PubRank

J Massagué

Author PubWeight™ 374.44‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 1986 10.00
2 Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994 9.48
3 Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 1995 9.03
4 TGF beta signals through a heteromeric protein kinase receptor complex. Cell 1992 8.12
5 Mechanism of activation of the TGF-beta receptor. Nature 1994 8.10
6 Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 1996 6.67
7 TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest 1999 5.30
8 Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature 1996 5.21
9 A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev 1999 5.13
10 Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 1995 4.94
11 GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J 1995 4.63
12 Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 1997 4.41
13 A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 1996 4.36
14 Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol 2001 4.22
15 Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev 1995 4.19
16 Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell 1998 3.86
17 Type beta transforming growth factor is an inhibitor of myogenic differentiation. Proc Natl Acad Sci U S A 1986 3.83
18 Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. Cell 1994 3.74
19 TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol 2001 3.69
20 Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell 1990 3.61
21 Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 1999 3.59
22 Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem 1992 3.57
23 The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors. Cell 1987 3.52
24 Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell 1993 3.51
25 Betaglycan presents ligand to the TGF beta signaling receptor. Cell 1993 3.48
26 Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell 1999 3.47
27 Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev 1997 3.45
28 The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature 1993 3.45
29 Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev 1997 3.33
30 A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 1997 3.29
31 Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science 1993 3.28
32 The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev 1997 3.28
33 Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta. J Biol Chem 1987 3.25
34 Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat Cell Biol 1999 3.25
35 Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 1999 3.16
36 Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev 1998 3.16
37 OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell 2000 3.12
38 Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 1997 3.12
39 Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature 1995 3.11
40 A Smad transcriptional corepressor. Cell 1999 3.07
41 A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis. Proc Natl Acad Sci U S A 1992 2.92
42 The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol Cell 2001 2.87
43 The TGF-beta family of growth and differentiation factors. Cell 1987 2.86
44 Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol 1995 2.80
45 SMADs: mediators and regulators of TGF-beta signaling. Curr Opin Genet Dev 1998 2.76
46 Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system. Cell 1991 2.73
47 Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit. J Biol Chem 1989 2.71
48 The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor. J Biol Chem 1982 2.62
49 Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Mol Cell Biol 1994 2.59
50 Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev 1997 2.59
51 Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program. Proc Natl Acad Sci U S A 2001 2.55
52 Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination. Nat Genet 2000 2.53
53 Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. Nature 1997 2.51
54 The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction. Cell 1989 2.49
55 Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells. J Biol Chem 1983 2.42
56 Cell adhesion protein receptors as targets for transforming growth factor-beta action. Cell 1987 2.41
57 Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell 1992 2.40
58 The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev 1997 2.35
59 Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. J Biol Chem 1997 2.32
60 Transforming growth factor-beta inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor. J Biol Chem 1989 2.29
61 Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts. Proc Natl Acad Sci U S A 1985 2.28
62 Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans. J Biol Chem 1988 2.28
63 Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction. J Biol Chem 1990 2.24
64 Determinants of specificity in TGF-beta signal transduction. Genes Dev 1998 2.23
65 Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. J Biol Chem 1996 2.19
66 Two forms of transforming growth factor-beta distinguished by multipotential haematopoietic progenitor cells. Nature 1987 2.13
67 Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol Cell Biol 1995 2.08
68 TbetaR-I(6A) is a candidate tumor susceptibility allele. Cancer Res 1999 1.99
69 Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region. Mol Cell Biol 1993 1.98
70 Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta. J Cell Biol 1989 1.97
71 Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines. J Biol Chem 1985 1.96
72 Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. Mol Cell 2001 1.95
73 Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Cell 1994 1.94
