Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.

PubWeight™: 3.11‹?› | Rank: Top 1%

🔗 View Article (PMID 8640796)

Published in Cancer Res on March 15, 1996

Authors

L E Gerweck1, K Seetharaman

Author Affiliations

1: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02192, USA.

Articles citing this

(truncated to the top 100)

Photodynamic therapy. J Natl Cancer Inst (1998) 12.83

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol (1999) 3.50

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas. Proc Natl Acad Sci U S A (2006) 2.55

MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol (2001) 2.33

Cathepsin D--many functions of one aspartic protease. Crit Rev Oncol Hematol (2008) 2.26

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med (2009) 2.13

Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer (2013) 1.93

Acidic stress promotes a glioma stem cell phenotype. Cell Death Differ (2010) 1.79

Multifunctional and stimuli-sensitive pharmaceutical nanocarriers. Eur J Pharm Biopharm (2008) 1.78

Causes and effects of heterogeneous perfusion in tumors. Neoplasia (1999) 1.76

Protons make tumor cells move like clockwork. Pflugers Arch (2009) 1.48

Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch. Proc Natl Acad Sci U S A (2005) 1.47

Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy. Angew Chem Int Ed Engl (2009) 1.44

Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn. Adv Immunol (2009) 1.42

Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm (2011) 1.42

pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation. Proc Natl Acad Sci U S A (2010) 1.38

Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery. Mol Pharm (2009) 1.38

Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain. Biochim Biophys Acta (2006) 1.37

Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res (2007) 1.35

Imaging in vivo extracellular pH with a single paramagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent. Mol Imaging (2012) 1.34

Family of pH (low) insertion peptides for tumor targeting. Proc Natl Acad Sci U S A (2013) 1.31

Multifunctional PEGylated 2C5-immunoliposomes containing pH-sensitive bonds and TAT peptide for enhanced tumor cell internalization and cytotoxicity. J Control Release (2011) 1.25

Drug delivery to solid tumors by elastin-like polypeptides. Adv Drug Deliv Rev (2010) 1.21

pHLIP-mediated translocation of membrane-impermeable molecules into cells. Chem Biol (2009) 1.16

Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone. Neoplasia (2001) 1.13

pH-dependent binding of the Epsin ENTH domain and the AP180 ANTH domain to PI(4,5)P2-containing bilayers. J Mol Biol (2007) 1.11

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors. Front Physiol (2014) 1.11

Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas. FASEB J (2010) 1.10

Polymeric conjugates for drug delivery. Chem Mater (2012) 1.06

The spatial organization of proton and lactate transport in a rat brain tumor. PLoS One (2011) 1.05

Immunoconjugates and long circulating systems: origins, current state of the art and future directions. Adv Drug Deliv Rev (2012) 1.05

Luminescent gold nanoparticles with pH-dependent membrane adsorption. J Am Chem Soc (2011) 1.04

Hypoxia inducible factor pathway inhibitors as anticancer therapeutics. Future Med Chem (2013) 1.03

Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: a 31P/1H MRSI and quantitative magnetic resonance imaging study. Neuro Oncol (2011) 1.02

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. J Transl Med (2013) 1.02

Recent advances in stealth coating of nanoparticle drug delivery systems. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2012) 1.02

Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes. Prog Lipid Res (2007) 1.02

Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress. Cancer Metab (2013) 1.01

Environmentally responsive peptides as anticancer drug carriers. Adv Drug Deliv Rev (2009) 1.01

Zwitterionic chitosan derivatives for pH-sensitive stealth coating. Biomacromolecules (2010) 1.00

The Valley of Death in anticancer drug development: a reassessment. Trends Pharmacol Sci (2012) 1.00

Low molecular-weight chitosan as a pH-sensitive stealth coating for tumor-specific drug delivery. Mol Pharm (2012) 1.00

The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions? Nanotechnol Sci Appl (2012) 1.00

Curb challenges of the "Trojan Horse" approach: smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery. Adv Drug Deliv Rev (2013) 0.97

Magnetic resonance spectroscopy to study hepatic metabolism in diffuse liver diseases, diabetes and cancer. World J Gastroenterol (2010) 0.97

Acid-mediated tumor proteolysis: contribution of cysteine cathepsins. Neoplasia (2013) 0.96

Reversible maleimide-thiol adducts yield glutathione-sensitive poly(ethylene glycol)-heparin hydrogels. Polym Chem (2013) 0.95

Targeting breast tumors with pH (low) insertion peptides. Mol Pharm (2014) 0.94

Microscopy and tunable resistive pulse sensing characterization of the swelling of pH-responsive, polymeric expansile nanoparticles. Nanoscale (2013) 0.94

Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification. Br J Cancer (2012) 0.93

Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles. Chem Sci (2012) 0.93

Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment. Philos Trans R Soc Lond B Biol Sci (2014) 0.92

Pericellular proteolysis in cancer. Genes Dev (2014) 0.92

Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability. Biochem J (2002) 0.91

Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites. Cancer Res (2015) 0.91

A ratiometric pH reporter for imaging protein-dye conjugates in living cells. J Am Chem Soc (2009) 0.91

pH dependent transfer of nano-pores into membrane of cancer cells to induce apoptosis. Sci Rep (2013) 0.91

Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer? Int J Hyperthermia (2010) 0.90

Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. Nat Rev Cancer (2015) 0.89

Noncanonical amino acids to improve the pH response of pHLIP insertion at tumor acidity. Angew Chem Int Ed Engl (2015) 0.89

Vitamin E analogues as inducers of apoptosis: structure-function relation. Br J Cancer (2003) 0.89

Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine. J Pharmacol Exp Ther (2009) 0.88

Plateau-phase cultures: an experimental model for identifying drugs which are bioactivated within the microenvironment of solid tumours. Br J Cancer (1997) 0.88

(15)N Hyperpolarization of Imidazole-(15)N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH. ACS Sens (2016) 0.88

Block copolymer micelles with acid-labile ortho ester side-chains: Synthesis, characterization, and enhanced drug delivery to human glioma cells. J Control Release (2010) 0.87

Concentration-independent pH detection with a luminescent dimetallic Eu(III)-based probe. J Am Chem Soc (2012) 0.87

Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3β/β-catenin Signaling. Theranostics (2016) 0.87

pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo. ACS Chem Biol (2014) 0.86

Multifunctional polymeric micelles for delivery of drugs and siRNA. Front Pharmacol (2014) 0.86

Tumor physiology and charge dynamics of anticancer drugs: implications for camptothecin-based drug development. Curr Med Chem (2011) 0.86

pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study. J Cereb Blood Flow Metab (2012) 0.86

The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells. Br J Cancer (1999) 0.86

The effects of host carbogen (95% oxygen/5% carbon dioxide) breathing on metabolic characteristics of Morris hepatoma 9618a. Br J Cancer (1998) 0.85

Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the transmembrane pH gradient. Br J Cancer (1998) 0.85

Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin. PLoS One (2012) 0.85

Alterations in proteolytic activity at low pH and its association with invasion: a theoretical model. Clin Exp Metastasis (1999) 0.85

Polymer nanostructures synthesized by controlled living polymerization for tumor-targeted drug delivery. J Control Release (2015) 0.84

Reversibly crosslinked nanocarriers for on-demand drug delivery in cancer treatment. Ther Deliv (2012) 0.83

Optical molecular imaging detects changes in extracellular pH with the development of head and neck cancer. Int J Cancer (2012) 0.83

Extracellular stability of nanoparticulate drug carriers. Arch Pharm Res (2013) 0.83

A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy. Cancer Discov (2012) 0.83

An acidic microenvironment impairs the generation of non-major histocompatibility complex-restricted killer cells. Immunology (2000) 0.83

Resveratrol-induced apoptosis is enhanced in low pH environments associated with cancer. J Cell Physiol (2012) 0.83

pH-controlled gas-generating mineralized nanoparticles: a theranostic agent for ultrasound imaging and therapy of cancers. ACS Nano (2015) 0.82

Probe for the measurement of cell surface pH in vivo and ex vivo. Proc Natl Acad Sci U S A (2016) 0.82

Zwitterionic chitosan-polyamidoamine dendrimer complex nanoparticles as a pH-sensitive drug carrier. Mol Pharm (2013) 0.82

How acidic is the lidocaine we are injecting, and how much bicarbonate should we add? Can J Plast Surg (2012) 0.82

The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A (2015) 0.81

In vivo tumour extracellular pH monitoring using electron paramagnetic resonance: the effect of X-ray irradiation. NMR Biomed (2014) 0.81

Reversion of pH-induced physiological drug resistance: a novel function of copolymeric nanoparticles. PLoS One (2011) 0.81

The molecular basis of ceramide-1-phosphate recognition by C2 domains. J Lipid Res (2012) 0.81

Conjugation of pH-responsive nanoparticles to neural stem cells improves intratumoral therapy. J Control Release (2014) 0.80

Modulation of autophagic activity by extracellular pH. Autophagy (2011) 0.80

Low molecular weight chitosan-coated polymeric nanoparticles for sustained and pH-sensitive delivery of paclitaxel. J Drug Target (2015) 0.79

Optical ATP biosensor for extracellular ATP measurement. Biosens Bioelectron (2013) 0.79

The mechanostability of isolated focal adhesions is strongly dependent on pH. Chem Biol (2012) 0.79

Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors. J Control Release (2015) 0.79

Towards longitudinal mapping of extracellular pH in gliomas. NMR Biomed (2016) 0.79

Design, synthesis, and evaluation of pH-dependent hydrolyzable emetine analogues as treatment for prostate cancer. J Med Chem (2012) 0.78

Nile Blue-based nanosized pH sensors for simultaneous far-red and near-infrared live bioimaging. J Am Chem Soc (2013) 0.78