Published in J Infect Dis on January 01, 2000
The CRISIS Prevention Study (CRISIS) | NCT00395161
Impact of CVVHD With Increased Adsorption Membranes in Septic Acute Kidney Injury | NCT01790620
Fast Assay for Pathogen Identification and Characterization (FAPIC) | NCT03841162
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol (2013) 4.38
Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med (2008) 2.93
Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future. BMC Med (2011) 2.44
New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev (2012) 2.01
Blood purification and mortality in sepsis: a meta-analysis of randomized trials. Crit Care Med (2013) 1.94
The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients. Clin Chest Med (2008) 1.86
Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome. Eur Respir J (2006) 1.82
Cytomegalovirus infection in critically ill patients: a systematic review. Crit Care (2009) 1.73
Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections. Clin Diagn Lab Immunol (2004) 1.65
The hyperferritinemic syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome. BMC Med (2013) 1.56
Genome-wide transcription profiling of human sepsis: a systematic review. Crit Care (2010) 1.48
Anesthetics impact the resolution of inflammation. PLoS One (2008) 1.42
The transcriptome of the fetal inflammatory response syndrome. Am J Reprod Immunol (2010) 1.37
Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis. Am J Respir Crit Care Med (2011) 1.27
Clinical review: sepsis and septic shock--the potential of gene arrays. Crit Care (2012) 1.25
ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nat Med (2011) 1.21
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill. Physiol Rev (2015) 1.20
Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with community-acquired sepsis, severe sepsis, and septic shock. Eur J Clin Microbiol Infect Dis (2006) 1.18
Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice. Am J Physiol Renal Physiol (2008) 1.17
Biomarkers and molecular analysis to improve bloodstream infection diagnostics in an emergency care unit. PLoS One (2014) 1.17
Regional and systemic cytokine responses to acute inflammation of the vermiform appendix. Ann Surg (2003) 1.16
The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer? Virulence (2013) 1.15
The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals. J Immunol (2009) 1.11
Prognostic value of phagocytic activity of neutrophils and monocytes in sepsis. Correlation to CD64 and CD14 antigen expression. Clin Exp Immunol (2008) 1.11
Identification of enhanced cytokine generation following sepsis. Dream of magic bullet for mortality prediction and therapeutic evaluation. Daru (2010) 1.09
CyProQuant-PCR: a real time RT-PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical use. BMC Immunol (2005) 1.06
Cytokine profiles in sepsis have limited relevance for stratifying patients in the emergency department: a prospective observational study. PLoS One (2011) 1.05
Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue. Int J Mol Med (2014) 1.01
Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design. Am J Respir Crit Care Med (2016) 1.01
Anesthetic isoflurane posttreatment attenuates experimental lung injury by inhibiting inflammation and apoptosis. Mediators Inflamm (2013) 0.99
Circulating inflammatory mediators in patients with fever: predicting bloodstream infection. Clin Diagn Lab Immunol (2001) 0.99
Neonatal sepsis and inflammatory mediators. Mediators Inflamm (2014) 0.98
Role of cytokines as a double-edged sword in sepsis. In Vivo (2013) 0.98
Subanesthetic isoflurane reduces zymosan-induced inflammation in murine Kupffer cells by inhibiting ROS-activated p38 MAPK/NF-κB signaling. Oxid Med Cell Longev (2014) 0.96
A predominantly anti-inflammatory cytokine profile is associated with disease severity in meningococcal sepsis. Intensive Care Med (2005) 0.96
Anti-inflammatory cytokines: important immunoregulatory factors contributing to chemotherapy-induced gastrointestinal mucositis. Chemother Res Pract (2012) 0.95
Heterogeneity in lipopolysaccharide responsiveness of endothelial cells identified by gene expression profiling: role of transcription factors. Clin Exp Immunol (2006) 0.95
Differential cytokine gene expression according to outcome in a hamster model of leptospirosis. PLoS Negl Trop Dis (2010) 0.93
Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance. Am J Respir Crit Care Med (2008) 0.93
Is there value in plasma cytokine measurements in patients with severe trauma and sepsis? Methods (2013) 0.93
Developments for improved diagnosis of bacterial bloodstream infections. Eur J Clin Microbiol Infect Dis (2014) 0.90
Rapid induction of autoantibodies during ARDS and septic shock. J Transl Med (2010) 0.89
Positive effect of septimeb™ on mortality rate in severe sepsis: a novel non antibiotic strategy. Daru (2012) 0.89
Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels. Cell Stress Chaperones (2011) 0.88
Comparative effects of carbapenems on bacterial load and host immune response in a Klebsiella pneumoniae murine pneumonia model. Antimicrob Agents Chemother (2010) 0.88
Biomarkers for Sepsis: What Is and What Might Be? Biomark Insights (2015) 0.87
Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study. Antimicrob Agents Chemother (2012) 0.87
Carbon dioxide pneumoperitoneum prevents mortality from sepsis. Surg Endosc (2006) 0.87
Period of irreversible therapeutic intervention during sepsis correlates with phase of innate immune dysfunction. J Biol Chem (2012) 0.86
Host gene expression profiling and in vivo cytokine studies to characterize the role of linezolid and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA) murine sepsis model. PLoS One (2013) 0.86
A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock. Int Immunopharmacol (2014) 0.85
Natural transmission of Plasmodium berghei exacerbates chronic tuberculosis in an experimental co-infection model. PLoS One (2012) 0.85
Cytokines and signaling molecules predict clinical outcomes in sepsis. PLoS One (2013) 0.85
The effect of parenteral selenium on outcomes of mechanically ventilated patients following sepsis: a prospective randomized clinical trial. Ann Intensive Care (2015) 0.83
Gene expression profiles characterize inflammation stages in the acute lung injury in mice. PLoS One (2010) 0.83
Risk factors and outcomes for prolonged versus brief fever: a prospective cohort study. Crit Care (2012) 0.83
Procalcitonin-guided antibiotic use in acute exacerbations of idiopathic pulmonary fibrosis. Int J Med Sci (2013) 0.83
Functional relevance of IL-10 promoter polymorphisms for sepsis development. Crit Care (2010) 0.83
Current views on the mechanisms of immune responses to trauma and infection. Cent Eur J Immunol (2015) 0.83
Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis. Crit Care (2015) 0.82
Formal modelling of toll like receptor 4 and JAK/STAT signalling pathways: insight into the roles of SOCS-1, interferon-β and proinflammatory cytokines in sepsis. PLoS One (2014) 0.82
Maternal serum soluble CD30 is increased in pregnancies complicated with acute pyelonephritis. J Matern Fetal Neonatal Med (2007) 0.82
IL-1beta induces an exaggerated pro- and anti-inflammatory response in peritoneal macrophages of children compared with adults. Pediatr Surg Int (2004) 0.82
Age- and gender-related differences of the immune function in a murine model of hemorrhagic shock: IL-10 restores immunodepression in aged females without reduction of mortality. Langenbecks Arch Surg (2007) 0.82
Investigating activity in hospitalized patients with chronic obstructive pulmonary disease: a pilot study. Heart Lung (2010) 0.82
Kallistatin treatment attenuates lethality and organ injury in mouse models of established sepsis. Crit Care (2015) 0.81
CD1d- and MR1-Restricted T Cells in Sepsis. Front Immunol (2015) 0.81
Procalcitonin as a predictor of sepsis and outcome in severe trauma patients: a prospective study. J Lab Physicians (2013) 0.81
Antigen-specific interferon-gamma responses and innate cytokine balance in TB-IRIS. PLoS One (2014) 0.81
Characterising cytokine gene expression signatures in patients with severe sepsis. Mediators Inflamm (2013) 0.81
Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice. PLoS One (2013) 0.81
The diagnostic and prognostic value of systems biology research in major traumatic and thermal injury: a review. Burns Trauma (2016) 0.81
Comparative effects of ciprofloxacin and ceftazidime on cytokine production in patients with severe sepsis caused by gram-negative bacteria. Antimicrob Agents Chemother (2004) 0.80
