Published in Proc Natl Acad Sci U S A on October 01, 1976
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev (1999) 3.19
DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell (2009) 2.84
Aging and replicative senescence have related effects on human stem and progenitor cells. PLoS One (2009) 2.62
Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. Proc Natl Acad Sci U S A (1998) 2.36
Cellular senescence and organismal aging. Mech Ageing Dev (2008) 1.92
Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev (2003) 1.78
Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc Natl Acad Sci U S A (1981) 1.73
Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop. J Allergy Clin Immunol (2011) 1.69
Effects of transplantation on the primitive immunohematopoietic stem cell. J Exp Med (1990) 1.68
Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells. Proc Natl Acad Sci U S A (1998) 1.61
Influence of anatomic site and age on the replication and differentiation of rat adipocyte precursors in culture. J Clin Invest (1983) 1.52
The effect of skeletal maturity on the regenerative function of intrinsic ACL cells. J Orthop Res (2010) 1.30
Colony size distributions as a measure of in vivo and in vitro aging. Proc Natl Acad Sci U S A (1978) 1.27
Donor age of human platelet lysate affects proliferation and differentiation of mesenchymal stem cells. PLoS One (2012) 1.18
Cellular senescence, ageing and disease. Age (Dordr) (2008) 1.17
Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors. Proc Natl Acad Sci U S A (1986) 1.06
Aging and the cornea. Br J Ophthalmol (1997) 1.04
Diabetes mellitus and genetic prediabetes. Decreased replicative capacity of cultured skin fibroblasts. J Clin Invest (1979) 1.01
Cellular aging--clonal senescence. A review (Part I). Am J Pathol (1977) 1.01
Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. Stem Cells (2014) 1.01
Aging and antimicrobial immunity. Impaired production of mediator T cells as a basis for the decreased resistance of senescent mice to listeriosis. J Exp Med (1981) 0.98
Regulation of senescence in cancer and aging. J Aging Res (2011) 0.98
Aging alters functionally human dermal papillary fibroblasts but not reticular fibroblasts: a new view of skin morphogenesis and aging. PLoS One (2008) 0.97
Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung. Am J Respir Cell Mol Biol (2014) 0.89
Progeroid syndromes: probing the molecular basis of aging? Mol Pathol (1997) 0.88
4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin. J Cell Biol (1984) 0.88
Cytokinetic analysis of the impaired proliferative response of peripheral lymphocytes from aged humans to phytohemagglutinin. J Exp Med (1979) 0.88
Stiffening of human skin fibroblasts with age. Biophys J (2010) 0.88
The effect of trisomy 21 on the patterns of polypeptide synthesis in human fibroblasts. Am J Hum Genet (1979) 0.86
Cellular aging, destabilization, and cancer. Proc Natl Acad Sci U S A (1996) 0.85
miR-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging. J Invest Dermatol (2014) 0.84
Ultimate erythropoietic repopulating abilities of fetal, young adult, and old adult cells compared using repeated irradiation. J Exp Med (1984) 0.84
Aging cell culture: methods and observations. Methods Mol Biol (2007) 0.83
A new form of Niemann-Pick disease characterised by temperature-labile sphingomyelinase. J Med Genet (1978) 0.83
Some in-vitro comparisons of synovial cells dispersed by trypsin from rheumatoid and nonrheumatoid synovium. Ann Rheum Dis (1981) 0.82
Decreased proliferative capacity of aged dermal fibroblasts in a three dimensional matrix is associated with reduced IGF1R expression and activation. Biogerontology (2014) 0.81
Cellular Senescence as the Causal Nexus of Aging. Front Genet (2016) 0.80
Comparative rates of decline in the primary cloning efficiencies of smooth muscle cells from the aging thoracic aorta of two murine species of contrasting maximum life span potentials. Am J Pathol (1983) 0.79
Irreversibility of cellular aging and neoplastic transformation: a clonal analysis. Proc Natl Acad Sci U S A (1996) 0.78
Effects of beta interferon on human fibroblasts at different population doubling levels. Proliferation, cell volume, thymidine uptake, and DNA synthesis. J Exp Med (1984) 0.78
Cell senescence culturing methods. Methods Mol Biol (2013) 0.78
Acrolein-exposed normal human lung fibroblasts in vitro: cellular senescence, enhanced telomere erosion, and degradation of werner's syndrome protein. Environ Health Perspect (2014) 0.77
Human replicative senescence. A molecular study. Am J Pathol (1995) 0.77
