Published in N Engl J Med on October 21, 1999
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol (2005) 5.88
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 4.71
Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol (2003) 4.31
The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol (2007) 3.33
Strategies for treating idiopathic pulmonary fibrosis. Nat Rev Drug Discov (2010) 3.20
Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J Clin Invest (2004) 2.10
Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis. J Pathol (2003) 1.71
The elusive goal of therapy for usual interstitial pneumonia. N Engl J Med (2004) 1.70
Disorders of lung matrix remodeling. J Clin Invest (2004) 1.69
Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med (2009) 1.61
Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2014) 1.61
Growth factors in idiopathic pulmonary fibrosis: relative roles. Respir Res (2001) 1.55
British Thoracic Society Study on cryptogenic fibrosing alveolitis: Response to treatment and survival. Thorax (2006) 1.39
Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling. Proc Am Thorac Soc (2006) 1.31
Gender-based differences in bleomycin-induced pulmonary fibrosis. Am J Pathol (2005) 1.25
Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol (2011) 1.24
Idiopathic pulmonary fibrosis: current understanding of the pathogenesis and the status of treatment. CMAJ (2004) 1.21
Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2. J Cell Biochem (2007) 1.20
Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. Am J Pathol (2004) 1.20
A review of current and novel therapies for idiopathic pulmonary fibrosis. J Thorac Dis (2013) 1.18
Mesenchymal cell survival in airway and interstitial pulmonary fibrosis. Fibrogenesis Tissue Repair (2010) 1.17
TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis. Am J Respir Cell Mol Biol (2005) 1.17
Role of Th2 responses in the development of allergen-induced airway remodelling in a murine model of allergic asthma. Br J Pharmacol (2003) 1.17
Determinants of initiation and progression of idiopathic pulmonary fibrosis. Respirology (2009) 1.16
The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease. Respir Res (2001) 1.08
A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice. Respir Res (2010) 1.07
Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis. Am J Respir Cell Mol Biol (2012) 1.06
PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis. Am J Pathol (2001) 1.05
Toll-like receptors, Notch ligands, and cytokines drive the chronicity of lung inflammation. Proc Am Thorac Soc (2007) 1.03
Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis. Am J Pathol (2005) 1.03
Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis. Proc Am Thorac Soc (2008) 0.99
Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia. J Clin Pathol (2004) 0.99
The role of PDGF in radiation oncology. Radiat Oncol (2007) 0.97
Novel advances in shotgun lipidomics for biology and medicine. Prog Lipid Res (2015) 0.95
Identification of human ccn2 (connective tissue growth factor) promoter polymorphisms. Mol Pathol (2001) 0.95
In situ assessment of oxidant and nitrogenic stress in bleomycin pulmonary fibrosis. Histochem Cell Biol (2005) 0.95
EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts. Respir Res (2006) 0.95
Pathogenesis, current treatments and future directions for idiopathic pulmonary fibrosis. Curr Opin Pharmacol (2013) 0.94
Current and novel drug therapies for idiopathic pulmonary fibrosis. Drug Des Devel Ther (2012) 0.93
Update on diagnosis and treatment of idiopathic pulmonary fibrosis. J Bras Pneumol (2015) 0.92
Pulmonary vaccination as a novel treatment for lung fibrosis. PLoS One (2012) 0.91
Update on therapeutic management of idiopathic pulmonary fibrosis. Ther Clin Risk Manag (2015) 0.91
Idiopathic pulmonary fibrosis : new concepts in pathogenesis and implications for drug therapy. Treat Respir Med (2006) 0.90
