Published in Lancet on January 29, 2000
Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update. Can Respir J (2007) 4.27
Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population based cohort study. Thorax (2006) 4.04
Health status measurement in chronic obstructive pulmonary disease. Thorax (2001) 3.07
The new contract: renaissance or requiem for general practice? Br J Gen Pract (2002) 3.01
Pulmonary rehabilitation. Thorax (2001) 2.63
Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. Chest (2008) 2.37
The minimal important difference of the hospital anxiety and depression scale in patients with chronic obstructive pulmonary disease. Health Qual Life Outcomes (2008) 2.07
Development of a self-reported Chronic Respiratory Questionnaire (CRQ-SR). Thorax (2001) 1.89
Exacerbation rate, health status and mortality in COPD--a review of potential interventions. Int J Chron Obstruct Pulmon Dis (2009) 1.85
Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review. BMJ (2001) 1.68
Cost effectiveness of an outpatient multidisciplinary pulmonary rehabilitation programme. Thorax (2001) 1.67
Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: a randomised controlled trial. Thorax (2003) 1.66
Rehabilitation for patients with chronic obstructive pulmonary disease: meta-analysis of randomized controlled trials. J Gen Intern Med (2003) 1.60
Exercise training and inspiratory muscle training in patients with bronchiectasis. Thorax (2005) 1.55
Chronic obstructive pulmonary disease . 7: Management of COPD. Thorax (2003) 1.47
Should geriatric medicine remain a specialty? No. BMJ (2008) 1.38
Self-administration and interviewer-administration of the German Chronic Respiratory Questionnaire: instrument development and assessment of validity and reliability in two randomised studies. Health Qual Life Outcomes (2004) 1.37
Combining scores from different patient reported outcome measures in meta-analyses: when is it justified? Health Qual Life Outcomes (2006) 1.36
Non-volitional assessment of skeletal muscle strength in patients with chronic obstructive pulmonary disease. Thorax (2003) 1.11
Improving the interpretation of quality of life evidence in meta-analyses: the application of minimal important difference units. Health Qual Life Outcomes (2010) 1.09
A structured exercise program for patients with advanced non-small cell lung cancer. J Thorac Oncol (2009) 1.06
Helping COPD patients change health behavior in order to improve their quality of life. Int J Chron Obstruct Pulmon Dis (2013) 1.03
The effect of complex interventions on depression and anxiety in chronic obstructive pulmonary disease: systematic review and meta-analysis. PLoS One (2013) 1.03
Overview of the prevalence, impact, and management of depression and anxiety in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2014) 1.02
Health status measurement: sensitivity of the self-reported Chronic Respiratory Questionnaire (CRQ-SR) in pulmonary rehabilitation. Thorax (2003) 1.01
A randomised controlled trial of four weeks versus seven weeks of pulmonary rehabilitation in chronic obstructive pulmonary disease. Thorax (2001) 0.99
Sustained effects of integrated COPD management on health status and exercise capacity in primary care patients. Int J Chron Obstruct Pulmon Dis (2010) 0.96
Muscle function in COPD: a complex interplay. Int J Chron Obstruct Pulmon Dis (2012) 0.96
Tackling COPD: a multicomponent disease driven by inflammation. MedGenMed (2006) 0.95
Focusing on outcomes: making the most of COPD interventions. Int J Chron Obstruct Pulmon Dis (2009) 0.94
Three years of pulmonary rehabilitation: inhibit the decline in airflow obstruction, improves exercise endurance time, and body-mass index, in chronic obstructive pulmonary disease. BMC Pulm Med (2009) 0.94
An Internet-Mediated Pedometer-Based Program Improves Health-Related Quality-of-Life Domains and Daily Step Counts in COPD: A Randomized Controlled Trial. Chest (2015) 0.93
Proportional assist ventilation as an aid to exercise training in severe chronic obstructive pulmonary disease. Thorax (2002) 0.92
A pilot study of pulmonary rehabilitation in primary care. Br J Gen Pract (2002) 0.92
Do the benefits gained using a short-term pulmonary rehabilitation program remain in COPD patients after participation? Lung (2007) 0.90
Integration of healthcare rehabilitation in chronic conditions. Int J Integr Care (2010) 0.90
Strategies for improving outcomes of COPD exacerbations. Int J Chron Obstruct Pulmon Dis (2006) 0.90
