Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

PubWeight™: 1.64‹?› | Rank: Top 3%

🔗 View Article (PMID 8226807)

Published in J Biol Chem on November 05, 1993

Authors

A Y Hung1, C Haass, R M Nitsch, W Q Qiu, M Citron, R J Wurtman, J H Growdon, D J Selkoe

Author Affiliations

1: Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115.

Articles citing this

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A (1999) 3.85

The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol (2010) 3.32

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron (2006) 2.76

Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci (2011) 2.47

APP processing in Alzheimer's disease. Mol Brain (2011) 2.02

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. EMBO J (1995) 1.76

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein. BMC Cell Biol (2005) 1.53

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proc Natl Acad Sci U S A (1996) 1.52

The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. J Neural Transm (Vienna) (2006) 1.50

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet (2009) 1.46

The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol Med (1996) 1.32

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. Proc Natl Acad Sci U S A (1994) 1.31

The role of G protein-coupled receptors in the pathology of Alzheimer's disease. Nat Rev Neurosci (2011) 1.30

Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease. PLoS One (2009) 1.19

Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc Natl Acad Sci U S A (1994) 1.17

Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein. EMBO J (1994) 1.13

Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. J Cell Biol (1995) 1.07

Neuroprotective strategies in Alzheimer's disease. NeuroRx (2004) 1.05

Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci U S A (1997) 1.04

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc Natl Acad Sci U S A (1995) 1.01

Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation. Proc Natl Acad Sci U S A (1999) 1.00

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. J Cell Mol Med (2008) 0.97

Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo. J Neurosci (2008) 0.95

Post-transcriptional contribution of a cAMP-dependent pathway to the formation of alpha- and beta/gamma-secretases-derived products of beta APP maturation in human cells expressing wild-type and Swedish mutated beta APP. Mol Med (1998) 0.95

Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry (2013) 0.95

Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system. Proc Natl Acad Sci U S A (1996) 0.95

Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. Biochem J (1995) 0.94

P2Y2 nucleotide receptor-mediated responses in brain cells. Mol Neurobiol (2010) 0.94

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proc Natl Acad Sci U S A (1997) 0.93

Elevated intracellular calcium concentration increases secretory processing of the amyloid precursor protein by a tyrosine phosphorylation-dependent mechanism. Biochem J (1996) 0.92

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines. Neurobiol Dis (2012) 0.90

Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts. Proc Natl Acad Sci U S A (1998) 0.89

Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C. J Neurochem (2008) 0.88

Activation of protein kinase C modulates BACE1-mediated beta-secretase activity. Neurobiol Aging (2006) 0.86

Protein kinase C-regulated aβ production and clearance. Int J Alzheimers Dis (2011) 0.86

SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation. Cell Death Dis (2014) 0.82

Phorbol esters affect multiple steps in beta-amyloid precursor protein trafficking and amyloid beta-protein production. Mol Med (1997) 0.81

A role for the beta-amyloid precursor protein in memory? Proc Natl Acad Sci U S A (1998) 0.81

Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1. Br J Pharmacol (1999) 0.80

Cholinergic septo-hippocampal innervation is required for trace eyeblink classical conditioning. Learn Mem (2005) 0.80

Cholinergic Mechanisms in the Cerebral Cortex: Beyond Synaptic Transmission. Neuroscientist (2015) 0.78

The choline-leakage hypothesis for the loss of acetylcholine in Alzheimer's disease. Biophys J (1997) 0.78

Apomorphine and Alzheimer Aβ: roles for regulated α cleavage, autophagy, and antioxidation? Ann Neurol (2011) 0.78

Bradykinin-induced amyloid precursor protein secretion: a protein kinase C-independent mechanism that is not altered in fibroblasts from patients with sporadic Alzheimer's disease. Biochem J (1998) 0.78

Disturbances in signal transduction mechanisms in Alzheimer's disease. Mol Cell Biochem (1996) 0.77

The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease. Cell Mol Neurobiol (2015) 0.76

New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer's disease. BMC Neurosci (2012) 0.76

Inhibition of peptide aggregation by means of enzymatic phosphorylation. Beilstein J Org Chem (2016) 0.75

Uncovering the Molecular Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network. PLoS One (2015) 0.75

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease. Front Mol Neurosci (2017) 0.75

