Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis.

PubWeight™: 1.37‹?› | Rank: Top 10%

🔗 View Article (PMC 28046)

Published in Proc Natl Acad Sci U S A on December 22, 1998

Authors

B List1, C F Barbas, R A Lerner

Author Affiliations

1: The Skaggs Institute for Chemical Biology and the Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Articles citing this

Origins of catalysis by computationally designed retroaldolase enzymes. Proc Natl Acad Sci U S A (2010) 1.27

Breaking the one antibody-one target axiom. Proc Natl Acad Sci U S A (2006) 1.26

Multiple event activation of a generic prodrug trigger by antibody catalysis. Proc Natl Acad Sci U S A (1999) 1.21

Robust design and optimization of retroaldol enzymes. Protein Sci (2012) 1.09

Evolution of a designed retro-aldolase leads to complete active site remodeling. Nat Chem Biol (2013) 1.07

The influence of protein dynamics on the success of computational enzyme design. J Am Chem Soc (2009) 1.04

Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J Mol Biol (2011) 1.04

Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation. Proc Natl Acad Sci U S A (2007) 1.04

Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task. Proc Natl Acad Sci U S A (2000) 0.89

Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. J Mol Biol (2013) 0.86

A fluorogenic aldehyde bearing a 1,2,3-triazole moiety for monitoring the progress of aldol reactions. J Org Chem (2009) 0.86

Multiple catalytic aldolase antibodies suitable for chemical programming. Bioorg Med Chem Lett (2009) 0.85

Chemically programmed antibodies targeting multiple alpha(v) integrins and their effects on tumor-related functions in vitro. Bioconjug Chem (2011) 0.84

Design of an allosterically regulated retroaldolase. Protein Sci (2015) 0.82

The effect of the hydrophobic environment on the retro-aldol reaction: comparison to a computationally-designed enzyme. Org Biomol Chem (2013) 0.79

Computational strategies for the design of new enzymatic functions. Arch Biochem Biophys (2015) 0.78

Discovery of a sensitive, selective, and tightly binding fluorogenic substrate of bovine plasma amine oxidase. J Org Chem (2009) 0.77

Catalytic diversity in self-propagating peptide assemblies. Nat Chem (2017) 0.77

Chemically Programmed Bispecific Antibodies in Diabody Format. J Biol Chem (2016) 0.76

Synthesis of an organoinsulin molecule that can be activated by antibody catalysis. Proc Natl Acad Sci U S A (2001) 0.75

Insights from molecular dynamics simulations for computational protein design. Mol Syst Des Eng (2017) 0.75

Articles by these authors

Nucleotide sequence of Moloney murine leukaemia virus. Nature (1981) 24.82

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell Biol (1988) 13.78

The structure of an antigenic determinant in a protein. Cell (1984) 10.85

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature (1996) 8.99

Immunogenic structure of the influenza virus hemagglutinin. Cell (1982) 8.93

Mitotic misregulation and human aging. Science (2000) 8.47

Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein. J Biol Chem (1977) 8.03

The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med (1967) 6.81

Biochemical evidence that MCF murine leukemia viruses are envelope (env) gene recombinants. Proc Natl Acad Sci U S A (1977) 6.80

Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG. J Virol (1995) 6.33

A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc Natl Acad Sci U S A (1991) 6.13

Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci U S A (1991) 5.94

Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1. J Virol (1994) 5.76

Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science (1989) 5.73

Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature (1982) 5.50

Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc Natl Acad Sci U S A (1998) 5.46

Tapping the immunological repertoire to produce antibodies of predetermined specificity. Nature (1982) 5.11

Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences. Proc Natl Acad Sci U S A (1999) 4.87

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proc Natl Acad Sci U S A (1983) 4.56

Chemical synthesis of a polypeptide predicted from nucleotide sequence allows detection of a new retroviral gene product. Nature (1980) 4.35

Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120. J Virol (1995) 4.33

Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family. Nature (1977) 4.31

Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci U S A (1981) 4.26

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature (1984) 4.05

Shwartzman reaction after human renal homotransplantation. N Engl J Med (1968) 4.05

Encoded combinatorial chemistry. Proc Natl Acad Sci U S A (1992) 4.00

Positive and negative regulation of endogenous genes by designed transcription factors. Proc Natl Acad Sci U S A (2000) 3.92

Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes. Science (1995) 3.82

Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1. Nat Med (1997) 3.63

Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70. J Exp Med (1976) 3.51

Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem (2001) 3.35

Sequence-specific antibodies show that maturation of Moloney leukemia virus envelope polyprotein involves removal of a COOH-terminal peptide. Proc Natl Acad Sci U S A (1981) 3.13

Design of polydactyl zinc-finger proteins for unique addressing within complex genomes. Proc Natl Acad Sci U S A (1997) 2.97

Building zinc fingers by selection: toward a therapeutic application. Proc Natl Acad Sci U S A (1995) 2.92

Nucleotide sequence of Moloney leukemia virus: 3' end reveals details of replications, analogy to bacterial transposons, and an unexpected gene. Proc Natl Acad Sci U S A (1980) 2.90

Antibody catalysis of the oxidation of water. Science (2001) 2.74

Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome. J Virol (1986) 2.71

Chemical characterization of a family of brain lipids that induce sleep. Science (1995) 2.69

Chemical basis of antigenic variation in foot-and-mouth disease virus. Nature (1984) 2.52

Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proc Natl Acad Sci U S A (1991) 2.42

Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum. J Exp Med (1966) 2.42

An Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA5) partly encoded by the transformation-associated Bam WYH region of EBV DNA: preferential expression in lymphoblastoid cell lines. Proc Natl Acad Sci U S A (1986) 2.42

Catalytic antibodies. Science (1986) 2.41

The oncornavirus glycoprotein gp69/71: a constituent of the surface of normal and malignant thymocytes. J Exp Med (1975) 2.37

Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix. J Mol Biol (1988) 2.33

Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn. J Mol Biol (1988) 2.30

Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies. J Virol (1998) 2.28

Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. Science (1997) 2.27

Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding. Biochemistry (1988) 2.21

Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site. AIDS (1995) 2.15

Immunopathogenicity and oncogenicity of murine leukemia viruses. I. Induction of immunologic disease and lymphoma in (BALB-c times NZB)F1 mice by Scripps leukemia virus. J Exp Med (1974) 2.12

Gene expression in synchronized lymphocytes: studies on the control of synthesis of immunoglobulin polypeptides. J Cell Physiol (1971) 2.11

In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. Proc Natl Acad Sci U S A (1992) 2.08

Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains. J Mol Biol (2000) 2.03

Human monoclonal antibodies against a plethora of viral pathogens from single combinatorial libraries. Proc Natl Acad Sci U S A (1993) 2.01

Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees. Proc Natl Acad Sci U S A (1983) 2.00

Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A. Science (1990) 1.98

Common 82-nucleotide sequence unique to brain RNA. Proc Natl Acad Sci U S A (1982) 1.98

From molecular diversity to catalysis: lessons from the immune system. Science (1995) 1.97

Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. Proc Natl Acad Sci U S A (1985) 1.97

Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy chain variable region-specific cDNA library. Proc Natl Acad Sci U S A (1989) 1.96

Identifier sequences are transcribed specifically in brain. Nature (1984) 1.95

Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem. Proc Natl Acad Sci U S A (1992) 1.93

CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range. J Mol Biol (1995) 1.90

Human antibody responses to HIV type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding. AIDS Res Hum Retroviruses (1996) 1.87

Antibodies that react with predetermined sites on proteins. Science (1983) 1.87

Recombinant human monoclonal antibody IgG1b12 neutralizes diverse human immunodeficiency virus type 1 primary isolates. AIDS Res Hum Retroviruses (1997) 1.84

Antibody catalysis of a disfavored chemical transformation. Science (1993) 1.82

Chemistry of antibody binding to a protein. Science (1987) 1.82

Folding of peptide fragments comprising the complete sequence of proteins. Models for initiation of protein folding. I. Myohemerythrin. J Mol Biol (1992) 1.79

Antibodies have the intrinsic capacity to destroy antigens. Proc Natl Acad Sci U S A (2000) 1.79

Human antibodies from combinatorial libraries. Adv Immunol (1994) 1.78

Antibodies of predetermined specificity in biology and medicine. Adv Immunol (1984) 1.77

Brain-specific genes have identifier sequences in their introns. Proc Natl Acad Sci U S A (1984) 1.71

Blue-fluorescent antibodies. Science (2000) 1.71

Properties of an oncornavirus glycoprotein: evidence for its presence on the surface of virions and infected cells. Virology (1973) 1.71

The induction of acute glomerulonephritis in rabbits with soluble antigens isolated from normal homologous and autologous urine. J Immunol (1968) 1.68

Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody IgG1b12. off. J Virol (1997) 1.66

Karyotypic, virologic, and immunologic analyses of two continuous lymphocyte lines established from New Zealand black mice: possible relationship of chromosomal mosaicism to autoimmunity. Proc Natl Acad Sci U S A (1972) 1.65

Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma. Science (1985) 1.63

Production of macrophage migration inhibition factor by continuous cell lines. J Exp Med (1972) 1.62

Phage display of combinatorial antibody libraries. Curr Opin Biotechnol (1997) 1.56

Isolation and characterization of plasma membrane associated immunoglobulin from cultured human diploid lymphocytes. J Mol Biol (1973) 1.56

Site-directed serology with synthetic peptides representing the large glycoprotein G of respiratory syncytial virus. Proc Natl Acad Sci U S A (1987) 1.55

Mechanisms of antibody binding to a protein. Science (1987) 1.55

Identification and characterization of a peptide that specifically binds the human, broadly neutralizing anti-human immunodeficiency virus type 1 antibody b12. J Virol (2001) 1.53

Cell cycle-dependent immune lysis of Moloney virus-transformed lymphocytes: presence of viral antigen, accessibility to antibody, and complement activation. Proc Natl Acad Sci U S A (1971) 1.53

Developmentally regulated proteins of the plasma membrane of Dictyostelium discoideum. The carbohydrate-binding protein. J Mol Biol (1976) 1.53

Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins. Curr Opin Biotechnol (2001) 1.52

Antibodies to chemically synthesized peptides predicted from DNA sequences as probes of gene expression. Cell (1981) 1.52

Structural markers on core protein p30 of murine leukemia virus: functional correlation with Fv-1 tropism. Proc Natl Acad Sci U S A (1978) 1.51

The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. J Cell Biol (1997) 1.51

Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes. Proc Natl Acad Sci U S A (1984) 1.50

Immunization of hu-PBL-SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries. Nature (1992) 1.50

Identification of a cell surface glycoprotein involved in cell aggregation in D. discoideum. Cell (1979) 1.49

Differential expression of two distinct xenotropic viruses in NZB mice. Clin Immunol Immunopathol (1980) 1.48