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The Flory isolated-pair hypothesis is not valid for polypeptide chains: implications for protein folding. Proc Natl Acad Sci U S A (2000) 3.39

Reassessing random-coil statistics in unfolded proteins. Proc Natl Acad Sci U S A (2004) 2.93

Exploring the folding landscape of a structured RNA. Proc Natl Acad Sci U S A (2001) 2.78

Energetics of the interaction between water and the helical peptide group and its role in determining helix propensities. Proc Natl Acad Sci U S A (2000) 2.17

Understanding the dielectric properties of liquid amides from a polarizable force field. J Phys Chem B (2008) 1.57

Sampling realistic protein conformations using local structural bias. PLoS Comput Biol (2006) 1.56

A novel method reveals that solvent water favors polyproline II over beta-strand conformation in peptides and unfolded proteins: conditional hydrophobic accessible surface area (CHASA). Protein Sci (2004) 1.52

The effects of threonine phosphorylation on the stability and dynamics of the central molecular switch region of 18.5-kDa myelin basic protein. PLoS One (2013) 1.46

Composites of local structure propensities: evidence for local encoding of long-range structure. Protein Sci (2002) 1.33

Redrawing the Ramachandran plot after inclusion of hydrogen-bonding constraints. Proc Natl Acad Sci U S A (2010) 1.29

Folding Trp-cage to NMR resolution native structure using a coarse-grained protein model. Biophys J (2004) 1.29

Building native protein conformation from highly approximate backbone torsion angles. Proc Natl Acad Sci U S A (2005) 1.28

Stereoelectronic and steric effects in side chains preorganize a protein main chain. Proc Natl Acad Sci U S A (2009) 1.17

PALSSE: a program to delineate linear secondary structural elements from protein structures. BMC Bioinformatics (2005) 1.12

Intrinsic backbone preferences are fully present in blocked amino acids. Proc Natl Acad Sci U S A (2006) 1.08

Reducing the computational complexity of protein folding via fragment folding and assembly. Protein Sci (2003) 1.04

Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR. J Mol Biol (2008) 1.01

Steric restrictions in protein folding: an alpha-helix cannot be followed by a contiguous beta-strand. Protein Sci (2004) 1.01

Are denatured proteins ever random coils? Proc Natl Acad Sci U S A (2000) 1.01

Secondary structure determines protein topology. Protein Sci (2006) 1.00

Assessing the solvent-dependent surface area of unfolded proteins using an ensemble model. Proc Natl Acad Sci U S A (2008) 1.00

Exploring the energy landscapes of protein folding simulations with Bayesian computation. Biophys J (2012) 0.97

On the role of structural class of a protein with two-state folding kinetics in determining correlations between its size, topology, and folding rate. Protein Sci (2007) 0.92

Physical-chemical determinants of turn conformations in globular proteins. Protein Sci (2007) 0.91

Recursive domains in proteins. Protein Sci (2002) 0.90

The impact of small molecule binding on the energy landscape of the intrinsically disordered protein C-myc. PLoS One (2012) 0.89

Novel p65 binding glucocorticoid-induced leucine zipper peptide suppresses experimental autoimmune encephalomyelitis. J Biol Chem (2011) 0.88

Assignment of PolyProline II conformation and analysis of sequence--structure relationship. PLoS One (2011) 0.87

Physical-chemical determinants of coil conformations in globular proteins. Protein Sci (2010) 0.87

Ligand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteins. PLoS Comput Biol (2013) 0.86

Thermodynamic environments in proteins: fundamental determinants of fold specificity. Protein Sci (2002) 0.86

Minimum message length inference of secondary structure from protein coordinate data. Bioinformatics (2012) 0.86

Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S. J Biol Chem (2010) 0.84

Counting peptide-water hydrogen bonds in unfolded proteins. Protein Sci (2011) 0.83

Analysis of loop boundaries using different local structure assignment methods. Protein Sci (2009) 0.82

