Published in Genes Dis on December 01, 2014
Wnt signaling in cartilage development and diseases: lessons from animal studies. Lab Invest (2015) 0.82
FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol (2016) 0.79
Bone morphogenetic protein 9 (BMP9) induces effective bone formation from reversibly immortalized multipotent adipose-derived (iMAD) mesenchymal stem cells. Am J Transl Res (2016) 0.78
Crude oil exposures reveal roles for intracellular calcium cycling in haddock craniofacial and cardiac development. Sci Rep (2016) 0.77
Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis. Dev Dyn (2016) 0.77
Associations between microRNA binding site SNPs in FGFs and FGFRs and the risk of non-syndromic orofacial cleft. Sci Rep (2016) 0.76
Whole Genome Sequencing Identifies a Missense Mutation in HES7 Associated with Short Tails in Asian Domestic Cats. Sci Rep (2016) 0.76
Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma. PLoS One (2015) 0.76
The formation of multivesicular bodies in activated blastocysts is influenced by autophagy and FGF signaling in mice. Sci Rep (2017) 0.75
Genetics of Short Stature. Endocrinol Metab Clin North Am (2017) 0.75
Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis. BBA Clin (2016) 0.75
lncRNA H19 mediates BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) through Notch signaling. Oncotarget (2017) 0.75
Cell signaling by receptor tyrosine kinases. Cell (2000) 18.16
FGF-21 as a novel metabolic regulator. J Clin Invest (2005) 10.69
Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev (2005) 9.62
Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer (2010) 8.55
Fibroblast growth factors. Genome Biol (2001) 7.32
Sunitinib: from rational design to clinical efficacy. J Clin Oncol (2007) 7.26
Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med (2004) 6.26
The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov (2009) 6.23
Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell (1994) 5.96
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem (2006) 5.78
Fgf10 is essential for limb and lung formation. Nat Genet (1999) 5.76
Modulating Hox gene functions during animal body patterning. Nat Rev Genet (2005) 5.10
Evolution of the Fgf and Fgfr gene families. Trends Genet (2004) 4.53
sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell (1998) 4.40
An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development (2000) 4.33
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell (1991) 4.31
Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology (2004) 4.25
Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol (2001) 4.11
Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev (2003) 4.08
Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev (1994) 3.97
Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. Science (1989) 3.83
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell (2001) 3.73
The triple origin of skull in higher vertebrates: a study in quail-chick chimeras. Development (1993) 3.65
Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature (2002) 3.47
Mesoderm induction in early Xenopus embryos by heparin-binding growth factors. Nature (1987) 3.31
Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Factor Rev (2005) 3.28
Cranial sutures as intramembranous bone growth sites. Dev Dyn (2000) 3.23
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev (1999) 3.15
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol (1991) 3.13
FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell (1994) 3.10
fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev (1994) 3.02
Fibroblast growth factor signaling during early vertebrate development. Endocr Rev (2005) 2.99
Functions and regulations of fibroblast growth factor signaling during embryonic development. Dev Biol (2005) 2.92
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development (1998) 2.90
Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem Biophys Res Commun (2000) 2.90
The roles of FGFs in the early development of vertebrate limbs. Genes Dev (1998) 2.86
Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene (2007) 2.83
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol Cell Biol (1996) 2.80
Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Dev (2002) 2.75
Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease. Circulation (1998) 2.74
Fibroblast growth factors and their receptors in cancer. Biochem J (2011) 2.66
The structure and development of cranial and facial sutures. J Anat (1956) 2.62
Craniosynostosis: genes and mechanisms. Hum Mol Genet (1997) 2.55
Sprouty, an intracellular inhibitor of Ras signaling. Cell (1999) 2.51
Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes. Nat Genet (1995) 2.49
The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues. Dev Biol (1983) 2.48
Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development (1992) 2.45
Achondroplasia is defined by recurrent G380R mutations of FGFR3. Am J Hum Genet (1995) 2.43
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev (2002) 2.41
Diverse forms of a receptor for acidic and basic fibroblast growth factors. Mol Cell Biol (1990) 2.33
A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia. Nat Genet (1995) 2.30
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest (2005) 2.25
Clinical spectrum of fibroblast growth factor receptor mutations. Hum Mutat (1999) 2.24
Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A (1996) 2.22
Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell (1996) 2.22
Craniosynostosis update 1987. Am J Med Genet Suppl (1988) 2.21
Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8. Dev Cell (2002) 2.19
Integration of FGF and TWIST in calvarial bone and suture development. Development (2000) 2.15
Midbrain development induced by FGF8 in the chick embryo. Nature (1996) 2.03
FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development (1998) 2.03
Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Development (1999) 2.02
Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. Development (1997) 2.01
Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition. Development (2004) 2.01
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Proc Natl Acad Sci U S A (2001) 1.96
The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3. J Biol Chem (2001) 1.95
Promotion and attenuation of FGF signaling through the Ras-MAPK pathway. Sci STKE (2004) 1.93
The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development (1997) 1.92
Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis. Am J Hum Genet (2002) 1.88
Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation. Cancer Res (2008) 1.87
Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. Dev Cell (2005) 1.84
Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand. Hum Mol Genet (1998) 1.83
Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science (1999) 1.81
FGF signaling in skeletal development. Front Biosci (1998) 1.81
A role for FGF-6 in skeletal muscle regeneration. Genes Dev (1997) 1.79
Keratinocyte growth factor: a unique player in epithelial repair processes. Cytokine Growth Factor Rev (1998) 1.78
Mutations in different components of FGF signaling in LADD syndrome. Nat Genet (2006) 1.76
Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074. Leukemia (2004) 1.71
Neural induction: toward a unifying mechanism. Nat Neurosci (2001) 1.68
Functions of fibroblast growth factors in vertebrate development. Cytokine Growth Factor Rev (1996) 1.66
The developmental fate of the cephalic mesoderm in quail-chick chimeras. Development (1992) 1.65
Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev (1998) 1.65
Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. Development (1995) 1.63
Novel FGFR3 mutations creating cysteine residues in the extracellular domain of the receptor cause achondroplasia or severe forms of hypochondroplasia. Eur J Hum Genet (2006) 1.63
Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development (1996) 1.61
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nat Cell Biol (2002) 1.61
FGF signalling: diverse roles during early vertebrate embryogenesis. Development (2010) 1.60
Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning. Genes Dev (2001) 1.55
Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis Cartilage (2005) 1.53
eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus. Development (1996) 1.53
Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell (2004) 1.52
eFGF regulates Xbra expression during Xenopus gastrulation. EMBO J (1994) 1.51
Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1). Hum Mol Genet (1996) 1.50
Neural crest induction by paraxial mesoderm in Xenopus embryos requires FGF signals. Development (2003) 1.49
FGF signalling in craniofacial development and developmental disorders. Oral Dis (2006) 1.49
Cranial sutures require tissue interactions with dura mater to resist osseous obliteration in vitro. J Bone Miner Res (1995) 1.48
Metacarpophalangeal analysis in Crouzon syndrome: additional evidence for phenotypic convergence with the acrocephalosyndactyly syndromes. Am J Med Genet (1997) 1.47
Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups. Development (2002) 1.43
Fibroblast growth factors as regulators of central nervous system development and function. Am J Physiol Regul Integr Comp Physiol (2003) 1.41
Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction. Dev Biol (2002) 1.39