Published in Hum Gene Ther on August 01, 1996
Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes. Proc Natl Acad Sci U S A (2003) 2.05
Nonviral gene delivery: what we know and what is next. AAPS J (2007) 2.04
Effects of nanomaterial physicochemical properties on in vivo toxicity. Adv Drug Deliv Rev (2009) 1.80
Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles. Bioconjug Chem (2007) 1.71
Breaking up the correlation between efficacy and toxicity for nonviral gene delivery. Proc Natl Acad Sci U S A (2007) 1.58
Conscripts of the infinite armada: systemic cancer therapy using nanomaterials. Nat Rev Clin Oncol (2010) 1.30
Monomolecular collapse of plasmid DNA into stable virus-like particles. Proc Natl Acad Sci U S A (1998) 1.28
Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics. J Pharm Sci (2011) 1.24
Cationic liposome-nucleic acid complexes for gene delivery and silencing: pathways and mechanisms for plasmid DNA and siRNA. Top Curr Chem (2010) 1.20
Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells. Int J Pharm (2010) 1.17
Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems. J Pharm Sci (2013) 1.16
Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Gene Ther (2007) 1.12
The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor. Biomaterials (2013) 1.10
Compacted DNA nanoparticle gene transfer of GDNF to the rat striatum enhances the survival of grafted fetal dopamine neurons. Cell Transplant (2009) 1.02
Labeling efficacy of superparamagnetic iron oxide nanoparticles to human neural stem cells: comparison of ferumoxides, monocrystalline iron oxide, cross-linked iron oxide (CLIO)-NH2 and tat-CLIO. Korean J Radiol (2007) 1.02
Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA. Br J Pharmacol (2009) 1.01
Endosomal escape and transfection efficiency of PEGylated cationic liposome-DNA complexes prepared with an acid-labile PEG-lipid. Biomaterials (2012) 0.97
Mixtures of poly(triethylenetetramine/cystamine bisacrylamide) and poly(triethylenetetramine/cystamine bisacrylamide)-g-poly(ethylene glycol) for improved gene delivery. Bioconjug Chem (2010) 0.97
Adipose-derived stromal cells overexpressing vascular endothelial growth factor accelerate mouse excisional wound healing. Mol Ther (2012) 0.96
DNA nanoparticles: detection of long-term transgene activity in brain using bioluminescence imaging. Mol Imaging (2011) 0.95
Combinatorial evaluation of cations, pH-sensitive and hydrophobic moieties for polymeric vector design. Mol Ther (2009) 0.94
Physico-chemical characteristics of lipoplexes influence cell uptake mechanisms and transfection efficacy. PLoS One (2009) 0.92
Optimizing targeted gene delivery: chemical modification of viral vectors and synthesis of artificial virus vector systems. AAPS J (2006) 0.91
Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis. J Clin Invest (2014) 0.91
Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-L-lysine. Biomaterials (2011) 0.91
Melittin derived peptides for nanoparticle based siRNA transfection. Biomaterials (2013) 0.91
C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation. J Exp Med (2005) 0.91
The effect of cholesterol domains on PEGylated liposomal gene delivery in vitro. Ther Deliv (2011) 0.89
Targeted vault nanoparticles engineered with an endosomolytic peptide deliver biomolecules to the cytoplasm. ACS Nano (2011) 0.89
Serum-free transfection of CHO cells with chemically defined transfection systems and investigation of their potential for transient and stable transfection. Cytotechnology (2009) 0.88
Uptake and transfection efficiency of PEGylated cationic liposome-DNA complexes with and without RGD-tagging. Biomaterials (2014) 0.88
Structure and biological activity of pathogen-like synthetic nanomedicines. Nanomedicine (2011) 0.87
Advances in Systemic siRNA Delivery. Drugs Future (2009) 0.87
Theranostic nanoparticles based on bioreducible polyethylenimine-coated iron oxide for reduction-responsive gene delivery and magnetic resonance imaging. Int J Nanomedicine (2014) 0.86
Optimizing cationic and neutral lipids for efficient gene delivery at high serum content. J Gene Med (2014) 0.85
