Extensive interplasmidic duplications change the virulence phenotype of the relapsing fever agent Borrelia turicatae.

PubWeight™: 1.26‹?› | Rank: Top 10%

🔗 View Article (PMID 10594835)

Published in Mol Microbiol on December 01, 1999

Authors

P M Penningon1, D Cadavid, J Bunikis, S J Norris, A G Barbour

Author Affiliations

1: Departments of Microbiology and Molecular Genetics and Medicine, B240 Med Sci I, University of California Irvine, Irvine, CA 92697-4025, USA.

Articles citing this

Antigenic variation in vector-borne pathogens. Emerg Infect Dis (2000) 2.39

Comparative analysis of the Borrelia garinii genome. Nucleic Acids Res (2004) 1.96

Outer membrane proteins of pathogenic spirochetes. FEMS Microbiol Rev (2004) 1.87

Typing African relapsing fever spirochetes. Emerg Infect Dis (2005) 1.49

Isogenic serotypes of Borrelia turicatae show different localization in the brain and skin of mice. Infect Immun (2001) 1.11

Surface protein variation by expression site switching in the relapsing fever agent Borrelia hermsii. Infect Immun (2000) 1.06

Multiple and Diverse vsp and vlp Sequences in Borrelia miyamotoi, a Hard Tick-Borne Zoonotic Pathogen. PLoS One (2016) 0.94

Crystal structure of neurotropism-associated variable surface protein 1 (Vsp1) of Borrelia turicatae. J Bacteriol (2006) 0.89

Interaction of a neurotropic strain of Borrelia turicatae with the cerebral microcirculation system. Infect Immun (2006) 0.88

The mammalian host response to borrelia infection. Wien Klin Wochenschr (2006) 0.87

Relapsing fever borreliosis in interleukin-10-deficient mice. Infect Immun (2008) 0.82

Understanding tropism and immunopathological mechanisms of relapsing fever spirochaetes. Clin Microbiol Infect (2009) 0.81

Chromosome and Linear Plasmid Sequences of a 2015 Human Isolate of the Tick-Borne Relapsing Fever Spirochete, Borrelia turicatae. Genome Announc (2016) 0.81

Characterisation of silent and active genes for a variable large protein of Borrelia recurrentis. BMC Infect Dis (2002) 0.78

Interaction of variable bacterial outer membrane lipoproteins with brain endothelium. PLoS One (2010) 0.76

Toward a Complete North American Borrelia miyamotoi Genome. Genome Announc (2017) 0.75

Transcriptional Profiling the 150 kb Linear Megaplasmid of Borrelia turicatae Suggests a Role in Vector Colonization and Initiating Mammalian Infection. PLoS One (2016) 0.75

Articles by these authors

Lyme disease-a tick-borne spirochetosis? Science (1982) 27.50

The spirochetal etiology of Lyme disease. N Engl J Med (1983) 21.59

Isolation and cultivation of Lyme disease spirochetes. Yale J Biol Med (1985) 20.49

Spirochetes isolated from the blood of two patients with Lyme disease. N Engl J Med (1983) 11.15

Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody. Infect Immun (1983) 9.60

Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science (1998) 7.96

Heterogeneity of major proteins in Lyme disease borreliae: a molecular analysis of North American and European isolates. J Infect Dis (1985) 7.69

A Borrelia-specific monoclonal antibody binds to a flagellar epitope. Infect Immun (1986) 6.80

Variation in a major surface protein of Lyme disease spirochetes. Infect Immun (1984) 6.68

Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi. Mol Microbiol (1989) 6.51

Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes. Cell (1997) 6.36

Biology of Borrelia species. Microbiol Rev (1986) 6.03

Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends. Science (1987) 5.80

Variable major proteins of Borrellia hermsii. J Exp Med (1982) 5.62

Natural Distribution of the Ixodes dammini spirochete. Science (1983) 5.24

Antigenic variability of Borrelia burgdorferi. Ann N Y Acad Sci (1988) 5.02

Spirochetes in Ixodes dammini and mammals from Connecticut. Am J Trop Med Hyg (1983) 4.86

Correlation between plasmid content and infectivity in Borrelia burgdorferi. Proc Natl Acad Sci U S A (2000) 4.81

Low-passage-associated proteins of Borrelia burgdorferi B31: characterization and molecular cloning of OspD, a surface-exposed, plasmid-encoded lipoprotein. Infect Immun (1992) 4.42

Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in the bacterium Borrelia hermsii. Nature (1985) 4.41

Megabase-sized linear DNA in the bacterium Borrelia burgdorferi, the Lyme disease agent. Proc Natl Acad Sci U S A (1989) 4.38

