PubRank

M Citron

Author PubWeight™ 76.80‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999 13.19
2 Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996 10.44
3 Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci 2001 3.85
4 alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. J Biol Chem 1999 2.91
5 Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. J Biol Chem 1999 2.86
6 The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med 1995 2.44
7 Abeta-generating enzymes: recent advances in beta- and gamma-secretase research. Neuron 2000 2.40
8 Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem 1997 2.33
9 Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiol Dis 1997 1.92
10 A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem 1999 1.87
11 Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine. Cancer Res 1996 1.68
12 The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Ann N Y Acad Sci 1996 1.67
13 The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem 1998 1.66
14 Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J Biol Chem 1993 1.64
15 HIV-1 vaccine development: constrained peptide immunogens show improved binding to the anti-HIV-1 gp41 MAb. Biochemistry 2003 1.59
16 A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase. J Biol Chem 2000 1.41
17 Expression analysis of BACE2 in brain and peripheral tissues. J Biol Chem 2000 1.36
18 Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs. J Biol Chem 2000 1.35
19 A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. J Med Chem 1998 1.25
20 The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing. J Biol Chem 1999 1.21
21 Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Biochemistry 1999 1.16
22 Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties. J Biol Chem 2000 1.16
23 Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. J Biol Chem 1998 1.13
24 Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice. Cancer Res 1992 1.07
25 beta-Amyloid, protein processing and Alzheimer's disease. Arzneimittelforschung 1995 1.02
26 The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein. J Biol Chem 1995 0.98
27 Delayed death from ingestion of a toothpick. N Engl J Med 1989 0.96
28 Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proc Natl Acad Sci U S A 1997 0.93
29 Transcriptional control via translational repression by c4 antisense RNA of bacteriophages P1 and P7. Genes Dev 1992 0.89
30 Calcified pulmonary metastases from medullary carcinoma of the thyroid. Comput Med Imaging Graph 1996 0.84
31 Combination chemotherapy for metastatic or recurrent carcinoma of the breast--a randomized phase III trial comparing CAF versus VATH versus VATH alternating with CMFVP: Cancer and Leukemia Group B Study 8281. J Clin Oncol 1995 0.84
32 Microcomputer produced anaglyphs for evaluation and therapy of binocular anomalies. J Am Optom Assoc 1983 0.83
33 Non-Hodgkin's lymphoma during pregnancy. Gynecol Oncol 1991 0.82
34 Greenfield filter as primary therapy for deep venous thrombosis and/or pulmonary embolism in patients with cancer. Surgery 1991 0.82
35 Caucasian family with two independent mutations: 2594delC in BRCA1 and 5392delAG in BRCA2 gene. Am J Med Genet 2001 0.81
36 Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease. J Med Chem 2000 0.81
37 Perplexing peroxisome proliferators. Environ Health Perspect 1995 0.80
38 O6-methylguanine-DNA methyltransferase in ovarian malignancy and its correlation with postoperative response to chemotherapy. Gynecol Oncol 1994 0.79
39 Greenfield filter instead of heparin as primary treatment for deep venous thrombosis or pulmonary embolism in patients with cancer. Cancer 1992 0.78
40 The direct influence of ship traffic on atmospheric PM2.5, PM10 and PAH in Venice. J Environ Manage 2011 0.77
41 Second-site suppressors of the bacteriophage P1 virs mutant reveal the interdependence of the c4, icd, and ant genes in the P1 immI operon. J Bacteriol 1994 0.75
42 P53 protein overexpression in lung adenocarcinomas in non-smokers. Oncol Rep 2011 0.75
43 A pharmacodynamic study of morphine and its glucuronide metabolites after single morphine dosing in cancer patients with pain. Cancer Invest 1997 0.75
44 Amyloid precursor protein processing in sterol regulatory element-binding protein site 2 protease-deficient Chinese hamster ovary cells. J Biol Chem 1998 0.75
45 O6-Alkylguanine-DNA alkyltransferase in normal colon tissue and colon cancer. Oncol Res 1997 0.75
46 Northern exposures: cleaning up Canada. Environ Health Perspect 1995 0.75
47 Tumor metastasis to an infusaport site. N Y State J Med 1990 0.75