therapeutic target for liver diseases. J Clin Exp Hepatol (2014) 0.87
Mitochondrial morphology-emerging role in bioenergetics. Free Radic Biol Med (2012) 0.87
Anti-oxidative and anti-inflammatory effects of spirulina on rat model of non-alcoholic steatohepatitis. J Clin Biochem Nutr (2012) 0.87
Concern Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic Ren2 rats. Am J Pathol (2009) 0.86
Trimetazidine: is it a promising drug for use in steatotic grafts? World J Gastroenterol (2006) 0.86
Decreasing mitochondrial fission alleviates hepatic steatosis in a murine model of nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol (2014) 0.85
Fatty liver disease in children: eat now pay later. Hepatol Int (2010) 0.85
Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis. Hepat Mon (2012) 0.84
An Intimate Relationship between ROS and Insulin Signalling: Implications for Antioxidant Treatment of Fatty Liver Disease. Int J Cell Biol (2014) 0.84
Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution. World J Gastroenterol (2010) 0.84
Binge ethanol-induced HDAC3 down-regulates Cpt1α expression leading to hepatic steatosis and injury. Alcohol Clin Exp Res (2013) 0.83
Pathophysiology of lipid droplet proteins in liver diseases. Exp Cell Res (2015) 0.83
Hepatic lipid metabolism changes in short- and long-term prehepatic portal hypertensive rats. World J Gastroenterol (2006) 0.81
Role of Mitochondria in Alcoholic Liver Disease. Curr Pathobiol Rep (2013) 0.81
High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice. Mol Metab (2014) 0.81
OXPHOS-Mediated Induction of NAD+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver Disease. PLoS One (2015) 0.81
Cardiovascular Disease and Myocardial Abnormalities in Nonalcoholic Fatty Liver Disease. Dig Dis Sci (2016) 0.80
Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model. Braz J Med Biol Res (2015) 0.80
Tumor necrosis factor-alpha, interleukin-1beta and nitric oxide: induction of liver megamitochondria in prehepatic portal hypertensive rats. World J Surg (2005) 0.80
Systematic analysis of the gene expression in the livers of nonalcoholic steatohepatitis: implications on potential biomarkers and molecular pathological mechanism. PLoS One (2012) 0.79
The non-invasive (13)C-methionine breath test detects hepatic mitochondrial dysfunction as a marker of disease activity in non-alcoholic steatohepatitis. Eur J Med Res (2011) 0.79
Flare-up of nonalcoholic steatohepatitis after hepatectomy resulted in hepatic failure in a patient with type 2 diabetes mellitus. Dig Dis Sci (2007) 0.78
PPARs and Mitochondrial Metabolism: From NAFLD to HCC. PPAR Res (2016) 0.77
Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol (2016) 0.77
Pediatric non-alcoholic steatohepatitis: the first report on the ultrastructure of hepatocyte mitochondria. World J Gastroenterol (2014) 0.77
Function of Autophagy in Nonalcoholic Fatty Liver Disease. Dig Dis Sci (2016) 0.76
NASH: The Hepatic injury of Metabolic syndrome: a brief update. Int J Health Sci (Qassim) (2009) 0.75
Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children. Clin Liver Dis (2015) 0.75
Electron Therapy Attenuated Elevated Alanine Aminotransferase and Oxidative Stress Values in Type 2 Diabetes-Induced Nonalcoholic Steatohepatitis of Rats. Cell Med (2013) 0.75
A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Potential of (99m)Tc-MIBI SPECT imaging for evaluating non-alcoholic steatohepatitis induced by methionine-choline-deficient diet in mice. EJNMMI Res (2014) 0.75
The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma. Sci Rep (2015) 0.75
Oxidative Stress in the Healthy and Wounded Hepatocyte: A Cellular Organelles Perspective. Oxid Med Cell Longev (2015) 0.75
Synergistic Effects of Cilostazol and Probucol on ER Stress-Induced Hepatic Steatosis via Heme Oxygenase-1-Dependent Activation of Mitochondrial Biogenesis. Oxid Med Cell Longev (2016) 0.75
