Gene transfer for cystic fibrosis.

A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia. Proc Natl Acad Sci U S A (2005) 1.17

Human coronavirus 229E infects polarized airway epithelia from the apical surface. J Virol (2000) 1.17

CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivo. Proc Natl Acad Sci U S A (2002) 0.98

Vesicular stomatitis virus G-pseudotyped lentivirus vectors mediate efficient apical transduction of polarized quiescent primary alveolar epithelial cells. J Virol (2001) 0.98

Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia. J Clin Invest (2000) 0.87

Heterogeneous spectrum of CFTR gene mutations in Korean patients with cystic fibrosis. Korean J Lab Med (2011) 0.87

Jaagsiekte sheep retrovirus Env protein stabilizes retrovirus vectors against inactivation by lung surfactant, centrifugation, and freeze-thaw cycling. J Virol (2001) 0.84

GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon. J Membr Biol (2003) 0.84

Bronchoalveolar fluid is not a major hindrance to virus-mediated gene therapy in cystic fibrosis. J Virol (2002) 0.80

A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells. PLoS One (2012) 0.77

CpG motifs in bacterial DNA trigger direct B-cell activation. Nature (1995) 12.24

Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J Virol (1998) 8.45

An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol (1998) 3.32

Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer. J Virol (1998) 3.25

Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia. J Biol Chem (1999) 3.04

Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis. Nat Genet (1992) 2.79

Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types. Nat Biotechnol (1996) 2.69

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nat Genet (1998) 2.65

Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo. J Clin Invest (1998) 2.51

Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol (1996) 1.99

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake. Proc Natl Acad Sci U S A (1994) 1.98

Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus. J Clin Invest (1999) 1.56

Influence of cell polarity on retrovirus-mediated gene transfer to differentiated human airway epithelia. J Virol (1998) 1.46

RGD inclusion in the hexon monomer provides adenovirus type 5-based vectors with a fiber knob-independent pathway for infection. J Virol (1999) 1.37

Monomolecular collapse of plasmid DNA into stable virus-like particles. Proc Natl Acad Sci U S A (1998) 1.28

Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manifestations of cystic fibrosis. J Clin Invest (1992) 1.13

Engineering novel cell surface receptors for virus-mediated gene transfer. J Biol Chem (1999) 1.03

A chimeric type 2 adenovirus vector with a type 17 fiber enhances gene transfer to human airway epithelia. J Virol (1999) 1.02