Published in Int J Biochem Cell Biol on October 01, 1999
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med (2002) 3.24
NF-κB addiction and its role in cancer: 'one size does not fit all'. Oncogene (2010) 2.56
The tyrosine kinase network regulating mast cell activation. Immunol Rev (2009) 2.29
Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. Cancer Res (2010) 2.06
Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other. J Exp Med (2000) 1.78
Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk. J Exp Med (2002) 1.77
Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation. Biochim Biophys Acta (2009) 1.75
Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation. Mol Cell Biol (2005) 1.67
Stem cell factor stimulates neurogenesis in vitro and in vivo. J Clin Invest (2002) 1.63
Regulation of mast cell responses in health and disease. Crit Rev Immunol (2011) 1.50
Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Mol Cell Biol (2003) 1.40
Our perception of the mast cell from Paul Ehrlich to now. Eur J Immunol (2009) 1.39
Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling. Mol Cell Biol (2006) 1.33
Activation and function of the mTORC1 pathway in mast cells. J Immunol (2008) 1.31
Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor (GIST). Int J Colorectal Dis (2006) 1.28
Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders. Br J Pharmacol (2008) 1.25
The tumor microenvironment in colorectal carcinogenesis. Cancer Microenviron (2010) 1.23
Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function. Exp Hematol (2007) 1.12
SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration. Mol Cell Biol (2004) 1.10
Mast cell function: a new vision of an old cell. J Histochem Cytochem (2014) 1.08
Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation. J Pharmacol Exp Ther (2007) 1.08
Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein. Mol Cell Biol (2003) 1.05
Calcium events in smooth muscles and their interstitial cells; physiological roles of sparks. J Physiol (2005) 1.05
Molecular diagnosis of mast cell disorders: a paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology. J Mol Diagn (2006) 1.05
Expression and mutation of c-kit gene in gastrointestinal stromal tumors. World J Gastroenterol (2003) 1.02
An update on molecular genetics of gastrointestinal stromal tumours. J Clin Pathol (2006) 1.00
Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes. Mol Cell Biol (2004) 1.00
The MAGE protein family and cancer. Curr Opin Cell Biol (2015) 1.00
c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways. Mol Cell Biol (2004) 0.98
Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo. Blood (2005) 0.98
Gene mutations and molecularly targeted therapies in acute myeloid leukemia. Am J Blood Res (2013) 0.95
A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. Exp Hematol (2008) 0.94
Embryonic and foetal Islet-1 positive cells in human hearts are also positive to c-Kit. Eur J Histochem (2011) 0.93
SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung. J Immunol (2009) 0.90
Novel NF1 gene mutation in a Japanese patient with neurofibromatosis type 1 and a gastrointestinal stromal tumor. J Gastroenterol (2006) 0.90
TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release. Eur J Immunol (2010) 0.90
Mast cell biology: introduction and overview. Adv Exp Med Biol (2011) 0.89
Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells. J Immunol (2009) 0.89
Sox4 is required for the survival of pro-B cells. J Immunol (2013) 0.89
Ntal/Lab/Lat2. Int J Biochem Cell Biol (2006) 0.89
Transgenerational genetic effects. Epigenomics (2010) 0.87
From the Biology of PP2A to the PADs for Therapy of Hematologic Malignancies. Front Oncol (2015) 0.87
A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsiveness. J Immunol (2010) 0.87
Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms. Immunol Allergy Clin North Am (2014) 0.86
Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation. Dev Biol (2009) 0.86
Aging Kit mutant mice develop cardiomyopathy. PLoS One (2012) 0.85
Enhanced expression of mast cell growth factor and mast cell activation in the bladder following the resolution of trinitrobenzenesulfonic acid (TNBS) colitis in female rats. Neurourol Urodyn (2007) 0.83
Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of Bcl-2. J Exp Med (2001) 0.83
The usefulness of c-Kit in the immunohistochemical assessment of melanocytic lesions. Eur J Histochem (2011) 0.83
Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilate in chimeric mice. World J Gastroenterol (2006) 0.83
Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice. Lab Invest (2012) 0.82
Identification of a novel point mutation of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea mutagenesis. Genetics (2005) 0.82
Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes. Zebrafish (2008) 0.81
Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease. Leukemia (2012) 0.81
Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells. Blood (2006) 0.80
Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis. J Biol Chem (2013) 0.79
Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis. J Immunol (2011) 0.79
Hotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivity. PLoS Comput Biol (2014) 0.79
Stem cell factor/c-Kit signaling in in vitro cultures supports early mouse embryonic development by accelerating proliferation via a mechanism involving Akt-downstream genes. J Assist Reprod Genet (2010) 0.79
Study of the role of "gatekeeper" mutations V654A and T670I of c-kit kinase in the interaction with inhibitors by means mixed molecular dynamics/docking approach. Bioinformation (2011) 0.79
Expression of c-kit protein in cancer vs. normal breast tissue. Contemp Oncol (Pozn) (2012) 0.77
Female reproductive aging is master-planned at the level of ovary. PLoS One (2014) 0.77
KIT associated intracellular tyrosines play an essential role in EpoR co-signaling. Cell Signal (2008) 0.77
Receptor-guided 3D-QSAR approach for the discovery of c-kit tyrosine kinase inhibitors. J Mol Model (2011) 0.76
Somatic DNA mutation analysis in targeted therapy of solid tumours. Transl Pediatr (2015) 0.76
Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic. Expert Rev Hematol (2014) 0.76
Spatial and temporal expression of c-Kit in the development of the murine submandibular gland. J Mol Histol (2014) 0.76
Lin-c-kit(+) BM-derived stem cells repair Infarcted Heart. J Stem Cells Regen Med (2010) 0.76
Poorly differentiated carcinoma of the rectum with aberrant immunophenotype: a case report. World J Gastroenterol (2007) 0.75
Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice. PLoS One (2015) 0.75
Cell-based phenotypic screening of mast cell degranulation unveils kinetic perturbations of agents targeting phosphorylation. Sci Rep (2016) 0.75
Comparative genomics of human stem cell factor (SCF). Mol Biol Res Commun (2017) 0.75