CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection.

PubWeight™: 2.43‹?› | Rank: Top 2%

🔗 View Article (PMID 10657654)

Published in J Immunol on February 15, 2000

Authors

T R Traynor1, W A Kuziel, G B Toews, G B Huffnagle

Author Affiliations

1: Pulmonary Division, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Articles citing this

Monocyte recruitment during infection and inflammation. Nat Rev Immunol (2011) 7.55

Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol (2008) 7.21

Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J Exp Med (2000) 3.15

Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection. Cell Host Microbe (2009) 2.81

Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis. J Exp Med (2005) 2.76

Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2001) 2.59

Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression. Infect Immun (2002) 1.89

Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion. Am J Pathol (2004) 1.87

Dendritic cell-mediated T cell polarization. Springer Semin Immunopathol (2004) 1.72

Macrophage M1/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infection. MBio (2013) 1.62

Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis. J Clin Invest (2003) 1.62

Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis. J Immunol (2010) 1.58

Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99. Am J Pathol (2009) 1.48

Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes. J Immunol (2009) 1.48

Adaptive immunity to fungi. Annu Rev Immunol (2012) 1.41

Regulation of inflammatory monocyte/macrophage recruitment from the bone marrow during murine cytomegalovirus infection: role for type I interferons in localized induction of CCR2 ligands. J Immunol (2009) 1.40

CCR2 mediates conventional dendritic cell recruitment and the formation of bronchovascular mononuclear cell infiltrates in the lungs of mice infected with Cryptococcus neoformans. J Immunol (2008) 1.39

Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. J Immunol (2010) 1.38

Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung. Am J Pathol (2009) 1.38

The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity. J Immunol (2009) 1.27

Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections. PLoS Pathog (2012) 1.26

Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans. Infect Immun (2009) 1.26

Regulatory effects of macrophage inflammatory protein 1alpha/CCL3 on the development of immunity to Cryptococcus neoformans depend on expression of early inflammatory cytokines. Infect Immun (2001) 1.22

Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model. Infect Immun (2008) 1.22

Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes. Immunity (2012) 1.17

Inflammatory monocytes mediate early and organ-specific innate defense during systemic candidiasis. J Infect Dis (2013) 1.15

The gamma interferon receptor is required for the protective pulmonary inflammatory response to Cryptococcus neoformans. Infect Immun (2005) 1.15

Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection. Am J Pathol (2010) 1.14

Recruitment of macrophages and polymorphonuclear leukocytes in Lyme carditis. Infect Immun (2006) 1.12

Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection. Infect Immun (2009) 1.12

T-cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking. Clin Exp Immunol (2002) 1.12

Inflammatory monocytes and the pathogenesis of viral encephalitis. J Neuroinflammation (2012) 1.08

Azithromycin alters macrophage phenotype and pulmonary compartmentalization during lung infection with Pseudomonas. Antimicrob Agents Chemother (2010) 1.06

TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans-infected lungs. Am J Pathol (2010) 1.06

Essential yet limited role for CCR2⁺ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming. Elife (2013) 1.06

Immune modulation mediated by cryptococcal laccase promotes pulmonary growth and brain dissemination of virulent Cryptococcus neoformans in mice. PLoS One (2012) 1.05

Impaired lung dendritic cell activation in CCR2 knockout mice. Am J Pathol (2004) 1.04

Protective efficacy of antigenic fractions in mouse models of cryptococcosis. Infect Immun (2004) 1.03

CCR2-antagonist prophylaxis reduces pulmonary immune pathology and markedly improves survival during influenza infection. J Immunol (2010) 0.99

Enhanced innate immune responsiveness to pulmonary Cryptococcus neoformans infection is associated with resistance to progressive infection. Infect Immun (2008) 0.98

Phagocytic activity and monocyte chemotactic protein expression by pulmonary macrophages in persistent pulmonary cryptococcosis. Infect Immun (2003) 0.97

CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease. Gut (2004) 0.96

Early induction of CCL7 downstream of TLR9 signaling promotes the development of robust immunity to cryptococcal infection. J Immunol (2012) 0.96

Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination. Am J Pathol (2012) 0.95

Chemokine control of West Nile virus infection. Exp Cell Res (2011) 0.95

Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection. J Immunol (2009) 0.93

Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria. Infect Immun (2003) 0.93

Molecular control of monocyte development. Cell Immunol (2014) 0.92

Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2. EMBO Mol Med (2014) 0.92

Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2. Respir Res (2004) 0.91

Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response. Infect Immun (2008) 0.90

