Published in Biophys J on February 01, 2000
Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor. Adv Drug Deliv Rev (2011) 1.11
Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore. PLoS Pathog (2014) 1.09
A Monte Carlo study of peptide insertion into lipid bilayers: equilibrium conformations and insertion mechanisms. Biophys J (2002) 1.02
The activity of the amphipathic peptide delta-lysin correlates with phospholipid acyl chain structure and bilayer elastic properties. Biophys J (2008) 1.00
Highly efficient macromolecule-sized poration of lipid bilayers by a synthetically evolved peptide. J Am Chem Soc (2014) 0.84
Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes. Sci Rep (2015) 0.80
Delivery of cancer therapeutics to extracellular and intracellular targets: Determinants, barriers, challenges and opportunities. Adv Drug Deliv Rev (2015) 0.79
Coupled folding and specific binding: fishing for amphiphilicity. Int J Mol Sci (2011) 0.75
Phosphorus assay in column chromatography. J Biol Chem (1959) 60.56
Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A (1987) 8.53
Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci U S A (1978) 6.55
Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature (1981) 5.66
Membrane pores induced by magainin. Biochemistry (1996) 3.97
The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy. Biochim Biophys Acta (1973) 3.83
Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes. Proc Natl Acad Sci U S A (1988) 3.51
Membrane thinning caused by magainin 2. Biochemistry (1995) 3.03
Neutron scattering in the plane of membranes: structure of alamethicin pores. Biophys J (1996) 2.63
Lipid-alamethicin interactions influence alamethicin orientation. Biophys J (1991) 2.33
X-ray diffraction study of lipid bilayer membranes interacting with amphiphilic helical peptides: diphytanoyl phosphatidylcholine with alamethicin at low concentrations. Biophys J (1995) 2.24
Molecular basis for membrane selectivity of an antimicrobial peptide, magainin 2. Biochemistry (1995) 2.18
pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact. Biochemistry (1984) 2.03
Pore formation and translocation of melittin. Biophys J (1997) 1.98
Mechanism of alamethicin insertion into lipid bilayers. Biophys J (1996) 1.92
Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA. Biochemistry (1990) 1.86
Cooperative membrane insertion of magainin correlated with its cytolytic activity. Biochim Biophys Acta (1994) 1.84
Synthetic magainin analogues with improved antimicrobial activity. FEBS Lett (1988) 1.77
Interaction of the mammalian antibacterial peptide cecropin P1 with phospholipid vesicles. Biochemistry (1995) 1.77
Sizing membrane pores in lipid vesicles by leakage of co-encapsulated markers: pore formation by melittin. Biophys J (1997) 1.76
Antimicrobial peptide pores in membranes detected by neutron in-plane scattering. Biochemistry (1995) 1.75
2H nuclear magnetic resonance order parameter profiles suggest a change of molecular shape for phosphatidylcholines containing a polyunsaturated acyl chain. Biophys J (1995) 1.72
Physicochemical determinants for the interactions of magainins 1 and 2 with acidic lipid bilayers. Biochim Biophys Acta (1991) 1.65
Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria. Biochim Biophys Acta (1997) 1.59
Quantitative studies on the melittin-induced leakage mechanism of lipid vesicles. Biochemistry (1998) 1.59
Action of melittin on the DPPC-cholesterol liquid-ordered phase: a solid state 2H-and 31P-NMR study. Biophys J (1995) 1.47
Molecular details of melittin-induced lysis of phospholipid membranes as revealed by deuterium and phosphorus NMR. Biochemistry (1986) 1.45
Pore-forming peptides induce rapid phospholipid flip-flop in membranes. Biochemistry (1994) 1.43
Mode of action of the antibacterial cecropin B2: a spectrofluorometric study. Biochemistry (1994) 1.37
Asymmetrical distribution of phospholipids in the membrane of Bacillus megaterium. J Mol Biol (1977) 1.37