Polyethylenimine-mediated gene delivery to the lung and therapeutic applications. Drug Des Devel Ther (2009) 0.84
Fluorescence microscopy colocalization of lipid-nucleic acid nanoparticles with wildtype and mutant Rab5-GFP: A platform for investigating early endosomal events. Biochim Biophys Acta (2015) 0.83
The spherulites(TM): a promising carrier for oligonucleotide delivery. Nucleic Acids Res (2000) 0.82
A pH and redox dual responsive 4-arm poly(ethylene glycol)-block-poly(disulfide histamine) copolymer for non-viral gene transfection in vitro and in vivo. Int J Mol Sci (2014) 0.82
Immunological hurdles to lung gene therapy. Clin Exp Immunol (2003) 0.82
Coupling of importin beta binding peptide on plasmid DNA: transfection efficiency is increased by modification of lipoplex's physico-chemical properties. BMC Biotechnol (2003) 0.81
Baculoviruses as Vectors for Gene Therapy against Human Prostate Cancer. J Biomed Biotechnol (2003) 0.80
In vivo gene targeting of IL-3 into immature hematopoietic cells through CD117 receptor mediated antibody gene delivery. Genet Vaccines Ther (2004) 0.80
Synthesis of a library of propargylated and PEGylated α-hydroxy acids toward "clickable" polylactides via hydrolysis of cyanohydrin derivatives. J Org Chem (2014) 0.79
Intrinsic dynamics of DNA-polymer complexes: a mechanism for DNA release. Mol Pharm (2012) 0.79
Functional properties and biodistribution of poly(triethylenetetramine/cystamine bisacrylamide) and poly(triethylenetetramine/cystamine bisacrylamide)- poly(ethylene glycol) mixtures formed with nucleic acid. J Control Release (2012) 0.78
Complement activation by merozoite antigens of Plasmodium falciparum. PLoS One (2014) 0.78
Regulating Biocompatibility of Carbon Spheres via Defined Nanoscale Chemistry and a Careful Selection of Surface Functionalities. Sci Rep (2015) 0.77
Polyion complex (PIC) particles: Preparation and biomedical applications. Eur Polym J (2016) 0.77
Preparation of DNA/Gold Nanoparticle Encapsulated in Calcium Phosphate. J Drug Deliv (2011) 0.77
Micelle-like nanoparticles as carriers for DNA and siRNA. Mol Pharm (2015) 0.77
Polyplex Evolution: Understanding Biology, Optimizing Performance. Mol Ther (2017) 0.76
Bioreducible polycations as shuttles for therapeutic nucleic acid and protein transfection. Antioxid Redox Signal (2014) 0.76
Non-covalent ligand conjugation to biotinylated DNA nanoparticles using TAT peptide genetically fused to monovalent streptavidin. J Drug Target (2012) 0.75
Post-Transcriptional Regulation of the GASC1 Oncogene with Active Tumor-Targeted siRNA-Nanoparticles. Mol Pharm (2016) 0.75
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature (2001) 19.67
Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature (2000) 18.26
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell (2001) 11.39
The marketplace in health care reform. The demographic limitations of managed competition. N Engl J Med (1993) 5.90
Randomised trial of monitoring, feedback, and management of care by telephone to improve treatment of depression in primary care. BMJ (2000) 5.45
Community-level comparisons between the grocery store environment and individual dietary practices. Prev Med (1991) 4.45
Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry (1996) 4.06
Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem (1994) 3.24
Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. Biochim Biophys Acta (1979) 3.20
Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell (2001) 2.99
Age-related changes in cortical blood flow activation during visual processing of faces and location. J Neurosci (1994) 2.92
PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther (1999) 2.90
The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J Biol Chem (1994) 2.84
Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein. Science (2000) 2.66
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest (1997) 2.48
H+- and Ca2+-induced fusion and destabilization of liposomes. Biochemistry (1985) 2.44
Base composition of ribosomal RNA precursors in the HeLa cell nucleolus: further evidence of non-conservative processing. J Mol Biol (1968) 2.40
