PubRank

J M Huibregtse

Author PubWeight™ 79.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990 20.60
2 The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 1993 12.41
3 Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature 1995 5.89
4 Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science 1999 4.21
5 In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res 1996 3.50
6 Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc Natl Acad Sci U S A 1994 3.12
7 The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO J 1992 2.97
8 Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol Cell Biol 2000 2.79
9 Rhabdoviruses and the cellular ubiquitin-proteasome system: a budding interaction. J Virol 2001 2.66
10 Functional domains of the Rsp5 ubiquitin-protein ligase. Mol Cell Biol 1999 2.15
11 The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells. J Biol Chem 1998 2.07
12 A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci U S A 1995 1.81
13 Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. Mol Cell Biol 1999 1.66
14 Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products. Cancer Surv 1992 1.63
15 Direct identification of small sequence changes in chromosomal DNA. Gene 1986 1.46
16 Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins. EMBO J 1992 1.43
17 Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins. J Virol 1992 1.41
18 Functions of human papillomavirus proteins. Curr Top Microbiol Immunol 1994 1.35
19 Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase. J Virol 2000 1.34
20 Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathway. Mol Cell Biol 2001 1.34
21 Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix. Br J Cancer 2004 1.30
22 The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing. Genomics 1997 1.24
23 Direct sequence and footprint analysis of yeast DNA by primer extension. Methods Enzymol 1991 1.08
24 Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J Biol Chem 2001 1.05
25 Cellular targets of the oncoproteins encoded by the cancer associated human papillomaviruses. Princess Takamatsu Symp 1991 0.92
26 Protein-DNA interactions in vivo--examining genes in Saccharomyces cerevisiae and Drosophila melanogaster by chromatin footprinting. Methods Cell Biol 1991 0.87