Transmembrane orientation of hydrophobic alpha-helices is regulated both by the relationship of helix length to bilayer thickness and by the cholesterol concentration. Biochemistry (1997) 1.36
Morphological changes of phosphatidylcholine bilayers induced by melittin: vesicularization, fusion, discoidal particles. Biochim Biophys Acta (1986) 1.35
The concentration-dependent membrane activity of cecropin A. Biochemistry (1997) 1.29
Effect of changing the size of lipid headgroup on peptide insertion into membranes. Biophys J (1997) 1.28
pH-dependent bilayer destabilization by an amphipathic peptide. Biochemistry (1987) 1.27
Modulation of magainin 2-lipid bilayer interactions by peptide charge. Biochemistry (1997) 1.24
Pore kinetics reflected in the dequenching of a lipid vesicle entrapped fluorescent dye. Biochim Biophys Acta (1995) 1.23
Molecular basis for prokaryotic specificity of magainin-induced lysis. Biochemistry (1995) 1.21
Kinetics of pore formation by an antimicrobial peptide, magainin 2, in phospholipid bilayers. Biochemistry (1995) 1.20
Pore formation induced by the peptide melittin in different lipid vesicle membranes. Biophys Chem (1996) 1.17
Transbilayer transport of ions and lipids coupled with mastoparan X translocation. Biochemistry (1996) 1.17
Support for the shape concept of lipid structure based on a headgroup volume approach. Biophys J (1993) 1.17
Mechanism of membrane damage induced by the amphipathic peptides gramicidin S and melittin. Biochim Biophys Acta (1989) 1.16
Precise quantitative determination of human blood lipids by thin-layer and triethylaminoethylcellulose column chromatography. I. Erythrocyte lipids. Anal Biochem (1970) 1.16
Membrane insertion and lateral diffusion of fluorescence-labelled cytochrome c oxidase subunit IV signal peptide in charged and uncharged phospholipid bilayers. Biochem J (1990) 1.15
Leakage of internal markers from erythrocytes and lipid vesicles induced by melittin, gramicidin S and alamethicin: a comparative study. Biochim Biophys Acta (1990) 1.10
Nuclear magnetic resonance investigation of hydrocarbon chain packing in bilayers of polyunsaturated phospholipids. Lipids (1996) 1.07
Reversible surface aggregation in pore formation by pardaxin. Biophys J (1996) 1.06
Lipid dependence of peptide-membrane interactions. Bilayer affinity and aggregation of the peptide alamethicin. FEBS Lett (1989) 1.00
Association of a pH-sensitive peptide with membrane vesicles: role of amino acid sequence. Biochemistry (1990) 0.98
Binding and state of aggregation of spin-labeled cecropin AD in phospholipid bilayers: effects of surface charge and fatty acyl chain length. Biochemistry (1994) 0.98
Modulation of melittin-induced lysis by surface charge density of membranes. Biophys J (1995) 0.94
Effect of cholesterol on the polymorphism of dipalmitoylphosphatidylcholine/melittin complexes: an NMR study. Biochim Biophys Acta (1993) 0.93
Antimicrobial peptides. Chairman's opening remarks. Ciba Found Symp (1994) 0.90
Influence of lipid chain unsaturation on melittin-induced micellization. Biophys J (1996) 0.89
Acyl chain length dependence in the stability of melittin-phosphatidylcholine complexes. A light scattering and 31P-NMR study. Biochim Biophys Acta (1995) 0.89
Reorientational dynamics in lipid vesicles and liposomes studied with ESR: effects of hydration, curvature and unsaturation. Biochim Biophys Acta (1989) 0.88
Action of phospholipase A2 and phospholipase C on Escherichia coli. Arch Biochem Biophys (1974) 0.88
Voltage-dependent pore activity of the peptide alamethicin correlated with incorporation in the membrane: salt and cholesterol effects. Biochim Biophys Acta (1988) 0.88
Orientation of the pore-forming peptide GALA in POPC vesicles determined by a BODIPY-avidin/biotin binding assay. Biophys J (1999) 0.87
Effect of cholesterol and charge on pore formation in bilayer vesicles by a pH-sensitive peptide. Biophys J (1996) 0.87
