Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia.

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Published in J Biol Chem on April 09, 1999

Authors

R W Walters1, T Grunst, J M Bergelson, R W Finberg, M J Welsh, J Zabner

Author Affiliations

1: Departments of Internal Medicine, Howard Hughes Medical Institute, Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.

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Calcium-activated potassium channels in canine airway smooth muscle. J Physiol (1986) 1.87

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Ca2+-dependent regulator. Production and characterization of a monospecific antibody. J Biol Chem (1978) 1.80

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