Published in Development on December 01, 1999
Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Dev (2002) 2.75
Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies. J Anat (2005) 2.58
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev (2002) 2.41
Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome. Proc Natl Acad Sci U S A (2000) 2.13
Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts. J Cell Biol (2000) 2.08
Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development. Development (2007) 2.01
Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome. Proc Natl Acad Sci U S A (2004) 2.01
Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol (2005) 2.00
Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. Nat Genet (2013) 1.87
Craniosynostosis. Eur J Hum Genet (2011) 1.84
A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci U S A (2004) 1.71
A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes. Proc Natl Acad Sci U S A (2001) 1.56
Derivation of the mammalian skull vault. J Anat (2001) 1.25
Runx1 and Runx2 cooperate during sternal morphogenesis. Development (2010) 1.24
Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev Biol (2009) 1.24
Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev (2007) 1.22
Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis. BMC Genomics (2007) 1.18
Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate. Proc Natl Acad Sci U S A (2010) 1.15
We have got you 'covered': how the meninges control brain development. Curr Opin Genet Dev (2011) 1.14
The growth and morphogenesis of the early mouse mandible: a quantitative analysis. J Anat (2003) 1.14
Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice. BMC Dev Biol (2010) 1.11
Fgf8 haploinsufficiency results in distinct craniofacial defects in adult zebrafish. Dev Biol (2007) 1.07
Tgfbr2 is required for development of the skull vault. Dev Biol (2009) 1.04
Defective osteoblast function in ICAP-1-deficient mice. Development (2007) 1.03
Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet (2010) 1.03
Brain phenotypes in two FGFR2 mouse models for Apert syndrome. Dev Dyn (2010) 1.02
Twist is required for establishment of the mouse coronal suture. J Anat (2005) 1.02
Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation. J Anat (2004) 1.02
A Genetic-Pathophysiological Framework for Craniosynostosis. Am J Hum Genet (2015) 1.02
Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice. J Bone Miner Res (2013) 1.01
Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice. J Biol Chem (2008) 0.97
FGF9 can induce endochondral ossification in cranial mesenchyme. BMC Dev Biol (2006) 0.96
Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models. Bone Res (2014) 0.95
Differential FGF ligands and FGF receptors expression pattern in frontal and parietal calvarial bones. Cells Tissues Organs (2009) 0.95
In vivo modulation of FGF biological activity alters cranial suture fate. Am J Pathol (2001) 0.95
Mesodermal expression of Fgfr2S252W is necessary and sufficient to induce craniosynostosis in a mouse model of Apert syndrome. Dev Biol (2012) 0.95
Further analysis of the Crouzon mouse: effects of the FGFR2(C342Y) mutation are cranial bone-dependent. Calcif Tissue Int (2013) 0.91
FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. PLoS One (2013) 0.89
A mathematical model for mechanotransduction at the early steps of suture formation. Proc Biol Sci (2013) 0.89
Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1. Am J Pathol (2001) 0.88
The BMP ligand Gdf6 prevents differentiation of coronal suture mesenchyme in early cranial development. PLoS One (2012) 0.86
Cranial bone morphometric study among mouse strains. BMC Evol Biol (2008) 0.86
Fibroblast growth factor (FGF) signaling in development and skeletal diseases. Genes Dis (2014) 0.85
Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2). J Biol Chem (2012) 0.81
Integration of multiple signaling pathways determines differences in the osteogenic potential and tissue regeneration of neural crest-derived and mesoderm-derived calvarial bones. Int J Mol Sci (2013) 0.81
Scalp fibroblasts have a shared expression profile in monogenic craniosynostosis. J Med Genet (2009) 0.81