A restatement of melittin-induced effects on the thermotropism of zwitterionic phospholipids. Biochim Biophys Acta (1984) 0.84
Interaction of wasp venom mastoparan with biomembranes. Biochim Biophys Acta (1990) 0.83
Amphipathic peptide affects the lateral domain organization of lipid bilayers. Biochim Biophys Acta (1997) 0.81
Delta-haemolysin from Staphylococcus aureus and model membranes. A solid-state 2H-NMR and 31P-NMR study. Eur J Biochem (1990) 0.79
Lecithin:cholesterol acyltransferase activation by synthetic amphipathic peptides. Proteins (1988) 0.78
Phase transitions in phospholipid vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol. Biochim Biophys Acta (1973) 4.25
Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry (1996) 4.06
Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem (1994) 3.24
Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. Biochim Biophys Acta (1979) 3.20
Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein. Science (2000) 2.66
H+- and Ca2+-induced fusion and destabilization of liposomes. Biochemistry (1985) 2.44
In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem (1997) 2.28
Mechanism of oligonucleotide release from cationic liposomes. Proc Natl Acad Sci U S A (1996) 2.19
Studies on membrane fusion. III. The role of calcium-induced phase changes. Biochim Biophys Acta (1977) 2.15
Effect of lipid composition and liposome size on toxicity and in vitro fungicidal activity of liposome-intercalated amphotericin B. Antimicrob Agents Chemother (1987) 2.14
Treatment of experimental invasive aspergillosis with novel amphotericin B/cholesterol-sulfate complexes. J Infect Dis (1989) 2.08
pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact. Biochemistry (1984) 2.03
The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther (1997) 1.96
Intracellular oligonucleotide hybridization detected by fluorescence resonance energy transfer (FRET). Nucleic Acids Res (1994) 1.88
Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum Gene Ther (1996) 1.87
Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA. Biochemistry (1990) 1.86
Van der Waals interactions between cell surfaces. J Membr Biol (1977) 1.71
Cyclic amphipathic peptide-DNA complexes mediate high-efficiency transfection of adherent mammalian cells. Proc Natl Acad Sci U S A (1993) 1.65
Rapid entry of bitter and sweet tastants into liposomes and taste cells: implications for signal transduction. Am J Physiol Cell Physiol (2000) 1.59
Gene expression following direct injection of DNA into liver. Hum Gene Ther (1994) 1.59
Specificity of Ca2+ and Mg2+ binding to phosphatidylserine vesicles and resultant phase changes of bilayer membrane structure. Biochim Biophys Acta (1978) 1.57
Permeability properties of phospholipid membranes: effect of cholesterol and temperature. Biochim Biophys Acta (1972) 1.56
Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. Biochemistry (1997) 1.56
Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes. Pharm Res (1992) 1.56
Membrane fusion activity of influenza virus. Effects of gangliosides and negatively charged phospholipids in target liposomes. Biochemistry (1989) 1.46
Rapid nuclear accumulation of injected oligodeoxyribonucleotides. New Biol (1990) 1.45
Interaction of the HIV-1 fusion peptide with phospholipid vesicles: different structural requirements for fusion and leakage. Biochemistry (1994) 1.43
Pore-forming peptides induce rapid phospholipid flip-flop in membranes. Biochemistry (1994) 1.43
Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Hum Gene Ther (1999) 1.39
Destabilization of phosphatidylethanolamine liposomes at the hexagonal phase transition temperature. Biochemistry (1986) 1.37
Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther (1996) 1.34
Branched polyamines cure prion-infected neuroblastoma cells. J Virol (2001) 1.32
Physicochemical characterization and purification of cationic lipoplexes. Biophys J (1999) 1.31
Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG--diortho ester--lipid conjugate. Bioconjug Chem (2001) 1.28
pH-dependent bilayer destabilization by an amphipathic peptide. Biochemistry (1987) 1.27
The pre-transmembrane region of the human immunodeficiency virus type-1 glycoprotein: a novel fusogenic sequence. FEBS Lett (2000) 1.27
Specificity of Na+ binding to phosphatidylserine vesicles from a 23Na NMR relaxation rate study. Biochim Biophys Acta (1979) 1.27
Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells. Cancer Res (2001) 1.26
Quantitative analysis of liposome-cell interactions in vitro: rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes. Biochemistry (1993) 1.26
Effect of serum components on the physico-chemical properties of cationic lipid/oligonucleotide complexes and on their interactions with cells. Biochim Biophys Acta (1998) 1.24
Fusion of phosphatidylethanolamine-containing liposomes and mechanism of the L alpha-HII phase transition. Biochemistry (1986) 1.24
Calcium- and magnesium-induced fusion of mixed phosphatidylserine/phosphatidylcholine vesicles: effect of ion binding. J Membr Biol (1981) 1.24
A common mechanism for influenza virus fusion activity and inactivation. Biochemistry (1993) 1.23
Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids. Pharm Res (1996) 1.23
Molecular mechanisms of calcium-induced membrane fusion. J Bioenerg Biomembr (1990) 1.22
Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices. Nucleic Acids Res (1992) 1.17
Kinetic and structural aspects of reconstitution of phosphatidylcholine vesicles by dilution of phosphatidylcholine-sodium cholate mixed micelles. Biochemistry (1986) 1.13
Modulation of the biological activity of bacterial endotoxin by incorporation into liposomes. J Immunol (1987) 1.11
Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in culture. Pharm Res (1990) 1.11
On the applicability of certain approximations of the Lifshitz theory to thin films. J Theor Biol (1972) 1.08
Reversible surface aggregation in pore formation by pardaxin. Biophys J (1996) 1.06
Mechanism of fusion of Sendai virus: role of hydrophobic interactions and mobility constraints of viral membrane proteins. Effects of polyethylene glycol. J Biol Chem (1989) 1.05
Fusion activity and inactivation of influenza virus: kinetics of low pH-induced fusion with cultured cells. J Gen Virol (1992) 1.03
Reversibility of sodium-induced aggregation of sonicated phosphatidylserine vesicles. Proc Natl Acad Sci U S A (1980) 1.02
Cation binding to membranes: competition between mono-, di- and trivalent cations. Bull Math Biol (1980) 1.01
Quantitative competition of calcium with sodium or magnesium for sorption sites on plasma membrane vesicles of melon (Cucumis melo L.) root cells. J Membr Biol (1994) 1.01
Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus. Biochim Biophys Acta (1995) 1.01
Antigene, ribozyme and aptamer nucleic acid drugs: progress and prospects. Pharm Res (1995) 1.00
Effect of liposome encapsulation on antigen presentation in vitro. Comparison of presentation by peritoneal macrophages and B cell tumors. J Immunol (1989) 1.00
Mass action kinetics of virus-cell aggregation and fusion. Biophys J (1988) 1.00
The rate of fusion of phospholipid vesicles and the role of bilayer curvature. Biochim Biophys Acta (1982) 1.00
Destabilization of phosphatidylethanolamine-containing liposomes: hexagonal phase and asymmetric membranes. Biochemistry (1987) 0.99
Acid- and calcium-induced structural changes in phosphatidylethanolamine membranes stabilized by cholesteryl hemisuccinate. Biochemistry (1985) 0.99
Association of a pH-sensitive peptide with membrane vesicles: role of amino acid sequence. Biochemistry (1990) 0.98
Fusion of influenza virus with cardiolipin liposomes at low pH: mass action analysis of kinetics and extent. Biochemistry (1986) 0.98
Enhanced transepithelial transport of peptides by conjugation to cholic acid. Bioconjug Chem (1997) 0.97