Differences in sociodemographic, health status, and lifestyle characteristics among American Indians by telephone coverage. Prev Med (1994) 2.37
In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem (1997) 2.28
The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther (1998) 2.19
Mechanism of oligonucleotide release from cationic liposomes. Proc Natl Acad Sci U S A (1996) 2.19
Design and gene delivery activity of modified polyethylenimines. Adv Drug Deliv Rev (2001) 2.18
Effect of lipid composition and liposome size on toxicity and in vitro fungicidal activity of liposome-intercalated amphotericin B. Antimicrob Agents Chemother (1987) 2.14
Distressed high utilizers of medical care. DSM-III-R diagnoses and treatment needs. Gen Hosp Psychiatry (1990) 2.13
Treatment of experimental invasive aspergillosis with novel amphotericin B/cholesterol-sulfate complexes. J Infect Dis (1989) 2.08
Frustrating patients: physician and patient perspectives among distressed high users of medical services. J Gen Intern Med (1991) 2.08
pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact. Biochemistry (1984) 2.03
A randomized trial of psychiatric consultation with distressed high utilizers. Gen Hosp Psychiatry (1992) 2.00
The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther (1997) 1.96
Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus. Gene Ther (2000) 1.90
High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proc Natl Acad Sci U S A (1992) 1.90
Intracellular oligonucleotide hybridization detected by fluorescence resonance energy transfer (FRET). Nucleic Acids Res (1994) 1.88
Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA. Biochemistry (1990) 1.86
Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc Natl Acad Sci U S A (1991) 1.85
Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc Natl Acad Sci U S A (1990) 1.79
Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo. J Gene Med (2001) 1.78
Environmental indicators: a tool for evaluating community-based health-promotion programs. Am J Prev Med (1993) 1.76
An RGD-oligolysine peptide: a prototype construct for integrin-mediated gene delivery. Hum Gene Ther (1998) 1.73
Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc Natl Acad Sci U S A (1992) 1.72
Effect of bronchial smooth muscle contraction on lung compliance. J Appl Physiol (1985) (1992) 1.68
Coronary disease severity and functional impairment: how strong is the relation? J Am Geriatr Soc (1996) 1.66
DNA/polyethylenimine transfection particles: influence of ligands, polymer size, and PEGylation on internalization and gene expression. AAPS PharmSci (2001) 1.66
Cyclic amphipathic peptide-DNA complexes mediate high-efficiency transfection of adherent mammalian cells. Proc Natl Acad Sci U S A (1993) 1.65
Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells. Proc Natl Acad Sci U S A (1990) 1.64
An opportunistic infection with Corynebacterium pyogenes producing empyema. Am J Clin Pathol (1970) 1.62
Do communities differ in health behaviors? J Clin Epidemiol (1993) 1.60
Gene expression following direct injection of DNA into liver. Hum Gene Ther (1994) 1.59
Gene therapy progress and prospects: synthetic polymer-based systems. Gene Ther (2008) 1.58
Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. Biochemistry (1997) 1.56
Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes. Pharm Res (1992) 1.56
Virus-mediated release of endosomal content in vitro: different behavior of adenovirus and rhinovirus serotype 2. J Cell Biol (1995) 1.55
Gestational age-dependent expression of IL-10 and its receptor in human placental tissues and isolated cytotrophoblasts. J Immunol (2000) 1.55
Radical resection and liver grafting as the two main components of surgical strategy in the treatment of proximal bile duct cancer. World J Surg (1988) 1.51
Non-viral approaches to gene therapy. Curr Opin Biotechnol (1993) 1.50
Cost-effectiveness comparisons using "real world" randomized trials: the case of new antidepressant drugs. J Clin Epidemiol (1995) 1.49
Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application. Gene Ther (2001) 1.47