Cellular aging is a critical determinant of primary cell resistance to v-src transformation. J Virol (1997) 0.77
A relationship exists between replicative senescence and cardiovascular health. Longev Healthspan (2013) 0.76
Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment. Sci Rep (2016) 0.76
Common Delayed Senescence of Melanocytes from Multiple Primary Melanoma Patients. J Invest Dermatol (2016) 0.75
Breathing to younger skin: 'reversing the molecular mechanism of skin aging with yoga'. Future Sci OA (2016) 0.75
Ubiquitous, heritable damage in cell populations that survive treatment with methotrexate. Proc Natl Acad Sci U S A (1997) 0.75
Actin in young and senescent fibroblasts. Biochem J (1978) 0.75
Senescence in the aging process. F1000Res (2017) 0.75
A computational modelling framework to quantify the effects of passaging cell lines. PLoS One (2017) 0.75
The serial cultivation of human diploid cell strains. Exp Cell Res (1961) 25.11
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res (1965) 21.61
Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest (1970) 6.44
Incorporation of 3H-uridine and 3H-uracil into RNA: a simple technique for the detection of mycoplasma contamination of cultured cells. Exp Cell Res (1974) 3.73
The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. J Gerontol (1976) 3.51
Altered enzymes in ageing human fibroblasts. Nature (1972) 2.06
Ageing of clones of mammalian cells. Nature (1973) 1.80
Diabetes mellitus and aging: diminished planting efficiency of cultured human fibroblasts. Proc Natl Acad Sci U S A (1969) 1.78
Normal production of erythrocytes by mouse marrow continuous for 73 months. Proc Natl Acad Sci U S A (1973) 1.62
Correlations between tests of aging in Hiroshima subjects--an attempt to define "physiologic age". Yale J Biol Med (1965) 1.31
Culture characteristics of human fibroblasts propagated serially. Am J Hyg (1957) 1.26
Increased nuclear sizes in senescent human diploid fibroblast cultures. Exp Cell Res (1976) 1.17
Relationship between cell replication and volume in senescent human diploid fibroblasts. Mech Ageing Dev (1976) 1.06
Aging of human fibroblasts in vitro. Correlations between DNA synthetic ability and cell size. Exp Cell Res (1975) 1.03
CHANGES WITH ADVANCING AGE IN THE CELL POPULATION OF HUMAN DERMIS. Gerontologia (1965) 0.97
Aging and cell division. Science (1975) 0.95
Assessment of biological age by multiple regression analysis. J Gerontol (1975) 0.94
THE LATENT PERIOD OF EXPLANTED ORGANS OF NEWBORN, ADULT AND SENILE RATS. Exp Cell Res (1964) 0.93
Alteration in cellular RNAs during the in vitro lifespan of cultured human diploid fibroblasts. Cell (1975) 0.92
On the fundamental morphology of the senile changes. Nagoya J Med Sci (1961) 0.91
A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 27.60
A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res (1988) 17.88
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. FEBS Lett (1988) 3.96
Incorporation of 3H-uridine and 3H-uracil into RNA: a simple technique for the detection of mycoplasma contamination of cultured cells. Exp Cell Res (1974) 3.73
The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. J Biol Chem (1989) 2.37
[Trials in fluorescnet photography of the cornea and the iris and its significance]. Ganka (1968) 2.10
Physical and enzymatic studies on poly d(I-C)-poly d(I-C), an unusual double-helical DNA. Nature (1970) 2.04
Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells. Mol Cell Biol (1991) 2.04
Three-dimensional structures of free form and two substrate complexes of an extradiol ring-cleavage type dioxygenase, the BphC enzyme from Pseudomonas sp. strain KKS102. J Mol Biol (1996) 1.98
Aging, natural death, and the compression of morbidity: another view. N Engl J Med (1983) 1.98
Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state. Science (1974) 1.95
Life extension. N Engl J Med (1985) 1.83
Infectious diseases in the elderly. Ann Intern Med (1983) 1.76
Fluorescence irido-corneal photography. Br J Ophthalmol (1969) 1.59
Isolation of a cDNA that hybrid selects antiproliferative mRNA from rat liver. Biochem Biophys Res Commun (1989) 1.54
Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats. Proc Natl Acad Sci U S A (1990) 1.51
Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli. Biochemistry (1996) 1.49
A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity. J Biol Chem (1989) 1.49
Differential regulation of human RecQ family helicases in cell transformation and cell cycle. Oncogene (2000) 1.46