The COPD Helplessness Index: a new tool to measure factors affecting patient self-management. Chest (2009) 0.89
Responsiveness of Various Exercise-Testing Protocols to Therapeutic Interventions in COPD. Pulm Med (2013) 0.89
Anxiety and depression-Important psychological comorbidities of COPD. J Thorac Dis (2014) 0.89
Does pulmonary rehabilitation work in clinical practice? A review on selection and dropout in randomized controlled trials on pulmonary rehabilitation. Clin Epidemiol (2010) 0.89
Cellular protein breakdown and systemic inflammation are unaffected by pulmonary rehabilitation in COPD. Thorax (2006) 0.88
COPD exacerbations. 4: Prevention. Thorax (2006) 0.88
RECODE: design and baseline results of a cluster randomized trial on cost-effectiveness of integrated COPD management in primary care. BMC Pulm Med (2013) 0.87
Benefits and costs of home-based pulmonary rehabilitation in chronic obstructive pulmonary disease - a multi-centre randomised controlled equivalence trial. BMC Pulm Med (2013) 0.87
Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group. Ann Am Thorac Soc (2015) 0.86
Does pulmonary rehabilitation address cardiovascular risk factors in patients with COPD? BMC Pulm Med (2011) 0.86
Distinguishing adult-onset asthma from COPD: a review and a new approach. Int J Chron Obstruct Pulmon Dis (2014) 0.85
Effective physiotherapy. BMJ (2001) 0.85
Efficacy of pulmonary rehabilitation in patients with moderate chronic obstructive pulmonary disease: a randomized controlled trial. BMC Fam Pract (2013) 0.84
Bedside Assessment of Quadriceps Muscle by Ultrasound after Admission for Acute Exacerbations of Chronic Respiratory Disease. Am J Respir Crit Care Med (2015) 0.83
Outpatient pulmonary rehabilitation in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2008) 0.83
Management of an acute exacerbation of copd: are we ignoring the evidence? Thorax (2002) 0.83
Enhancing physical performance in chronic obstructive pulmonary disease. Thorax (2001) 0.83
Effect of treatments on the progression of COPD: report of a workshop held in Leuven, 11-12 March 2004. Thorax (2005) 0.83
Admission prevention in COPD: non-pharmacological management. BMC Med (2013) 0.83
Pulmonary rehabilitation and COPD: providing patients a good environment for optimizing therapy. Int J Chron Obstruct Pulmon Dis (2013) 0.83
Effects of an animated diagram and video-based online breathing program for dyspnea in patients with stable COPD. Patient Prefer Adherence (2013) 0.82
How long should outpatient pulmonary rehabilitation be? A randomised controlled trial of 4 weeks versus 7 weeks. Thorax (2006) 0.82
Smoking cessation therapy with varenicline. Int J Chron Obstruct Pulmon Dis (2008) 0.81
Chronic obstructive pulmonary disease exacerbations: latest evidence and clinical implications. Ther Adv Chronic Dis (2014) 0.81
Long-term evaluation of home-based pulmonary rehabilitation in patients with COPD. Int J Chron Obstruct Pulmon Dis (2015) 0.81
Optimizing economic outcomes in the management of COPD. Int J Chron Obstruct Pulmon Dis (2008) 0.81
Improving outcomes for people with COPD by developing networks of general practices: evaluation of a quality improvement project in east London. NPJ Prim Care Respir Med (2014) 0.81
Home-based pulmonary rehabilitation program: Effect on exercise tolerance and quality of life in chronic obstructive pulmonary disease patients. Ann Thorac Med (2010) 0.81
Behavioral medicine approaches to chronic obstructive pulmonary disease. Ann Behav Med (2012) 0.80
A pulmonary rehabilitation program reduces levels of anxiety and depression in COPD patients. Multidiscip Respir Med (2013) 0.80
Association of depression with disease severity in patients with chronic obstructive pulmonary disease. Lung (2014) 0.80
Desensitization to dyspnea in COPD with specificity for exercise training mode. Int J Chron Obstruct Pulmon Dis (2009) 0.79
Pulmonary rehabilitation for patients with chronic pulmonary disease (COPD): an evidence-based analysis. Ont Health Technol Assess Ser (2012) 0.79
A combination of resistance and endurance training increases leg muscle strength in COPD: An evidence-based recommendation based on systematic review with meta-analyses. Chron Respir Dis (2015) 0.79
Analysis of diaphragmatic movement before and after pulmonary rehabilitation using fluoroscopy imaging in patients with COPD. Int J Chron Obstruct Pulmon Dis (2015) 0.78
Long-term effects of a maintenance program after supervised or self-monitored training programs in patients with COPD. Lung (2003) 0.78