Chlamydia trachomatis has penicillin-binding proteins but not detectable muramic acid. J Bacteriol (1982) 4.33

Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete. J Clin Invest (1983) 4.08

Antigenic variation is associated with DNA rearrangements in a relapsing fever Borrelia. Cell (1985) 3.78

The cryptic ospC gene of Borrelia burgdorferi B31 is located on a circular plasmid. Infect Immun (1993) 3.50

A single recombinant plasmid expressing two major outer surface proteins of the Lyme disease spirochete. Science (1985) 3.42

Organization of genes encoding two outer membrane proteins of the Lyme disease agent Borrelia burgdorferi within a single transcriptional unit. Infect Immun (1986) 3.39

Antibody-resistant mutants of Borrelia burgdorferi: in vitro selection and characterization. J Exp Med (1992) 3.30

Adherence of Borrelia burgdorferi to the proteoglycan decorin. Infect Immun (1995) 2.96

Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine. J Exp Med (1993) 2.96

Erythema chronicum migrans--a tickborne spirochetosis. Acta Trop (1983) 2.85

Clonal polymorphisms of outer membrane protein OspB of Borrelia burgdorferi. Infect Immun (1989) 2.76

Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion. Infect Immun (1998) 2.73

DNA characterization of the spirochete that causes Lyme disease. J Clin Microbiol (1984) 2.71

Heterogeneity of outer membrane proteins in Borrelia burgdorferi: comparison of osp operons of three isolates of different geographic origins. Infect Immun (1992) 2.67

Purification of Treponema pallidum, Nichols strain, by Percoll density gradient centrifugation. Sex Transm Dis (1985) 2.63

Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi. Infect Immun (1998) 2.56

Cloning of 18S and 25S rDNAs from the pathogenic fungus Cryptococcus neoformans. J Bacteriol (1989) 2.55

The western black-legged tick, Ixodes pacificus: a vector of Borrelia burgdorferi. Am J Trop Med Hyg (1985) 2.50

Linear- and circular-plasmid copy numbers in Borrelia burgdorferi. J Bacteriol (1992) 2.45

High- and low-infectivity phenotypes of clonal populations of in vitro-cultured Borrelia burgdorferi. Infect Immun (1995) 2.39

Polymorphisms of major surface proteins of Borrelia burgdorferi. Zentralbl Bakteriol Mikrobiol Hyg A (1986) 2.33

In vitro inhibition of Borrelia burgdorferi growth by antibodies. J Infect Dis (1993) 2.31

Clinical outcomes of natalizumab-associated progressive multifocal leukoencephalopathy. Neurology (2011) 2.26

Outer surface protein A (OspA) from the Lyme disease spirochete, Borrelia burgdorferi: high level expression and purification of a soluble recombinant form of OspA. Protein Expr Purif (1990) 2.23

Linear plasmids of Borrelia burgdorferi have a telomeric structure and sequence similar to those of a eukaryotic virus. J Bacteriol (1991) 2.15

Neuroborreliosis during relapsing fever: review of the clinical manifestations, pathology, and treatment of infections in humans and experimental animals. Clin Infect Dis (1998) 2.15

Absence of lipopolysaccharide in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun (1987) 2.15

Variable major proteins of Borrelia hermsii. Epitope mapping and partial sequence analysis of CNBr peptides. J Exp Med (1985) 2.12

Enzyme-linked immunosorbent assays for Lyme disease: reactivity of subunits of Borrelia burgdorferi. J Infect Dis (1989) 2.12

An outbreak of giardiasis in a group of campers. Am J Trop Med Hyg (1976) 2.04

The relapsing fever agent Borrelia hermsii has multiple copies of its chromosome and linear plasmids. Genetics (1992) 2.00

Role of attached lipid in immunogenicity of Borrelia burgdorferi OspA. Infect Immun (1993) 1.98

Human antibody responses to VlsE antigenic variation protein of Borrelia burgdorferi. J Clin Microbiol (1999) 1.95

A flagella-less mutant of Borrelia burgdorferi. Structural, molecular, and in vitro functional characterization. J Clin Invest (1991) 1.95

A Lyme borreliosis cycle in seabirds and Ixodes uriae ticks. Nature (1993) 1.91

Disruption of the genes encoding antigen 85A and antigen 85B of Mycobacterium tuberculosis H37Rv: effect on growth in culture and in macrophages. Infect Immun (2000) 1.90

A family of surface-exposed proteins of 20 kilodaltons in the genus Borrelia. Infect Immun (1994) 1.89

Juxtaposition of expressed variable antigen genes with a conserved telomere in the bacterium Borrelia hermsii. Proc Natl Acad Sci U S A (1990) 1.87

