SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung.

PubWeight™: 0.90‹?›

🔗 View Article (PMID 20042576)

Published in J Immunol on December 30, 2009

Authors

Li Zhang1, Sun Young Oh, Xinxing Wu, Min Hee Oh, Fan Wu, John T Schroeder, Clifford M Takemoto, Tao Zheng, Zhou Zhu

Author Affiliations

1: Division of Allergy and Clinical Immunology, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.

Articles cited by this

Interleukin-13: central mediator of allergic asthma. Science (1998) 14.05

Requirement for IL-13 independently of IL-4 in experimental asthma. Science (1998) 10.76

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature (1988) 6.35

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med (1996) 6.34

National surveillance for asthma--United States, 1980-2004. MMWR Surveill Summ (2007) 6.05

Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest (2000) 4.16

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. Am J Pathol (2005) 3.88

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet (2008) 3.71

Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med (1997) 3.33

Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol (1994) 3.32

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet (1993) 3.11

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles. Cell (1990) 2.95

Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med (1997) 2.36

"Viable motheaten," a new allele at the motheaten locus. I. Pathology. Am J Pathol (1984) 2.26

Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest (2006) 2.12

Early signaling pathways activated by c-Kit in hematopoietic cells. Int J Biochem Cell Biol (1999) 1.95

Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J Hered (1976) 1.94

Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med (2004) 1.91

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling. Semin Immunol (2000) 1.77

NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation. Blood (2004) 1.46

IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-kappa B is decisively involved in the expression of IL-9. J Immunol (2001) 1.46

Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J Immunol (1976) 1.43

SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol (1998) 1.41

Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor. Arthritis Rheum (1998) 1.37

Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Nat Genet (1996) 1.31

Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics (1981) 1.30

Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways. J Immunol (2002) 1.29

Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant. J Immunol (2004) 1.23

Diminished cell proliferation associated with the death-protective activity of Bcl-2. J Biol Chem (1996) 1.23

Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells. Cell Signal (2007) 1.21

T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice. Clin Immunol Immunopathol (1995) 1.20

src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. J Clin Invest (2003) 1.19

B and T cells are not required for the viable motheaten phenotype. J Exp Med (1996) 1.14

Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1. Immunol Res (2006) 1.08

Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1. J Exp Med (1996) 1.04

Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung. J Allergy Clin Immunol (2006) 1.02

A critical role of SHP-1 in regulation of type 2 inflammation in the lung. Am J Respir Cell Mol Biol (2008) 1.01

Rodent and human mast cells produce functionally significant intracellular reactive oxygen species but not nitric oxide. J Biol Chem (2004) 1.01

Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition. J Immunol (2007) 0.98

Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling. Biochem J (2002) 0.97

SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo. J Immunol (2009) 0.97

Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway. Mol Cell Biol (1996) 0.95

Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation. Am J Respir Cell Mol Biol (2008) 0.94

Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1. J Immunol (2008) 0.91

Negative regulation of myeloid cell proliferation and function by the SH2 domain-containing tyrosine phosphatase-1. J Immunol (1999) 0.88

Articles by these authors

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17

Assessing computational tools for the discovery of transcription factor binding sites. Nat Biotechnol (2005) 14.29

Epidemiology of human infections with avian influenza A(H7N9) virus in China. N Engl J Med (2013) 7.52

Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science (2004) 6.28

Regulation of inflammatory responses by IL-17F. J Exp Med (2008) 5.56

Preventing chronic diseases in China. Lancet (2005) 4.86

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med (2002) 4.65

Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell (2006) 4.51

p63 protects the female germ line during meiotic arrest. Nature (2006) 3.98

Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med (2007) 3.91

Intradiscal injection therapy for degenerative chronic discogenic low back pain with end plate Modic changes. Spine J (2010) 3.55

The way forward. Lancet (2007) 3.28

Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med (2006) 3.25

TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species. PLoS Biol (2010) 3.21

Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. Blood (2008) 3.05

China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up. Int J Epidemiol (2011) 2.82

Cohort profile: the Kadoorie Study of Chronic Disease in China (KSCDC). Int J Epidemiol (2005) 2.70

New insights into the pathogenesis of asthma. J Clin Invest (2003) 2.66

Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med (2006) 2.63

Noonan syndrome: clinical features, diagnosis, and management guidelines. Pediatrics (2010) 2.56

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest (2002) 2.52

Bacterial c-di-GMP is an immunostimulatory molecule. J Immunol (2007) 2.13

Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J Clin Invest (2004) 2.10

T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol (2009) 1.99

Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest (2003) 1.90

The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol (2011) 1.81

IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol (2002) 1.81

The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Dev Cell (2011) 1.73

The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. Allergy Asthma Immunol Res (2011) 1.69

Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Semin Cell Dev Biol (2002) 1.62

Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. J Clin Invest (2005) 1.61

Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J Immunol (2007) 1.60

Expression of activation markers on basophils in a controlled model of anaphylaxis. J Allergy Clin Immunol (2007) 1.55

Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. J Immunol (2005) 1.53

Roles for the type III TGF-beta receptor in human cancer. Cell Signal (2010) 1.50

The endothelial nitric oxide synthase gene is associated with coronary artery disease: a meta-analysis. Cardiology (2010) 1.47

Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation. Am J Physiol Lung Cell Mol Physiol (2006) 1.44

Retrospective comparison of retroperitoneal laparoscopic versus open dismembered pyeloplasty for ureteropelvic junction obstruction. J Urol (2006) 1.44