Fluorescent differential display: arbitrarily primed RT-PCR fingerprinting on an automated DNA sequencer. FEBS Lett (1994) 1.45
Protein structure, ribonuclease-S and nucleotide interactions. Cold Spring Harb Symp Quant Biol (1972) 1.44
Refined crystal structure of the complex of subtilisin BPN' and Streptomyces subtilisin inhibitor at 1.8 A resolution. J Mol Biol (1991) 1.44
Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member. J Biol Chem (1998) 1.43
Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Structure (1996) 1.42
Pro- and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain. Exp Neurol (2001) 1.42
Age-dependent changes in mobility and separation of the nematode Caenorhabditis elegans. Exp Gerontol (1980) 1.33
Mycoplasma contamination of cultured amniotic fluid cells: potential hazard to prenatal chromosomal diagnosis. Science (1974) 1.32
Severe pulmonary involvement in adult Gaucher's disease. Report of three cases and review of the literature. Am J Med (1977) 1.31
Crystal structure of an aromatic ring opening dioxygenase LigAB, a protocatechuate 4,5-dioxygenase, under aerobic conditions. Structure (1999) 1.27
Colony size distributions as a measure of in vivo and in vitro aging. Proc Natl Acad Sci U S A (1978) 1.27
PcpA, which is involved in the degradation of pentachlorophenol in Sphingomonas chlorophenolica ATCC39723, is a novel type of ring-cleavage dioxygenase. FEBS Lett (1999) 1.24
Three-dimensional crystal structure of recombinant murine interferon-beta. EMBO J (1992) 1.23
A preliminay investigation on the molecular structure of rice dwarf virus ribonucleic acid. J Mol Biol (1966) 1.23
mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway. Cell Growth Differ (1998) 1.23
The human preproendothelin-1 gene: possible regulation by endothelial phosphoinositide turnover signaling. J Cardiovasc Pharmacol (1989) 1.22
A new human diploid cell strain, TIG-1, for the research on cellular aging. Exp Gerontol (1980) 1.18
Life span of the wild and mutant nematode Caenorhabditis elegans. Effects of sex, sterilization, and temperature. Exp Gerontol (1982) 1.18
Crystal structures of Streptomyces subtilisin inhibitor and its complex with subtilisin BPN'. Nature (1979) 1.17
Increased nuclear sizes in senescent human diploid fibroblast cultures. Exp Cell Res (1976) 1.17
Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J Clin Invest (1988) 1.16
Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis. Exp Cell Res (1976) 1.15
Crystal structure of recombinant native SDF-1alpha with additional mutagenesis studies: an attempt at a more comprehensive interpretation of accumulated structure-activity relationship data. J Interferon Cytokine Res (2000) 1.15
Crystal structure of a bacterial protein proteinase inhibitor (Streptomyces subtilisin inhibitor) at 2.6 A resolution. J Mol Biol (1979) 1.15
Geriatrics and gerontology: imperatives in education and training. Ann Intern Med (1986) 1.14
Diseases and disorders of aging: an hypothesis. J Chronic Dis (1986) 1.14
Hyperoxia induces the differentiated neuronal phenotype of PC12 cells by producing reactive oxygen species. Biochem Biophys Res Commun (1997) 1.13
In utero diagnosis of Niemann-Pick disease. Am J Hum Genet (1971) 1.12
Projecting the older population of the United States: lessons from the past and prospects for the future. Milbank Q (1988) 1.10
Tissue factor, osteopontin, alphavbeta3 integrin expression in microvasculature of gliomas associated with vascular endothelial growth factor expression. Br J Cancer (2000) 1.09
Drug efficacy of praziquantel and albendazole in school children in Mwea Division, Central Province, Kenya. Acta Trop (2007) 1.09
Crystal structure at 2.6 A resolution of the complex of subtilisin BPN' with streptomyces subtilisin inhibitor. J Mol Biol (1984) 1.09
Isolation and structure of an antimitotic cyclic peptide, ustiloxin F: chemical interrelation with a homologous peptide, ustiloxin B. J Antibiot (Tokyo) (1998) 1.09
DNA damage and repair with age in individual human lymphocytes. Mutat Res (1990) 1.09
A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. Genomics (1999) 1.09
cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA. Biochem Biophys Res Commun (1991) 1.08
Abundant alkali-sensitive sites in DNA of human and mouse sperm. Exp Cell Res (1989) 1.08
Comparison of methods for the detection of Mycoplasmal contamination of cell cultures: a review. In Vitro (1975) 1.07
Tissue-specific differences in cultured human diploid fibroblasts. Exp Cell Res (1977) 1.07
Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int J Radiat Biol (1994) 1.07