Roles of FGFR3 during morphogenesis of Meckel's cartilage and mandibular bones. Dev Biol (2008) 0.81
Msx1 and Dlx5 function synergistically to regulate frontal bone development. Genesis (2010) 0.80
A model for the pharmacological treatment of crouzon syndrome. Neurosurgery (2006) 0.80
Understanding craniosynostosis as a growth disorder. Wiley Interdiscip Rev Dev Biol (2016) 0.79
Comparative study on the cellular activities of osteoblast-like cells and new bone formation of anorganic bone mineral coated with tetra-cell adhesion molecules and synthetic cell binding peptide. J Periodontal Implant Sci (2011) 0.79
Molecular analysis of coronal perisutural tissues in a craniosynostotic rabbit model using polymerase chain reaction suppression subtractive hybridization. Plast Reconstr Surg (2011) 0.78
Mouse models of Apert syndrome. Childs Nerv Syst (2012) 0.77
Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation. Biochem Biophys Res Commun (2009) 0.77
Signaling networks in joint development. Dev Dyn (2016) 0.75
Generating anatomical variation through mutations in networks - implications for evolution. J Anat (2014) 0.75
The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape. G3 (Bethesda) (2017) 0.75
Modeling craniofacial and skeletal congenital birth defects to advance therapies. Hum Mol Genet (2016) 0.75
Bone marker gene expression in calvarial bones: different bone microenvironments. J Biol Res (Thessalon) (2017) 0.75
The Morphogenesis of Cranial Sutures in Zebrafish. PLoS One (2016) 0.75
E-Cadherin and FGFR1 Expression in Mouse Osteoblastogenesis in Normoxic Cultures. Int J Biomed Sci (2017) 0.75
Suppressor of Fused Restraint of Hedgehog Activity Level is Critical for Osteogenic Proliferation and Differentiation during Calvarial Bone Development. J Biol Chem (2017) 0.75
The detection of subtelomeric chromosomal rearrangements in idiopathic mental retardation. Nat Genet (1995) 4.25
Exclusive paternal origin of new mutations in Apert syndrome. Nat Genet (1996) 3.05
A review of the molecular genetics of the human alpha-globin gene cluster. Blood (1989) 2.84
Analysis of limb reduction defects in babies exposed to chorionic villus sampling. Lancet (1994) 2.73
Genetics of craniofacial development and malformation. Nat Rev Genet (2001) 2.51
Detection of breakpoints in submicroscopic chromosomal translocation, illustrating an important mechanism for genetic disease. Lancet (1989) 2.28
A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome. Am J Hum Genet (1997) 2.22
Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat Genet (2000) 2.14
A comprehensive screen for TWIST mutations in patients with craniosynostosis identifies a new microdeletion syndrome of chromosome band 7p21.1. Am J Hum Genet (1998) 2.00
DNA testing for fragile X syndrome in schools for learning difficulties. Arch Dis Child (1995) 1.98
Differential effects of FGFR2 mutations on syndactyly and cleft palate in Apert syndrome. Am J Hum Genet (1996) 1.86
Paternal origin of FGFR2 mutations in sporadic cases of Crouzon syndrome and Pfeiffer syndrome. Am J Hum Genet (2000) 1.85
Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand. Hum Mol Genet (1998) 1.83
X-linked alpha-thalassemia/mental retardation (ATR-X) syndrome: localization to Xq12-q21.31 by X inactivation and linkage analysis. Am J Hum Genet (1992) 1.72
Functions of fibroblast growth factors and their receptors. Curr Biol (1995) 1.70
Epidermal mosaicism producing localised acne: somatic mutation in FGFR2. Lancet (1998) 1.66
A newly defined X linked mental retardation syndrome associated with alpha thalassaemia. J Med Genet (1991) 1.61
Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. Nat Genet (2000) 1.55
Potential gene conversion and source genes for recently integrated Alu elements. Genome Res (2000) 1.54
De novo alu-element insertions in FGFR2 identify a distinct pathological basis for Apert syndrome. Am J Hum Genet (1999) 1.50
Posterior lenticonus: clinical patterns and genetics. J Pediatr Ophthalmol Strabismus (1993) 1.49
Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B. Am J Hum Genet (2000) 1.48
De novo truncation of chromosome 16p and healing with (TTAGGG)n in the alpha-thalassemia/mental retardation syndrome (ATR-16). Am J Hum Genet (1993) 1.46