Adjuvant interferon gamma in patients with drug - resistant pulmonary tuberculosis: a pilot study. BMC Infect Dis (2004) 0.89
Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis. J Clin Invest (2004) 0.88
Glucocorticoids and TGF-beta1 synergize in augmenting fibroblast mediated contraction of collagen gels. Inflammation (2001) 0.86
PPARγ activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines. Mucosal Immunol (2015) 0.86
Glucocorticoids modulate TGF-beta production by human fetal lung fibroblasts. Inflammation (2003) 0.86
Interferon gamma-1b for the treatment of idiopathic pulmonary fibrosis. N Engl J Med (1999) 0.85
Idiopathic interstitial pneumonias: progress in classification, diagnosis, pathogenesis and management. Trans Am Clin Climatol Assoc (2004) 0.84
Pirfenidone treatment of idiopathic pulmonary fibrosis. Ther Clin Risk Manag (2011) 0.83
Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats. Chin Med (2011) 0.83
IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells. PLoS One (2012) 0.82
A critical assessment of treatment options for idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis (2005) 0.81
An alternative therapy for idiopathic pulmonary fibrosis by doxycycline through matrix metalloproteinase inhibition. Lung India (2011) 0.81
Glucocorticoids modulate TGF-beta production. Inflammation (2002) 0.81
Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice. Respir Res (2014) 0.81
Lipidomics revealed idiopathic pulmonary fibrosis-induced hepatic lipid disorders corrected with treatment of baicalin in a murine model. AAPS J (2015) 0.80
Characterization of lymphocyte populations in nonspecific interstitial pneumonia. Respir Res (2005) 0.80
Interferon gamma-1b for the treatment of idiopathic pulmonary fibrosis. N Engl J Med (2000) 0.80
Anti-cytokine therapy in fibrosing alveolitis: where are we now? Respir Res (2000) 0.78
Interleukin-12 is not essential for silicosis in mice. Part Fibre Toxicol (2006) 0.78
Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice. Oncotarget (2016) 0.77
Advances in the management of idiopathic pulmonary fibrosis. F1000 Med Rep (2010) 0.77
Autoantibodies in cryptogenic fibrosing alveolitis. Respir Res (2001) 0.77
Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action. Am J Physiol Renal Physiol (2005) 0.77
Effect of montelukast, a cysteinyl receptor antagonist, on myofibroblasts in interstitial lung disease. J Clin Immunol (2004) 0.77
Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury. J Cell Commun Signal (2015) 0.77
Genetic analysis of sporadic and familial interstitial pneumonia. Proc Am Thorac Soc (2008) 0.76
Clinical trials of investigational agents for IPF: a review of a Cochrane report. Respir Res (2013) 0.75
Interferon gamma-1b therapy for cryptogenic fibrosing alveolitis. Thorax (2000) 0.75
Interferon gamma-1b for pulmonary fibrosis. N Engl J Med (2004) 0.75
Pirfenidone in the treatment of idiopathic pulmonary fibrosis: an evidence-based review of its place in therapy. Core Evid (2016) 0.75
Interferon gamma-1b for pulmonary fibrosis. N Engl J Med (2004) 0.75
[Differential therapy of pulmonary fibrosis]. Internist (Berl) (2006) 0.75
Long-term treatment of pulmonary hypertension with aerosolized iloprost. Eur Respir J (2001) 3.27
Fever: pathogenesis, pathophysiology, and purpose. Ann Intern Med (1979) 2.17
Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem (1999) 1.59
Calcium channel blockers activate the interleukin-6 gene via the transcription factors NF-IL6 and NF-kappaB in primary human vascular smooth muscle cells. Circulation (1999) 1.55
Significantly worse survival of patients with NIH-defined chronic graft-versus-host disease and thrombocytopenia or progressive onset type: results of a prospective study. Leukemia (2011) 1.15
Release of endogenous pyrogen-activating factor from concanavalin A-stimulated human lymphocytes. J Exp Med (1980) 1.13
Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix. Proc Natl Acad Sci U S A (1996) 1.12
Platelet-derived growth factor stimulates the secretion of hyaluronic acid by proliferating human vascular smooth muscle cells. Proc Natl Acad Sci U S A (1995) 1.01
Expressions of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes are stimulated by recombinant platelet-derived growth factor isomers. Proc Natl Acad Sci U S A (1991) 1.01
Cytokine expression in bronchial biopsies of cystic fibrosis patients with and without acute exacerbation. Eur Respir J (1999) 1.01
Human migration inhibitory factor: purification and immunochemical characterization. J Exp Med (1978) 1.01
Positron emission tomography with fluorine-18-2-fluoro-2-deoxy-D-glucose (F18-FDG) does not visualize extranodal B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT)-type. Ann Oncol (1999) 0.99
Isolation and characterization of an RNA-proteolipid complex associated with the malignant state in humans. Proc Natl Acad Sci U S A (1985) 0.99
Lipopolysaccharide and interleukin 1 augment the effects of hypoxia and inflammation in human pulmonary arterial tissue. Proc Natl Acad Sci U S A (1996) 0.98
[Austrian Society for Lung Diseases and Tuberculosis: Consensus on diagnosis and therapy of bronchial asthma in adults. Revised draft 1999]. Wien Klin Wochenschr (1999) 0.97
Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD. Thorax (2003) 0.97
Renin profiling to select antihypertensive baseline drugs. Renin inhibitors for high-renin and calcium entry blockers for low-renin patients. Am J Med (1984) 0.94
Treatment with epoprostenol reverts nitric oxide non-responsiveness in patients with primary pulmonary hypertension. Heart (2000) 0.92
Comparable postoperative pulmonary atelectasis in patients given 30% or 80% oxygen during and 2 hours after colon resection. Anesthesiology (1999) 0.91
Nonspecific resistance to bacterial infections. Enhancement by ubiquinone-8. J Exp Med (1978) 0.91
Manidipine regulates the transcription of cytokine genes. Proc Natl Acad Sci U S A (1992) 0.90
Intracellular interleukin 6 mediates platelet-derived growth factor-induced proliferation of nontransformed cells. Proc Natl Acad Sci U S A (1995) 0.90
Chitinosans as tableting excipients for modified release delivery systems. Int J Pharm (1999) 0.89
Nephrotic syndrome complicating chronic visceral leishmaniasis: re-emergence in patients with AIDS. Clin Nephrol (2008) 0.89
[Pathogen resistance and other risk factors in the frequency of lower limb amputations in patients with the diabetic foot syndrome]. Vnitr Lek (2002) 0.89
The differential distribution of hyaluronic acid in the layers of human atheromatic aortas is associated with vascular smooth muscle cell proliferation and migration. Atherosclerosis (1998) 0.89
Lyophilization of cationic lipid-protamine-DNA (LPD) complexes. J Pharm Sci (2000) 0.88
Plasmid maintenance assay based on green fluorescent protein and FACS of mammalian cells. Biotechniques (1998) 0.87
Macrophage migration inhibition factor: interactions with calcium, magnesium, and cyclic AMP. J Immunol (1978) 0.87
Effects of amlodipine on gene expression and extracellular matrix formation in human vascular smooth muscle cells and fibroblasts: implications for vascular protection. Int J Cardiol (1997) 0.86
Preparation of gadopentetic acid-loaded chitosan microparticles for gadolinium neutron-capture therapy of cancer by a novel emulsion-droplet coalescence technique. Chem Pharm Bull (Tokyo) (1999) 0.85
125I-8-L-arginine vasopressin binding to human mononuclear phagocytes. J Clin Invest (1981) 0.85
The impact of lag time on the estimation of pharmacokinetic parameters. I. One-compartment open model. Pharm Res (1993) 0.85
Changes in tissue sensitivity to vasopressin in hereditary hypothalamic diabetes insipidus. Klin Wochenschr (1981) 0.85
Pharmacological analysis of the iridoid oleuropein. Arzneimittelforschung (1972) 0.85
