Astrocyte nitric oxide causes neuronal mitochondrial damage, but antioxidant release limits neuronal cell death.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 10672277)

Published in Ann N Y Acad Sci on January 01, 1999

Authors

R Stone1, V C Stewart, R D Hurst, J B Clark, S J Heales

Author Affiliations

1: Department of Neurochemistry, Institute of Neurology, Queen Square, London, England.

Articles by these authors

The Role of Peroxide in the Biological Effects of Irradiated Broth. J Bacteriol (1948) 6.42

Mitochondrial complex I deficiency in Parkinson's disease. Lancet (1989) 5.72

The Production of Mutations in Staphylococcus aureus by Chemical Treatment of the Substrate. J Bacteriol (1947) 5.22

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet (2005) 4.12

Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem (1990) 4.03

The Rôle of Mutation and of Selection in the Frequency of Mutants Among Microörganisms Grown on Irradiated Substrate. Proc Natl Acad Sci U S A (1948) 2.55

The metabolism of rat brain mitochondria. Preparation and characterization. J Biol Chem (1970) 2.37

Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport (1996) 2.18

Epizootiology of neoplasms in bony fish of North America. Sci Total Environ (1990) 2.13

NO way back: nitric oxide and programmed cell death in Arabidopsis thaliana suspension cultures. Plant J (2000) 1.97

Mitochondrial myopathies: clinical and biochemical features of 30 patients with major deletions of muscle mitochondrial DNA. Ann Neurol (1989) 1.88

Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration. J Biol Chem (1998) 1.84

Mitochondrial encephalomyopathies: biochemical studies in two cases revealing defects in the respiratory chain. Brain (1982) 1.80

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem (2002) 1.74

A mitochondrial myopathy characterized by a deficiency in reducible cytochrome b. Brain (1977) 1.69

Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J Neurochem (1994) 1.67

Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease. J Neurochem (1990) 1.66

Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. J Neurochem (1995) 1.66

A rapid method for the preparation of relatively pure metabolically competent synaptosomes from rat brain. Biochem J (1978) 1.64

Adaptation of the nitrate reductase and Griess reaction methods for the measurement of serum nitrate plus nitrite levels. Ann Clin Biochem (1997) 1.63

Possible horizontal transfer of Drosophila genes by the mite Proctolaelaps regalis. Science (1991) 1.61

The diabetic Zucker fatty rat. Proc Soc Exp Biol Med (1983) 1.54

Polyphenolic phytochemicals--just antioxidants or much more? Cell Mol Life Sci (2007) 1.53

Nitric oxide, mitochondria and neurological disease. Biochim Biophys Acta (1999) 1.52

Diagnostic importance of Clostridium perfringens enterotoxin analysis in recurring enteritis among elderly, chronic care psychiatric patients. J Clin Microbiol (1986) 1.52

Distribution of mRNAs encoding the peroxisome proliferator-activated receptor alpha, beta, and gamma and the retinoid X receptor alpha, beta, and gamma in rat central nervous system. J Neurochem (1998) 1.51

Preparation and properties of mitochondria derived from synaptosomes. Biochem J (1976) 1.51

Toxic effects of human eosinophil products on isolated rat heart cells in vitro. Biochem J (1982) 1.46

Relationship of pili to colonial morphology among pathogenic and nonpathogenic species of Neisseria. Infect Immun (1977) 1.44

Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochem Res (2001) 1.42

In vitro models for the blood-brain barrier. Toxicol In Vitro (2005) 1.41

Synaptic and non-synaptic mitochondria from rat brain: isolation and characterization. J Neurochem (1977) 1.40

Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice. Arterioscler Thromb Vasc Biol (2001) 1.40

Preparation of synaptic and nonsynaptic mitochondria from mammalian brain. Methods Enzymol (1979) 1.39

Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport. Biochem J (1979) 1.39

Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5'-methyl nicotinamide. Biochim Biophys Acta (1971) 1.35

The effect of aspirin and smoking on urinary excretion profiles of lactulose and mannitol in young women: toward a dynamic, aspirin augmented, test of gut mucosal permeability. Neurogastroenterol Motil (2012) 1.34

Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration. Neurosci Lett (1995) 1.34

Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases. J Neurochem (1997) 1.33

Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochem Biophys Res Commun (1996) 1.27

Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria. J Neurochem (1996) 1.26

Ancestral divergence of Rickettsia bellii from the spotted fever and typhus groups of Rickettsia and antiquity of the genus Rickettsia. Int J Syst Bacteriol (1994) 1.25

Botulism in an adult associated with food-borne intestinal infection with Clostridium botulinum. N Engl J Med (1986) 1.24

Reoxygenation-dependent decrease in mitochondrial NADH:CoQ reductase (Complex I) activity in the hypoxic/reoxygenated rat heart. Biochem J (1991) 1.23

Inhibition of pyruvate and beta-hydroxybutyrate oxidation in rat brain mitochondria by phenylpyruvate and alpha-ketoisocaproate. FEBS Lett (1974) 1.22

