Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets.

PubWeight™: 1.03‹?› | Rank: Top 15%

🔗 View Article (PMID 10603493)

Published in Trends Pharmacol Sci on December 01, 1999

Authors

C Ward1, I Dransfield, E R Chilvers, C Haslett, A G Rossi

Author Affiliations

1: The Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh Medical School, Teviot Place, Edinburgh, UK EH8 9AG. c.ward@ed.ac.uk

Articles citing this

Anti-inflammatory and proresolving lipid mediators. Annu Rev Pathol (2008) 2.68

TNF ligands and receptors--a matter of life and death. Br J Pharmacol (2002) 1.57

Chronic inflammation: a failure of resolution? Int J Exp Pathol (2007) 1.54

Role of neutrophils in innate immunity: a systems biology-level approach. Wiley Interdiscip Rev Syst Biol Med (2010) 1.37

The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival. Am J Pathol (2004) 0.99

Role of caspases in dexamethasone-induced apoptosis and activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase in human eosinophils. Clin Exp Immunol (2000) 0.98

Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation. Respir Res (2005) 0.95

Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages. Br J Pharmacol (2004) 0.89

Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation. Clin Exp Allergy (2006) 0.88

Anti-inflammatory effect of Viscum album agglutinin-I (VAA-I): induction of apoptosis in activated neutrophils and inhibition of lipopolysaccharide-induced neutrophilic inflammation in vivo. Clin Exp Immunol (2004) 0.87

Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis. Br J Pharmacol (2003) 0.86

GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism. Br J Pharmacol (2004) 0.85

Nuclear factor-kappaB regulates inflammatory cell apoptosis and phagocytosis in rat carrageenin-sponge implant model. Am J Pathol (2004) 0.85

Activation of neutrophils by nanoparticles. ScientificWorldJournal (2011) 0.82

The effect of dexamethasone on the generation of plasma DNA from dead and dying cells. Am J Pathol (2004) 0.79

Phagocytic clearance of apoptotic cells: role in lung disease. Expert Rev Respir Med (2008) 0.78

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis. J Inflamm (Lond) (2009) 0.78

Surface oxidation of UHMWPE for orthopedic use increases apoptosis and necrosis in human granulocytes. J Mater Sci Mater Med (2003) 0.77

Articles by these authors

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest (1989) 7.60

Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups. Lancet (1993) 6.39

Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide. Am J Pathol (1985) 5.02

Phagocyte recognition of cells undergoing apoptosis. Immunol Today (1993) 4.77

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature (1990) 4.67

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J Clin Invest (1992) 4.40

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J Immunol (1992) 3.79

Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat Med (1997) 2.98

Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. J Leukoc Biol (1993) 2.97

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med (1999) 2.92

In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes. J Immunol (1996) 2.74

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase. J Clin Invest (1986) 2.22

Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression. J Immunol (1994) 2.17

Role of selectins in development of adult respiratory distress syndrome. Lancet (1994) 2.14

Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J Immunol (1996) 2.10

Dissociation of neutrophil emigration and metabolic activity in lobar pneumonia and bronchiectasis. Eur Respir J (1997) 2.10

Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. J Immunol (1999) 2.09

Effect of oral salbutamol and slow-release aminophylline on exercise tolerance in chronic bronchitis. Thorax (1981) 2.06

Impairment of function in aging neutrophils is associated with apoptosis. J Immunol (1993) 2.05

Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism. J Clin Invest (1989) 1.93

Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes. Clin Sci (Lond) (1992) 1.91

NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro. J Biol Chem (1999) 1.89

In vivo measurement of neutrophil activity in experimental lung inflammation. Am J Respir Crit Care Med (1994) 1.88

The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo. Biochem Biophys Res Commun (1993) 1.88

Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2. J Leukoc Biol (1992) 1.85

Neutrophil apoptosis and clearance from neonatal lungs. Lancet (1991) 1.76

Granulocyte apoptosis and the control of inflammation. Philos Trans R Soc Lond B Biol Sci (1994) 1.75

Monocyte retention and migration in pulmonary inflammation. Requirement for neutrophils. Lab Invest (1988) 1.72

Neutrophil priming: pathophysiological consequences and underlying mechanisms. Clin Sci (Lond) (1998) 1.69

Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis. Mediation by alpha v beta 3/CD36/thrombospondin recognition mechanism and lack of phlogistic response. Am J Pathol (1996) 1.64

Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. Blood (1997) 1.63

Secretory leukocyte proteinase inhibitor is preferentially increased in patients with acute respiratory distress syndrome. Eur Respir J (1999) 1.56

The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome. Ann Intern Med (1996) 1.56

Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5. J Immunol (1992) 1.56

Kinetics of pulmonary neutrophil recruitment and clearance in a natural and spontaneously resolving model of airway inflammation. Clin Exp Allergy (2005) 1.54

Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance. Clin Exp Allergy (2011) 1.53

The pulmonary vascular sequestration of neutrophils in endotoxemia is initiated by an effect of endotoxin on the neutrophil in the rabbit. Am Rev Respir Dis (1987) 1.52

Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose/fucose-specific lectin. J Immunol (1994) 1.50

Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol (2001) 1.49

Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma. J Clin Invest (1998) 1.46

Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthma. Allergy (2004) 1.46

Pulmonary endothelial permeability and circulating neutrophil-endothelial markers in patients undergoing esophagogastrectomy. Crit Care Med (2000) 1.44

Elafin (elastase-specific inhibitor) has anti-microbial activity against gram-positive and gram-negative respiratory pathogens. FEBS Lett (1999) 1.41

Regulation of macrophage phagocytosis of apoptotic cells by cAMP. J Immunol (1998) 1.41

Hypoxia prolongs neutrophil survival in vitro. FEBS Lett (1995) 1.40

Time to extend 'the timetable of tuberculosis'? Respir Med (1994) 1.37

The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway. Cancer Res (1998) 1.37

Heterogeneity of [3H]inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes. Characterization and validation of a radioreceptor assay. Biochem J (1990) 1.34

Physiological neutrophil sequestration in the lung: visual evidence for localization in capillaries. J Appl Physiol (1985) (1987) 1.33

Functional and clinical consequences of Fc receptor polymorphic and copy number variants. Clin Exp Immunol (2009) 1.31

ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase. Cell Death Differ (2006) 1.30

Regulation of cell adhesion molecule expression and function associated with neutrophil apoptosis. Blood (1995) 1.30

Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation. Am J Respir Crit Care Med (2001) 1.29

Cellular mechanisms of acute lung injury: implications for future treatment in the adult respiratory distress syndrome. Thorax (1992) 1.28

Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac. J Immunol (2001) 1.28

Quantification of right to left shunt at rest and during exercise in patients with pulmonary arteriovenous malformations. Thorax (1992) 1.27

Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes. Cell Death Differ (2000) 1.26

Neutrophil-mediated pulmonary vascular injury. Synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimuli on vascular permeability and neutrophil sequestration in the lung. Am Rev Respir Dis (1987) 1.25

Granulocyte clearance by apoptosis in the resolution of inflammation. Semin Cell Biol (1995) 1.24

The requirement for polymorphonuclear leukocytes in the late asthmatic response and heightened airways reactivity in an animal model. Am Rev Respir Dis (1986) 1.22

Pulmonary fibrosis correlates with duration of tissue neutrophil activation. Am J Respir Crit Care Med (1998) 1.22

The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS). Mol Med (2001) 1.21

Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. Am J Physiol (1999) 1.18

CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages. J Immunol (1997) 1.18

Dibutyryl cyclic AMP stimulation of a monocyte-like cell line, U937: a model for monocyte chemotaxis and Fc receptor-related functions. Immunology (1988) 1.16

Oligosaccharide-mediated interactions of the envelope glycoprotein gp120 of HIV-1 that are independent of CD4 recognition. AIDS (1989) 1.11

Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection. J Immunol (2001) 1.11

Human monocyte adherence: a primary effect of chemotactic factors on the monocyte to stimulate adherence to human endothelium. J Immunol (1987) 1.11

Priming differentially regulates neutrophil adhesion molecule expression/function. Immunology (1996) 1.10

Agents that elevate cAMP inhibit human neutrophil apoptosis. Biochem Biophys Res Commun (1995) 1.10

Phagocytosis of opsonized apoptotic cells: roles for 'old-fashioned' receptors for antibody and complement. Clin Exp Immunol (2004) 1.08

Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro. J Clin Invest (1993) 1.07

Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation. J Endocrinol (2003) 1.07