Mutations in the third immunoglobulin domain of the fibroblast growth factor receptor-2 gene in Crouzon syndrome. Hum Mol Genet (1995) 1.45
CD34 expression patterns during early mouse development are related to modes of blood vessel formation and reveal additional sites of hematopoiesis. Blood (1997) 1.40
Prevalence of Pro250Arg mutation of fibroblast growth factor receptor 3 in coronal craniosynostosis. Lancet (1997) 1.40
Development and tissue origins of the mammalian cranial base. Dev Biol (2008) 1.36
The non-deletion type of alpha thalassaemia/mental retardation: a recognisable dysmorphic syndrome with X linked inheritance. J Med Genet (1991) 1.36
Fgfr2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2. Development (1997) 1.34
A long-range restriction map between the alpha-globin complex and a marker closely linked to the polycystic kidney disease 1 (PKD1) locus. Genomics (1990) 1.28
Haploinsufficiency of the human homeobox gene ALX4 causes skull ossification defects. Nat Genet (2001) 1.26
Genotype-phenotype correlation for nucleotide substitutions in the IgII-IgIII linker of FGFR2. Hum Mol Genet (1997) 1.25
Localisation of human alpha globin to 16p13.3----pter. J Med Genet (1988) 1.22
Epidemiology and genetics of craniosynostosis. Am J Med Genet (2000) 1.19
A novel mutation, Ala315Ser, in FGFR2: a gene-environment interaction leading to craniosynostosis? Eur J Hum Genet (2000) 1.17
Expression patterns of Twist and Fgfr1, -2 and -3 in the developing mouse coronal suture suggest a key role for twist in suture initiation and biogenesis. Mech Dev (2000) 1.14
The genetics of mental retardation. Br Med Bull (1996) 1.11
Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster. Blood (1990) 1.09
Analysis of cranial neural crest cell migration and early fates in postimplantation rat chimaeras. J Embryol Exp Morphol (1986) 1.09
Interstitial deletion of 2q associated with craniosynostosis, ocular coloboma, and limb abnormalities: cytogenetic and molecular investigation. Am J Med Genet (1997) 1.01
Dominant coloboma-microphthalmos syndrome associated with sensorineural hearing loss, hematuria, and cleft lip/palate. Am J Med Genet (1997) 0.99
A novel phenotypic pattern in X-linked inheritance: craniofrontonasal syndrome maps to Xp22. Hum Mol Genet (1997) 0.98
A survey of TWIST for mutations in craniosynostosis reveals a variable length polyglycine tract in asymptomatic individuals. Hum Mutat (2001) 0.97
The gene for spondyloepiphyseal dysplasia (SEDL) maps to Xp22 between DXS16 and DXS92. Genomics (1993) 0.97
Migration of cranial neural crest cells to the pharyngeal arches and heart in rat embryos. Cell Tissue Res (1992) 0.97
Brachydactyly type B: linkage to chromosome 9q22 and evidence for genetic heterogeneity. Am J Hum Genet (1999) 0.97
Growth and development of pattern in the cranial neural epithelium of rat embryos during neurulation. J Embryol Exp Morphol (1981) 0.95
The distribution of fibronectin, laminin and entactin in the neurulating rat embryo studied by indirect immunofluorescence. J Embryol Exp Morphol (1986) 0.95
Limited proteolysis and proton NMR spectroscopy of Bacillus stearothermophilus pyruvate dehydrogenase multienzyme complex. Eur J Biochem (1982) 0.95
Genetic patterning of the developing mouse tail at the time of posterior neuropore closure. Dev Dyn (1997) 0.93
Conserved use of a non-canonical 5' splice site (/GA) in alternative splicing by fibroblast growth factor receptors 1, 2 and 3. Hum Mol Genet (1998) 0.92
Expression of Fgf-3 in relation to hindbrain segmentation, otic pit position and pharyngeal arch morphology in normal and retinoic acid-exposed mouse embryos. Anat Embryol (Berl) (1996) 0.91
A cytogenetic deletion, del(17)(q11.22q21.1), in a patient with sporadic neurofibromatosis type 1 (NF1) associated with dysmorphism and developmental delay. J Med Genet (1996) 0.89
Localization of the genetic locus for Saethre-Chotzen syndrome to a 6 cM region of chromosome 7 using four cases with apparently balanced translocations at 7p21.2. Hum Mol Genet (1994) 0.89
The alpha-thalassemias. Ann N Y Acad Sci (1990) 0.88
Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud. Development (1998) 0.88