IL-1α reversibly inhibits skeletal muscle ryanodine receptor. a novel mechanism for critical illness myopathy? Am J Respir Cell Mol Biol (2014) 0.80
Peritoneal wash contents used to predict mortality in a murine sepsis model. J Surg Res (2015) 0.80
Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression. Pharmacol Res (2016) 0.79
Identification of four novel serum protein biomarkers in sepsis patients encoded by target genes of sepsis-related miRNAs. Clin Sci (Lond) (2014) 0.79
The soluble tumor necrosis factor receptor I is an early predictor of local infective complications after colorectal surgery. J Clin Immunol (2002) 0.79
Mechanisms regulating monocyte CXCL8 secretion in neurocysticercosis and the effect of antiparasitic therapy. J Immunol (2010) 0.78
Serum and bal beta-D-glucan for the diagnosis of Pneumocystis pneumonia in HIV positive patients. Respir Med (2014) 0.78
Indication for a role of regulatory T cells for the advent of influenza A (H1N1)-related pneumonia. Clin Exp Immunol (2010) 0.78
Circulating Cytokines and Nitric Oxide are Involved in the Inhibition of Neutrophil Migration in Patients with Uterine Cervical Neoplasia. Clin Med Insights Oncol (2012) 0.78
Excessive Pro-Inflammatory Serum Cytokine Concentrations in Virulent Canine Babesiosis. PLoS One (2016) 0.78
Genetic susceptibility to inflammatory injury and various adverse outcomes. J Extra Corpor Technol (2009) 0.78
Proinflammatory cytokines in peritonitis. J Med Life (2011) 0.78
Cytokine profile in elderly patients with sepsis. Indian J Crit Care Med (2009) 0.78
Treatment of Experimental Candida Sepsis with a Janus Kinase Inhibitor Controls Inflammation and Prolongs Survival. Antimicrob Agents Chemother (2015) 0.78
Increased inflammatory markers with altered antioxidant status persist after clinical recovery from severe sepsis: a correlation with low HDL cholesterol and albumin. Clin Exp Med (2015) 0.78
Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model. Mediators Inflamm (2015) 0.77
The impact of two different transfusion strategies on patient immune response during major abdominal surgery: a preliminary report. J Immunol Res (2014) 0.77
Sequential Serum Cytokine Levels of TNF-Alpha, IL-4 and IL-12 are Associated with Prognosis in Plasmodium falciparum Malaria. Indian J Clin Biochem (2013) 0.76
GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation. Cell Death Dis (2016) 0.76
Mathematical Model of Innate and Adaptive Immunity of Sepsis: A Modeling and Simulation Study of Infectious Disease. Biomed Res Int (2015) 0.76
Resuscitation with hydroxyethyl starch 130/0.4 attenuates intestinal injury in a rabbit model of sepsis. Indian J Pharmacol (2015) 0.76
IL-10 in antilipopolysaccharide immunity against systemic Klebsiella infections. Mediators Inflamm (2006) 0.76
Addressing the Complications of Ebola and Other Viral Hemorrhagic Fever Infections: Using Insights from Bacterial and Fungal Sepsis. PLoS Pathog (2015) 0.76
Acute acalculous cholecystitis-like phenotype in scavenger receptor A knock-out mice. J Surg Res (2011) 0.76
Evaluation of selected interleukins in patients with different gastric neoplasms: a preliminary report. Sci Rep (2015) 0.76
Serum Procalcitonin Is a Candidate Biomarker to Differentiate Bacteremia from Disease Flares in Patients with Inflammatory Bowel Disease. Gut Liver (2016) 0.75
STARD-compliant article: The utility of red cell distribution width to predict mortality for septic patients visiting the emergency department. Medicine (Baltimore) (2016) 0.75
Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics. Semin Arthritis Rheum (2008) 1.95
Neutrophil deformability in patients with sepsis, septic shock, and adult respiratory distress syndrome. Crit Care Med (2000) 1.53
Varicella pneumonia in adults. A review of pulmonary manifestations, risk factors and treatment. Respiration (1992) 1.45
A survey of bloodborne viruses and associated risk behaviours in Greek prisons. Addiction (1998) 1.30
Phagocytosis and algicidal activity of human polymorphonuclear neutrophils against Prototheca wickerhamii. J Infect Dis (1981) 1.23
Flavobacterium meningosepticum meningitis in a newborn infant. Treatment with intraventricular erythromycin. J Pediatr (1974) 1.22
Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis. J Antimicrob Chemother (1999) 1.20
Prevalence of hepatitis B and C virus infection in the general population and selected groups in South-Western Greece. Eur J Epidemiol (2003) 1.19
