Published in Clin Exp Metastasis on July 01, 1999
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression. Semin Cancer Biol (2008) 1.91
Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis (2008) 1.44
Expression of hypoxia-inducible carbonic anhydrases in brain tumors. Neuro Oncol (2005) 0.97
Tumour-stromal interactions in acid-mediated invasion: a mathematical model. J Theor Biol (2010) 0.94
Homing of cancer cells to the bone. Cancer Microenviron (2011) 0.92
Investigating mechanisms of alkalinization for reducing primary breast tumor invasion. Biomed Res Int (2013) 0.85
Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells. Mol Cancer (2017) 0.78
Theoretical predictions of lactate and hydrogen ion distributions in tumours. PLoS One (2013) 0.75
A cellular automaton model examining the effects of oxygen, hydrogen ions and lactate on early tumour growth. J Math Biol (2013) 0.75
Acid-mediated tumour cell invasion: a discrete modelling approach using the extended Potts model. Clin Exp Metastasis (2013) 0.75
Intracellular pH. Physiol Rev (1981) 16.27
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res (1989) 12.85
A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature (1994) 9.31
Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J (1991) 8.29
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med (1997) 6.86
Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res (1989) 5.62
Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst (1997) 5.07
Biology and biochemistry of proteinases in tumor invasion. Physiol Rev (1993) 4.17
Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol (1995) 3.39
Metabolic regulation via intracellular pH. Am J Physiol (1984) 3.37
Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res (1996) 3.11
Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta (1989) 2.87
Protons and anaerobiosis. Science (1983) 2.68
Acidic pH enhances the invasive behavior of human melanoma cells. Clin Exp Metastasis (1996) 2.44
Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J (1993) 2.28
A reaction-diffusion model of cancer invasion. Cancer Res (1996) 2.01
Regulation of intracellular pH in eukaryotic cells. Biochem J (1988) 1.94
Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Res (1994) 1.91
The role of proteolytic enzymes in cancer invasion and metastasis. Clin Exp Metastasis (1992) 1.86
Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH. J Cell Physiol (1992) 1.77
The regulation of the intracellular pH in cells from vertebrates. Eur J Biochem (1988) 1.68
Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts. J Cell Biol (1990) 1.62
Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells. Am J Physiol (1993) 1.57
Therapeutic attack of hypoxic cells of solid tumors: presidential address. Cancer Res (1988) 1.54
Mechanisms and consequences of pH-mediated cell regulation. Annu Rev Physiol (1986) 1.37
In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells. Cancer Res (1988) 1.30
Mathematical modelling of avascular-tumour growth. IMA J Math Appl Med Biol (1997) 1.28
Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats. Cancer Res (1988) 1.14
Rate of growth of solid tumours as a problem of diffusion. Growth (1966) 1.13
Requirement of the Na+/H+ exchanger for tumor growth. Cancer Res (1989) 1.13
Metabolic consequences of a reversed pH gradient in rat tumors. Cancer Res (1994) 1.07
Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines. J Biol Chem (1992) 1.05
Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions. Cancer Res (1992) 1.04
Tumour biology. Membrane proteases in focus. Nature (1994) 1.01
Complex roles of matrix metalloproteinases in tumor progression. Curr Top Microbiol Immunol (1996) 1.00
Expression of five cathepsins in murine melanomas of varying metastatic potential and normal tissues. Cancer Res (1989) 0.98
Pattern formation and spatiotemporal irregularity in a model for macrophage-tumour interactions. J Theor Biol (1997) 0.92
Mathematical modelling of tumour acidity: regulation of intracellular pH. J Theor Biol (1999) 0.92
Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras-transformed NIH 3T3 cells. Mol Carcinog (1992) 0.91
Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D. Int J Cancer (1996) 0.91
Mathematical models for tumour angiogenesis: numerical simulations and nonlinear wave solutions. Bull Math Biol (1995) 0.91
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells. Clin Exp Metastasis (1997) 0.91
Increased release of tumour cells by collagenase at acid pH: a possible mechanism for metastasis. Experientia (1979) 0.91
Characterization of an extracellular matrix-degrading protease derived from a highly metastatic tumor cell line. Eur J Cancer Clin Oncol (1985) 0.90
Oncogenes, anti-oncogenes and the immune response to cancer: a mathematical model. Proc Biol Sci (1992) 0.89
Biological inferences from a mathematical model for malignant invasion. Invasion Metastasis (1996) 0.89
Cytosolic pH regulation in mouse macrophages. Proton extrusion by plasma-membrane-localized H(+)-ATPase. Biochem J (1992) 0.88
A latent Mr 94,000 gelatin-degrading metalloprotease induced during differentiation of HL-60 promyelocytic leukemia cells: a member of the collagenase family of enzymes. Cancer Res (1990) 0.84
Regulation of intracellular pH in the hepatocyte. Mechanisms and physiological implications. J Hepatol (1996) 0.81
Partial purification and characterization of serum protease from tumor-bearing rats which cleaves type IV collagen. Invasion Metastasis (1986) 0.77
Altered glucose metabolism and the invasive tumor phenotype. Int J Oncol (1996) 0.75
A mathematical model for the production and secretion of tumour angiogenesis factor in tumours. IMA J Math Appl Med Biol (1990) 0.75
Mathematical modelling of flow through vascular networks: implications for tumour-induced angiogenesis and chemotherapy strategies. Bull Math Biol (2002) 1.50
A mechanochemical model for adult dermal wound contraction and the permanence of the contracted tissue displacement profile. J Theor Biol (1995) 1.24
Mathematical modelling of extracellular matrix dynamics using discrete cells: fiber orientation and tissue regeneration. J Theor Biol (1999) 1.20
Early surgical intervention for aortic insufficiency due to bacterial endocarditis. Ann Thorac Surg (1967) 1.06
Dictyostelium discoideum: cellular self-organization in an excitable biological medium. Proc Biol Sci (1995) 1.06
Intravesical Bacillus Calmette-Guerin in Ta and T1 Bladder Cancer. Cochrane Database Syst Rev (2000) 1.05
Modeling the effects of transforming growth factor-beta on extracellular matrix alignment in dermal wound repair. Wound Repair Regen (2001) 1.05
Stereo-specific cytotoxic effects of gossypol enantiomers and gossypolone in tumour cell lines. Cancer Lett (1999) 1.04
A mathematical model for collagen fibre formation during foetal and adult dermal wound healing. Proc Biol Sci (1996) 1.02
Lipoprotein oxidation and its significance for atherosclerosis: a mathematical approach. Bull Math Biol (2002) 1.00
Histones and cancer test. Nature (1973) 0.95
Structure-activity studies on gossypol in tumor cell lines. Anticancer Drugs (2000) 0.94
Surgical correction of ventricular septal defect following acute myocardial infarction. Ann Thorac Surg (1969) 0.94
Total body clearance and platinum accumulation in patients treated with cis-dichlorodiammine platinum (II) Ther Drug Monit (1984) 0.94
Pattern formation and spatiotemporal irregularity in a model for macrophage-tumour interactions. J Theor Biol (1997) 0.92
Mathematical modelling of tumour acidity: regulation of intracellular pH. J Theor Biol (1999) 0.92
How far can a juxtacrine signal travel? Proc Biol Sci (1999) 0.91
Biological inferences from a mathematical model for malignant invasion. Invasion Metastasis (1996) 0.89
Mathematical modelling of juxtacrine cell signalling. Math Biosci (1998) 0.88
Role of fibroblast migration in collagen fiber formation during fetal and adult dermal wound healing. Bull Math Biol (1997) 0.87
Mathematical modelling of juxtacrine patterning. Bull Math Biol (2000) 0.87