Mutational analysis in X-linked spondyloepiphyseal dysplasia tarda. J Clin Endocrinol Metab (2001) 0.87
Prevention of spinal neural tube defects in the curly tail mouse mutant by a specific effect of retinoic acid. Dev Dyn (1994) 0.86
Apoptotic cell death in neuronal differentiation of P19 EC cells: cell death follows reentry into S phase. J Cell Physiol (1997) 0.86
Linkage of otopalatodigital syndrome type 2 (OPD2) to distal Xq28: evidence for allelism with OPD1. Am J Hum Genet (2001) 0.86
Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma. Development (1995) 0.86
ACTH receptor mutation in a girl with familial glucocorticoid deficiency. Clin Genet (1998) 0.86
Isodisomy in BWS chromosomes. Nature (1991) 0.85
Dominant inheritance of optic pits. Am J Ophthalmol (1998) 0.84
Interactions between retinoids and TGF beta s in mouse morphogenesis. Development (1992) 0.84
Characterisation of the human snail (SNAI1) gene and exclusion as a major disease gene in craniosynostosis. Hum Genet (1999) 0.84
Genetic patterning of the posterior neuropore region of curly tail mouse embryos: deficiency of Wnt5a expression. Int J Dev Biol (1998) 0.84
Heparitinase treatment of rat embryos during cranial neurulation. Anat Embryol (Berl) (1989) 0.84
Genetic heterogeneity in heterocellular hereditary persistence of fetal hemoglobin. Blood (1997) 0.83
The kinetic behaviour of the cranial neural epithelium during neurulation in the rat. J Embryol Exp Morphol (1985) 0.83
Treatment of mice with retinoids in vivo and in vitro. Skeletal staining. Methods Mol Biol (1999) 0.83
Morphogenesis of Doublefoot (Dbf), a mouse mutant with polydactyly and craniofacial defects. J Anat (1998) 0.83
Genetic mapping of Xp22.12-p22.31, with a refined localization for spondyloepiphyseal dysplasia (SEDL). Hum Genet (1995) 0.83
Prorhombomeric subdivision of the mammalian embryonic hindbrain: is it functionally meaningful? Int J Dev Biol (1997) 0.83
Interaction of incontinentia pigmenti and factor VIII mutations in a female with biased X inactivation, resulting in haemophilia. J Med Genet (1993) 0.82
The effects of retinoid status on TGF beta expression during mouse embryogenesis. Anat Embryol (Berl) (1995) 0.81
The ontogenesis of cranial neuromeres in the rat embryo. I. A scanning electron microscope and kinetic study. J Embryol Exp Morphol (1985) 0.80
Culture of rat embryos with beta-D-xyloside: evidence of a role for proteoglycans in neurulation. J Anat (1982) 0.80
A high-resolution genetic, physical, and comparative gene map of the doublefoot (Dbf) region of mouse chromosome 1 and the region of conserved synteny on human chromosome 2q35. Genomics (2001) 0.80
Effects of all-trans-retinoic acid on skeletal pattern, 5'HoxD gene expression, and RAR beta 2/beta 4 promoter activity in embryonic mouse limbs. Dev Genet (1996) 0.79
The ontogenesis of cranial neuromeres in the rat embryo. II. A transmission electron microscope study. J Embryol Exp Morphol (1985) 0.79
Distribution of all-trans-, 13-cis- and 9-cis-retinoic acid to whole rat embryos and maternal serum following oral administration of a teratogenic dose of all-trans-retinoic acid. Pharmacol Toxicol (1995) 0.79
Retinoic acid specifically downregulates Fgf4 and inhibits posterior cell proliferation in the developing mouse autopod. J Anat (2001) 0.78
The functional basis of tissue-specific retinoic acid signalling in embryos. Semin Cell Dev Biol (1997) 0.78
Effects of the curly tail genotype on neuroepithelial integrity and cell proliferation during late stages of primary neurulation. J Anat (2001) 0.76
Pfeiffer syndrome is not caused by haploinsufficient mutations of FGFR2. J Craniofac Genet Dev Biol (2001) 0.75
Update on a child with bilateral posterior lenticonus. J Pediatr Ophthalmol Strabismus (1995) 0.75
Errors in human gene mapping 11. Am J Hum Genet (1993) 0.75
Patterson-Stevenson-Fontaine syndrome: 30-year follow-up and clinical details of a further affected case. Am J Med Genet (1997) 0.75
Burning down DEFECT11. Am J Med Genet (2001) 0.75
Newly recognised craniosynostosis syndrome that does not map to known disease loci. Am J Med Genet (2000) 0.75
Megalocornea, developmental retardation and dysmorphic features: two further patients. Clin Dysmorphol (1994) 0.75