Vaginal isolates of Staphylococcus aureus associated with toxic shock syndrome. Infect Immun (1981) 1.84

Emerging bacterial zoonotic and vector-borne diseases. Ecological and epidemiological factors. JAMA (1996) 1.82

An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo. Infect Immun (1993) 1.79

Nucleotide sequence and analysis of the gene in Borrelia burgdorferi encoding the immunogenic P39 antigen. FEMS Microbiol Lett (1994) 1.77

Serum IL-17F does not predict poor response to IM IFNβ-1a in relapsing-remitting MS. Neurology (2012) 1.76

In vitro antimicrobial susceptibility testing of Borrelia burgdorferi: a microdilution MIC method and time-kill studies. J Clin Microbiol (1992) 1.75

Access of antibody or trypsin to an integral outer membrane protein (P66) of Borrelia burgdorferi is hindered by Osp lipoproteins. Infect Immun (1999) 1.74

Immunochemical analysis of Lyme disease spirochetes. Yale J Biol Med (1985) 1.74

Expert advice and patient expectations: laboratory testing and antibiotics for Lyme disease. JAMA (1998) 1.73

Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis. J Exp Med (1994) 1.73

Properties of penicillin-binding proteins in Neisseria gonorrhoeae. Antimicrob Agents Chemother (1981) 1.72

Isolation and characterization of the Lyme disease spirochete from the skin of patients with erythema chronicum migrans. J Am Acad Dermatol (1985) 1.71

The biology, pathology, and immunology of syphilis. Int Rev Exp Pathol (1983) 1.70

The Oms66 (p66) protein is a Borrelia burgdorferi porin. Infect Immun (1997) 1.65

In vitro cultivation of Treponema pallidum: independent confirmation. Infect Immun (1982) 1.61

Antigenic complexity of Treponema pallidum: antigenicity and surface localization of major polypeptides. J Immunol (1984) 1.60

Antigenic variation and strain heterogeneity in Borrelia spp. Res Microbiol (1993) 1.60

Characterization of a manganese-dependent regulatory protein, TroR, from Treponema pallidum. Proc Natl Acad Sci U S A (1999) 1.57

Subtelomeric expression regions of Borrelia hermsii linear plasmids are highly polymorphic. Mol Microbiol (1992) 1.55

Cloning and sequence analysis of linear plasmid telomeres of the bacterium Borrelia burgdorferi. Mol Microbiol (1990) 1.54

The variable antigens Vmp7 and Vmp21 of the relapsing fever bacterium Borrelia hermsii are structurally analogous to the VSG proteins of the African trypanosome. Mol Microbiol (1990) 1.52

Arthritis severity and spirochete burden are determined by serotype in the Borrelia turicatae-mouse model of Lyme disease. Infect Immun (1997) 1.51

Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog. Gene (1997) 1.50

Structural analysis of the variable major proteins of Borrelia hermsii. J Exp Med (1983) 1.50

Occupational lead poisoning in the United States: clinical and biochemical findings related to blood lead levels. Br J Ind Med (1979) 1.50

Borrelia burgdorferi mutant lacking Osp: biological and immunological characterization. Infect Immun (1995) 1.49

Antigen diversity in the bacterium B. hermsii through "somatic" mutations in rearranged vmp genes. Cell (1994) 1.44

Immunologic and genetic analyses of VmpA of a neurotropic strain of Borrelia turicatae. Infect Immun (1997) 1.42

Action of penicillin on Borrelia hermsii. Antimicrob Agents Chemother (1982) 1.42

Comparative analysis and immunological characterization of the Borrelia Bdr protein family. Infect Immun (1999) 1.40

Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins. Infect Immun (1998) 1.40

Antibodies to Lyme-disease spirochaete in European lymphocytic meningoradiculitis (Bannwarth's syndrome) Lancet (1983) 1.39

Isolation of a spirochete from the soft tick, Ornithodoros coriaceus: a possible agent of epizootic bovine abortion. Science (1985) 1.39

The etiologic agent of Lyme disease in deer flies, horse flies, and mosquitoes. J Infect Dis (1986) 1.38

Bacteriophage in the Ixodes dammini spirochete, etiological agent of Lyme disease. J Bacteriol (1983) 1.38

Activation of a vmp pseudogene in Borrelia hermsii: an alternate mechanism of antigenic variation during relapsing fever. Mol Microbiol (1994) 1.36

Analysis of Borrelia burgdorferi vlsE gene expression and recombination in the tick vector. Infect Immun (2001) 1.32

Conversion of a linear to a circular plasmid in the relapsing fever agent Borrelia hermsii. J Bacteriol (1996) 1.31