Published in Exp Cell Res on November 25, 1999
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev (2003) 5.91
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev (2001) 5.12
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell (2002) 5.06
AKT plays a central role in tumorigenesis. Proc Natl Acad Sci U S A (2001) 4.88
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol (2003) 3.84
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med (2005) 3.60
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell (2007) 3.54
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest (2001) 3.29
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci U S A (2003) 3.28
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice. Genes Dev (2006) 2.76
Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br J Cancer (2002) 2.44
Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice. Blood (2004) 2.23
Akt1 in endothelial cell and angiogenesis. Cell Cycle (2006) 2.22
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol (2002) 2.15
The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol Cell Biol (2001) 2.11
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J Clin Invest (2004) 2.09
Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling. J Virol (2001) 2.07
Physiological regulation of Akt activity and stability. Am J Transl Res (2010) 1.95
Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol Cell Biol (2004) 1.85
Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev (2003) 1.78
Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. J Exp Med (2002) 1.78
Main roads to melanoma. J Transl Med (2009) 1.67
Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance. Diabetes (2008) 1.65
Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells. Gut (2003) 1.62
Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest (2004) 1.59
eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia? Schizophr Bull (2007) 1.57
Retracted Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells. Cancer Prev Res (Phila) (2009) 1.57
Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J Biol Chem (2007) 1.52
Inhibitory role of alpha 6 beta 4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on alpha 3 beta 1 integrin. J Cell Biol (2001) 1.49
PAK1 as a therapeutic target. Expert Opin Ther Targets (2010) 1.48
Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J Virol (2002) 1.44
Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol (2000) 1.42
Akt kinases in breast cancer and the results of adjuvant therapy. Breast Cancer Res (2003) 1.41
Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells. Mol Cell (2008) 1.36
Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Mol Cell Biol (2002) 1.36
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BMC Mol Biol (2001) 1.36
Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol Cell Biol (2004) 1.35
The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. Curr Genomics (2007) 1.33
Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha. Mol Cell Biol (2004) 1.33
Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. Mol Cell Biol (2006) 1.33
The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation. Blood (2007) 1.33
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. Carcinogenesis (2008) 1.32
AKT/GSK3 signaling pathway and schizophrenia. Front Mol Neurosci (2012) 1.25
MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Mol Cell Biol (2006) 1.23
AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2. Br J Cancer (2003) 1.22
Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum. Ann N Y Acad Sci (2012) 1.22
Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation. Proc Natl Acad Sci U S A (2003) 1.21
Suppression of radiation-induced salivary gland dysfunction by IGF-1. PLoS One (2009) 1.21
Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Mol Cell Biol (2009) 1.19
Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J (2005) 1.18
Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain. Blood (2008) 1.17
Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae. J Immunol (2009) 1.17
Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease. Pharmacol Ther (2007) 1.17
Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play? Breast Cancer Res (2001) 1.17
Gene expression in a Drosophila model of mitochondrial disease. PLoS One (2010) 1.16
Molecular targets of opiate drug abuse in neuroAIDS. Neurotox Res (2005) 1.16
PKB and megalin determine the survival or death of renal proximal tubule cells. Proc Natl Acad Sci U S A (2006) 1.16
The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt. Oncogene (2009) 1.14
mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition. Mol Cell Biol (2009) 1.13
Combined treatment with EGFR inhibitors and arsenite upregulated apoptosis in human EGFR-positive melanomas: a role of suppression of the PI3K-AKT pathway. Oncogene (2005) 1.13
Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies. Eur J Cancer (2012) 1.11
AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture. Oncogene (2006) 1.11
Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells. PLoS One (2013) 1.11
TGFβ- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR). J Cell Physiol (2011) 1.09
Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis (2012) 1.08
Distribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrain. Neuroscience (2010) 1.08
ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. Mol Cell Biol (2009) 1.08
LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma. J Cancer Res Clin Oncol (2009) 1.07
Loss of ypk1 function causes rapamycin sensitivity, inhibition of translation initiation and synthetic lethality in 14-3-3-deficient yeast. Genetics (2002) 1.06
Synergistic suppression of apoptosis in salivary acinar cells by IGF1 and EGF. Cell Death Differ (2003) 1.04
Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B. Mol Cancer (2006) 1.04
Protein kinase B phosphorylates AHNAK and regulates its subcellular localization. J Cell Biol (2001) 1.04
CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation. Cell Prolif (2011) 1.03
Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia. J Clin Invest (2013) 1.03
Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol (2006) 1.02
Natural biology of polyomavirus middle T antigen. Microbiol Mol Biol Rev (2001) 1.02
The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells. Oncogene (2010) 1.01
A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. Curr Genet (2004) 1.00
4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management. Neoplasia (2003) 1.00
Up-regulation of PIK3CA promotes metastasis in gastric carcinoma. World J Gastroenterol (2010) 1.00
High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass. Open Endocrinol J (2010) 0.99
Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells. J Cereb Blood Flow Metab (2006) 0.97
PTEN expression causes feedback upregulation of insulin receptor substrate 2. Mol Cell Biol (2001) 0.97
Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era. PLoS One (2012) 0.97
Nodal and lefty signaling regulates the growth of pancreatic cells. Dev Dyn (2008) 0.96
The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models. Front Oncol (2014) 0.96
Engineered early embryonic cardiac tissue increases cardiomyocyte proliferation by cyclic mechanical stretch via p38-MAP kinase phosphorylation. Tissue Eng Part A (2009) 0.96
A G(i) -independent mechanism mediating Akt phosphorylation in platelets. J Thromb Haemost (2010) 0.95
AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells. Cell Cycle (2009) 0.95
The Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer. PLoS One (2014) 0.95
Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. J Biol Chem (2011) 0.94
Akt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β₃ affinity modulation. Br J Cancer (2012) 0.94
Targeting the PI3-kinase/Akt/mTOR signaling pathway. Surg Oncol Clin N Am (2013) 0.94
The midblastula transition in Xenopus embryos activates multiple pathways to prevent apoptosis in response to DNA damage. Proc Natl Acad Sci U S A (2001) 0.94
Divergence in the anti-apoptotic signalling pathways used by nerve growth factor and basic fibroblast growth factor (bFGF) in PC12 cells: rescue by bFGF involves protein kinase C delta. Biochem J (2000) 0.93
Akt isoforms and glucose homeostasis - the leptin connection. Trends Endocrinol Metab (2010) 0.93
Akt2 inhibition enables the forkhead transcription factor FoxO3a to have a repressive role in estrogen receptor alpha transcriptional activity in breast cancer cells. Mol Cell Biol (2009) 0.93
Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study. BMC Cancer (2007) 0.93
c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem (2010) 0.92
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev (1998) 6.89
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev (1997) 5.58
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev (2001) 5.12
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes Dev (1994) 3.70
Attenuation in the control of SV40 gene expression. Cell (1982) 3.32
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene (2006) 3.17
Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci U S A (2001) 3.02
Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol Cell Biol (1999) 2.93
Neoplastic transformation by the human gene N-myc. Mol Cell Biol (1987) 2.17
Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest. Mol Endocrinol (1998) 2.06
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Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation. Cancer Res (1994) 1.52
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Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol Cell Biol (1998) 1.41
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Repeated CT elements bound by zinc finger proteins control the absolute and relative activities of the two principal human c-myc promoters. Mol Cell Biol (1993) 1.29
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB. J Neurosci (1999) 1.24
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Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt. J Biol Chem (2000) 1.17
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