Effects of different force fields and temperatures on the structural character of Abeta (12-28) peptide in aqueous solution. Int J Mol Sci (2011) 0.82

Lysozyme among the Lilliputians. Proc Natl Acad Sci U S A (2000) 0.80

Native and nonnative conformational preferences in the urea-unfolded state of barstar. Protein Sci (2004) 0.80

Bhageerath-H: a homology/ab initio hybrid server for predicting tertiary structures of monomeric soluble proteins. BMC Bioinformatics (2014) 0.80

The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface. RNA (2016) 0.79

PolyprOnline: polyproline helix II and secondary structure assignment database. Database (Oxford) (2014) 0.78

Piecewise linear approximation of protein structures using the principle of minimum message length. Bioinformatics (2011) 0.78

Proline rich motifs as drug targets in immune mediated disorders. Int J Pept (2012) 0.78

Electrostatic screening and backbone preferences of amino acid residues in urea-denatured ubiquitin. Protein Sci (2007) 0.77

Residual interactions in unfolded bile acid-binding protein by 19F NMR. Protein Sci (2011) 0.76

Interconnection of salt-induced hydrophobic compaction and secondary structure formation depends on solution conditions: revisiting early events of protein folding at single molecule resolution. J Biol Chem (2012) 0.76

Efficient Parameter Estimation of Generalizable Coarse-Grained Protein Force Fields Using Contrastive Divergence: A Maximum Likelihood Approach. J Chem Theory Comput (2013) 0.76

Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation. Drug Des Devel Ther (2014) 0.76

Novel Nuclear Factor-KappaB Targeting Peptide Suppresses β-Amyloid Induced Inflammatory and Apoptotic Responses in Neuronal Cells. PLoS One (2016) 0.75

A New Secondary Structure Assignment Algorithm Using Cα Backbone Fragments. Int J Mol Sci (2016) 0.75

A Single Stereodynamic Center Modulates the Rate of Self-Assembly in a Biomolecular System. Angew Chem Int Ed Engl (2015) 0.75

How cooperative are protein folding and unfolding transitions? Protein Sci (2016) 0.75

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The hydrophobic moment detects periodicity in protein hydrophobicity. Proc Natl Acad Sci U S A (1984) 6.36

The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. Proteins (1989) 5.72

Protein design by binary patterning of polar and nonpolar amino acids. Science (1993) 5.13

The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding. J Mol Biol (1995) 5.00

Elucidating the folding problem of helical peptides using empirical parameters. Nat Struct Biol (1994) 4.66

Turns in peptides and proteins. Adv Protein Chem (1985) 4.05

ON THE ENZYMIC ACTIVITY OF SUBTILISIN-MODIFIED RIBONUCLEASE. Proc Natl Acad Sci U S A (1958) 3.55

Is protein folding hierarchic? I. Local structure and peptide folding. Trends Biochem Sci (1999) 3.27

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Side-chain entropy opposes alpha-helix formation but rationalizes experimentally determined helix-forming propensities. Proc Natl Acad Sci U S A (1992) 2.42

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Structural and dynamic characterization of partially folded states of apomyoglobin and implications for protein folding. Nat Struct Biol (1998) 2.36

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Folding of protein G B1 domain studied by the conformational characterization of fragments comprising its secondary structure elements. Eur J Biochem (1995) 2.15

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Detection and characterization of an early folding intermediate of T4 lysozyme using pulsed hydrogen exchange and two-dimensional NMR. Biochemistry (1992) 1.96

LINUS: a hierarchic procedure to predict the fold of a protein. Proteins (1995) 1.94

Solution conformations and thermodynamics of structured peptides: molecular dynamics simulation with an implicit solvation model. J Mol Biol (1998) 1.85

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A peptide model of a protein folding intermediate. Nature (1988) 1.68

Protein folding--what's the question? Proc Natl Acad Sci U S A (1993) 1.59

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Peptide models of protein folding initiation sites. 1. Secondary structure formation by peptides corresponding to the G- and H-helices of myoglobin. Biochemistry (1993) 1.49