Articles by these authors

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (1999) 13.19

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med (1996) 10.44

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology (1992) 9.30

Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology (1996) 8.82

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature (1999) 8.28

Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci (1996) 7.19

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A (1986) 6.56

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature (1992) 6.51

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science (2001) 6.17

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol (1997) 6.02

Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science (1982) 5.42

Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases. Ann Neurol (1988) 4.76

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem (1999) 4.64

Skeletal and CNS defects in Presenilin-1-deficient mice. Cell (1997) 4.50

Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genet (1993) 4.49

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science (2001) 4.18

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med (1997) 4.10

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc Natl Acad Sci U S A (1987) 4.04

Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology (2004) 4.00

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci (1999) 3.92

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci (2001) 3.85

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A (1999) 3.85

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem (1998) 3.77

Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy. Neurology (2006) 3.68

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature (1983) 3.67

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry (2000) 3.31

Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J Neurochem (1986) 3.31

Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science (1987) 3.23

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature (1992) 3.22

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science (2000) 3.16

X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation. Proc Natl Acad Sci U S A (1986) 3.14

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell (1988) 3.11

Imaging amyloid deposition in Lewy body diseases. Neurology (2008) 3.09

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. J Biol Chem (1999) 2.91

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell (1993) 2.89

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. J Biol Chem (1999) 2.86

DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology (2007) 2.86

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol (2000) 2.84

A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain. Life Sci (1967) 2.84

Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science (1992) 2.82

Treatment for Alzheimer's disease? N Engl J Med (1992) 2.72

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep (2001) 2.70

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem (1995) 2.68

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J Biol Chem (1999) 2.57

Control of enzymatic synthesis of adrenaline in the adrenal medulla by adrenal cortical steroids. J Biol Chem (1966) 2.55

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans (2002) 2.55

Brain serotonin content: physiological regulation by plasma neutral amino acids. Science (1972) 2.54

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science (1992) 2.50

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis (1996) 2.50

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. J Neurosci (2000) 2.49

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med (1995) 2.44

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem (2001) 2.42

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research. Neuron (2000) 2.40

Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem (2001) 2.40

Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry (1992) 2.36

Head injury and the risk of AD in the MIRAGE study. Neurology (2000) 2.34

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem (1997) 2.33

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol (2000) 2.30

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. J Biol Chem (2000) 2.27

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease. J Biol Chem (1992) 2.26

The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease. Alzheimer Dis Assoc Disord (1992) 2.24

Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles. Proc Natl Acad Sci U S A (1984) 2.22

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci (2000) 2.22

Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study. Neurology (2008) 2.16

Prevention of preterm birth: early detection and aggressive treatment with terbutaline. South Med J (1993) 2.10

A Neural Dissociation within Language: Evidence that the Mental Dictionary Is Part of Declarative Memory, and that Grammatical Rules Are Processed by the Procedural System. J Cogn Neurosci (1997) 2.04

Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease. Nature (1989) 2.04

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42. J Biol Chem (1997) 2.02

White matter pathology isolates the hippocampal formation in Alzheimer's disease. Neurobiol Aging (2010) 2.01

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. J Biol Chem (1993) 2.01

Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med (1989) 2.01

Brain serotonin content: physiological dependence on plasma tryptophan levels. Science (1971) 2.00

Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies. Brain Res (1984) 1.98

Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. Proc Natl Acad Sci U S A (1987) 1.98

Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol (1989) 1.95

Protein topology of presenilin 1. Neuron (1996) 1.94

Donepezil therapy in clinical practice: a randomized crossover study. Arch Neurol (2000) 1.93

Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiol Dis (1997) 1.92

Acute cortisone administration impairs retrieval of long-term declarative memory in humans. Nat Neurosci (2000) 1.90

Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum. J Neurosci (1982) 1.88

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat Cell Biol (2000) 1.87

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem (1999) 1.87

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med (1996) 1.86

Evidence for a membrane defect in Alzheimer disease brain. Proc Natl Acad Sci U S A (1992) 1.86

Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old? Neurology (1996) 1.85

The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochem Soc Trans (2005) 1.84

Permeability and residual plasma volume of human, Dutch variant, and rat amyloid beta-protein 1-40 at the blood-brain barrier. Neurobiol Dis (1997) 1.83

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. J Biol Chem (1999) 1.82

Generation of amyloid beta protein from its precursor is sequence specific. Neuron (1995) 1.82

Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol (2001) 1.81