On the correlation between HII phase and the contact-induced destabilization of phosphatidylethanolamine-containing membranes. Proc Natl Acad Sci U S A (1985) 0.97
Molecular modeling of the intestinal bile acid carrier: a comparative molecular field analysis study. J Comput Aided Mol Des (1997) 0.97
Potent inhibition of viral fusion by the lipophosphoglycan of Leishmania donovani. Biochemistry (1995) 0.95
Effects of replacement of the hydroxyl group of cholesterol and tocopherol on the thermotropic behavior of phospholipid membranes. Biochemistry (1985) 0.93
Interactions of La2+ with phosphatidylserine vesicles: binding, phase transition, leakage, 31P-NMR and fusion. Biochim Biophys Acta (1981) 0.93
Sedimentation field flow fractionation of liposomes. Science (1982) 0.92
Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes. J Biol Chem (2000) 0.92
Cationic lipids are essential for gene delivery mediated by intravenous administration of lipoplexes. Gene Ther (1999) 0.92
Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells. Biochim Biophys Acta (1999) 0.91
Kinetics of phospholipid membrane fusion induced by surfactant apoproteins A and B. Biochim Biophys Acta (1996) 0.91
Fluorometric determination of deoxyribonuclease I activity with PicoGreen. Anal Biochem (2000) 0.91
Temperature dependence of divalent cation induced fusion of phosphatidylserine liposomes: evaluation of the kinetic rate constants. Biochemistry (1985) 0.91
Real-time kinetic measurements of the interactions between lactogenic hormones and prolactin-receptor extracellular domains from several species support the model of hormone-induced transient receptor dimerization. J Biol Chem (1996) 0.90
Kinetics and extent of fusion between Sendai virus and erythrocyte ghosts: application of a mass action kinetic model. Biochemistry (1986) 0.90
Mass action analysis of kinetics and extent of fusion between Sendai virus and phospholipid vesicles. Biochemistry (1986) 0.90
Kinetic measurements of fusion of phosphatidylserine-containing vesicles by electron microscopy and fluorometry. Biochim Biophys Acta (1988) 0.90
Antigen presentation by B cells and macrophages of cytochrome c and its antigenic fragment when conjugated to the surface of liposomes. Vaccine (1989) 0.90
Binding of monovalent cations to phosphatidylserine and modulation of Ca2+- and Mg2+-induced vesicle fusion. Biochim Biophys Acta (1983) 0.89
Intratracheal gene delivery to the mouse airway: characterization of plasmid DNA expression and pharmacokinetics. Gene Ther (1995) 0.89
Organo-clay formulations of the hydrophobic herbicide norflurazon yield reduced leaching. J Agric Food Chem (2000) 0.89
Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity. Pharm Res (1997) 0.89
Surface aggregation and membrane penetration by peptides: relation to pore formation and fusion. Mol Membr Biol (1999) 0.88
The use of a new radioactive-iodine labeled lipid marker to follow in vivo disposition of liposomes: comparison with an encapsulated aqueous space marker. Res Commun Chem Pathol Pharmacol (1982) 0.88
Incorporation of LPS in liposomes diminishes its ability to induce tumoricidal activity and tumor necrosis factor secretion in murine macrophages. J Leukoc Biol (1988) 0.88
Aggregation of phospholipid vesicles by water-soluble polymers. Biophys J (1996) 0.87
Effect of cholesterol and charge on pore formation in bilayer vesicles by a pH-sensitive peptide. Biophys J (1996) 0.87
Synexin enhances the aggregation rate but not the fusion rate of liposomes. Biochemistry (1988) 0.87
A simple in vitro model to study the release kinetics of liposome encapsulated material. J Control Release (1998) 0.87
Lipoplex-mediated gene delivery to the lung occurs within 60 minutes of intravenous administration. Hum Gene Ther (1999) 0.87
Orientation of the pore-forming peptide GALA in POPC vesicles determined by a BODIPY-avidin/biotin binding assay. Biophys J (1999) 0.87