Published in J Biol Chem on December 17, 1999
Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism. Nat Chem Biol (2013) 1.26
Pore-forming toxins: ancient, but never really out of fashion. Nat Rev Microbiol (2015) 1.08
Dual chaperone role of the C-terminal propeptide in folding and oligomerization of the pore-forming toxin aerolysin. PLoS Pathog (2011) 1.00
More than a pore: the cellular response to cholesterol-dependent cytolysins. Toxins (Basel) (2013) 0.83
Cholera toxin B subunits assemble into pentamers--proposition of a fly-casting mechanism. PLoS One (2010) 0.83
Preliminary crystallographic analysis of two oligomerization-deficient mutants of the aerolysin toxin, H132D and H132N, in their proteolyzed forms. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.81
Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process. Nat Commun (2016) 0.79
Construction of an aerolysin nanopore in a lipid bilayer for single-oligonucleotide analysis. Nat Protoc (2017) 0.75
VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. J Cell Biol (1992) 4.81
The focusing positions of polypeptides in immobilized pH gradients can be predicted from their amino acid sequences. Electrophoresis (1993) 4.64
Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings. Nature (1988) 4.41
Sexual health of teenagers in England and Wales: analysis of national data. BMJ (1999) 3.54
The bacterial porin superfamily: sequence alignment and structure prediction. Mol Microbiol (1991) 3.45
Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem (2000) 3.12
Assessing the impact of national anti-HIV sexual health campaigns: trends in the transmission of HIV and other sexually transmitted infections in England. Sex Transm Infect (2001) 3.09
A 'molten-globule' membrane-insertion intermediate of the pore-forming domain of colicin A. Nature (1991) 2.77
A comparison of subcutaneous low-molecular-weight heparin with warfarin sodium for prophylaxis against deep-vein thrombosis after hip or knee implantation. N Engl J Med (1993) 2.76
From proteins to proteomes: large scale protein identification by two-dimensional electrophoresis and amino acid analysis. Biotechnology (N Y) (1996) 2.75
Use of human patient simulation to teach emergency medicine trainees advanced airway skills. J Accid Emerg Med (1999) 2.72
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br J Pharmacol (1992) 2.50
The use of self-rating scales in a single-patient multiple cross-over trial. Br J Psychiatry (1968) 2.48
Genitourinary medicine services in the United Kingdom are failing to meet current demand. Int J STD AIDS (2001) 2.47
The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein. EMBO J (1996) 2.28
Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states. Nature (1994) 2.18
Bacterial pore-forming toxins: the (w)hole story? Cell Mol Life Sci (2008) 2.16
A cyclin associated with the CDK-activating kinase MO15. Nature (1994) 2.05
Chlamydia trachomatis in the United Kingdom: a systematic review and analysis of prevalence studies. Sex Transm Infect (2004) 2.05
A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum. J Cell Biol (1998) 2.04
Involvement of the transmembrane protein p23 in biosynthetic protein transport. J Cell Biol (1997) 2.00
Annexin II is a major component of fusogenic endosomal vesicles. J Cell Biol (1993) 1.99
A self-rating scale of distress. Psychol Med (1973) 1.94
Pep5, a new lantibiotic: structural gene isolation and prepeptide sequence. Arch Microbiol (1989) 1.85
Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol. Mol Biol Cell (1997) 1.84
Structure of the membrane-pore-forming fragment of colicin A. Nature (1989) 1.80
Trends in HIV testing and recording of HIV status in the UK primary care setting: a retrospective cohort study 1995-2005. Sex Transm Infect (2009) 1.74
Protein expression profiles in human breast ductal carcinoma and histologically normal tissue. Electrophoresis (1997) 1.74
Structural and functional alterations of a colicin-resistant mutant of OmpF porin from Escherichia coli. Proc Natl Acad Sci U S A (1994) 1.74
Refined structure of the pore-forming domain of colicin A at 2.4 A resolution. J Mol Biol (1992) 1.70
Systemic lupus erythematosus in migrants from west Africa compared with Afro-Caribbean people in the UK. Lancet (2001) 1.69
VIP36, a novel component of glycolipid rafts and exocytic carrier vesicles in epithelial cells. EMBO J (1994) 1.67
In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. EMBO J (1995) 1.66
Rapid increase in gonorrhoea and syphilis diagnoses in England in 2011. Euro Surveill (2012) 1.62
Plasma protein map: an update by microsequencing. Electrophoresis (1993) 1.60
Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60
Prodromal symptoms in affective disorders. Am J Psychiatry (1991) 1.59
Epidemiology. Foot-and-mouth disease under control in the UK. Nature (2001) 1.57
Pulmonary function and cardiovascular risk factor relationships in black and in white young men and women. The CARDIA Study. Chest (1991) 1.54
The pore-forming toxin proaerolysin is activated by furin. J Biol Chem (1998) 1.54
Structural gene isolation and prepeptide sequence of gallidermin, a new lanthionine containing antibiotic. FEMS Microbiol Lett (1989) 1.53
Managing acute anaphylaxis. New guidelines emphasise importance of intramuscular adrenaline. BMJ (1999) 1.52
Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2. Proc Natl Acad Sci U S A (1998) 1.51
Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA. Eur J Biochem (1999) 1.51
Accident and emergency doctors lack proper training in trauma. BMJ (1995) 1.49
Amygdala and ventral anterior cingulate activation predicts treatment response to cognitive behaviour therapy for post-traumatic stress disorder. Psychol Med (2007) 1.46
