PubRank

C F Barbas

Author PubWeight™ 132.69‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG. J Virol 1995 6.33
2 A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc Natl Acad Sci U S A 1991 6.13
3 Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1. J Virol 1994 5.76
4 Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc Natl Acad Sci U S A 1998 5.46
5 Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences. Proc Natl Acad Sci U S A 1999 4.87
6 Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120. J Virol 1995 4.33
7 Positive and negative regulation of endogenous genes by designed transcription factors. Proc Natl Acad Sci U S A 2000 3.92
8 Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes. Science 1995 3.82
9 Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1. Nat Med 1997 3.63
10 Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem 2001 3.35
11 Design of polydactyl zinc-finger proteins for unique addressing within complex genomes. Proc Natl Acad Sci U S A 1997 2.97
12 Building zinc fingers by selection: toward a therapeutic application. Proc Natl Acad Sci U S A 1995 2.92
13 Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proc Natl Acad Sci U S A 1991 2.42
14 Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies. J Virol 1998 2.28
15 Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site. AIDS 1995 2.15
16 In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. Proc Natl Acad Sci U S A 1992 2.08
17 Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains. J Mol Biol 2000 2.03
18 Human monoclonal antibodies against a plethora of viral pathogens from single combinatorial libraries. Proc Natl Acad Sci U S A 1993 2.01
19 CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range. J Mol Biol 1995 1.90
20 Human antibody responses to HIV type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding. AIDS Res Hum Retroviruses 1996 1.87
21 Recombinant human monoclonal antibody IgG1b12 neutralizes diverse human immunodeficiency virus type 1 primary isolates. AIDS Res Hum Retroviruses 1997 1.84
22 Human antibodies from combinatorial libraries. Adv Immunol 1994 1.78
23 Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody IgG1b12. off. J Virol 1997 1.66
24 Phage display of combinatorial antibody libraries. Curr Opin Biotechnol 1997 1.56
25 Identification and characterization of a peptide that specifically binds the human, broadly neutralizing anti-human immunodeficiency virus type 1 antibody b12. J Virol 2001 1.53
26 Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins. Curr Opin Biotechnol 2001 1.52
27 Immunization of hu-PBL-SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries. Nature 1992 1.50
28 Human combinatorial antibody libraries to hepatitis B surface antigen. Proc Natl Acad Sci U S A 1992 1.43
29 Antibodies without immunization. Science 1992 1.41
30 Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice. Proc Natl Acad Sci U S A 1994 1.40
31 Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion. Proc Natl Acad Sci U S A 2000 1.40
32 Neutralizing recombinant human antibodies to a conformational V2- and CD4-binding site-sensitive epitope of HIV-1 gp120 isolated by using an epitope-masking procedure. J Immunol 1995 1.39
33 T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery. Gene Ther 2006 1.38
34 Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis. Proc Natl Acad Sci U S A 1998 1.37
35 Mapping the protein surface of human immunodeficiency virus type 1 gp120 using human monoclonal antibodies from phage display libraries. J Mol Biol 1997 1.33
36 The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies. J Biol Chem 2000 1.32
37 Alphav integrins mediate adhesion and migration of breast carcinoma cell lines. Clin Exp Metastasis 1998 1.29
38 Chemically regulated zinc finger transcription factors. J Biol Chem 2000 1.29
39 In vitro antigen challenge of human antibody libraries for vaccine evaluation: the human immunodeficiency virus type 1 envelope. J Virol 1996 1.28
40 Methods for the generation of chicken monoclonal antibody fragments by phage display. J Immunol Methods 2000 1.27
41 Synergistic neutralization of a chimeric SIV/HIV type 1 virus with combinations of human anti-HIV type 1 envelope monoclonal antibodies or hyperimmune globulins. AIDS Res Hum Retroviruses 1997 1.26
42 Multiple event activation of a generic prodrug trigger by antibody catalysis. Proc Natl Acad Sci U S A 1999 1.21
43 An allosteric Ca2+ binding site on the beta3-integrins that regulates the dissociation rate for RGD ligands. J Biol Chem 1996 1.14
44 A binary plasmid system for shuffling combinatorial antibody libraries. Proc Natl Acad Sci U S A 1992 1.11
