Published in J Clin Invest on November 01, 1999
Increased islet apoptosis in Pdx1+/- mice. J Clin Invest (2003) 2.91
Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications. Rev Diabet Stud (2012) 1.42
A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis. Mol Genet Metab (2007) 1.38
A novel hypomorphic PDX1 mutation responsible for permanent neonatal diabetes with subclinical exocrine deficiency. Diabetes (2009) 1.34
Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am J Hum Genet (2001) 1.26
MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3. Mol Cell Biol (2007) 1.18
Research resource: the pdx1 cistrome of pancreatic islets. Mol Endocrinol (2012) 1.17
Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1. J Clin Invest (2001) 1.15
Pdx1 and other factors that regulate pancreatic beta-cell survival. Diabetes Obes Metab (2009) 1.09
The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci U S A (2007) 1.08
Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes. Nat Clin Pract Endocrinol Metab (2008) 1.07
Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism. Mol Cell Biol (2008) 1.07
Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies. Int J Endocrinol (2014) 1.04
Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. Mol Cell Biol (2004) 1.04
Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase. Proteins (2010) 1.03
Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes. J Clin Invest (2010) 1.02
Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc Natl Acad Sci U S A (2011) 0.99
Genomic sequencing of key genes in mouse pancreatic cancer cells. Curr Mol Med (2012) 0.96
Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus. Diabetes (2013) 0.94
RB regulates pancreas development by stabilizing Pdx1. EMBO J (2011) 0.93
Parallel retention of Pdx2 genes in cartilaginous fish and coelacanths. Mol Biol Evol (2010) 0.93
Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans. BMC Med Genet (2005) 0.90
Fetal PGC-1α overexpression programs adult pancreatic β-cell dysfunction. Diabetes (2012) 0.89
HNF1A gene polymorphisms and cardiovascular risk factors in individuals with late-onset autosomal dominant diabetes: a cross-sectional study. Cardiovasc Diabetol (2009) 0.89
Mechanisms of non-apoptotic programmed cell death in diabetes and heart failure. Cell Cycle (2010) 0.88
Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes. Cell Stem Cell (2016) 0.87
Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes. Diabet Med (2011) 0.84
Generating NMR chemical shift assignments of intrinsically disordered proteins using carbon-detected NMR methods. Anal Biochem (2013) 0.82
Birth weight and risk of type 2 diabetes in the black women's health study: does adult BMI play a mediating role? Diabetes Care (2014) 0.82
Vertically integrated translational studies of PDX1 as a therapeutic target for pancreatic cancer via a novel bifunctional RNAi platform. Cancer Gene Ther (2014) 0.82
Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment. Sci Rep (2015) 0.82
Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice. Am J Physiol Gastrointest Liver Physiol (2011) 0.81
Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression. Biochem J (2002) 0.80
Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta Cells. Front Endocrinol (Lausanne) (2015) 0.78
Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev (2016) 0.78
Tshz1 Regulates Pancreatic β-Cell Maturation. Diabetes (2015) 0.77
Complexity of type 2 diabetes mellitus data sets emerging from nutrigenomic research: a case for dimensionality reduction? Mutat Res (2007) 0.77
Role of pancreatic transcription factors in maintenance of mature β-cell function. Int J Mol Sci (2015) 0.77
The genetics of type 2 diabetes. Br J Clin Pharmacol (2001) 0.76
Replication of Interactions between Genome-Wide Genetic Variants and Body Mass Index in Fasting Glucose and Insulin Levels. Genomics Inform (2014) 0.75
Intestinal Pdx1 mediates nutrient metabolism gene networks and maternal expression is essential for perinatal growth in mice. Biochem Biophys Res Commun (2012) 0.75
The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion. PLoS One (2013) 0.75
Genomic organisation of the seven ParaHox genes of coelacanths. J Exp Zool B Mol Dev Evol (2013) 0.75
Type 2 diabetes mellitus and its complications: from the molecular biology to the clinical practice. Rev Diabet Stud (2004) 0.75
Insulin-promoter-factor 1 is required for pancreas development in mice. Nature (1994) 10.13
Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1) Nature (1996) 6.72
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet (1997) 5.47
IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J (1993) 5.46
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature (1996) 5.32
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev (1998) 5.25
Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet (1997) 4.40
Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY. Nat Genet (1997) 4.19