Mouse adenovirus type 1 infection of macrophages. Virology (2009) 0.90

Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections. Mucosal Immunol (2014) 0.90

Absence of interleukin-4 determines less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response. Infect Immun (2004) 0.89

A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. Am J Physiol Lung Cell Mol Physiol (2012) 0.89

IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and -dependent mechanisms. Am J Pathol (2012) 0.89

Ontogeny of myeloid cells. Front Immunol (2014) 0.87

Successful protection against tularemia in C57BL/6 mice is correlated with expansion of Francisella tularensis-specific effector T cells. Clin Vaccine Immunol (2014) 0.87

Mononuclear phagocyte-mediated antifungal immunity: the role of chemotactic receptors and ligands. Cell Mol Life Sci (2015) 0.83

Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection. Infect Immun (2010) 0.83

Monocyte-mediated defense against bacteria, fungi, and parasites. Semin Immunol (2016) 0.82

Genetics of sarcoidosis: candidate genes and genome scans. Proc Am Thorac Soc (2007) 0.82

Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. Mucosal Immunol (2014) 0.81

STAT1 Signaling within Macrophages Is Required for Antifungal Activity against Cryptococcus neoformans. Infect Immun (2015) 0.81

IL-23 induces atopic dermatitis-like inflammation instead of psoriasis-like inflammation in CCR2-deficient mice. PLoS One (2013) 0.81

Tipping the balance in favor of protective immunity during influenza virus infection. Proc Natl Acad Sci U S A (2009) 0.81

Urokinase-deficient mice fail to generate a type 2 immune response following schistosomal antigen challenge. Infect Immun (2004) 0.81

Adaptive immunity to fungi. Cold Spring Harb Perspect Med (2014) 0.80

Cryptococcal heat shock protein 70 homolog Ssa1 contributes to pulmonary expansion of Cryptococcus neoformans during the afferent phase of the immune response by promoting macrophage M2 polarization. J Immunol (2015) 0.80

Characterization of chemokine and chemokine receptor expression during Pneumocystis infection in healthy and immunodeficient mice. Microbes Infect (2015) 0.79

Paracoccidioides brasilinsis-induced migration of dendritic cells and subsequent T-cell activation in the lung-draining lymph nodes. PLoS One (2011) 0.79

Cryptococcus neoformans growth and protection from innate immunity are dependent on expression of a virulence-associated DEAD-box protein, Vad1. Infect Immun (2012) 0.79

Type I IFN Induction via Poly-ICLC Protects Mice against Cryptococcosis. PLoS Pathog (2015) 0.78

Characteristics and outcomes of cryptococcal meningitis in HIV seronegative children in Beijing, China, 2002-2013. BMC Infect Dis (2016) 0.78

Arachidonic acid metabolites in pathogenic yeasts. Lipids Health Dis (2012) 0.77

The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway. Infect Immun (2015) 0.77

Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2. Clin Vaccine Immunol (2006) 0.76

Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin. Immunol Res (2014) 0.76

An association between pulmonary Mycobacterium avium-intracellulare complex infections and biomarkers of Th2-type inflammation. Respir Res (2017) 0.75

Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection. J Immunol (2017) 0.75

Eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2(-/-) mice. Mucosal Immunol (2016) 0.75

Immunoregulation in Fungal Diseases. Microorganisms (2016) 0.75

Innate Immune Responses to Cryptococcus. J Fungi (Basel) (2017) 0.75

Articles by these authors

Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. J Clin Invest (1990) 5.21

Histopathologic variability in usual and nonspecific interstitial pneumonias. Am J Respir Crit Care Med (2001) 4.01

Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol (1980) 4.00

Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells. Cell (1988) 3.88

A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection. Infect Immun (1989) 3.18

CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J Exp Med (2000) 3.09

Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am J Pathol (2000) 2.98

Radiological versus histological diagnosis in UIP and NSIP: survival implications. Thorax (2003) 2.54

Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infect Immun (1997) 2.54

CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells. Nat Immunol (2000) 2.49

Idiopathic pulmonary fibrosis: predicting response to therapy and survival. Am J Respir Crit Care Med (1998) 2.43

CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation. J Exp Med (2000) 2.40

Protection from pulmonary fibrosis in the absence of CCR2 signaling. J Immunol (2001) 2.38

The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection. J Immunol (1995) 2.37

Steroids in idiopathic pulmonary fibrosis: a prospective assessment of adverse reactions, response to therapy, and survival. Am J Med (2001) 2.35

Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis (1999) 2.35

Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans. J Immunol (1990) 2.28

Clinical significance of histological classification of idiopathic interstitial pneumonia. Eur Respir J (2002) 2.19

Afferent phase production of TNF-alpha is required for the development of protective T cell immunity to Cryptococcus neoformans. J Immunol (1996) 2.12

The 'microflora hypothesis' of allergic diseases. Clin Exp Allergy (2005) 2.03

Regulation of T-cell receptor gamma-chain RNA expression in murine Thy-1+ dendritic epidermal cells. Nature (1987) 2.00

Inducible expression of inflammatory chemokines in respiratory syncytial virus-infected mice: role of MIP-1alpha in lung pathology. J Virol (2001) 1.88

Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine. J Immunol (2000) 1.86

"The good, the bad, and the ugly." The role of chemokines in models of human disease. J Immunol (1996) 1.85

The accessory cell function of human alveolar macrophages in specific T cell proliferation. J Immunol (1984) 1.81

Down-regulation of the afferent phase of T cell-mediated pulmonary inflammation and immunity by a high melanin-producing strain of Cryptococcus neoformans. J Immunol (1995) 1.80

Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins. Infect Immun (2001) 1.76

Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol (1999) 1.69

RANTES promotes growth and survival of human first-trimester forebrain astrocytes. Nat Cell Biol (2001) 1.63

Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice. J Immunol (1999) 1.61

The relationship of inoculum size to lung bacterial clearance and phagocytic cell response in mice. Am Rev Respir Dis (1979) 1.61

Early cytokine production in pulmonary Cryptococcus neoformans infections distinguishes susceptible and resistant mice. Am J Respir Cell Mol Biol (1995) 1.59

GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. J Immunol (2000) 1.58

A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours. Nature (1988) 1.55

Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus. Virology (2001) 1.47

The role of methotrexate in the management of steroid-dependent asthma. Chest (1994) 1.46

Interferon-gamma activates rat alveolar macrophages for anticryptococcal activity. Am J Respir Cell Mol Biol (1991) 1.45

Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model. J Clin Invest (1996) 1.45

Production and function of murine macrophage inflammatory protein-1 alpha in bleomycin-induced lung injury. J Immunol (1994) 1.42

The role of macrophage inflammatory protein-1 alpha/CCL3 in regulation of T cell-mediated immunity to Cryptococcus neoformans infection. J Immunol (2000) 1.39

Macrophage inflammatory protein-1alpha (MIP-1alpha) is required for the efferent phase of pulmonary cell-mediated immunity to a Cryptococcus neoformans infection. J Immunol (1997) 1.39

Natural and perturbed distributions of Langerhans cells: responses to ultraviolet light, heterotopic skin grafting, and dinitrofluorobenzene sensitization. J Invest Dermatol (1980) 1.39

Pulmonary inflammation induced by incomplete or inactivated adenoviral particles. Hum Gene Ther (1995) 1.38

Corneal allografts fail to express Ia antigens. Nature (1979) 1.38

Experimental murine pulmonary cryptococcosis. Differences in pulmonary inflammation and lymphocyte recruitment induced by two encapsulated strains of Cryptococcus neoformans. Lab Invest (1994) 1.37

Effect of granulocyte-macrophage colony-stimulating factor on rat alveolar macrophage anticryptococcal activity in vitro. J Immunol (1994) 1.36

Role of natural killer cells in resistance to Cryptococcus neoformans infections in mice. Am J Pathol (1987) 1.34

Impaired functional activity of alveolar macrophages from GM-CSF-deficient mice. Am J Physiol Lung Cell Mol Physiol (2001) 1.33

Legionella pneumophila replicates within rat alveolar epithelial cells. J Infect Dis (1993) 1.32

Induction of lung fibrosis in the mouse by intratracheal instillation of fluorescein isothiocyanate is not T-cell-dependent. Am J Pathol (1999) 1.28

Murine natural killer cells do not express functional transcripts of the alpha-, beta-, or gamma-chain genes of the T cell receptor. J Immunol (1986) 1.28

CC chemokine receptor 2 is required for macrophage infiltration and vascular hypertrophy in angiotensin II-induced hypertension. Hypertension (2000) 1.27

Lack of CCR2 results in increased mortality and impaired leukocyte activation and trafficking following infection of the central nervous system with a neurotropic coronavirus. J Immunol (2001) 1.27

Pulmonary function measures predict mortality differently in IPF versus combined pulmonary fibrosis and emphysema. Eur Respir J (2010) 1.26