Strategies to improve anxiety and depression in patients with COPD: a mental health perspective. Neuropsychiatr Dis Treat (2016) 0.78
Impact of diabetes, chronic heart failure, congenital heart disease and chronic obstructive pulmonary disease on acute and chronic exercise responses. Can J Cardiol (2007) 0.78
The relationships of self-efficacy, physical activity, and paid work to health-related quality of life among patients with chronic obstructive pulmonary disease (COPD). J Multidiscip Healthc (2014) 0.78
Angiotensin-Converting Enzyme Inhibition as an Adjunct to Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.78
Long-Term Effects of an Internet-Mediated Pedometer-Based Walking Program for Chronic Obstructive Pulmonary Disease: Randomized Controlled Trial. J Med Internet Res (2016) 0.77
Value of supplemental interventions to enhance the effectiveness of physical exercise during respiratory rehabilitation in COPD patients. A systematic review. Respir Res (2004) 0.77
A short questionnaire for the assessment of quality of life in patients with chronic obstructive pulmonary disease: psychometric properties of VQ11. Health Qual Life Outcomes (2013) 0.77
Sing Your Lungs Out: a qualitative study of a community singing group for people with chronic obstructive pulmonary disease (COPD). BMJ Open (2016) 0.77
Chronic disease self-management and exercise in COPD as pulmonary rehabilitation: a randomized controlled trial. Int J Chron Obstruct Pulmon Dis (2014) 0.77
Non-invasive ventilation (NIV) as an aid to rehabilitation in acute respiratory disease. BMC Pulm Med (2011) 0.77
Update on the management of chronic obstructive pulmonary disease. F1000 Med Rep (2010) 0.77
Measurement of the validity and reliability of the persian translation of the saint george respiratory questionnaire for patients with chronic obstructive pulmonary disease. Open Respir Med J (2009) 0.77
Comparison of two different levels of physical training in patients with moderate to severe COPD. Lung (2005) 0.76
Validation of a new questionnaire with generic and disease-specific qualities: the McGill COPD Quality of Life Questionnaire. Can Respir J (2012) 0.76
Improvements in exercise capacity during a 4-weeks pulmonary rehabilitation program for COPD patients do not correspond with improvements in self-reported health status or quality of life. Int J Chron Obstruct Pulmon Dis (2007) 0.76
A controlled study of community-based exercise training in patients with moderate COPD. BMC Pulm Med (2014) 0.76
Do supervised weekly exercise programs maintain functional exercise capacity and quality of life, twelve months after pulmonary rehabilitation in COPD? BMC Pulm Med (2007) 0.76
Retrospective survival in elderly COPD patients receiving pulmonary rehabilitation; a study including maintenance rehabilitation. BMC Res Notes (2014) 0.75
Maintaining Gains Following Pulmonary Rehabilitation. Lung (2015) 0.75
Improving outcomes in chronic obstructive pulmonary disease: the role of the interprofessional approach. Int J Chron Obstruct Pulmon Dis (2015) 0.75
Optimizing nonpharmacological management following an acute exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2014) 0.75
Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial. Psychosom Med (2016) 0.75
Long-term Exercise After Pulmonary Rehabilitation (LEAP): Design and rationale of a randomized controlled trial of Tai Chi. Contemp Clin Trials (2015) 0.75
Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev (1994) 4.95
Influence of platelet size on outcome after myocardial infarction. Lancet (1991) 4.12
Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol (2004) 4.12
A randomized controlled trial of acetyl salicylic acid in the secondary prevention of mortality from myocardial infarction. Br Med J (1974) 3.80
Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci U S A (1979) 3.79
Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol (1995) 3.69
Cloned pigs produced by nuclear transfer from adult somatic cells. Nature (2000) 3.51
Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA. Proc Natl Acad Sci U S A (1988) 3.34
Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia. BMJ (1989) 3.34
Seronegative Lyme disease. Dissociation of specific T- and B-lymphocyte responses to Borrelia burgdorferi. N Engl J Med (1988) 3.26
A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia. N Engl J Med (1997) 3.12
Intestinal fluid and electrolyte transport in human cholera. J Clin Invest (1970) 3.09