Linkage of type 2 diabetes to the glucokinase gene. Lancet (1992) 2.64
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature (1992) 2.59
Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol (1996) 2.14
An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). Mol Cell Biol (1998) 1.72
Regulatory factor linked to late-onset diabetes? Nature (1998) 1.55
XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol Endocrinol (1994) 1.54
Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells. J Biol Chem (1999) 1.53
Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest (1998) 1.51
Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K. Diabetes (1997) 1.29
PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes (1996) 1.27
Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Proc Natl Acad Sci U S A (1996) 1.23
Functional characterization of the transactivation properties of the PDX-1 homeodomain protein. Mol Cell Biol (1997) 1.21
Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene. Endocrinology (1996) 1.04
Mutations in hepatocyte nuclear factor 1beta are not a common cause of maturity-onset diabetes of the young in the U.K. Diabetes (1998) 0.98
Insulin promoter factor 1 gene is not a major cause of maturity-onset diabetes of the young in French Caucasians. Diabetes (1998) 0.91
Impaired expression of transcription factor IUF1 in a pancreatic beta-cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis). FEBS Lett (1997) 0.91
Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene. Diabetes (1996) 0.81
Mutations in the coding region of the insulin promoter factor 1 gene are not a common cause of maturity-onset diabetes of the young in Japanese subjects. Diabetes (1998) 0.79
The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum (1990) 27.50
Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med (2001) 10.54
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Proc Natl Acad Sci U S A (1993) 9.47
A standardized psychiatric interview for use in community surveys. Br J Prev Soc Med (1970) 9.38
Tracing European founder lineages in the Near Eastern mtDNA pool. Am J Hum Genet (2000) 7.06
Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation (1996) 6.20
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol (1999) 5.43
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature (1996) 5.32
The Serostatus Approach to Fighting the HIV Epidemic: prevention strategies for infected individuals. Am J Public Health (2001) 5.32
Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med (1999) 5.01
A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severity. J Med Genet (1989) 4.42
Paleolithic and neolithic lineages in the European mitochondrial gene pool. Am J Hum Genet (1996) 4.23
Maturity-onset diabetes of the young (MODY): how many cases are we missing? Diabetologia (2010) 4.13
Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation (1994) 3.44
Post-translational proteolysis in polypeptide hormone biosynthesis. Annu Rev Physiol (1982) 3.43
A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet (2001) 3.26
Effect of luminal growth factor preservation on intestinal growth. Lancet (1993) 3.25
Increasing body weight predicts the earlier onset of insulin-dependant diabetes in childhood: testing the 'accelerator hypothesis' (2). Diabet Med (2005) 3.21
Mental health care in the community: an evaluative study. Psychol Med (1975) 3.13
Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation (1996) 3.07
Cardiovascular disease and mortality in a community-based cohort with mild renal insufficiency. Kidney Int (1999) 2.95
The development of a computerized assessment for minor psychiatric disorder. Psychol Med (1988) 2.95
Corn pollen deposition on milkweeds in and near cornfields. Proc Natl Acad Sci U S A (2001) 2.94
A study of the classification of mental ill-health in general practice. Psychol Med (1985) 2.88
Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension (1998) 2.86
Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction. N Engl J Med (1997) 2.81
Copper metallothionein of yeast, structure of the gene, and regulation of expression. Proc Natl Acad Sci U S A (1984) 2.74
Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. Am J Cardiol (2001) 2.57
Mutations in the glucokinase gene of the fetus result in reduced birth weight. Nat Genet (1998) 2.53
Structure of HIV-1 reverse transcriptase/DNA complex at 7 A resolution showing active site locations. Nature (1992) 2.52
Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study) Am J Cardiol (1999) 2.51
Birth of a relativistic outflow in the unusual γ-ray transient Swift J164449.3+573451. Nature (2011) 2.47
Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young. Diabetologia (2008) 2.44
ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. J Thromb Haemost (2007) 2.38
Feasibility of pooling sera for HIV-1 viral RNA to diagnose acute primary HIV-1 infection and estimate HIV incidence. AIDS (2000) 2.37
Thrombophilia in pregnancy: a systematic review. Br J Haematol (2006) 2.33
Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nat Genet (2000) 2.28
Prognosis after the onset of coronary heart disease. An investigation of differences in outcome between the sexes according to initial coronary disease presentation. Circulation (1993) 2.27
Mutations in hepatocyte nuclear factor-1beta and their related phenotypes. J Med Genet (2005) 2.24
Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype. Diabetologia (2006) 2.24
Prognosis after first myocardial infarction. Comparison of Q-wave and non-Q-wave myocardial infarction in the Framingham Heart Study. JAMA (1992) 2.22
Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study. Clin Pharmacol Ther (2010) 2.22
Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia (2006) 2.14
Distribution and categorization of echocardiographic measurements in relation to reference limits: the Framingham Heart Study: formulation of a height- and sex-specific classification and its prospective validation. Circulation (1997) 2.14
Improved genetic testing for monogenic diabetes using targeted next-generation sequencing. Diabetologia (2013) 2.13
Antibiotic susceptibility profiles for group B streptococci isolated from neonates, 1995-1998. Clin Infect Dis (2000) 2.10
The association of chronic cough with the risk of myocardial infarction: the Framingham Heart Study. Am J Med (1999) 2.09
Epidemiologic and microbiologic correlates of Chlamydia trachomatis infection in sexual partnerships. JAMA (1996) 2.07
Mount st. Helens ash from the 18 may 1980 eruption: chemical, physical, mineralogical, and biological properties. Science (1980) 2.06
Left ventricular mass and risk of stroke in an elderly cohort. The Framingham Heart Study. JAMA (1994) 2.03
Letter: Post-herpes zoster neuralgia: response to vitamin E therapy. Arch Dermatol (1973) 2.02
The Wessex Growth Study: first report. Acta Paediatr Scand Suppl (1989) 2.02
Capsular polysaccharide types of group B streptococcal isolates from neonates with early-onset systemic infection. J Infect Dis (1998) 2.01
The genetic abnormality in the beta cell determines the response to an oral glucose load. Diabetologia (2002) 1.99
A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young. Hum Mol Genet (2001) 1.98
Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes. Diabetes (1999) 1.97
Erosion of incisors in cattle on self-fed silage with enzyme additive. Vet Rec (1992) 1.94
Golgi/granule processing of peptide hormone and neuropeptide precursors: a minireview. J Cell Biochem (1984) 1.93
Sugar transport in rat liver lysosomes. Direct demonstration by using labelled sugars. Biochem J (1983) 1.90
The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes. Diabetologia (2012) 1.89
A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain. Neurology (2007) 1.89
Blood pressure response during treadmill testing as a risk factor for new-onset hypertension. The Framingham heart study. Circulation (1999) 1.87
Links between passive smoking and disease: a best-evidence synthesis. A report of the Working Group on Passive Smoking. Clin Invest Med (1990) 1.87
Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta. Kidney Int (2000) 1.87
An evaluation of continuation therapy with tricyclic antidepressants in depressive illness. Psychol Med (1973) 1.85
Positive and negative regulation of the human insulin gene by multiple trans-acting factors. J Biol Chem (1990) 1.84
The relationship between eye movements and spatial attention. Q J Exp Psychol A (1986) 1.82
Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation. Diabet Med (2008) 1.82
Echocardiographic features of the right heart in sleep-disordered breathing: the Framingham Heart Study. Am J Respir Crit Care Med (2001) 1.81
Determinants of heart rate variability. J Am Coll Cardiol (1996) 1.79
Prevalence and clinical implications of the inter-arm blood pressure difference: A systematic review. J Hum Hypertens (2006) 1.77
First UK survey of paediatric type 2 diabetes and MODY. Arch Dis Child (2004) 1.70
Differential control of systolic and diastolic blood pressure : factors associated with lack of blood pressure control in the community. Hypertension (2000) 1.70
Association of blood pressure with fibrinolytic potential in the Framingham offspring population. Circulation (2000) 1.70
Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease. Proc Natl Acad Sci U S A (1982) 1.70
Referral rates for diagnostic testing support an incidence of permanent neonatal diabetes in three European countries of at least 1 in 260,000 live births. Diabetologia (2009) 1.70
Islet autoantibodies can discriminate maturity-onset diabetes of the young (MODY) from Type 1 diabetes. Diabet Med (2011) 1.68
Prophylactic lithium: another therapeutic myth? An examination of the evidence to date. Lancet (1968) 1.66
The contribution of the intrinsic muscles to grip and pinch strength. J Hand Surg Am (1999) 1.66
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J Mol Biol (1996) 1.65