Granulocyte-alveolar-macrophage interaction in the pulmonary clearance of Staphylococcus aureus. Am Rev Respir Dis (1983) 1.24

Immune enhancement of pulmonary clearance of nontypable Haemophilus influenzae. Infect Immun (1988) 1.23

Regulatory effects of macrophage inflammatory protein 1alpha/CCL3 on the development of immunity to Cryptococcus neoformans depend on expression of early inflammatory cytokines. Infect Immun (2001) 1.22

T cell receptor genes do not rearrange or express functional transcripts in natural killer cells of scid mice. J Immunol (1987) 1.21

Murine natural killer cells express functional Fc gamma receptor II encoded by the Fc gamma R alpha gene. J Exp Med (1989) 1.20

The chemokine receptor CCR2 is involved in macrophage recruitment to the injured peripheral nervous system. J Neuroimmunol (2000) 1.19

Antigen presentation by guinea pig alveolar macrophages. J Immunol (1981) 1.19

Use of JH4 joining segment gene by an anti-arsonate antibody that bears the major A-strain cross-reactive idiotype but displays diminished antigen binding. J Immunol (1984) 1.18

Mononuclear cells in human lung parenchyma. Characterization of a potent accessory cell not obtained by bronchoalveolar lavage. Am Rev Respir Dis (1987) 1.18

Regulation of the expression of multiple class II genes in murine B cells by B cell stimulatory factor-1 (BSF-1). J Immunol (1986) 1.17

Cyclosporin A inhibits the growth of Cryptococcus neoformans in a murine model. Infect Immun (1988) 1.16

Effect of systemic immunization on pulmonary clearance of Haemophilus influenzae type b. Infect Immun (1985) 1.16

Macrophage inflammatory protein 1alpha/CCL3 is required for clearance of an acute Klebsiella pneumoniae pulmonary infection. Infect Immun (2001) 1.14

Alterations in the pattern of arachidonate metabolism accompany rat macrophage differentiation in the lung. J Immunol (1990) 1.14

Langerhans cells: sentinels of skin associated lymphoid tissue. J Invest Dermatol (1980) 1.12

Treatment of murine cryptococcosis with cyclosporin-A in normal and athymic mice. Am Rev Respir Dis (1989) 1.12

Depletion of murine CD8+ T cells in vivo decreases pulmonary clearance of a moderately virulent strain of Cryptococcus neoformans. J Lab Clin Med (1993) 1.12

IL-2-induced signal transduction involves the activation of nuclear NF-kappa B expression. J Immunol (1992) 1.12

Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2000) 1.10

CD8 cells play a critical role in delayed type hypersensitivity to intact Cryptococcus neoformans. J Immunol (1994) 1.10

A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor. J Immunol (1991) 1.09

Inability of human alveolar macrophages to stimulate resting T cells correlates with decreased antigen-specific T cell-macrophage binding. J Immunol (1986) 1.09

Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1alpha or its CCR5 receptor. Eur J Immunol (2000) 1.09

Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice. Clin Exp Allergy (2007) 1.09

The chemokine receptor CCR2 mediates the binding and internalization of monocyte chemoattractant protein-1 along brain microvessels. J Neurosci (2001) 1.05

Different patterns of arachidonate metabolism in autologous human blood monocytes and alveolar macrophages. J Immunol (1989) 1.05

Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide. J Immunol (1997) 1.04

The role of C5 in polymorphonuclear leukocyte recruitment in response to Streptococcus pneumoniae. Am Rev Respir Dis (1984) 1.04

Natural killer cell function in human lung is compartmentalized. Am Rev Respir Dis (1987) 1.02

Natural killer cells in the thymus. Studies in mice with severe combined immune deficiency. J Immunol (1990) 1.02

Androstenedione metabolism in human alveolar macrophages. J Clin Endocrinol Metab (1983) 1.02

Separation of potent and poorly functional human lung accessory cells based on autofluorescence. J Leukoc Biol (1989) 1.02

Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21. Eur Respir J (2007) 1.01

Leukocyte recruitment during pulmonary Cryptococcus neoformans infection. Immunopharmacology (2000) 0.99

Focal interstitial CC chemokine receptor 7 (CCR7) expression in idiopathic interstitial pneumonia. J Clin Pathol (2006) 0.99

Role of C5 and recruited neutrophils in early clearance of nontypable Haemophilus influenzae from murine lungs. Infect Immun (1985) 0.99

Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia. J Clin Pathol (2004) 0.99

Mechanisms of complement-mediated clearance of bacteria from the murine lung. Am Rev Respir Dis (1982) 0.98