| Rank |
Title |
Year |
PubWeight™‹?› |
|
1
|
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group.
|
1993
|
102.56
|
|
2
|
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
|
2002
|
101.79
|
|
3
|
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.
|
2005
|
74.55
|
|
4
|
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
|
2004
|
71.08
|
|
5
|
Prevention of HIV-1 infection with early antiretroviral therapy.
|
2011
|
69.36
|
|
6
|
Improved survival with ipilimumab in patients with metastatic melanoma.
|
2010
|
67.34
|
|
7
|
Vitamin D deficiency.
|
2007
|
59.34
|
|
8
|
Atherosclerosis--an inflammatory disease.
|
1999
|
59.28
|
|
9
|
A gene-expression signature as a predictor of survival in breast cancer.
|
2002
|
58.15
|
|
10
|
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.
|
2001
|
56.11
|
|
11
|
Sorafenib in advanced hepatocellular carcinoma.
|
2008
|
54.30
|
|
12
|
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
|
1998
|
53.26
|
|
13
|
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
|
2012
|
52.99
|
|
14
|
Early goal-directed therapy in the treatment of severe sepsis and septic shock.
|
2001
|
51.99
|
|
15
|
The quality of health care delivered to adults in the United States.
|
2003
|
50.33
|
|
16
|
Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.
|
2010
|
50.17
|
|
17
|
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.
|
2004
|
49.19
|
|
18
|
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.
|
2004
|
49.02
|
|
19
|
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network.
|
2000
|
48.03
|
|
20
|
Effects of intensive glucose lowering in type 2 diabetes.
|
2008
|
47.90
|
|
21
|
Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.
|
1995
|
47.15
|
|
22
|
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma.
|
2009
|
46.35
|
|
23
|
Improved survival with vemurafenib in melanoma with BRAF V600E mutation.
|
2011
|
45.46
|
|
24
|
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.
|
2001
|
44.67
|
|
25
|
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
|
2012
|
44.56
|
|
26
|
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
|
2008
|
43.36
|
|
27
|
Emergence of a novel swine-origin influenza A (H1N1) virus in humans.
|
2009
|
42.75
|
|
28
|
Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group.
|
2000
|
41.18
|
|
29
|
Computed tomography--an increasing source of radiation exposure.
|
2007
|
41.06
|
|
30
|
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
|
2004
|
41.02
|
|
31
|
Intensive insulin therapy in critically ill patients.
|
2001
|
40.00
|
|
32
|
Dabigatran versus warfarin in patients with atrial fibrillation.
|
2009
|
39.97
|
|
33
|
Adherence to medication.
|
2005
|
39.77
|
|
34
|
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma.
|
2007
|
39.39
|
|
35
|
An association between air pollution and mortality in six U.S. cities.
|
1993
|
38.84
|
|
36
|
Incidence of adverse events and negligence in hospitalized patients. Results of the Harvard Medical Practice Study I.
|
1991
|
38.78
|
|
37
|
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
|
2008
|
38.76
|
|
38
|
Reduced lung-cancer mortality with low-dose computed tomographic screening.
|
2011
|
38.61
|
|
39
|
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.
|
2010
|
36.78
|
|
40
|
Inhibition of mutated, activated BRAF in metastatic melanoma.
|
2010
|
36.57
|
|
41
|
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection.
|
2002
|
36.55
|
|
42
|
Staphylococcus aureus infections.
|
1998
|
36.39
|
|
43
|
Screening and prostate-cancer mortality in a randomized European study.
|
2009
|
35.94
|
|
44
|
The occurrence of sleep-disordered breathing among middle-aged adults.
|
1993
|
35.93
|
|
45
|
Rehospitalizations among patients in the Medicare fee-for-service program.
|
2009
|
35.68
|
|
46
|
10-year follow-up of intensive glucose control in type 2 diabetes.
|
2008
|
35.49
|
|
47
|
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.
|
2003
|
35.39
|
|
48
|
Tumor angiogenesis: therapeutic implications.
|
1971
|
35.36
|
|
49
|
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
|
2012
|
35.24
|
|
50
|
The spread of obesity in a large social network over 32 years.
|
2007
|
34.75
|