Appearance of hypoxanthine guanine phosphoribosyltransferase activity as a consequence of mycoplasma contamination. Nature (1975) 1.07
Relationship between cell replication and volume in senescent human diploid fibroblasts. Mech Ageing Dev (1976) 1.06
Replication rate and lifespan of cultured fibroblasts in Down's syndrome. Proc Soc Exp Biol Med (1972) 1.06
Crystal structure of 2-hydroxyl-6-oxo-6-phenylhexa-2,4-dienoic acid (HPDA) hydrolase (BphD enzyme) from the Rhodococcus sp. strain RHA1 of the PCB degradation pathway. J Mol Biol (2001) 1.05
Apoptosis in rat cardiac myocytes induced by Fas ligand: priming for Fas-mediated apoptosis with doxorubicin. J Mol Cell Cardiol (2000) 1.05
Malignant transformation of NIH3T3 cells by overexpression of mot-2 protein. Oncogene (1998) 1.03
A microgel electrophoresis technique for the direct quantitation of DNA damage and repair in individual fibroblasts cultured on microscope slides. Mutat Res (1991) 1.03
Lip pits and congenital absence of second premolars: varied expression of the Lip Pits syndrome. J Med Genet (1973) 1.02
Elevated levels of mortalin expression in human brain tumors. Exp Cell Res (1997) 1.02
In utero diagnosis of globoid cell leukodystrophy (Krabb's disease). Biochem Biophys Res Commun (1971) 1.02
Basic studies for the practical use of bitterness inhibitors: selective inhibition of bitterness by phospholipids. Pharm Res (1997) 1.01
In vivo analysis of cellular replication. Proc Natl Acad Sci U S A (1977) 1.00
Synthesis and anti-tubulin activity of ustiloxin D derivatives. J Antibiot (Tokyo) (1998) 1.00
A highly expressed 81 kDa protein in immortalized mouse fibroblast: its proliferative function and identity with ezrin. Oncogene (1996) 1.00
Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) mortalin/GRP75/peptide-binding protein 74 (PBP74) and GRP94. Biochem J (2001) 0.99
Endothelin stimulates hypertrophy and contractility of neonatal rat cardiac myocytes in a serum-free medium. FEBS Lett (1990) 0.99
Presynaptic effects of botulinum toxin type A on the neuronally evoked response of albino and pigmented rabbit iris sphincter and dilator muscles. Jpn J Ophthalmol (2000) 0.98
Hyaluronate synthetase inhibition by normal and transformed human fibroblasts during growth reduction. J Cell Biol (1987) 0.98
Reinitiation of host DNA synthesis in senescent human diploid cells by infection with Simian virus 40. Exp Cell Res (1983) 0.98
Differential activities of two distinct endothelin family peptides on ileum and coronary artery. FEBS Lett (1989) 0.97
Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells. Biochem Biophys Res Commun (1990) 0.97
5-Bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type or species. J Biochem (1999) 0.97
The utilization of bromodeoxyuridine incorporation into DNA for the analysis of cellular kinetics. Exp Cell Res (1976) 0.96
Cyclin D1 inhibits cell proliferation through binding to PCNA and cdk2. Exp Cell Res (1999) 0.96
Endothelin-1 is produced and secreted by neonatal rat cardiac myocytes in vitro. Biochem Biophys Res Commun (1993) 0.95
hst-1 transforming protein: expression in silkworm cells and characterization as a novel heparin-binding growth factor. Oncogene (1988) 0.95
Switch of coenzyme specificity of mouse lung carbonyl reductase by substitution of threonine 38 with aspartic acid. J Biol Chem (1997) 0.95
An N-terminal region of mot-2 binds to p53 in vitro. Neoplasia (2001) 0.95
Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells. J Biol Chem (1993) 0.94
Senescent cells are resistant to death despite low Bcl-2 level. Mech Ageing Dev (2001) 0.94
Mosquito vectors of bancroftian filariasis in Kwale District, Kenya. East Afr Med J (1997) 0.94
A novel in vitro assay system for transendothelial tumor cell invasion: significance of E-selectin and alpha 3 integrin in the transendothelial invasion by HT1080 fibrosarcoma cells. Clin Exp Metastasis (1994) 0.94
Cluster outbreak of Pneumocystis pneumonia among kidney transplant patients within a single center. Transplant Proc (2009) 0.93
Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-1. Exp Cell Res (1997) 0.93
Correlation between complementation group for immortality and the cellular distribution of mortalin. Exp Cell Res (1995) 0.93
Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts. Exp Cell Res (1993) 0.93
Studies on the binding of adenylyl-3', 5'-cytidine to ribonuclease. Biochim Biophys Acta (1978) 0.93
The crystal structure of ribonuclease Rh from Rhizopus niveus at 2.0 A resolution. J Mol Biol (1996) 0.93