Maintenance of genomic imprinting at the Arabidopsis medea locus requires zygotic DDM1 activity. Genes Dev (1999) 2.97
Peak expiratory flow rates before and after exercise in schoolchildren. Arch Dis Child (1974) 2.93
Transdermal nicotine for active ulcerative colitis. N Engl J Med (1994) 2.90
Double-blind trials. Br J Psychiatry (1990) 2.88
Formation of glutamine from [13n]ammonia, [13n]dinitrogen, and [14C]glutamate by heterocysts isolated from Anabaena cylindrica. J Bacteriol (1977) 2.88
Early restaging positron emission tomography with ( 18)F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin's lymphoma. Ann Oncol (2002) 2.86
Pathway of nitrogen metabolism after fixation of 13N-labeled nitrogen gas by the cyanobacterium, Anabaena cylindrica. J Biol Chem (1976) 2.85
Audit of a tuberculosis contact tracing clinic. BMJ (1992) 2.80
High interlaboratory reproducibility of DNA sequence-based typing of bacteria in a multicenter study. J Clin Microbiol (2006) 2.80
Mortality in vegetarians and nonvegetarians: detailed findings from a collaborative analysis of 5 prospective studies. Am J Clin Nutr (1999) 2.78
Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS-M. Nat Genet (1996) 2.77
The pathways of assimilation of 13NH4+ by the cyanobacterium, Anabaena cylindrica. J Biol Chem (1977) 2.77
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature (1997) 2.74
Cost effectiveness of HMG-CoA reductase inhibitor (statin) treatment related to the risk of coronary heart disease and cost of drug treatment. Heart (1999) 2.69
Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats. J Biol Chem (1979) 2.66
A systematic review and economic evaluation of statins for the prevention of coronary events. Health Technol Assess (2007) 2.62
Detecting and reducing hospital adverse events: outcomes of the Wimmera clinical risk management program. Med J Aust (2001) 2.61
Dietary habits and mortality in 11,000 vegetarians and health conscious people: results of a 17 year follow up. BMJ (1996) 2.61
Breakfast and dietary aspects of Crohn's disease. Br Med J (1978) 2.57
Initial organic products of assimilation of [N]ammonium and [N]nitrate by tobacco cells cultured on different sources of nitrogen. Plant Physiol (1978) 2.54
Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet (1996) 2.48
Interim report on pandemic H1N1 influenza virus infections in South Africa, April to October 2009: epidemiology and factors associated with fatal cases. Euro Surveill (2009) 2.47
Helicobacter pylori infection rates in relation to age and social class in a population of Welsh men. Gut (1991) 2.45
Randomized clinical trial of laparoscopic Nissen fundoplication compared with proton-pump inhibitors for treatment of chronic gastro-oesophageal reflux. Br J Surg (2005) 2.42
Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging. Br J Surg (2003) 2.40
What is the optimum duration of anticoagulation for the management of patients with idiopathic deep venous thrombosis and pulmonary embolism? J R Coll Physicians Edinb (2010) 2.36
Four country healthcare associated infection prevalence survey 2006: overview of the results. J Hosp Infect (2008) 2.35
Lymph node tuberculosis: a comparison of various methods of treatment. Tubercle (1977) 2.35
Cis and trans mRNA splicing in C. elegans. Trends Genet (1988) 2.34
A community survey of asthmatic characteristics. Thorax (1975) 2.33
Huntington's Chorea in South Wales. A genetic and epidemiological study. Clin Genet (1981) 2.31
Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis. Gut (1994) 2.28
Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet (1986) 2.24
Controlled randomised crossover trial of the effects of physiotherapy on mobility in chronic multiple sclerosis. J Neurol Neurosurg Psychiatry (2001) 2.23
Effects of anti-mite measures on children with mite-sensitive asthma: a controlled trial. Thorax (1980) 2.20
Indoor moulds and asthma. J R Soc Health (1988) 2.19
Sources and incidence of airborne Aspergillus fumigatus (Fres). Clin Allergy (1976) 2.17
Levamisole: a dangerous new cocaine adulterant. Clin Pharmacol Ther (2010) 2.17
An updatable holographic three-dimensional display. Nature (2008) 2.14
Legume-Rhizobium interactions: cowpea root exudate elicits faster nodulation response by Rhizobium species. Appl Environ Microbiol (1982) 2.14
Accuracy of intraoperative frozen-section analysis of axillary nodes. Edinburgh Breast Unit team. Br J Surg (1999) 2.10
Asthma admissions and thunderstorms: a study of pollen, fungal spores, rainfall, and ozone. QJM (2001) 2.10