Dose-response study of N,N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale. Arch Gen Psychiatry (1994) 1.46
A symptom questionnaire. J Clin Psychiatry (1987) 1.46
Capillaroscopic observations in rheumatic diseases. Ann Rheum Dis (1970) 1.45
Histiocytic necrotizing lymphadenitis, Kikuchi-Fujimoto's disease, associated with systemic lupus erythemotosus. QJM (1997) 1.45
Purification and analysis of authentic CLIP-170 and recombinant fragments. J Biol Chem (1999) 1.43
Adventures of a pore-forming toxin at the target cell surface. Trends Microbiol (2000) 1.43
Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.41
Fungal osteomyelitis of the temporal bone: a review of reported cases. Ear Nose Throat J (1993) 1.41
Pore-forming toxins and cellular non-immune defenses (CNIDs). Curr Opin Microbiol (2007) 1.40
Measurement of dijet azimuthal decorrelations in pp collisions at sqrt(s)=7 TeV. Phys Rev Lett (2011) 1.39
Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein. J Mol Biol (1999) 1.39
Spreading of membranes at the air/water interface. Chem Phys Lipids (1976) 1.38
Detection of pulsed gamma rays above 100 GeV from the Crab pulsar. Science (2011) 1.38
The bacterial toxin toolkit. Nat Rev Mol Cell Biol (2001) 1.37
Protection of cattle from bovine herpesvirus type I (BHV-1) infection by immunization with individual viral glycoproteins. Virology (1987) 1.36
Functional somatic symptoms and hypochondriasis. A survey of empirical studies. Arch Gen Psychiatry (1985) 1.36
Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells. FEBS Lett (2000) 1.35
Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor. J Biol Chem (1996) 1.35
Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections. Phys Rev Lett (2012) 1.34
Membrane topology and site-specific mutagenesis of Pseudomonas aeruginosa porin OprD. Mol Microbiol (1995) 1.33
Surveillance of sexually transmitted infections in primary care. Sex Transm Infect (2003) 1.32
Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32
Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors. Nature (1999) 1.32
Functional domains of colicin A. Mol Microbiol (1988) 1.31
First observation of the Greisen-Zatsepin-Kuzmin suppression. Phys Rev Lett (2008) 1.29
European consensus statement on the terminology used in the management of lupus glomerulonephritis. Lupus (2009) 1.28
Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells. Blood (1997) 1.27
Observation of associated near-side and away-side long-range correlations in sqrt[s(NN)]=5.02 TeV proton-lead collisions with the ATLAS detector. Phys Rev Lett (2013) 1.27
A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease. Eur J Biochem (1994) 1.26
Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains. J Biol Chem (2001) 1.26
A controlled study of imagery rehearsal for chronic nightmares in sexual assault survivors with PTSD: a preliminary report. J Trauma Stress (2000) 1.26
Uncoupled steps of the colicin A pore formation demonstrated by disulfide bond engineering. J Biol Chem (1994) 1.24
The migration of Proteus mirabilis and other urinary tract pathogens over Foley catheters. BJU Int (2002) 1.24
Transcytosis of the polymeric Ig receptor requires phosphorylation of serine 664 in the absence but not the presence of dimeric IgA. Cell (1993) 1.23
Site-directed mutagenesis of the COOH-terminal region of colicin A: effect on secretion and voltage-dependent channel activity. Proc Natl Acad Sci U S A (1987) 1.23
Intensified shigellosis epidemic associated with sexual transmission in men who have sex with men--Shigella flexneri and S. sonnei in England, 2004 to end of February 2015. Euro Surveill (2015) 1.22
The citrus canker epidemic in Florida: the scientific basis of regulatory eradication policy for an invasive species. Phytopathology (2001) 1.21
Recruitment of elderly volunteers for a multicenter clinical trial: the SHEP pilot study. Control Clin Trials (1986) 1.21
The voltage-dependent activity of Escherichia coli porins in different planar bilayer reconstitutions. Eur J Biochem (1989) 1.21
Crystal structure of a colicin N fragment suggests a model for toxicity. Structure (1998) 1.20
The selectivity filter of voltage-dependent channels formed by phosphoporin (PhoE protein) from E. coli. EMBO J (1986) 1.20
A pilot validation in 10 European Union Member States of a point prevalence survey of healthcare-associated infections and antimicrobial use in acute hospitals in Europe, 2011. Euro Surveill (2015) 1.19
Search for dark matter candidates and large extra dimensions in events with a photon and missing transverse momentum in pp collision data at sqrt[s]=7 TeV with the ATLAS detector. Phys Rev Lett (2013) 1.19
Isolation, molecular and functional properties of the C-terminal domain of colicin A. EMBO J (1983) 1.19
The aerolysin membrane channel is formed by heptamerization of the monomer. EMBO J (1992) 1.19
Compliance to treatment for hypertension in elderly patients: the SHEP pilot study. Systolic Hypertension in the Elderly Program. J Gerontol (1987) 1.18
Human liver protein map: a reference database established by microsequencing and gel comparison. Electrophoresis (1992) 1.18
Rendering a membrane protein soluble in water: a common packing motif in bacterial protein toxins. Trends Biochem Sci (1993) 1.17
Fatal Clostridium perfringens sepsis from a pooled platelet transfusion. Transfus Med (1998) 1.17
Molecular co-operation between protein PAM and streptokinase for plasmin acquisition by Streptococcus pyogenes. J Biol Chem (1998) 1.17
Aerolysin--the ins and outs of a model channel-forming toxin. Mol Microbiol (1996) 1.15
Insights into membrane insertion based on studies of colicins. Trends Biochem Sci (1990) 1.15