Long-term outcomes of initial antidepressant drug choice in a "real world" randomized trial. Arch Fam Med (1999) 1.47
Rapid nuclear accumulation of injected oligodeoxyribonucleotides. New Biol (1990) 1.45
High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes. Hum Gene Ther (1992) 1.45
Direct demonstration that the abundant 6-kilobase herpes simplex virus type 1 mRNA mapping between 0.23 and 0.27 map units encodes the major capsid protein VP5. J Virol (1984) 1.44
Nomenclature for synthetic gene delivery systems. Hum Gene Ther (1997) 1.44
Pore-forming peptides induce rapid phospholipid flip-flop in membranes. Biochemistry (1994) 1.43
Conference report: community-based health promotion--state of the art and recommendations for the future. Am J Prev Med (1997) 1.41
Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Hum Gene Ther (1999) 1.39
2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event. Nucleic Acids Res (1991) 1.39
Angiogenesis in the mouse lung. Am J Pathol (2000) 1.38
On the purported discovery of the bronchial circulation by Leonardo da Vinci. J Appl Physiol (1985) (1992) 1.38
Destabilization of phosphatidylethanolamine liposomes at the hexagonal phase transition temperature. Biochemistry (1986) 1.37
Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjug Chem (1993) 1.35
Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther (1996) 1.34
Branched polyamines cure prion-infected neuroblastoma cells. J Virol (2001) 1.32
Physicochemical characterization and purification of cationic lipoplexes. Biophys J (1999) 1.31
Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery. Gene Ther (1997) 1.30
Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus. Gene Ther (1994) 1.29
A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse. Mech Dev (2000) 1.29
Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG--diortho ester--lipid conjugate. Bioconjug Chem (2001) 1.28
pH-dependent bilayer destabilization by an amphipathic peptide. Biochemistry (1987) 1.27
Evaluating community-based nutrition programs: assessing the reliability of a survey of grocery store product displays. Am J Public Health (1990) 1.27
Physician staffing ratios in staff-model HMOs: a cautionary tale. Health Aff (Millwood) (1997) 1.27
Bid-induced release of AIF from mitochondria causes immediate neuronal cell death. Cell Death Differ (2008) 1.27
Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells. Cancer Res (2001) 1.26
Regulation of the tissue factor promoter in endothelial cells. Binding of NF kappa B-, AP-1-, and Sp1-like transcription factors. J Biol Chem (1995) 1.26
Effect of serum components on the physico-chemical properties of cationic lipid/oligonucleotide complexes and on their interactions with cells. Biochim Biophys Acta (1998) 1.24
NK-kappa B subunit-specific regulation of the I kappa B alpha promoter. J Biol Chem (1994) 1.24
Can measures of the grocery store environment be used to track community-level dietary changes? Prev Med (1993) 1.24
Fusion of phosphatidylethanolamine-containing liposomes and mechanism of the L alpha-HII phase transition. Biochemistry (1986) 1.24
Implementation of the Henry J. Kaiser Family Foundation's Community Health Promotion Grant Program: a process evaluation. Milbank Q (1998) 1.23
Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids. Pharm Res (1996) 1.23
DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety. Bioconjug Chem (1992) 1.21
Evaluating community-based nutrition programs: comparing grocery store and individual-level survey measures of program impact. Prev Med (1995) 1.21
A systematic approach to diabetes management in the post-DCCT era. Diabetes Care (1994) 1.19
Complement 1 inhibitor is a regulator of the alternative complement pathway. J Exp Med (2001) 1.18
Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices. Nucleic Acids Res (1992) 1.17
Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid. Virology (1994) 1.16
Characterization of a sucrase gene from Staphylococcus xylosus. J Bacteriol (1993) 1.15
Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Oncogene (2006) 1.14