The Role of Lipid and Lipoprotein Metabolism in Non-Alcoholic Fatty Liver Disease. Children (Basel) (2017) 0.75
Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology (1999) 3.99
A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis. Am J Gastroenterol (2001) 3.16
Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol (1989) 3.11
Cybrids in Alzheimer's disease: a cellular model of the disease? Neurology (1997) 2.85
Cardiorespiratory fitness and brain atrophy in early Alzheimer disease. Neurology (2008) 2.56
Outpatient surgical treatment of cervical radiculopathy. J Neurosurg (1997) 2.34
Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol (1996) 2.22
Cytochrome oxidase deficiency in Alzheimer's disease. Neurology (1990) 1.96
Neuroleptic medications inhibit complex I of the electron transport chain. Ann Neurol (1993) 1.82
Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc Natl Acad Sci U S A (1997) 1.80
Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines. Exp Neurol (2000) 1.80
Phenotypic variation in biotinidase deficiency. J Pediatr (1983) 1.74
Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds. Am J Med (2000) 1.67
Evidence for a defect in NADH: ubiquinone oxidoreductase (complex I) in Huntington's disease. Neurology (1990) 1.67
A defect in mitochondrial electron-transport activity (NADH-coenzyme Q oxidoreductase) in Leber's hereditary optic neuropathy. N Engl J Med (1989) 1.61
Role of mitochondria in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord (2000) 1.51
Hepatitis C-induced hepatic allograft injury is associated with a pretransplantation elevated viral replication rate. Hepatology (2000) 1.50
Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease. Biochim Biophys Acta (1997) 1.44
Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology (1994) 1.43
Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease. Neurology (2010) 1.41
Immunoproliferative small intestinal disease: a frequently missed diagnosis. Indian J Gastroenterol (1996) 1.41
Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J Neurosci (1997) 1.36
Functional mitochondria are required for amyloid beta-mediated neurotoxicity. FASEB J (2001) 1.29
The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochim Biophys Acta (1999) 1.23
Mitochondrial function in Parkinson's disease. Lancet (1989) 1.20
Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways. Ann Neurol (2000) 1.20
Multiplex fluorescence-based primer extension method for quantitative mutation analysis of mitochondrial DNA and its diagnostic application for Alzheimer's disease. Nucleic Acids Res (1997) 1.18
Cytochrome c oxidase in Alzheimer's disease brain: purification and characterization. Neurology (1995) 1.17
Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease. J Neurol Sci (1991) 1.12
Deficient biotinidase activity in late-onset multiple carboxylase deficiency. N Engl J Med (1983) 1.12
Mitochondria in sporadic amyotrophic lateral sclerosis. Exp Neurol (1998) 1.09
Oral ribavirin therapy for subacute sclerosing panencephalitis. J Infect Dis (1989) 1.08
Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease. J Neurochem (1997) 1.08
Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro. J Neurochem (2001) 1.06
Enbucrilate for gastric varices: extended experience in 92 patients. Aliment Pharmacol Ther (2007) 1.05
Creation and characterization of mitochondrial DNA-depleted cell lines with "neuronal-like" properties. J Neurochem (1996) 1.04
Mitochondrial dysfunction in idiopathic Parkinson disease. Am J Hum Genet (1998) 1.04
Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family. Ann Neurol (1998) 1.04
Clonal analysis of focal nodular hyperplasia of the liver. Am J Pathol (1996) 1.03
Intracranial tuberculomas: MRI signal intensity correlation with histopathology and localised proton spectroscopy. Magn Reson Imaging (1993) 0.98