Risk Factors for Venous Thromboembolism in Pediatric Trauma Patients and Validation of a Novel Scoring System: The Risk of Clots in Kids With Trauma Score. Pediatr Crit Care Med (2016) 1.42

Multiple ion binding equilibria, reaction kinetics, and thermodynamics in dynamic models of biochemical pathways. Methods Enzymol (2009) 1.41

Evolving renorrhaphy technique for retroperitoneal laparoscopic partial nephrectomy: single-surgeon series. Int J Urol (2014) 1.40

Experimental evidence of core modification in the near drip-line nucleus 23O. Phys Rev Lett (2002) 1.40

Renal pedicle lymphatic disconnection for chyluria via retroperitoneoscopy and open surgery: report of 53 cases with followup. J Urol (2005) 1.38

Solitary large hepatocellular carcinoma: a specific subtype of hepatocellular carcinoma with good outcome after hepatic resection. Ann Surg (2009) 1.37

The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol (2004) 1.37

The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption. J Pediatr (2008) 1.36

Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling. J Invest Dermatol (2008) 1.35

ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest (2005) 1.31

Drinking behaviour among men and women in China: the 2007 China Chronic Disease and Risk Factor Surveillance. Addiction (2011) 1.31

Novel avian influenza A(H7N9) virus in tree sparrow, Shanghai, China, 2013. Emerg Infect Dis (2014) 1.30

Intensive cytokine induction in pandemic H1N1 influenza virus infection accompanied by robust production of IL-10 and IL-6. PLoS One (2011) 1.30

Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro. J Allergy Clin Immunol (2003) 1.27

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma. Hepatology (2013) 1.26

IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J Immunol (2011) 1.25

Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion. J Allergy Clin Immunol (2005) 1.25

Undifferentiated small round cell sarcomas with rare EWS gene fusions: identification of a novel EWS-SP3 fusion and of additional cases with the EWS-ETV1 and EWS-FEV fusions. J Mol Diagn (2007) 1.19

Human antibody responses to avian influenza A(H7N9) virus, 2013. Emerg Infect Dis (2014) 1.19

Interleukin-13 and leukotrienes: an intersection of pathogenetic schema. Am J Respir Cell Mol Biol (2003) 1.18

Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis. Blood (2010) 1.17

Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease. Pediatr Blood Cancer (2008) 1.16

TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. J Allergy Clin Immunol (2007) 1.16

Technique of anatomical retroperitoneoscopic adrenalectomy with report of 800 cases. J Urol (2007) 1.14

Iodine nutrition and the prevalence of thyroid disease after salt iodization: a cross-sectional survey in Shanghai, a coastal area in China. PLoS One (2012) 1.14

Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J Immunol (2009) 1.13

Prevalence of hypertension in overweight and obese children from a large school-based population in Shanghai, China. BMC Public Health (2013) 1.10

High-level expression of Notch1 increased the risk of metastasis in T1 stage clear cell renal cell carcinoma. PLoS One (2012) 1.09

Posttranscriptional regulation of IL-13 in T cells: role of the RNA-binding protein HuR. J Allergy Clin Immunol (2008) 1.08

IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung. J Immunol (2008) 1.07

Decreased expression of inhibitor of growth 4 correlated with poor prognosis of hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev (2009) 1.06

Cigarette smoking and changing trends of lung cancer incidence by histological subtype among Chinese male population. Lung Cancer (2009) 1.06

Inhibition of invasion and metastasis of hepatocellular carcinoma cells via targeting RhoC in vitro and in vivo. Clin Cancer Res (2008) 1.06

Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs. Am J Respir Cell Mol Biol (2010) 1.05

Interface magnetism in epitaxial BiFeO3-La0.7Sr0.3MnO3 heterostructures integrated on Si(100). Nano Lett (2013) 1.05

Live poultry market closure and control of avian influenza A(H7N9), Shanghai, China. Emerg Infect Dis (2014) 1.05

High human bocavirus viral load is associated with disease severity in children under five years of age. PLoS One (2013) 1.04

Co-variations and clustering of chronic disease behavioral risk factors in China: China Chronic Disease and Risk Factor Surveillance, 2007. PLoS One (2012) 1.03

Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells. Biol Cell (2006) 1.03

Clinical efficacy and safety of buyang huanwu decoction for acute ischemic stroke: a systematic review and meta-analysis of 19 randomized controlled trials. Evid Based Complement Alternat Med (2012) 1.03

Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung. J Allergy Clin Immunol (2006) 1.02

A database of thermodynamic properties of the reactions of glycolysis, the tricarboxylic acid cycle, and the pentose phosphate pathway. Database (Oxford) (2011) 1.01

A critical role of SHP-1 in regulation of type 2 inflammation in the lung. Am J Respir Cell Mol Biol (2008) 1.01

Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. Biochem Biophys Res Commun (2004) 1.01

Detailed enzyme kinetics in terms of biochemical species: study of citrate synthase. PLoS One (2008) 1.00

KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation. Blood (2011) 0.99

[Status and trends of breast cancer mortality in Chinese females]. Zhonghua Yu Fang Yi Xue Za Zhi (2011) 0.99

A new method to guard inpatient medication safety by the implementation of RFID. J Med Syst (2008) 0.99

Regulation of CFTR channels by HCO(3)--sensitive soluble adenylyl cyclase in human airway epithelial cells. Am J Physiol Cell Physiol (2005) 0.99