(-)-Adrenaline-induced, calcium-dependent phosphorylation of proteins in human platelets. J Clin Invest (1985) 0.84
Physicochemical characterization of a polypeptide present in uremic serum that inhibits the biological activity of polymorphonuclear cells. Proc Natl Acad Sci U S A (1990) 0.84
Pharmacological studies on substances of plant origin with coronary dilatating and antiarrhythmic action. Comp Med East West (1978) 0.84
Diagnostic and prognostic value of RNA-proteolipid in sera of patients with malignant disorders following therapy: first clinical evaluation of a novel tumor marker. Cancer Res (1987) 0.83
A granulocyte inhibitory protein overexpressed in chronic renal disease regulates expression of interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A (1994) 0.82
111In-DOTA-lanreotide scintigraphy in patients with tumors of the lung. J Nucl Med (2001) 0.82
Effects of aspirin on platelet aggregation as a function of dosage and time. Clin Pharmacol Ther (1980) 0.82
Antihypertensive therapy with the long-acting calcium antagonist nitrendipine. J Cardiovasc Pharmacol (1984) 0.82
A 340 kDa hyaluronic acid secreted by human vascular smooth muscle cells regulates their proliferation and migration. Glycobiology (1998) 0.81
On the origin of prostaglandin and its role in the sympathetic nerve transmission in vas deferens. Gen Pharmacol (1980) 0.81
The use of chitosan gels as matrices for electrically-modulated drug delivery. J Control Release (2001) 0.81
Solubility and dissolution of triamcinolone acetonide. J Pharm Sci (1973) 0.81
Plants and hypotensive, antiatheromatous and coronarodilatating action. Am J Chin Med (1979) 0.80
Distinct effects of Broncho-Vaxom (OM-85 BV) on gp130 binding cytokines. Thorax (2000) 0.80
In vitro inhibition of cyclic 3' 5',-AMP-phosphodiesterase by a group of structural analogues of glaucine. Acta Physiol Pharmacol Bulg (1980) 0.79
Aqueous solubility of 14C-triamcinolone acetonide. J Pharm Sci (1976) 0.79
Induction of interleukin 6 and interleukin 8 expression by Broncho-Vaxom (OM-85 BV) via C-Fos/serum responsive element. Thorax (1996) 0.79
Aerosolized iloprost therapy could not replace long-term IV epoprostenol (prostacyclin) administration in severe pulmonary hypertension. Chest (2001) 0.79
Effects of trovafloxacin on the IL-1-dependent activation of E-selectin in human endothelial cells in vitro. Immunopharmacology (2000) 0.79
Rapid activation of human platelets by low concentrations of low-density lipoprotein via phosphatidylinositol cycle. Eur J Biochem (1988) 0.79
Hypogastric nerve from guinea-pig releases prostaglandin-like substance. Gen Pharmacol (1981) 0.79
Interactions between 8-L-arginine vasopressin and prostaglandin E2 in human mononuclear phagocytes. J Clin Invest (1983) 0.79
Experimental pharmacological study of three species from genus Salvia. Acta Physiol Pharmacol Bulg (1984) 0.79
Use of chitosan in compressed tablets of diclofenac sodium: inhibition of drug release in an acidic environment. Pharm Dev Technol (1997) 0.79
Dissociation of human interferon-gamma-like activity from migration-inhibition factor. Cell Immunol (1984) 0.78
Pharmacological studies of a group of semi-synthetic structural analogues of glaucine. Acta Physiol Pharmacol Bulg (1979) 0.78
Cyclosporin A: pharmacologic activity on the immune system and effects in clinical organ transplantation. Klin Wochenschr (1983) 0.78
Decomposition of cannabidiol in chloroform solution. J Pharm Sci (1974) 0.78
Hotspot decorations map plasmonic patterns with the resolution of scanning probe techniques. Phys Rev Lett (2011) 0.78
Low-density lipoprotein: an old substance with a new function? Trends Pharmacol Sci (1988) 0.78
Inhibition of mitogen-induced lymphokine production by cyclosporin A. Klin Wochenschr (1980) 0.78
Pulmonary and systemic effects of inhaled PACAP38 in healthy male subjects. Eur J Clin Invest (2007) 0.78
