Published in Clin Exp Allergy on January 01, 2000
Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin Microbiol Rev (2010) 2.32
N-acetylcysteine attenuates TNF-alpha-induced p38 MAP kinase activation and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells. Br J Pharmacol (2001) 1.08
Role of p38 MAPK and NF-kB for chemokine release in coculture of human eosinophils and bronchial epithelial cells. Clin Exp Immunol (2005) 1.07
Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells. Br J Pharmacol (2003) 1.06
The role of MAP kinases in intracellular signal transduction in bronchial epithelium. Clin Exp Allergy (2000) 1.03
Activation of p38 mitogen-activated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils. Clin Exp Immunol (2002) 0.89
LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes. J Lipids (2011) 0.88
Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells. Exp Lung Res (2009) 0.86
Bluetongue virus and double-stranded RNA increase human vascular permeability: role of p38 MAPK. J Clin Immunol (2006) 0.85
Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress. Am J Pathol (2008) 0.77
Information theoretic approach to complex biological network reconstruction: application to cytokine release in RAW 264.7 macrophages. BMC Syst Biol (2014) 0.75
Amantadine inhibits RANTES production by influenzavirus-infected human bronchial epithelial cells. Br J Pharmacol (2001) 0.75
TNF-α-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis. Cell Death Dis (2017) 0.75
In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell (1985) 11.63
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science (1997) 9.53
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature (1990) 8.94
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature (1999) 7.31
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science (1995) 6.81
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science (1998) 6.62
Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1982) 5.04
Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell (1991) 4.98
Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside. Ann Neurol (2001) 4.96
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol (1994) 4.86
Acetylation of chromosome squashes of Drosophila melanogaster decreases the background in autoradiographs from hybridization with [125I]-labeled RNA. J Histochem Cytochem (1978) 4.61
Peopling of the Americas, founded by four major lineages of mitochondrial DNA. Mol Biol Evol (1993) 4.50
GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell (1987) 4.50
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination. Nature (1992) 4.43
Function of positive regulatory gene gal4 in the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae: evidence that the GAL81 region codes for part of the gal4 protein. J Bacteriol (1980) 4.36
Amplification of inflammation in emphysema and its association with latent adenoviral infection. Am J Respir Crit Care Med (2001) 4.25
Genetic control of galactokinase synthesis in Saccharomyces cerevisiae: evidence for constitutive expression of the positive regulatory gene gal4. J Bacteriol (1978) 4.18
Interaction of super-repressible and dominant constitutive mutations for the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae. Mol Gen Genet (1977) 4.14
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature (1999) 4.01
Growth stasis by accumulated L-alpha-glycerophosphate in Escherichia coli. J Bacteriol (1965) 4.01
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell (2000) 3.90
Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J Biol Chem (1999) 3.67
Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme. Cell (1995) 3.64
MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Mol Cell Biol (1993) 3.54
Man's place in Hominoidea revealed by mitochondrial DNA genealogy. J Mol Evol (1992) 3.53
Expression and function of c-kit in hemopoietic progenitor cells. J Exp Med (1991) 3.48
TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science (1996) 3.48
A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. Mol Cell Biol (1993) 3.47
A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. J Exp Med (1992) 3.37
IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol Cell Biol (1989) 3.17
Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J Cell Biol (2000) 3.13
Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science (2001) 3.13
S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein. Cell (1990) 3.09
Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures. J Exp Med (1990) 3.05
Initiation of meiosis in yeast mutants defective in adenylate cyclase and cyclic AMP-dependent protein kinase. Cell (1983) 2.91
Cell division cycle genes nda2 and nda3 of the fission yeast Schizosaccharomyces pombe control microtubular organization and sensitivity to anti-mitotic benzimidazole compounds. J Mol Biol (1983) 2.77
Recessive mutations conferring resistance to carbon catabolite repression of galactokinase synthesis in Saccharomyces cerevisiae. J Bacteriol (1983) 2.73
A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana. Proc Natl Acad Sci U S A (1996) 2.72
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem (1996) 2.64
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J (1999) 2.54
Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. Proc Natl Acad Sci U S A (1988) 2.54
TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. J Biol Chem (2000) 2.53
Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat Med (1999) 2.51
Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med (1989) 2.49
In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development. EMBO J (1991) 2.48
Control of cell division in Saccharomyces cerevisiae mutants defective in adenylate cyclase and cAMP-dependent protein kinase. Exp Cell Res (1983) 2.48
Zygotic Drosophila E-cadherin expression is required for processes of dynamic epithelial cell rearrangement in the Drosophila embryo. Genes Dev (1996) 2.43
The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates. Cell (2001) 2.43
Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature (1999) 2.42
Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by PCR using type-specific primers. J Clin Microbiol (2001) 2.42
Stimulation of tyrosine aminotransferase synthesis by dexamethasone phosphate in cell culture. J Mol Biol (1968) 2.41
Combination therapy with fluconazole and flucytosine for cryptococcal meningitis in Ugandan patients with AIDS. Clin Infect Dis (1998) 2.40
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J Biol Chem (1999) 2.40
IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. Mol Cell Biol (1990) 2.40
Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J (2001) 2.37
Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function. Development (1991) 2.35
CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiae. Mol Cell Biol (1988) 2.33
MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae. EMBO J (1994) 2.32
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature (1999) 2.32
Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites. J Comp Neurol (2001) 2.31
Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum Genet (1998) 2.27
Tyrosine transaminase induction in mammalian cells in tissue culture. Cold Spring Harb Symp Quant Biol (1966) 2.26
Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. Proc Natl Acad Sci U S A (1991) 2.26
IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell (1992) 2.25
Temperature-sensitive mutations in Drosophila melanogaster,I. Relative frequencies among gamma-ray and chemically induced sex-linked recessive lethals and semilethals. Proc Natl Acad Sci U S A (1967) 2.22
Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. Science (1994) 2.21
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol (1999) 2.21
The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3. Nature (1998) 2.18
Identification of the gene loci that predispose to rheumatoid arthritis. Int Immunol (1998) 2.16
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J (1998) 2.15
Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol (1995) 2.14
Identification of the structural gene and nonsense alleles for adenylate cyclase in Saccharomyces cerevisiae. J Bacteriol (1984) 2.09
Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol (2001) 2.09
The sequence of the Cu-Zn superoxide dismutase gene of Drosophila. Nucleic Acids Res (1987) 2.07
Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol (1997) 2.07
Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions. Cancer Res (1997) 2.06
Cyclic AMP may not be involved in catabolite repression in Saccharomyes cerevisiae: evidence from mutants capable of utilizing it as an adenine source. J Bacteriol (1982) 2.05
Heat shock response of Saccharomyces cerevisiae mutants altered in cyclic AMP-dependent protein phosphorylation. Mol Cell Biol (1987) 2.05
Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology (1999) 2.03
Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats. Hepatology (1999) 2.02
NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease. Neurosci Lett (1997) 2.01
Loss of beta-catenin expression associated with disease progression in malignant melanoma. Br J Dermatol (2001) 2.00
UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans. Neuron (2001) 1.98
Diurnal variation of intraocular pressure in primary open-angle glaucoma. Am J Ophthalmol (1975) 1.98
Regulation of the yeast pheromone response pathway by G protein subunits. EMBO J (1990) 1.97
Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. J Cell Biol (1999) 1.96
Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M. Oncogene (1995) 1.94
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol Cell Biol (2001) 1.93
Post-transcriptional regulation through the HO 3'-UTR by Mpt5, a yeast homolog of Pumilio and FBF. EMBO J (2001) 1.93
Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway. Mol Cell Biol (1999) 1.92
Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res (2001) 1.91
Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone. FEBS Lett (2001) 1.90
Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. J Clin Invest (2000) 1.90
Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast. Proc Natl Acad Sci U S A (1996) 1.89
Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. J Biol Chem (2001) 1.86
Amyloid plaques in Creutzfeldt-Jakob disease stain with prion protein antibodies. Ann Neurol (1986) 1.85
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J Biol Chem (1994) 1.84
A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats. Cardiovasc Res (2001) 1.84
p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis. Mol Cell Biol (1999) 1.83