Cerebrospinal fluid concentrations of pterins and metabolites of serotonin and dopamine in a pediatric reference population. Pediatr Res (1993) 1.22

A mitochondrial myopathy with a deficiency of respiratory chain NADH-CoQ reductase activity. J Neurol Sci (1979) 1.21

Development of mitochondrial energy metabolism in rat brain. Biochem J (1977) 1.16

The development of enzymes of energy metabolism in the brain of a precocial (guinea pig) and non-precocial (rat) species. J Neurochem (1980) 1.15

Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione. Free Radic Biol Med (1996) 1.14

Metabolism of rat brain mitochondria. Studies on the potassium ion-stimulated oxidation of pyruvate. Biochem J (1971) 1.14

Differential effects of 2-oxo acids on pyruvate utilization and fatty acid synthesis in rat brain. Biochem J (1974) 1.13

Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochem Biophys Res Commun (1995) 1.10

beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Lett (1999) 1.10

Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiol Dis (2002) 1.10

The activities of nicotinamide mononucleotide adenylyltransferase and of nicotinamide-adenine dinucleotide kinase in the livers of rats subjected to different hormonal treatments. Biochem J (1965) 1.08

X. The Surgical Treatment of Acute Gonorrhoeal Epididymitis by Epididymotomy. Ann Surg (1914) 1.07

Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system. Prog Neurobiol (1997) 1.07

Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern. Biochem J (1985) 1.06

Threshold effects in synaptosomal and nonsynaptic mitochondria from hippocampal CA1 and paramedian neocortex brain regions. J Neurochem (1997) 1.05

Effect of phenylpyruvate on enzymes involved in fatty acid synthesis in rat brain. Biochem J (1973) 1.05

Control of the steady-state concentrations of the nicotinamide nucleotides in rat liver. Biochem J (1969) 1.03

Evidence for increased nitric oxide production in multiple sclerosis. J Neurol Neurosurg Psychiatry (1995) 1.03

Energy metabolism of adult astrocytes in vitro. Neuroscience (1996) 1.03

Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration? J Neurochem (2003) 1.03

Peroxynitrite and brain mitochondria: evidence for increased proton leak. J Neurochem (1998) 1.02

D-3-hydroxybutyrate dehydrogenase from Rhodopseudomonas spheroides. Kinetic mechanism from steady-state kinetics of the reaction catalysed by the enzyme in solution and covalently attached to diethylaminoethylcellulose. Biochem J (1973) 1.01

The development of tuberculosis in Afro-Asian immigrants. Tubercle (1979) 1.00

Pigment of Nocardia corallina. J Bacteriol (1966) 0.99

Age dependent changes in the cerebrospinal fluid concentration of nitrite and nitrate. Ann Clin Biochem (1996) 0.99

Mitochondrial DNA (mtDNA) diseases: correlation of genotype to phenotype. Biochim Biophys Acta (1995) 0.99

Tetrahydrobiopterin deficiency and brain nitric oxide synthase in the hph1 mouse. J Inherit Metab Dis (1995) 0.97

Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene. Hum Mol Genet (1996) 0.97

Side-to-side isoperistaltic strictureplasty in extensive Crohn's disease: a prospective longitudinal study. Ann Surg (2000) 0.97

Graft-versus-host disease induced by small bowel allografts. Clinical course and pathology. Transplantation (1986) 0.96

Comparative studies on glutamate metabolism in synpatic and non-synaptic rat brain mitochondria. Biochem J (1977) 0.96

Investigation into the role of N-acetylaspartate in cerebral osmoregulation. J Neurochem (1995) 0.96

Lipogenesis in the brain of suckling rats. Studies on the mechansim of mitochondrial-cytosolic carbon transfer. Biochem J (1980) 0.96

The potential role of nitric oxide in multiple sclerosis. Mult Scler (1998) 0.96

The assumption that nitric oxide inhibits mitochondrial ATP synthesis is correct. FEBS Lett (1999) 0.96

Selective inhibition of bacterial enzymes by free fatty acids. J Bacteriol (1969) 0.95

Neurochemical effects following peripheral administration of tetrahydropterin derivatives to the hph-1 mouse. J Neurochem (1996) 0.95

The effect of a toxin from Bacteroides ureolyticus on the mucosal epithelium of human and bovine oviducts. Br J Exp Pathol (1988) 0.95

Glutamate metabolism and transport in rat brain mitochondria. Biochem J (1976) 0.95

Mechanisms of intracellular calcium regulation in adult astrocytes. Neuroscience (1996) 0.94

Molecular basis of mitochondrial myopathies: polypeptide analysis in complex-I deficiency. Lancet (1988) 0.94

Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion. Brain Res (1998) 0.93

Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochem Res (1995) 0.93

Extracellular N-acetylaspartate in the rat brain: in vivo determination of basal levels and changes evoked by high K+. J Neurochem (1994) 0.92

Upregulation of intercellular adhesion molecule-1 expression on human endothelial cells by tumour necrosis factor-alpha in an in vitro model of the blood-brain barrier. Brain Res (1999) 0.92