Published in J Clin Invest on July 01, 2001
Increased islet apoptosis in Pdx1+/- mice. J Clin Invest (2003) 2.91
Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci U S A (2002) 2.20
Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest (2002) 1.95
Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY) (2011) 1.39
A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis. Mol Genet Metab (2007) 1.38
Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proc Natl Acad Sci U S A (2003) 1.19
Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. Mol Cell Biol (2004) 1.04
Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes (2012) 0.99
Modeling multiple sclerosis in laboratory animals. Semin Immunopathol (2009) 0.94
Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2. Mol Cell Biol (2006) 0.88
β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia. Int J Endocrinol (2011) 0.84
Biallelic PDX1 (insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency. Diabet Med (2013) 0.82
A new mouse model for temporal- and tissue-specific control of extracellular superoxide dismutase. Genesis (2009) 0.82
Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cells. Biochem J (2007) 0.82
Conditional gene expression systems in the transgenic rat brain. BMC Biol (2012) 0.81
PDX-1 interaction and regulation of the Pancreatic Derived Factor (PANDER, FAM3B) promoter. Biochim Biophys Acta (2008) 0.79
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A (1992) 35.45
Transcriptional activation by tetracyclines in mammalian cells. Science (1995) 13.90
Simplified mammalian DNA isolation procedure. Nucleic Acids Res (1991) 12.56
Insulin-promoter-factor 1 is required for pancreas development in mice. Nature (1994) 10.13
Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature (1985) 9.78
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development (1996) 9.58
Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature (1988) 8.74
Mitotic misregulation and human aging. Science (2000) 8.47
Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology (1990) 6.34
Sir2 links chromatin silencing, metabolism, and aging. Genes Dev (2000) 5.95
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A (1996) 5.93
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet (1997) 5.47
IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J (1993) 5.46
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev (1998) 5.25
Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science (2000) 4.53
Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet (1997) 4.40
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell (1997) 4.20
Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes (1995) 3.47
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01
Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev (1992) 2.86
Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol (1993) 2.57
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes (2000) 2.50
Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 2.39
Maintenance of functional equivalence during paralogous Hox gene evolution. Nature (2000) 2.24
Gene transfer into mouse embryos: production of transgenic mice by pronuclear injection. Methods Enzymol (1983) 2.23
Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol (1996) 2.14
The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes. Mol Cell Biol (1992) 1.97
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest (1999) 1.89
Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol Endocrinol (1994) 1.89
Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. J Clin Invest (1999) 1.60
Regulatory factor linked to late-onset diabetes? Nature (1998) 1.55
The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Mol Cell Biol (2000) 1.55
Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. J Biol Chem (1997) 1.53
The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression. Mol Endocrinol (1995) 1.52
Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest (1998) 1.51
Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. Proc Natl Acad Sci U S A (1995) 1.45
Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol Cell Biol (1997) 1.43
Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology (1999) 1.41
Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription. Mol Cell Biol (1999) 1.38
Transcribing pancreas. Diabetes (1998) 1.36
Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression. Mol Cell Biol (2000) 1.31
PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes (1996) 1.27
Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc Natl Acad Sci U S A (1996) 1.27
Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus. J Clin Invest (1998) 1.24
Glucose induces insulin gene transcription in a murine pancreatic beta-cell line. J Biol Chem (1991) 1.19
Effects of gender on neuroendocrine and metabolic counterregulatory responses to exercise in normal man. J Clin Endocrinol Metab (2000) 1.18
Hedgehog signaling regulation of insulin production by pancreatic beta-cells. Diabetes (2000) 1.14
Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene). Diabetes (2000) 1.09
Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy. Diabetes (1997) 1.07
Stabilization of plasma glucose during fasting; Normal variations in two separate studies. N Engl J Med (1974) 1.03