Brucella arthritis. Scand J Rheumatol (1986) 1.15
Monoclonal antibodies detect monocyte/macrophage activation and differentiation antigens and identify functionally distinct subpopulations of human rheumatoid synovial tissue macrophages. Am J Pathol (1991) 1.11
Molecular epidemiology of hepatitis C virus (HCV) in Greece: temporal trends in HCV genotype-specific incidence and molecular characterization of genotype 4 isolates. J Viral Hepat (2006) 1.08
Interaction between Clostridium difficile and polymorphonuclear leucocytes from the elderly and post-operative cancer patients: phagocytosis and bactericidal function. Med Microbiol Immunol (1984) 1.00
Pharmacokinetics and penetration characteristics of cefazolin into human spinal fluid. Curr Ther Res Clin Exp (1976) 0.99
Procalcitonin as an early indicator of outcome in sepsis: a prospective observational study. J Hosp Infect (2010) 0.94
Acute prostatitis caused by Raoultella planticola in a renal transplant recipient: a novel case. Transpl Infect Dis (2014) 0.90
Vancomycin versus placebo for treating persistent fever in patients with neutropenic cancer receiving piperacillin-tazobactam monotherapy. Clin Infect Dis (2003) 0.89
Non-Hodgkin's lymphoma and tuberculosis coexistence in the same organs: a report of two cases. Postgrad Med J (2008) 0.89
Significant epidemiological changes in chronic hepatitis C infection: results of the nationwide HEPNET-GREECE cohort study. Hippokratia (2011) 0.88
Prevalence patterns and genotypes of GB virus C/hepatitis G virus among imprisoned intravenous drug users. J Med Virol (1998) 0.86
Streptococcus pneumoniae septic arthritis in adults. Clin Microbiol Infect (2004) 0.85
Bacteremic pneumonia due to gram-negative bacilli. Arch Intern Med (1983) 0.84
Intensive care unit patients with acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia: suggested predictors of hospital outcome. Crit Care Med (1991) 0.83
Increased adherence to human epithelial cells of resistant Pseudomonas aeruginosa strains. J Infect (1980) 0.83
Absorption of ciprofloxacin in patients with diabetic gastroparesis. Antimicrob Agents Chemother (1995) 0.83
Aqueous humor penetration of ciprofloxacin in the human eye. Arch Ophthalmol (1988) 0.82
Two episodes of leukoencephalitis associated with recombinant hepatitis B vaccination in a single patient. Clin Infect Dis (2001) 0.82
Staphylococcus aureus in toxic-shock syndrome. J Infect Dis (1981) 0.81
Pharmacokinetics of doripenem in CSF of patients with non-inflamed meninges. J Antimicrob Chemother (2012) 0.81
Pasteurella multocida bacteremia, spontaneous bacterial peritonitis and septic arthritis in a cirrhotic patient. Hippokratia (2010) 0.81
Results of a prospective, randomized, double blind comparison of the efficacy and the safety of sequential ciprofloxacin (intravenous/oral)+metronidazole (intravenous/oral) with ceftriaxone (intravenous)+metronidazole (intravenous/oral) for the treatment of intra-abdominal infections. Int J Antimicrob Agents (2003) 0.81
Comparative effects of ciprofloxacin and ceftazidime on cytokine production in patients with severe sepsis caused by gram-negative bacteria. Antimicrob Agents Chemother (2004) 0.80
Monotherapy with intravenous followed by oral high-dose ciprofloxacin versus combination therapy with ceftazidime plus amikacin as initial empiric therapy for granulocytopenic patients with fever. Antimicrob Agents Chemother (2000) 0.80
Interaction of subminimal inhibitory concentrations of clindamycin and gram-negative aerobic organisms: effects on adhesion and polymorphonuclear leukocyte function. J Antimicrob Chemother (1985) 0.80
Use of oral ciprofloxacin in community-acquired pneumonia. J Chemother (1989) 0.80
Effects of subinhibitory concentrations of cefotaxime on adhesion and polymorphonuclear leukocyte function with gram-negative bacteria. J Antimicrob Chemother (1984) 0.79
In-vivo effects of clindamycin on polymorphonuclear leucocyte phagocytosis and killing of gram-negative organisms. J Antimicrob Chemother (1987) 0.79
Effect of cytokines and colony-stimulating factors on passive polymorphonuclear leukocyte deformability in vitro. Cytokine (2000) 0.79
Periapical abscesses: causal bacteria and antibiotic sensitivity. J Chemother (1997) 0.79