74 Rapamycin resistance tied to defective regulation of p27Kip1. Mol Cell Biol 1996 1.89
75 Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms. J Biol Chem 1990 1.86
76 Cellular distribution of type I and type II receptors for transforming growth factor-beta. J Biol Chem 1986 1.82
77 Activation of signalling by the activin receptor complex. Mol Cell Biol 1996 1.79
78 TGF-beta receptors and actions. Biochim Biophys Acta 1994 1.78
79 Physical and functional interaction of SMADs and p300/CBP. J Biol Chem 1998 1.77
80 Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell 1994 1.76
81 Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells. Science 1988 1.72
82 Identification of receptors for type-beta transforming growth factor. Methods Enzymol 1987 1.72
83 Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors. J Biol Chem 1999 1.71
84 E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest. Mol Cell Biol 1999 1.71
85 Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II. J Biol Chem 1991 1.71
86 Glycogen synthase: a new activity ratio assay expressing a high sensitivity to the phosphorylation state. FEBS Lett 1979 1.69
87 Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family. Cell 1995 1.68
88 Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract. Cancer Res 1998 1.68
89 Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Science 2000 1.66
90 The antiproliferative effect of type beta transforming growth factor occurs at a level distal from receptors for growth-activating factors. J Biol Chem 1986 1.65
91 Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling. EMBO J 1996 1.61
92 Multiple modes of repression by the Smad transcriptional corepressor TGIF. J Biol Chem 1999 1.61
93 Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. J Cell Biol 1994 1.59
94 Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway. Mol Cell Biol 1999 1.57
95 Regulation of cell adhesion receptors by transforming growth factor-beta. Regulation of vitronectin receptor and LFA-1. J Biol Chem 1989 1.57
96 The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation. Nat Cell Biol 2000 1.55
97 The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors. EMBO J 1998 1.54
98 Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process. Proc Natl Acad Sci U S A 1991 1.53
99 The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGF alpha into soluble growth factor. Cell 1992 1.51
100 Stimulation by insulin-like growth factors is required for cellular transformation by type beta transforming growth factor. J Biol Chem 1985 1.47
101 The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor. J Biol Chem 1988 1.47
102 Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J 2001 1.47
103 Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism. J Cell Biol 1995 1.46
104 Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function. Mol Cell Biol 1991 1.43
105 Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. J Biol Chem 1999 1.42
106 Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation. Proc Natl Acad Sci U S A 1990 1.40
107 Epidermal growth factor-like transforming growth factor. I. Isolation, chemical characterization, and potentiation by other transforming factors from feline sarcoma virus-transformed rat cells. J Biol Chem 1983 1.38
108 Smad transcriptional corepressors in TGF beta family signaling. Curr Top Microbiol Immunol 2001 1.37
109 The Smad transcriptional corepressor TGIF recruits mSin3. Cell Growth Differ 2001 1.36
110 Role of transforming growth factor-beta in chondrogenic pattern formation in the embryonic limb: stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-beta and evidence for endogenous TGF-beta-like activity. Dev Biol 1991 1.35
111 Nomenclature: vertebrate mediators of TGFbeta family signals. Cell 1996 1.34
112 Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex. Mol Cell Biol 1994 1.32
113 Reconstitution and transphosphorylation of TGF-beta receptor complexes. EMBO J 1994 1.30
114 Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. J Biol Chem 1989 1.30
115 TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads. Mol Med Today 1998 1.30
116 Loss of receptors for transforming growth factor beta in human T-cell malignancies. Proc Natl Acad Sci U S A 1994 1.29
117 Multiple signals activate cleavage of the membrane transforming growth factor-alpha precursor. J Biol Chem 1991 1.28
118 Subunit structure of a high-affinity receptor for type beta-transforming growth factor. Evidence for a disulfide-linked glycosylated receptor complex. J Biol Chem 1985 1.28
119 Identification of a Drosophila activin receptor. Proc Natl Acad Sci U S A 1993 1.23
120 The high affinity insulin receptor mediates growth stimulation in rat hepatoma cells. J Biol Chem 1982 1.21
121 Identifying site-specific metastasis genes and functions. Cold Spring Harb Symp Quant Biol 2005 1.21
122 Role of disulfides in the subunit structure of the insulin receptor. Reduction of class I disulfides does not impair transmembrane signalling. J Biol Chem 1982 1.20
123 Binding of two growth factor families to separate domains of the proteoglycan betaglycan. J Biol Chem 1992 1.20
124 Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms. J Biol Chem 1992 1.18
125 Carboxy-terminally truncated Gli3 proteins associate with Smads. Nat Genet 1998 1.17
126 Transforming growth factor beta induces myoblast differentiation in the presence of mitogens. Proc Natl Acad Sci U S A 1992 1.16
127 The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons. Proc Natl Acad Sci U S A 1996 1.15
128 Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucose. FEBS Lett 1977 1.15