Design, synthesis and characterisation of a 34-residue polypeptide that interacts with nucleic acids. Nature (1979) 1.45

Assigning secondary structure from protein coordinate data. Proteins (1999) 1.40

Dissecting the structure of a partially folded protein. Circular dichroism and nuclear magnetic resonance studies of peptides from ubiquitin. J Mol Biol (1993) 1.39

Subdomain interactions as a determinant in the folding and stability of T4 lysozyme. Protein Sci (1998) 1.39

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Local interactions in protein folding: lessons from the alpha-helix. J Biol Chem (1997) 1.29

Folding of peptide fragments comprising the complete sequence of proteins. Models for initiation of protein folding. II. Plastocyanin. J Mol Biol (1992) 1.29

The native state of apomyoglobin described by proton NMR spectroscopy: interaction with the paramagnetic probe HyTEMPO and the fluorescent dye ANS. Protein Sci (1994) 1.12

Touring the landscapes: partially folded proteins examined by hydrogen exchange. Structure (1997) 1.10

The number of turns in globular proteins. Nature (1977) 1.06

Interactions between hydrophobic side chains within alpha-helices. Protein Sci (1995) 1.06

Folding of an isolated ribonuclease H core fragment. Protein Sci (1999) 1.00

Residual helical and turn structure in the denatured state of staphylococcal nuclease: analysis of peptide fragments. Fold Des (1997) 0.95

1H, 13C and 15N assignments and chemical shift-derived secondary structure of intestinal fatty acid-binding protein. J Biomol NMR (1995) 0.90

A test of the relationship between sequence and structure in proteins: excision of the heme binding site in apocytochrome b5. Protein Sci (1998) 0.87

Hydrophobicity of amino acid residues in globular proteins. Science (1985) 5.64

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Prediction of chain turns in globular proteins on a hydrophobic basis. Nature (1978) 3.61

Loops in globular proteins: a novel category of secondary structure. Science (1986) 3.48

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Side-chain entropy opposes alpha-helix formation but rationalizes experimentally determined helix-forming propensities. Proc Natl Acad Sci U S A (1992) 2.42

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Modeling unfolded states of proteins and peptides. II. Backbone solvent accessibility. Biochemistry (1997) 1.64

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A protein taxonomy based on secondary structure. Nat Struct Biol (1999) 1.29

Local interactions in protein folding: lessons from the alpha-helix. J Biol Chem (1997) 1.29

The T-to-R transformation in hemoglobin: a reevaluation. Proc Natl Acad Sci U S A (1994) 1.28

The protein-folding problem: the native fold determines packing, but does packing determine the native fold? Proc Natl Acad Sci U S A (1991) 1.26

Is counterion delocalization responsible for collapse in RNA folding? Biochemistry (2000) 1.19

Molten globular characteristics of the native state of apomyoglobin. Nat Struct Biol (1994) 1.19

Sequence determinants of the capping box, a stabilizing motif at the N-termini of alpha-helices. Protein Sci (1994) 1.19

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Interior turns in globular proteins. Nature (1983) 1.07

The number of turns in globular proteins. Nature (1977) 1.06

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Identifying two ancient enzymes in Archaea using predicted secondary structure alignment. Nat Struct Biol (1999) 1.05

Effects of alanine substitutions in alpha-helices of sperm whale myoglobin on protein stability. Protein Sci (1993) 1.00

A new algorithm for finding the peptide chain turns in a globular protein. J Mol Biol (1977) 0.98

Seeking an ancient enzyme in Methanococcus jannaschii using ORF, a program based on predicted secondary structure comparisons. Proc Natl Acad Sci U S A (1998) 0.96

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Vigorous, aerobic exercise versus general motor training activities: effects on maladaptive and stereotypic behaviors of adults with both autism and mental retardation. J Autism Dev Disord (1994) 0.95

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