Gender differences in counterregulation to hypoglycaemia. Diabetologia (1993) 1.01
Relative roles of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycaemia in male and female humans. Diabetologia (1994) 1.00
Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. Endocrinology (1999) 0.98
Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression. Trends Endocrinol Metab (2008) 0.96
Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats. Am J Physiol (1995) 0.95
The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers. Dev Biol (1997) 0.92
Effects of insulin on the counterregulatory response to equivalent hypoglycemia in normal females. Am J Physiol (1993) 0.89
Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells. Endocrinology (2001) 0.86
Oligonucleotide-mediated modulation of mammalian gene expression. FASEB J (1995) 0.82
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev (1992) 7.66
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet (1997) 5.47
Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science (1988) 5.29
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes (1999) 5.10
Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques (1990) 5.02
Natural genetic transformation of Streptococcus mutans growing in biofilms. J Bacteriol (2001) 4.50
Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study. Leukemia (2011) 4.47
Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet (1997) 4.40
The joining of ribosomal subunits in eukaryotes requires eIF5B. Nature (2000) 4.01
Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature (1998) 3.77
Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J Neurosci (1999) 3.73
The glucagon-like peptides. Endocr Rev (1999) 3.51
Retracted Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains. EMBO J (1990) 3.29
Bronchoscopic assessment of the evolution of endobronchial tuberculosis. Chest (2000) 3.24
Pre-proparathyroid hormone: a direct translation product of parathyroid messenger RNA. Proc Natl Acad Sci U S A (1974) 3.24
Germline and somatic transformation of mating Tetrahymena thermophila by particle bombardment. Genetics (1997) 3.04
Survey of extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea. J Clin Microbiol (1999) 3.04
Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol (1996) 2.98
Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes (2001) 2.95
B cell differentiation and isotype switching is related to division cycle number. J Exp Med (1996) 2.90
IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J (1994) 2.89
The prevalence of premature ejaculation and its clinical characteristics in Korean men according to different definitions. Int J Impot Res (2012) 2.88
Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci U S A (1987) 2.79
Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Immunity (1995) 2.74
A menopause-specific quality of life questionnaire: development and psychometric properties. Maturitas (1996) 2.74
Localization of a gene for partial epilepsy to chromosome 10q. Nat Genet (1995) 2.72
Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest (1987) 2.70
PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins. J Biol Chem (2001) 2.67
Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord. J Neurosci (1995) 2.62
High-level expression of M13 gene II protein from an inducible polycistronic messenger RNA. Gene (1985) 2.56
Risk of death from intercurrent disease is not excessively increased by modern postoperative radiotherapy for high-risk resected non-small-cell lung carcinoma. J Clin Oncol (2001) 2.55
Viral kinetics in patients with chronic hepatitis C treated with standard or peginterferon alpha2a. Gastroenterology (2001) 2.53
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature (1993) 2.52
Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo. J Clin Invest (1998) 2.51
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes (2000) 2.50
Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab (2001) 2.49
Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. Circ Res (1998) 2.49
Association of the metabolic syndrome with intracranial atherosclerotic stroke. Neurology (2005) 2.45
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes (1999) 2.44
Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins. Proc Natl Acad Sci U S A (1988) 2.40
An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. Proc Natl Acad Sci U S A (1994) 2.38
Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Mol Cell Biol (2000) 2.36
Malaria situation analysis and stratification in bandar abbas county, southern iran, 2004-2008. Iran J Arthropod Borne Dis (2010) 2.34
Ultrafast x-ray diffraction of transient molecular structures in solution. Science (2005) 2.29
Adding posterior lumbar interbody fusion to pedicle screw fixation and posterolateral fusion after decompression in spondylolytic spondylolisthesis. Spine (Phila Pa 1976) (1997) 2.26
Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene (2008) 2.26
Pre-proparathyroid hormone: analysis of radioactive tryptic peptides and amino acid sequence. Biochemistry (1976) 2.25
Increased risk of Alzheimer's disease in mothers of adults with Down's syndrome. Lancet (1994) 2.24
Odontogenic keratocyst: Review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2001) 2.23
Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem (1986) 2.22
Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects. Diabetes Care (1992) 2.21
Cyclic adenosine 3',5'-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocr Rev (1993) 2.21
A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Hum Immunol (2000) 2.21
Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast. Science (1998) 2.20
Effects of different hematocrit levels on glucose measurements with handheld meters for point-of-care testing. Arch Pathol Lab Med (2000) 2.17
Randomised clinical trial: the effects of Helicobacter pylori eradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer. Aliment Pharmacol Ther (2013) 2.17
Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin 2 (MFN2) mutations. Brain (2006) 2.16
Patterns of sensory dysfunction in lateral medullary infarction. Clinical-MRI correlation. Neurology (1997) 2.15
Clinical outcomes of endoscopic submucosal dissection (ESD) for treating early gastric cancer: comparison with endoscopic mucosal resection after circumferential precutting (EMR-P). Dig Liver Dis (2008) 2.11
C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci U S A (1993) 2.09
Pre-proparathyroid hormone; amino acid sequence, chemical synthesis, and some biological studies of the precursor region. Proc Natl Acad Sci U S A (1978) 2.07
Pulmonary tuberculosis: CT findings--early active disease and sequential change with antituberculous therapy. Radiology (1993) 2.06
Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology (1996) 2.06
Parathyroid hormone: secretion and metabolism in vivo. Proc Natl Acad Sci U S A (1971) 2.04
Single photon emission computed tomography-EEG relations in temporal lobe epilepsy. Neurology (1997) 2.03
Proparathyroid hormone: identification of a biosynthetic precursor to parathyroid hormone. Proc Natl Acad Sci U S A (1972) 1.97
Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes (1997) 1.96
Specificity of cotranslational amino-terminal processing of proteins in yeast. Biochemistry (1987) 1.95
Oxygen effects on glucose meter measurements with glucose dehydrogenase- and oxidase-based test strips for point-of-care testing. Crit Care Med (2001) 1.94
Atypical manifestations of reversible posterior leukoencephalopathy syndrome: findings on diffusion imaging and ADC mapping. Neuroradiology (2004) 1.94
Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A (1984) 1.93
Structural determinants for transcriptional activation by cAMP-responsive DNA elements. J Biol Chem (1988) 1.93
Comparison of endoscopic and robotic thyroidectomy. Ann Surg Oncol (2010) 1.93
Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene (1994) 1.91
EBUS-TBNA in the differential diagnosis of pulmonary artery sarcoma and thromboembolism. Eur Respir J (2011) 1.90
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest (1999) 1.89
Chemotherapeutic trial to control enterobiasis in schoolchildren. Korean J Parasitol (1997) 1.86
Expression of androgen receptors in primary breast cancer. Ann Oncol (2009) 1.85
A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families. JAMA (2001) 1.82
Aspirin use and bleeding risk after endoscopic submucosal dissection in patients with gastric neoplasms. Endoscopy (2012) 1.81
An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene. Mol Cell Biol (1990) 1.81
Carbapenem resistance mechanisms in Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother (2001) 1.81
Allelotype of human ovarian cancer. Cancer Res (1991) 1.79
Phylogenetic analysis of hepatitis C virus isolates and their correlation to viremia, liver function tests, and histology. Hepatology (1996) 1.77
Parathyroid Hormone in Human Plasma: IMMUNOCHEMICAL CHARACTERIZATION AND BIOLOGICAL IMPLICATIONS. J Clin Invest (1972) 1.77
Analysis of errors in medical rapid prototyping models. Int J Oral Maxillofac Surg (2002) 1.76
Point-of-care glucose testing: effects of critical care variables, influence of reference instruments, and a modular glucose meter design. Arch Pathol Lab Med (2000) 1.76
Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression. J Biol Chem (1987) 1.75
Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women. Int J Obes (Lond) (2006) 1.74
Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J Clin Invest (1986) 1.73
Isolation of ara-lac gene fusions in Salmonella typhimurium LT2 by using transducing bacteriophage Mu d (Apr lac). J Bacteriol (1980) 1.72
Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa. Hepatology (1997) 1.72
Reliability of seizure classification using a semistructured interview. Neurology (1993) 1.71
Non-surgical management of microperforation induced by EMR of the stomach. Dig Liver Dis (2006) 1.71
Prevalence of mental retardation and developmental disabilities: estimates from the 1994/1995 National Health Interview Survey Disability Supplements. Am J Ment Retard (2001) 1.70
Management of treatment-emergent peripheral neuropathy in multiple myeloma. Leukemia (2011) 1.70
Spectrum of lateral medullary syndrome. Correlation between clinical findings and magnetic resonance imaging in 33 subjects. Stroke (1994) 1.67
Pre-proparathyroid hormone. Evidence for an early biosynthetic precursor of proparathyroid hormone. J Biol Chem (1976) 1.67