On the effects of diazepam, hyoscine and oxotremorine on acetylcholine release from the cerebral cortex. Acta Physiol Pharmacol Bulg (1983) 0.78
Effect of ginseng on the brain biogenic monoamines and 3',5'-AMP system. Experiments on rats. Arzneimittelforschung (1978) 0.77
Regulation of human endothelial nitric oxide synthase by hypoxia and inflammation in human pulmonary arteries--implications for the therapy of pulmonary hypertension in COPD patients. Acta Anaesthesiol Scand Suppl (1996) 0.76
Beta 2-adrenoceptor density on membranes and on intact mononuclear cells in essential hypertension. Res Exp Med (Berl) (1983) 0.76
[The Bulgarian drug Satal as a therapeutic agent in industrial lead poisoning]. Gig Tr Prof Zabol (1965) 0.76
Mechanisms of antifibrotic action of interferon gamma-1b in pulmonary fibrosis. Wien Klin Wochenschr (2000) 0.76
High salt intake blunts plasma catecholamine and renin responses to exercise: less suppressive epinephrine in borderline essential hypertension. J Cardiovasc Pharmacol (1984) 0.76
The role of 3',5'-AMP system in amino acid transport across the blood-brain barrier. Acta Biol Med Ger (1974) 0.76
Ca(2+)-channel blockers modulate the expression of interleukin-6 and interleukin-8 genes in human vascular smooth muscle cells. J Mol Cell Cardiol (1995) 0.76
Aerosolised iloprost improves pulmonary haemodynamics in patients with primary pulmonary hypertension receiving continuous epoprostenol treatment. Thorax (2001) 0.75
Anionic gels as vehicles for electrically-modulated drug delivery. I. Solvent and drug transport phenomena. Pharm Res (1996) 0.75
Participation of adrenergic mechanisms in brain acetylcholine release produced by centrophenoxine. Acta Physiol Pharmacol Bulg (1979) 0.75
Bulgarian traditional medicine: a source of ideas for phytopharmacological investigations. J Ethnopharmacol (1986) 0.75
Facile synthesis of a chitosan hybrid of a laminin-related peptide and its antimetastatic effect in mice. J Pharm Pharmacol (2000) 0.75
[Histological aspects of amenorrhea]. Akush Ginekol (Sofiia) (1972) 0.75
[The chemistry and pharmacology of flavonoid fractions with a hypotensive effect isolated from wild geraniums]. Eksp Med Morfol (1972) 0.75
[On the effect of certain psychopharmacological drugs on the function of the adrenal cortex]. Probl Endokrinol Gormonoter (1969) 0.75
Comparative studies of colon reactivity of healthy and ionization-radiated guinea-pigs to some spasmogens and their antagonists. Acta Physiol Pharmacol Bulg (1978) 0.75
Ontogenetic development of 3,5-adenosine monophosphate phosphodiesterase in guinea pig and rat ileum. Acta Biol Med Ger (1979) 0.75
[A study on the addictive action of pentazocine]. Eksp Med Morfol (1974) 0.75
[Decubital lesions]. Stomatologiia (Sofiia) (1973) 0.75
Role of calcium in the mechanism of action of the prostaglandins E1 and F2 alpha as well as of their antagonist polyphloretin phosphate (PPP). Acta Physiol Pharmacol Bulg (1978) 0.75
Effect of acute radiation sickness on the reactivity of guinea-pig colon and rabbit duodenum to acetylcholine, histamine and serotonin, and to their combinations with benactyzine and pyrimetine. Acta Physiol Pharmacol Bulg (1978) 0.75
[The effect of some neurotropic substances on the permeability of the placental barrier]. Akush Ginekol (Sofiia) (1966) 0.75
Effect of centrophenoxine on acetylcholine release in perfused cerebral ventricles of cats under dynamic electrophysiological control. Acta Physiol Pharmacol Bulg (1979) 0.75
Behavioural reactions and changes in the spontaneous and evoked EEG-activity upon microinjection of noradrenaline and isoprenaline in cat nucleus raphe dorsalis. Acta Physiol Pharmacol Bulg (1979) 0.75
The character of the antagonism by polyphloretin phosphate of contractions to prostaglandins E1 and F 2alpha in guinea-pig ileum. J Pharm Pharmacol (1978) 0.75
[Effect of ionizing radiation on cerebral phosphodiesterase]. Eksp Med Morfol (1978) 0.75