45 Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein. Virology 1998 1.08
46 Design of novel sequence-specific DNA-binding proteins. Curr Opin Chem Biol 2000 1.07
47 Catalytic direct asymmetric Michael reactions: taming naked aldehyde donors. Org Lett 2001 1.07
48 In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy. Proc Natl Acad Sci U S A 2001 1.04
49 Effective ex vivo neutralization of human immunodeficiency virus type 1 in plasma by recombinant immunoglobulin molecules. J Virol 1996 1.03
50 Antibodies from libraries. Nature 1992 1.02
51 Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1. Acta Crystallogr D Biol Crystallogr 2001 1.01
52 On the use of combinatorial antibody libraries to clone the "fossil record" of an individual's immune response. Proc Natl Acad Sci U S A 1991 0.98
53 Molecular cloning, nucleotide sequence and fine-structural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose-1,6-biphosphate aldolase to class I and class II aldolases. Mol Microbiol 1989 0.96
54 The antibody catalysis route to the total synthesis of epothilones. Proc Natl Acad Sci U S A 1998 0.96
55 Generation and characterization of a recombinant human CCR5-specific antibody. A phage display approach for rabbit antibody humanization. J Biol Chem 2000 0.95
56 The maltose-binding protein as a scaffold for monovalent display of peptides derived from phage libraries. Anal Biochem 1998 0.95
57 The nature of the autoimmune antibody repertoire in human immunodeficiency virus type 1 infection. Proc Natl Acad Sci U S A 1994 0.94
58 Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein. Mol Med 1998 0.93
59 Human antibodies to HIV-1 by recombinant DNA methods. Chem Immunol 1993 0.92
60 On roads not taken in the evolution of protein catalysts: antibody steroid isomerases that use an enamine mechanism. Proc Natl Acad Sci U S A 1997 0.91
61 Drug-inducible and simultaneous regulation of endogenous genes by single-chain nuclear receptor-based zinc-finger transcription factor gene switches. Gene Ther 2008 0.90
62 A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries. Proc Natl Acad Sci U S A 1998 0.90
63 Direct selection for a catalytic mechanism from combinatorial antibody libraries. Proc Natl Acad Sci U S A 1994 0.90
64 Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task. Proc Natl Acad Sci U S A 2000 0.89
65 Identification of a region in the integrin beta3 subunit that confers ligand binding specificity. J Biol Chem 1997 0.89
66 Recombinant rabbit Fab with binding activity to type-1 plasminogen activator inhibitor derived from a phage-display library against human alpha-granules. Gene 1996 0.84
67 Surface plasmon resonance based kinetic studies of zinc finger-DNA interactions. J Immunol Methods 1995 0.84
68 An efficient benchtop system for multigram-scale kinetic resolutions using aldolase antibodies. Chemistry 2000 0.84
69 Benzoate X receptor zinc-finger gene switches for drug-inducible regulation of transcription. Gene Ther 2011 0.83
70 Building synthetic antibodies as adhesive ligands for integrins. J Biol Chem 1994 0.83
71 Human monoclonal antibodies: recent achievements. Hosp Pract (Off Ed) 1994 0.83
72 Sets of aldolase antibodies with antipodal reactivities. Formal synthesis of epothilone E by large-scale antibody-catalyzed resolution of thiazole aldol. Org Lett 1999 0.82
73 Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis. Gene 1993 0.78
74 Making enzymes. Harvey Lect 2004 0.76
75 Synthesis of five enantiomerically pure haptens designed for in vitro evolution of antibodies with peptidase activity. Bioorg Med Chem 1996 0.76
76 Visualizing antibody-catalyzed retro-aldol-retro-Michael reactions. Bioorg Med Chem Lett 2001 0.76
77 Alchemy, enzymes, and the blind-watchmaker. Nat Biotechnol 1998 0.75
78 Synthesis of an organoinsulin molecule that can be activated by antibody catalysis. Proc Natl Acad Sci U S A 2001 0.75
79 Enantioselective aldol cyclodehydrations catalyzed by antibody 38C2. Org Lett 1999 0.75
80 Human monoclonal Fab fragments specific for viral antigens from combinatorial IgA libraries. Immunotechnology 1995 0.75
81 Using the process of reactive immunization to induce catalytic antibodies with complex mechanisms: aldolases. Acta Chem Scand 1996 0.75
82 Retracted Simultaneous, phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody enhances antiangiogenic effects in vivo. Klin Padiatr 2006 0.75
83 Purification of storage granule protein-23. A novel protein identified by phage display technology and interaction with type I plasminogen activator inhibitor. J Biol Chem 1996 0.75