Adherence of Candida albicans to epithelial cells from normal and cancerous urinary bladders. Int Urol Nephrol (1994) 0.78
Interaction of subminimal inhibitory concentrations of clindamycin and Escherichia coli: effects on adhesion and polymorphonuclear leukocyte function. J Antimicrob Chemother (1984) 0.78
Antinuclear antibodies in visceral leishmaniasis. J Infect (1994) 0.78
Penetration of ciprofloxacin into human cerebrospinal fluid in patients with inflamed and non-inflamed meninges. Eur J Clin Microbiol Infect Dis (1991) 0.78
A comparative study on aztreonam, ceftazidime and amikacin in the treatment of complicated urinary tract infections. J Chemother (1991) 0.77
Interleukin-6 and C-reactive protein as early markers of sepsis in patients with diabetic ketoacidosis or hyperosmosis. Diabetologia (2001) 0.77
Miliary tuberculosis secondary to transurethral bacillus Calmette-Guérin administration for superficial transitional cell carcinoma of the bladder. J Natl Cancer Inst (1990) 0.77
Penetration of intact blood-brain barrier by doripenem. Antimicrob Agents Chemother (2011) 0.76
Defective phagocytic and bactericidal function of polymorphonuclear leucocytes in patients with beta-thalassaemia major. J Infect (1984) 0.76
Defective adherence of polymorphonuclear leukocytes to nylon induced by thalassemic serum. J Infect Dis (1982) 0.76
Use of ciprofloxacin in biliary sepsis. Infection (1988) 0.76
Sequential intravenous/oral therapy with ciprofloxacin in severe infection. Am J Med (1989) 0.76
Enhancement of polymorphonuclear leukocyte function against gram-positive aerobic organisms grown in the presence of lincomycin. Infection (1985) 0.75
Management of brain abscesses with sequential intravenous/oral antibiotic therapy. Eur J Clin Microbiol Infect Dis (2000) 0.75
Fibrinogen enhances complement-mediated augmentation of retention of polymorphonuclear leukocytes by nylon columns. Infect Immun (1981) 0.75
In vivo potentiation of polymorphonuclear leukocyte function by ciprofloxacin. J Chemother (1993) 0.75
Trimethoprim, sulphamethoxazole, bacterial adhesion and polymorphonuclear leucocyte function. J Antimicrob Chemother (1990) 0.75
Enhanced chemotaxis to gentamicin-resistant strains of Pseudomonas aeruginosa. J Infect Dis (1980) 0.75
An increased number of circulating gamma/delta TCR + T cells in patients with chronic viral hepatitis. FEMS Immunol Med Microbiol (1995) 0.75
Bacterial endocarditis with dual presentation as endophthalmitis and glomerulonephritis. Eur J Intern Med (2006) 0.75
Three cases of varicella thrombophlebitis as a complication of varicella zoster virus infection. Eur J Clin Microbiol Infect Dis (1993) 0.75
Indolent fever, weight loss and spleen infiltrate. Scand J Gastroenterol (2008) 0.75
Primary sternal osteomyelitis. Eur J Cardiothorac Surg (1993) 0.75
Polymorphonuclear leukocyte rigidity is defective in patients with chronic renal failure. Nephrol Dial Transplant (2000) 0.75
In vivo potentiation of polymorphonuclear leukocyte chemotaxis by clindamycin. Infection (1994) 0.75
Reducing mortality from gram-negative bacterial infections. Geriatrics (1982) 0.75
Detection of hepatitis B virus DNA in chronic carriers of hepatitis B surface antigen in southwestern Greece. Eur J Clin Microbiol Infect Dis (1995) 0.75
Post-radiation scleredema adultorum and diffuse eosinophilic fasciitis in the same patient. Scand J Rheumatol (2010) 0.75
Polymorphonuclear leukocyte function in children with recurrent infections. J Chemother (1989) 0.75
Phagocytosis and antimicrobicidal activity of polymorphonuclear leucocytes against gentamicin-sensitive and resistant strains of Pseudomonas aeruginosa. J Infect (1983) 0.75
Transient improvement of polymorphonuclear leukocyte function by splenectomy in beta-thalassemia. Med Microbiol Immunol (1987) 0.75
Concurrent bacterial lung infection in patients with AIDS, PCP, and respiratory failure. Chest (1992) 0.75
Porphyria cutanea tarda and beta-thalassaemia major: causal or casual? J Eur Acad Dermatol Venereol (2010) 0.75
Remote abscess formation during interferon-alpha therapy for viral hepatitis. Clin Microbiol Infect (2003) 0.75
The effects of lipids on the immune response of patients with cancer. J Nutr Health Aging (2000) 0.75
Cost-minimisation analysis of sequential treatment with ofloxacin or ciprofloxacin in hospitalised patients. Pharmacoeconomics (1997) 0.75