Published in J Exp Med on February 21, 2000
Translating costimulation blockade to the clinic: lessons learned from three pathways. Immunol Rev (2009) 1.66
Toll-like receptors in tumor immunotherapy. Clin Cancer Res (2007) 1.60
Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure. Am J Transplant (2011) 1.30
CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase. J Clin Invest (2007) 1.23
Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation. J Immunol (2009) 1.21
The CD40/CD40L costimulatory pathway in inflammatory bowel disease. Gut (2004) 1.18
Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest (2001) 1.14
Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154. J Clin Invest (2006) 1.08
CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function. J Exp Med (2010) 1.03
Induction of transplantation tolerance in non-human primate preclinical models. Philos Trans R Soc Lond B Biol Sci (2005) 1.02
Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells. Nat Immunol (2001) 1.01
Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells. J Immunol (2000) 1.01
Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates. Am J Transplant (2011) 0.99
Costimulation blockade: current perspectives and implications for therapy. Transplantation (2013) 0.95
The classical complement pathway in transplantation: unanticipated protective effects of C1q and role in inductive antibody therapy. Am J Transplant (2008) 0.92
Potential role of soluble CD40 in the humoral immune response impairment of uraemic patients. Immunology (2003) 0.92
Costimulatory pathways in transplantation. Semin Immunol (2011) 0.90
Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance. J Immunol (2012) 0.90
The signaling role of CD40 ligand in platelet biology and in platelet component transfusion. Int J Mol Sci (2014) 0.86
Transplant acceptance following anti-CD4 versus anti-CD40L therapy: evidence for differential maintenance of graft-reactive T cells. Am J Transplant (2008) 0.86
Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory pool. Immunology (2001) 0.84
Potential importance of B cells in aging and aging-associated neurodegenerative diseases. Semin Immunopathol (2017) 0.83
Role of co-stimulation in Leishmaniasis. Int J Biol Sci (2011) 0.83
Activation-associated phenotype of CD3 T cells in acute graft-versus-host disease. Clin Exp Immunol (2006) 0.82
T cell tolerance induced by therapeutic antibodies. Philos Trans R Soc Lond B Biol Sci (2005) 0.81
Requirement of transmembrane domain for CD154 association to lipid rafts and subsequent biological events. PLoS One (2012) 0.80
The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells. J Exp Med (2004) 0.79
CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling. Am J Pathol (2010) 0.78
CD40 expression in Wehi-164 cell line. Cytotechnology (2010) 0.75
Intratumoral injection of Ad-ISF35 (Chimeric CD154) breaks tolerance and induces lymphoma tumor regression. Hum Gene Ther (2015) 0.75
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 16.28
The mechanism of action of cyclosporin A and FK506. Immunol Today (1992) 7.57
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature (1996) 6.61
The B7 and CD28 receptor families. Immunol Today (1994) 6.38
Activation of human dendritic cells through CD40 cross-linking. J Exp Med (1994) 6.16
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci U S A (1989) 5.07
T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol Cell Biol (1987) 4.76
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med (1999) 3.41
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A (1997) 3.25
Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature (1989) 3.23
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med (1999) 3.17
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature (1995) 3.07
B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity (1999) 2.94
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med (1999) 2.74
Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur J Immunol (1995) 2.71
The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells. J Immunol (1993) 2.53
Co-stimulation in T cell responses. Curr Opin Immunol (1997) 2.35
Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity (1996) 2.24
CD40 ligand-transduced co-stimulation of T cells in the development of helper function. Nature (1995) 2.23
Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci U S A (1995) 2.06
Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity (1996) 2.05
Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help). J Exp Med (1992) 2.03
CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function. J Immunol (1994) 1.87
CD40 preferentially costimulates activation of CD4+ T lymphocytes. J Immunol (1994) 1.56
Regulation of expression of the ligand for CD40 on T helper lymphocytes. J Immunol (1993) 1.36
Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: preservation of kidney function. J Immunol (1998) 1.32
CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge. J Immunol (1998) 1.32
Induction of B cell costimulatory function by recombinant murine CD40 ligand. Eur J Immunol (1994) 1.29
Patterns of virus burden and T cell phenotype are established early and are correlated with the rate of disease progression in human immunodeficiency virus type 1-infected persons. J Infect Dis (1996) 1.22
Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. J Clin Invest (1994) 1.15
Regulation of CD154 (CD40 ligand) mRNA stability during T cell activation. J Immunol (1999) 1.14
CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L. J Immunol (1996) 1.13
A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice. J Immunol (1997) 1.08
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. J Immunol (1999) 1.08
Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28. J Immunol (1998) 1.08
The CD40 pathway in allograft rejection, acceptance, and tolerance. Curr Opin Immunol (1997) 1.07
Evidence for a critical role for IL-2 in CD40-mediated activation of naive B cells by primary CD4 T cells. J Immunol (1998) 1.07
CD28 co-stimulation stabilizes the expression of the CD40 ligand on T cells. Int Immunol (1998) 1.02
Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J Immunol (1996) 1.00
Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-gamma production. Eur J Immunol (1996) 0.98
Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes. J Clin Invest (1996) 0.97
CD40 ligand signals optimize T helper cell cytokine production: role in Th2 development and induction of germinal centers. Eur J Immunol (1998) 0.94
Induction of allograft tolerance in the absence of Fas-mediated apoptosis. J Immunol (1999) 0.94
Emerging cytokine family. Nature (1992) 0.90
Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes. FEBS Lett (1997) 0.90
A fundamental difference in the capacity to induce proliferation of naive T cells between CD28 and other co-stimulatory molecules. Eur J Immunol (1998) 0.89
The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency. Semin Immunol (1994) 0.89
Prolongation of primate cardiac allograft survival by treatment with ANTI-CD40 ligand (CD154) antibody. Transplantation (1999) 0.86
Characterization of RNA binding proteins associated with CD40 ligand (CD154) mRNA turnover in human T lymphocytes. J Immunol (1999) 0.84
The CD40-ligand stimulates T-lymphocytes via the neutral sphingomyelinase: a novel function of the CD40-ligand as signalling molecule. FEBS Lett (1997) 0.80
Impaired induction of the apoptosis-protective protein Bcl-xL in activated PBMC from asymptomatic HIV-infected individuals. J Clin Immunol (1997) 0.78
Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science (1989) 7.78
Midlife hand grip strength as a predictor of old age disability. JAMA (1999) 6.23
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A (1989) 5.97
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77
Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res (2001) 5.48
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci U S A (1989) 5.07
Unassigned or nonsense codons in Micrococcus luteus. J Mol Biol (1993) 4.50
An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA. Mol Cell Biol (1991) 3.48
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med (1999) 3.41
CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J Immunol (1996) 3.40
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A (1997) 3.25
Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry. J Immunol (1986) 3.08
Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells. J Immunol (1997) 2.98
Persistent calcium elevation correlates with the induction of surface immunoglobulin-mediated B cell DNA synthesis. J Exp Med (1993) 2.88
Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab (2010) 2.85
CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes. J Immunol (1990) 2.84
Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc Natl Acad Sci U S A (1995) 2.77
Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med (1996) 2.60
Isolation of a new herpesvirus from human CD4+ T cells. Proc Natl Acad Sci U S A (1990) 2.60
cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. Mol Cell Biol (1992) 2.55
Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes. Proc Natl Acad Sci U S A (1987) 2.53
Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules. J Immunol (1995) 2.52
Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression. Am J Transplant (2010) 2.37
Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. Cancer Res (1997) 2.28
AU RNA-binding factors differ in their binding specificities and affinities. J Biol Chem (1992) 2.25
CD28 ligation in T-cell activation: evidence for two signal transduction pathways. Blood (1990) 2.21
Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study. Arterioscler Thromb Vasc Biol (2000) 2.16
Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol Rev (1997) 2.13
Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation. Science (1996) 2.11
Grip strength changes over 27 yr in Japanese-American men. J Appl Physiol (1985) (1998) 2.10
Precautions in medical care of, and in handling materials from, patients with transmissible virus dementia (Creutzfeldt-Jakob disease). N Engl J Med (1977) 2.10
Monoclonal antibody-defined functional epitopes on the adhesion-promoting glycoprotein complex (CDw18) of human neutrophils. Blood (1986) 2.07
CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction. J Immunol (1998) 2.01
Extradural tethering effect as one mechanism of radiculopathy complicating posterior decompression of the cervical spinal cord. Spine (Phila Pa 1976) (1996) 2.00
Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. J Exp Med (2001) 1.99
Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells. J Clin Invest (1998) 1.99
Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1. Proc Natl Acad Sci U S A (1990) 1.96
Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease. Am J Transplant (2011) 1.96
A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J Immunol (1986) 1.95
The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol Cell Biol (1993) 1.94
Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo. FASEB J (2001) 1.91
Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression. J Immunol (1986) 1.89
IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma. Proc Natl Acad Sci U S A (1989) 1.89
Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4. Science (1990) 1.89
Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation. Eur J Immunol (1989) 1.88
Constitutive cell surface association between CD4 and CCR5. Proc Natl Acad Sci U S A (1999) 1.88
Neuroectodermal tumours in children born after assisted conception. Lancet (1991) 1.87
The historical roots of our ecologic crisis. Science (1967) 1.79
Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells. Science (1997) 1.79
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. Proc Natl Acad Sci U S A (1999) 1.79
Brief report: treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation. N Engl J Med (1994) 1.77
A dot hybridisation assay for detection of rotavirus. Lancet (1983) 1.75
Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction. J Biol Chem (1995) 1.72
An HIV-1-infected T cell clone defective in IL-2 production and Ca2+ mobilization after CD3 stimulation. J Immunol (1991) 1.70
Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor. Eur J Immunol (1988) 1.68
Multiple mechanisms regulate c-myc gene expression during normal T cell activation. EMBO J (1988) 1.66
Recombinant human erythropoietin for autologous blood donation: effects on perioperative red-blood-cell and serum erythropoietin production. Lancet (1992) 1.66
Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division. Proc Natl Acad Sci U S A (1995) 1.65
Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft. Diabetologia (2009) 1.65
CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr Biol (1997) 1.63
MHC class II gene silencing in trophoblast cells is caused by inhibition of CIITA expression. Am J Reprod Immunol (1998) 1.63
A cluster of chromosome 11p13 translocations found via distinct D-D and D-D-J rearrangements of the human T cell receptor delta chain gene. EMBO J (1988) 1.63
Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. Transplantation (2001) 1.62
Guanfacine treatment of cognitive impairment in schizophrenia. Neuropsychopharmacology (2001) 1.61
Symptoms, cognitive functioning, and adaptive skills in geriatric patients with lifelong schizophrenia: a comparison across treatment sites. Am J Psychiatry (1998) 1.60
Hepatitis C virus seropositivity at the time of renal transplantation in the United States: associated factors and patient survival. Am J Transplant (2001) 1.60
Association between cyclosporin neurotoxicity and hypomagnesaemia. Lancet (1984) 1.60
Gender role expectations of pain: relationship to sex differences in pain. J Pain (2001) 1.59
Genetic relatedness among human rotaviruses as determined by RNA hybridization. Infect Immun (1982) 1.58
High expression of macrophage migration inhibitory factor in human melanoma cells and its role in tumor cell growth and angiogenesis. Biochem Biophys Res Commun (1999) 1.58
Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques. Am J Transplant (2012) 1.54
Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes. J Clin Invest (1986) 1.53
An unusual type of hangman's fracture. Neurosurgery (1990) 1.51
Cumulative exposure to gamma interferon-dependent chemokines CXCL9 and CXCL10 correlates with worse outcome after lung transplant. Am J Transplant (2011) 1.51
Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. Am J Transplant (2014) 1.50
Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins. J Exp Med (1997) 1.50
Daytime sleepiness is associated with 3-year incident dementia and cognitive decline in older Japanese-American men. J Am Geriatr Soc (2001) 1.48
Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation. Am J Transplant (2010) 1.48
Increases in T cell telomere length in HIV infection after antiretroviral combination therapy for HIV-1 infection implicate distinct population dynamics in CD4+ and CD8+ T cells. Clin Immunol (1999) 1.47
The longitudinal stability of cognitive impairment in schizophrenia. Mini-mental state scores at one- and two-year follow-ups in geriatric in-patients. Br J Psychiatry (1995) 1.46
Prospective study of pneumonia hospitalizations and mortality of U.S. older people: the role of chronic conditions, health behaviors, and nutritional status. Public Health Rep (1989) 1.46
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells. J Exp Med (1992) 1.44
Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14. J Immunol (1993) 1.44
Six-year follow-up study of cognitive and functional status across the lifespan in schizophrenia: a comparison with Alzheimer's disease and normal aging. Am J Psychiatry (2001) 1.43
Rat-bite fever as a cause of septic arthritis: a diagnostic dilemma. Ann Rheum Dis (1987) 1.43