129 Transforming growth factor-beta (TGF-beta) receptor proteoglycan. Cell surface expression and ligand binding in the absence of glycosaminoglycan chains. J Biol Chem 1989 1.13
130 Role of the juxtamembrane domains of the transforming growth factor-alpha precursor and the beta-amyloid precursor protein in regulated ectodomain shedding. J Biol Chem 1997 1.12
131 Type beta transforming growth factor from feline sarcoma virus-transformed rat cells. Isolation and biological properties. J Biol Chem 1984 1.11
132 Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events. Mol Cell Biol 1991 1.10
133 Human platelet-derived transforming growth factor-beta stimulates parameters of bone growth in fetal rat calvariae. Endocrinology 1986 1.09
134 Integral membrane glycoprotein properties of the prohormone pro-transforming growth factor-alpha. Nature 1987 1.09
135 Heterodimeric transforming growth factor beta. Biological properties and interaction with three types of cell surface receptors. J Biol Chem 1988 1.08
136 Cell adhesion to collagen and decreased myogenic gene expression implicated in the control of myogenesis by transforming growth factor beta. J Biol Chem 1990 1.06
137 Evidence for the involvement of protein kinase activity in transforming growth factor-beta signal transduction. Mol Cell Biol 1992 1.04
138 Generation of transforming growth factor-alpha from the cell surface by an O-glycosylation-independent multistep process. J Biol Chem 1990 1.02
139 Juxtacrine cell signaling molecules. Curr Opin Cell Biol 1993 1.02
140 Biologically active precursor for transforming growth factor type alpha, released by retrovirally transformed cells. Proc Natl Acad Sci U S A 1986 1.01
141 Signaling activity of homologous and heterologous transforming growth factor-beta receptor kinase complexes. J Biol Chem 1995 1.01
142 Cyclins, Cdks, and cyclin kinase inhibitors. Cold Spring Harb Symp Quant Biol 1994 0.99
143 Internalization of transforming growth factor-beta and its receptor in BALB/c 3T3 fibroblasts. J Cell Physiol 1986 0.98
144 Cyclin-dependent kinase inhibitor p57KIP2 in soft tissue sarcomas and Wilms'tumors. Cancer Res 1996 0.97
145 Activated release of membrane-anchored TGF-alpha in the absence of cytosol. J Cell Biol 1993 0.97
146 Structural properties of a soluble bioactive precursor for transforming growth factor-alpha. J Biol Chem 1988 0.96
147 The inactivation of glycogen phosphorylase is not a prerequisite for the activation of liver glycogen synthase. FEBS Lett 1979 0.96
148 Transforming growth factor-beta modulates the high-affinity receptors for epidermal growth factor and transforming growth factor-alpha. J Cell Biol 1985 0.95
149 Characterization of high molecular weight transforming growth factor alpha produced by rat hepatocellular carcinoma cells. Biochemistry 1988 0.95
150 Purification of the transforming growth factor-beta (TGF-beta) binding proteoglycan betaglycan. J Biol Chem 1991 0.94
151 The type II TGF-beta receptor signals diverse responses in cooperation with the type I receptor. Cold Spring Harb Symp Quant Biol 1992 0.93
152 Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line. Cancer Res 2001 0.93
153 Interaction of transforming growth factor-beta receptor I with farnesyl-protein transferase-alpha in yeast and mammalian cells. J Biol Chem 1996 0.91
154 A surface component on GH3 pituitary cells that recognizes transforming growth factor-beta, activin, and inhibin. J Biol Chem 1988 0.91
155 Isoform-specific transforming growth factor-beta binding proteins with membrane attachments sensitive to phosphatidylinositol-specific phospholipase C. J Biol Chem 1991 0.90
156 Transforming growth factors. Isolation, characterization, and interaction with cellular receptors. Prog Med Virol 1985 0.89
157 Transforming growth factor receptor gene TGFBR2 maps to human chromosome band 3p22. Genomics 1994 0.87
158 Interrelationships among receptor structures for insulin and peptide growth factors. Fed Proc 1983 0.87
159 Neurotrophic factors. Crossing receptor boundaries. Nature 1996 0.86
160 Transforming growth factor-beta receptors and binding proteoglycans. J Cell Sci Suppl 1990 0.86
161 Genomic organization of the human p57KIP2 gene and its analysis in the G401 Wilms' tumor assay. Cancer Res 1996 0.86
162 Different sensitivity of the transforming growth factor-beta cell cycle arrest pathway to c-Myc and MDM-2. J Biol Chem 2000 0.85
163 BMP signaling and vertebrate limb development. Cold Spring Harb Symp Quant Biol 1997 0.84
164 Insulin counteraction of alpha-adrenergic effects on liver glycogen metabolism. Biochim Biophys Acta 1978 0.84
165 Wounding Smad. Nat Cell Biol 1999 0.83
166 Synthesis of glycogen from fructose in the presence of elevated levels of glycogen phosphorylase a in rat hepatocytes. Mol Cell Biochem 1980 0.80
167 Dexamethasone enhancement of betaglycan (TGF-beta type III receptor) gene expression in osteoblast-like cells. Exp Cell Res 1994 0.80
168 XTrR-I is a TGFbeta receptor and overexpression of truncated form of the receptor inhibits axis formation and dorsalising activity. Mech Dev 1998 0.80
169 Modulation of type alpha transforming growth factor receptors by a phorbol ester tumor promoter. J Cell Biochem 1985 0.79
170 Purification of type-alpha transforming growth factor from transformed cells. Methods Enzymol 1987 0.77
171 Networks of tumor suppressors. Workshop: tumor suppressor networks. EMBO Rep 2000 0.75
172 Multiple phosphorylation of rabbit muscle glycogen synthase by glycogen synthase kinase-1. Relationship between phosphorylation state and kinetic properties. FEBS Lett 1979 0.75
173 Identification of receptor proteins for type-alpha transforming growth factor. Methods Enzymol 1987 0.75