Mathematical modeling of corneal epithelial wound healing. Math Biosci (1994) 0.86
A mathematical model for the capillary endothelial cell-extracellular matrix interactions in wound-healing angiogenesis. IMA J Math Appl Med Biol (1997) 0.86
A mathematical model for fibro-proliferative wound healing disorders. Bull Math Biol (1996) 0.85
Mathematical modelling of anisotropy in fibrous connective tissue. Math Biosci (1999) 0.85
Antigen CA125 in tumor tissue and serum from patients with adenocarcinoma of the ovary. Gynecol Oncol (1988) 0.84
Lateral induction by juxtacrine signaling is a new mechanism for pattern formation. Dev Biol (2000) 0.84
Keratinocyte growth factor signalling: a mathematical model of dermal-epidermal interaction in epidermal wound healing. Math Biosci (2000) 0.83
Mathematical modelling of nitric oxide activity in wound healing can explain keloid and hypertrophic scarring. J Theor Biol (2000) 0.83
Modelling tumour acidity and invasion. Novartis Found Symp (2001) 0.82
Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. Melanoma Res (1997) 0.82
Modelling the macrophage invasion of tumours: effects on growth and composition. IMA J Math Appl Med Biol (1998) 0.81
Evaluation of an immunoradiometric assay for the detection of an ovarian tumour marker, CA125, in serum. Ann Clin Biochem (1986) 0.80
Cellular automata and integrodifferential equation models for cell renewal in mosaic tissues. J R Soc Interface (2010) 0.80
Serum haptoglobin and alpha 1-acid glycoprotein as indicators of the effectiveness of cis-diamminedichloroplatinum (CDDP) in ovarian cancer patients--a preliminary report. Eur J Cancer Clin Oncol (1984) 0.80
Changes in serum acute phase proteins in breast cancer patients receiving methotrexate infusion therapy. Clin Biochem (1982) 0.80
A mathematical model for fibroblast and collagen orientation. Bull Math Biol (1998) 0.79
Re: Pharmacokinetics and dosage reduction of cis-diammine(1,1-cyclobutanedicarboxylato)platinum in patients with impaired renal function. Cancer Res (1987) 0.79
Coronary arteriography: indications, techniques, complications. Ann Thorac Surg (1968) 0.79
A possible in-vitro blood test for cancer. Lancet (1973) 0.79
A Nonlocal Model for Contact Attraction and Repulsion in Heterogeneous Cell Populations. Bull Math Biol (2015) 0.79
How does cellular contact affect differentiation mediated pattern formation? Bull Math Biol (2010) 0.77
The mathematical modelling of cell kinetics in corneal epithelial wound healing. J Theor Biol (1999) 0.77
Internal thoracic (mammary) arteriography. A questionable index of myocardial revascularization. J Thorac Cardiovasc Surg (1970) 0.77
Spatially varying equilibria of mechanical models: application to dermal wound contraction. Math Biosci (1998) 0.77
Changes in serum acute phase proteins in ovarian cancer patients receiving cis-diamminedichloroplatinum (CDDP) infusion therapy. Clin Biochem (1984) 0.76
CA125 in ovarian tumour tissue at second laparotomy. Br J Cancer (1989) 0.75
Cystic fluid-platinum kinetics in ovarian cancer patients: relevance to cis-dichlorodiammine platinum (II) sensitivity testing in vitro. Br J Cancer (1985) 0.75
Biliary excretion of platinum in a patient treated with cis-dichlorodiammineplatinum (II). Antimicrob Agents Chemother (1985) 0.75
OC125 immunoscintigraphy in ovarian carcinoma: a comparison with alternative methods of assessment. Clin Oncol (R Coll Radiol) (1990) 0.75
Cancer detection with human peripheral lymphocytes: a word of caution. Med Hypotheses (1976) 0.75
Carotid sinus nerve stimulation treatment of angina refractory to other surgical procedures. Ann Thorac Surg (1971) 0.75
Acute phase glycoproteins in sera of patients with sarcomas receiving methotrexate infusion therapy. Clin Biochem (1985) 0.75
Dihydrofolate reductase inhibition assay for methotrexate. Ann Clin Biochem (1985) 0.75
An unusual case of cyanotic heart disease. Dis Chest (1968) 0.75
A modified pharmacokinetic model for platinum disposition in ovarian cancer patients receiving cisplatin. Eur J Clin Pharmacol (1987) 0.75