Predicting splice variant from DNA chip expression data. Genome Res (2001) 2.09
Changing pattern of the detection of locoregional relapse in breast cancer: the Edinburgh experience. Br J Cancer (2007) 2.07
Bicycle injuries in children. Br Med J (1977) 2.07
Protozoa as sources of antigen in 'humidifier fever'. Nature (1976) 2.06
Inheritance and expression of chimeric genes in the progeny of transgenic maize plants. Biotechnology (N Y) (1990) 2.05
Smoking habits in psoriasis: a case control study. Br J Dermatol (1992) 2.03
Marginal zone B-cell lymphomas of different sites share similar cytogenetic and morphologic features. Blood (1996) 2.02
A life table for onset of Huntington's chorea. Ann Hum Genet (1981) 2.02
Wheezing, dampness, and coal fires. Community Med (1981) 2.02
[Some reflextions apropos of 45 cases of malarial comas confirmed parasitologically in children under 6 years old]. Med Trop (Mars) (1969) 2.01
Prevalence of coronary heart disease in the rural population of Thiruvananthapuram district, Kerala, India. Int J Cardiol (1993) 2.00
Absence of the pigments of photosystem II of photosynthesis in heterocysts of a blue-green alga. Nature (1970) 2.00
Non-invasive diagnosis of coronary artery disease by quantitative stress echocardiography: optimal diagnostic models using off-line tissue Doppler in the MYDISE study. Eur Heart J (2003) 1.99
Manipulation of the cervical spine--a pilot study. J R Coll Gen Pract (1983) 1.97
Attaining a correct diagnosis of COPD in general practice. Respir Med (2004) 1.97
Inflammatory response and body composition in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2001) 1.94
Family size and paternal unemployment in relation to myocardial infarction. J Epidemiol Community Health (1980) 1.93
Rapid loss of Oct-4 and pluripotency in cultured rodent blastocysts and derivative cell lines. Biol Reprod (2003) 1.91
Objective birth data and the prediction of child abuse. Arch Dis Child (1981) 1.91
The effects of discontinuing long-term diuretic therapy in the elderly. Age Ageing (1977) 1.90
The implementation of guidelines and computerised forms improves the completeness of cancer pathology reporting. The CROPS project: a randomised controlled trial in pathology. Eur J Cancer (2002) 1.88
Familial prevalence of inflammatory bowel disease in relatives of patients with Crohn's disease. Br Med J (1980) 1.88
Huntington's chorea. The basis for long-term prevention. Lancet (1979) 1.87
Association between postpartum thyroid dysfunction and thyroid antibodies and depression. BMJ (1992) 1.86
Insertion of part of an intron into the 5' untranslated region of a Caenorhabditis elegans gene converts it into a trans-spliced gene. Mol Cell Biol (1991) 1.85
A comparison of noncontrast computerized tomography with excretory urography in the assessment of acute flank pain. J Urol (1999) 1.85
Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. Genes Dev (1990) 1.83
Flexible induction dose regimen for warfarin and prediction of maintenance dose. Br Med J (Clin Res Ed) (1984) 1.83
Rectal carcinoma: thin-section MR imaging for staging in 28 patients. Radiology (1999) 1.82
Factors influencing age at onset and duration of survival in Huntington's chorea. Ann Hum Genet (1981) 1.79
Survey of pulmonary tuberculosis in south and west Wales (1976-8). Br Med J (Clin Res Ed) (1982) 1.78
Anticoagulants in venous thromboembolism. BMJ (1988) 1.77
[Clinical and parasitic latency in filariasis due to Loa loa and Onchocerca volvulus]. Bull Soc Pathol Exot Filiales (1970) 1.76
Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide. Clin Sci (Lond) (2001) 1.76
Antenatal screening by measurement of symphysis-fundus height. Br Med J (Clin Res Ed) (1982) 1.75
Alternatives to randomisation in the evaluation of public-health interventions: statistical analysis and causal inference. J Epidemiol Community Health (2009) 1.74
Diagnosing asthma by questionnaire in epidemiological surveys. Clin Exp Allergy (1992) 1.73
Evaluation of axillary lymph nodes using touch imprint cytology and immunohistochemistry. Br J Surg (2002) 1.72
Follicular adenoma with papillary architecture: a lesion mimicking papillary thyroid carcinoma. Histopathology (2001) 1.72
How does the prevalence of specific morbidities compare with measures of socio-economic status at small area level? J Public Health Med (1999) 1.71
Does health education prevent childhood accidents? Postgrad Med J (1984) 1.69
Cost effectiveness of an outpatient multidisciplinary pulmonary rehabilitation programme. Thorax (2001) 1.67