PubRank

Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A)

Journal PubWeight™ 194403.92‹?›

Top papers

Rank Title Year PubWeight™‹?›
1 DNA sequencing with chain-terminating inhibitors. 1977 790.54
2 Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. 1979 365.71
3 A new method for sequencing DNA. 1977 250.51
4 Improved tools for biological sequence comparison. 1988 193.60
5 Cluster analysis and display of genome-wide expression patterns. 1998 192.97
6 Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. 2005 167.46
7 Significance analysis of microarrays applied to the ionizing radiation response. 2001 132.88
8 Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. 1980 109.70
9 One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. 2000 96.90
10 Genomic sequencing. 1984 92.36
11 Statistical significance for genomewide studies. 2003 88.64
12 Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. 1972 83.88
13 Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. 1975 77.46
14 Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. 1979 72.18
15 Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. 2001 71.82
16 Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form. 1969 71.62
17 Rapid and efficient site-specific mutagenesis without phenotypic selection. 1985 68.48
18 Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. 2001 68.44
19 The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. 1974 62.91
20 Amino acid substitution matrices from protein blocks. 1992 61.33
21 Prospective identification of tumorigenic breast cancer cells. 2003 59.17
22 Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA. 1972 57.06
23 Nucleotide sequence of the rightward operator of phage lambda. 1975 56.75
24 Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. 2009 54.68
25 Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination. 1983 54.64
26 A Reversible Photoreaction Controlling Seed Germination. 1952 53.37
27 Rapid similarity searches of nucleic acid and protein data banks. 1983 53.12
28 A default mode of brain function. 2001 50.73
29 Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. 1990 50.63
30 Genetic Control of Biochemical Reactions in Neurospora. 1941 50.06
31 TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE. 1958 50.05
32 Genetic Factors Affecting the Strength of Linkage in Drosophila. 1917 49.95
33 Strategies for multilocus linkage analysis in humans. 1984 48.41
34 A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells. 1967 48.10
35 An index to quantify an individual's scientific research output. 2005 46.59
36 A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. 1985 46.59
37 Transformation of yeast. 1978 46.46
38 Enhanced graphic matrix analysis of nucleic acid and protein sequences. 1981 46.11
39 Broad host range DNA cloning system for gram-negative bacteria: construction of a gene bank of Rhizobium meliloti. 1980 45.02
40 A gene atlas of the mouse and human protein-encoding transcriptomes. 2004 44.81
41 Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. 1979 44.75
42 The Effect of Temperature on Linkage in the Second Chromosome of Drosophila. 1917 43.20
43 Microbial diversity in the deep sea and the underexplored "rare biosphere". 2006 42.38
44 Electrostatics of nanosystems: application to microtubules and the ribosome. 2001 42.14
45 Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. 1977 41.76
46 Mathematical model for studying genetic variation in terms of restriction endonucleases. 1979 41.08
47 Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes. 1977 40.24
48 A microRNA expression signature of human solid tumors defines cancer gene targets. 2006 40.09
49 Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. 1999 39.79
50 Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. 1998 39.20
Next 50