Propionate inhibition of succinate:CoA ligase (GDP) and the citric acid cycle in mitochondria. Pediatr Res (1980) 0.97
Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kappaB in cellular models of Parkinson's disease. J Neurochem (2000) 0.96
Use of cytoplasmic hybrid cell lines for elucidating the role of mitochondrial dysfunction in Alzheimer's disease and Parkinson's disease. Ann N Y Acad Sci (1999) 0.96
Prediction of liver allograft fibrosis after transplantation for hepatitis C virus: persistent elevation of serum transaminase levels versus necroinflammatory activity. Liver Transpl (2000) 0.96
Mitochondrial dysfunction in cybrid lines expressing mitochondrial genes from patients with progressive supranuclear palsy. J Neurochem (2000) 0.96
Friedreich ataxia: III. Mitochondrial malic enzyme deficiency. Neurology (1982) 0.94
Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells. Brain Res (2001) 0.92
Spin trapping of azidyl and hydroxyl radicals in azide-inhibited rat brain submitochondrial particles. Arch Biochem Biophys (1994) 0.92
Further evidence for mitochondrial dysfunction in progressive supranuclear palsy. Exp Neurol (2001) 0.91
Inhibitory effects of sodium valproate on oxidative phosphorylation. Neurology (1981) 0.90
Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids. Biochem Biophys Res Commun (1998) 0.90
Disrupted mitochondrial electron transport function increases expression of anti-apoptotic bcl-2 and bcl-X(L) proteins in SH-SY5Y neuroblastoma and in Parkinson disease cybrid cells through oxidative stress. J Neurosci Res (2000) 0.89
Metatarsal stress fractures. Am J Sports Med (1980) 0.88
Brain mitochondrial metabolism in experimental thiamine deficiency. Neurology (1984) 0.87
Human mitochondrial electron transport chain: assay of succinate: cytochrome c reductase in leukocytes, platelets and cultured fibroblasts. Biochem Med (1981) 0.87
Pancreatic adenocarcinoma in the pregnant patient: case report and review of the literature. Cancer (1997) 0.87
Carnitine deficiency, organic acidemias, and Reye's syndrome. Neurology (1985) 0.86
Diagnosis of spinal muscular atrophy in an SMN non-deletion patient using a quantitative PCR screen and mutation analysis. J Med Genet (1998) 0.86
Salicylate-induced loose coupling: protonmotive force measurements. Biochem Pharmacol (1985) 0.86
Maternal inheritance in Parkinson's disease. Ann Neurol (1997) 0.86
Association of the mitochondrial 8344 MERRF mutation with maternally inherited spinocerebellar degeneration and Leigh disease. Neurology (1996) 0.86
Cytochrome oxidase inhibition: a novel animal model of Alzheimer's disease. J Geriatr Psychiatry Neurol (1992) 0.85
Friedreich ataxia. II. Normal kinetics of lipoamide dehydrogenase. Neurology (1979) 0.85
Overlap between Majewski and hydrolethalus syndromes: a report of two cases. Am J Med Genet (1992) 0.85
L-dopa increases nigral production of hydroxyl radicals in vivo: potential L-dopa toxicity? Neuroreport (1994) 0.84
Hypomelanosis of Ito: association with a chromosomal abnormality. Neurology (1985) 0.83
Biochemical analysis of cybrids expressing mitochondrial DNA from Contursi kindred Parkinson's subjects. Exp Neurol (2001) 0.83
Endoscopic ultrasonographic evaluation of the rectum in cirrhotic portal hypertension. Gastrointest Endosc (1993) 0.83
Lipoamide dehydrogenase deficiency with primary lactic acidosis: favorable response to treatment with oral lipoic acid. J Pediatr (1984) 0.82
Characterization of cybrid cell lines containing mtDNA from Huntington's disease patients. Biochem Biophys Res Commun (1999) 0.82
Predictive value of intraoperative biopsies and liver function tests for preservation injury in orthotopic liver transplantation. Hepatology (1997) 0.82
Friedreich's ataxia: I. Normal pyruvate dehydrogenase complex activity in platelets. Ann Neurol (1978) 0.81