Published in Proc Natl Acad Sci U S A on March 14, 2000
Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. Proc Natl Acad Sci U S A (2000) 3.32
Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. Proc Natl Acad Sci U S A (2002) 2.14
An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. Proc Natl Acad Sci U S A (2001) 2.00
Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase. Proc Natl Acad Sci U S A (2001) 1.84
Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. Proc Natl Acad Sci U S A (2001) 1.81
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein. Proc Natl Acad Sci U S A (2003) 1.80
A revised annotation and comparative analysis of Helicobacter pylori genomes. Nucleic Acids Res (2003) 1.59
Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis. J Bacteriol (2000) 1.42
Fosmidomycin for the treatment of malaria. Parasitol Res (2002) 1.40
Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase. Proc Natl Acad Sci U S A (2002) 1.38
Targeting the formation of the cell wall core of M. tuberculosis. Infect Disord Drug Targets (2007) 1.33
Terpene Specialized Metabolism in Arabidopsis thaliana. Arabidopsis Book (2011) 1.30
The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. Plant Physiol (2005) 1.25
Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development. Proc Natl Acad Sci U S A (2002) 1.23
Conserved 'hypothetical' proteins: new hints and new puzzles. Comp Funct Genomics (2001) 1.22
GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. J Bacteriol (2001) 1.21
1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus. J Bacteriol (2001) 1.19
Biosynthesis of isoprenoids: crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase. Proc Natl Acad Sci U S A (2003) 1.18
Structure and synthesis of polyisoprenoids used in N-glycosylation across the three domains of life. Biochim Biophys Acta (2009) 1.17
Characterization of the depletion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase in Escherichia coli and Bacillus subtilis. J Bacteriol (2002) 1.14
Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato. Proc Natl Acad Sci U S A (2000) 1.10
The lytB gene of Escherichia coli is essential and specifies a product needed for isoprenoid biosynthesis. J Bacteriol (2001) 1.08
Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. Plant Physiol (2001) 1.08
The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target. Tuberculosis (Edinb) (2008) 1.07
Chlamydial histone-DNA interactions are disrupted by a metabolite in the methylerythritol phosphate pathway of isoprenoid biosynthesis. Proc Natl Acad Sci U S A (2004) 1.05
Methylerythritol phosphate pathway of isoprenoid biosynthesis. Annu Rev Biochem (2013) 1.02
Mechanistic aspects of carotenoid biosynthesis. Chem Rev (2013) 1.02
Isoprenoid biosynthesis in Synechocystis sp. strain PCC6803 is stimulated by compounds of the pentose phosphate cycle but not by pyruvate or deoxyxylulose-5-phosphate. J Bacteriol (2002) 1.00
Abscisic Acid biosynthesis and response. Arabidopsis Book (2002) 0.98
Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana. Proc Natl Acad Sci U S A (2000) 0.98
Current development in isoprenoid precursor biosynthesis and regulation. Curr Opin Chem Biol (2013) 0.95
Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF. Chem Biol (2010) 0.94
The sorbitol phosphotransferase system is responsible for transport of 2-C-methyl-D-erythritol into Salmonella enterica serovar typhimurium. J Bacteriol (2004) 0.93
Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). PLoS One (2009) 0.93
Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications. 3 Biotech (2014) 0.93
Isoprenoid biosynthesis in chloroplasts via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) from Arabidopsis thaliana is a [4Fe-4S] protein. J Biol Inorg Chem (2005) 0.91
Functional evidence for the involvement of Arabidopsis IspF homolog in the nonmevalonate pathway of plastid isoprenoid biosynthesis. Planta (2005) 0.91
A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy. J Med Chem (2009) 0.90
Lethal mutations in the isoprenoid pathway of Salmonella enterica. J Bacteriol (2006) 0.90
Probing phosphorylation by non-mammalian isoprenoid biosynthetic enzymes using (1)H-(31)P-(31)P correlation NMR spectroscopy. Mol Biosyst (2009) 0.88
Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.88
Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway. Biochemistry (2006) 0.87
2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity. ACS Chem Biol (2012) 0.86
Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. PLoS One (2011) 0.82
Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. PLoS One (2012) 0.81
Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). PLoS One (2014) 0.81
RNA-Seq mediated root transcriptome analysis of Chlorophytum borivilianum for identification of genes involved in saponin biosynthesis. Funct Integr Genomics (2015) 0.81
The amino-terminal conserved domain of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase is critical for its function in oxygen-evolving photosynthetic organisms. Plant Signal Behav (2015) 0.80
Biosynthesis of isoprenoids in plants: structure of the 2C-methyl-D-erithrytol 2,4-cyclodiphosphate synthase from Arabidopsis thaliana. Comparison with the bacterial enzymes. Protein Sci (2007) 0.78
A whole-cell phenotypic screening platform for identifying methylerythritol phosphate pathway-selective inhibitors as novel antibacterial agents. Antimicrob Agents Chemother (2012) 0.76
Synthetic Routes to Methylerythritol Phosphate Pathway Intermediates and Downstream Isoprenoids. Curr Org Chem (2014) 0.76
Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids. Microbiol Spectr (2014) 0.75
Involvement of the gut chemosensory system in the regulation of colonic anion secretion. Biomed Res Int (2015) 0.75
Transcriptional analysis of a gene cluster involved in glucose tolerance in Zymomonas mobilis: evidence for an osmoregulated promoter. J Bacteriol (2005) 0.75
Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF. Medchemcomm (2013) 0.75
Metabolic engineering of Bacillus subtilis for terpenoid production. Appl Microbiol Biotechnol (2015) 0.75
The complete genome sequence of Escherichia coli K-12. Science (1997) 84.27
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science (1999) 7.54
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Proc Natl Acad Sci U S A (1998) 3.86
Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol. Proc Natl Acad Sci U S A (1997) 3.39
Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. Proc Natl Acad Sci U S A (1998) 3.27
The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms. Chem Biol (1998) 3.23
Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement. Proc Natl Acad Sci U S A (1997) 2.64
A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. Proc Natl Acad Sci U S A (1998) 2.59
Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol. Proc Natl Acad Sci U S A (1999) 2.47
Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Proc Natl Acad Sci U S A (2000) 2.30
Isoprenoid biosynthesis via a mevalonate-independent pathway in plants: cloning and heterologous expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from peppermint. Arch Biochem Biophys (1999) 1.86
Cloning and heterologous expression of a cDNA encoding 1-deoxy-D-xylulose-5-phosphate reductoisomerase of Arabidopsis thaliana. FEBS Lett (1999) 1.79
Dedicated roles of plastid transketolases during the early onset of isoprenoid biogenesis in pepper fruits1. Plant Physiol (1998) 1.72
Incorporation of 1-deoxy-D-xylulose into isoprene and phytol by higher plants and algae. FEBS Lett (1997) 1.42
Effect of oxidative stress on the biosynthesis of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate and isoprenoids by several bacterial strains. Arch Microbiol (1998) 1.24
Structure determination of a novel cyclic phosphocompound isolated from Desulfovibrio desulfuricans. Biochem J (1992) 1.08
The ability of bacteria to synthesize a new cyclopyrophosphate correlates with their tolerance to redox-cycling drugs: on a crossroad of chemotherapy, environmental toxicology and immunobiochemical problems. Biofactors (1992) 0.93
VITAMIN A AND ROD-CONE DARK ADAPTATION IN CIRRHOSIS OF THE LIVER. Science (1938) 8.91
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem (1985) 8.60
THE REGENERATION OF VISUAL PURPLE IN SOLUTION. Science (1936) 8.53
Jasmonic acid is a signal transducer in elicitor-induced plant cell cultures. Proc Natl Acad Sci U S A (1992) 5.86
Phytochelatins: the principal heavy-metal complexing peptides of higher plants. Science (1985) 5.75
Phytochelatins, a class of heavy-metal-binding peptides from plants, are functionally analogous to metallothioneins. Proc Natl Acad Sci U S A (1987) 4.90
Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal. Tob Control (2008) 4.37
Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase). Proc Natl Acad Sci U S A (1989) 4.31
Analysis, cloning, and high-level expression of 2,4-dichlorophenoxyacetate monooxygenase gene tfdA of Alcaligenes eutrophus JMP134. J Bacteriol (1987) 4.01
ROD-CONE DARK ADAPTATION AND VITAMIN A. Science (1938) 3.74
The octadecanoic pathway: signal molecules for the regulation of secondary pathways. Proc Natl Acad Sci U S A (1995) 3.37
Analysis of a chemical plant defense mechanism in grasses. Science (1997) 3.30
The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms. Chem Biol (1998) 3.23
Chemical syntheses and properties of hydroxycinnamoyl-coenzyme A derivatives. Z Naturforsch C (1975) 2.93
THE DIFFUSION COEFFICIENT AND MOLECULAR SIZE OF VISUAL PURPLE. Science (1937) 2.75
Biosynthesis of isoprenoids via the non-mevalonate pathway. Cell Mol Life Sci (2004) 2.68
Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement. Proc Natl Acad Sci U S A (1997) 2.64
Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol. Proc Natl Acad Sci U S A (1999) 2.47
Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin. Proc Natl Acad Sci U S A (1996) 2.45
Deoxyxylulose phosphate pathway to terpenoids. Trends Plant Sci (2001) 2.31
Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Proc Natl Acad Sci U S A (2000) 2.30
Signaling in the elicitation process is mediated through the octadecanoid pathway leading to jasmonic acid. Proc Natl Acad Sci U S A (1993) 2.27
The cDNA clone for strictosidine synthase from Rauvolfia serpentina. DNA sequence determination and expression in Escherichia coli. FEBS Lett (1988) 2.05
ENERGY AT THE THRESHOLD OF VISION. Science (1941) 2.01
Anthraquinone production by cell suspension cultures of Morinda citrifolia. Planta Med (1975) 1.95
Intensity discrimination and its relation to the adaptation of the eye. J Physiol (1936) 1.89
Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. Proc Natl Acad Sci U S A (2001) 1.81
Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc Natl Acad Sci U S A (2010) 1.72
Retrobiosynthetic analysis of carbon fixation in the phototrophic eubacterium Chloroflexus aurantiacus. Eur J Biochem (1993) 1.70
Differential stimulation of capped mRNA translation in vitro by cap binding protein. Nature (1980) 1.69
13C-NMR study of autotrophic CO2 fixation pathways in the sulfur-reducing Archaebacterium Thermoproteus neutrophilus and in the phototrophic Eubacterium Chloroflexus aurantiacus. Eur J Biochem (1992) 1.67
Autotrophic CO(2) fixation by Chloroflexus aurantiacus: study of glyoxylate formation and assimilation via the 3-hydroxypropionate cycle. J Bacteriol (2001) 1.63
An optomechanical transducer in the blue light receptor phototropin from Avena sativa. Proc Natl Acad Sci U S A (2001) 1.63
Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism. Eur J Biochem (1993) 1.53
Noninvasive estimation of pulmonary artery diastolic pressure in patients with tricuspid regurgitation by Doppler echocardiography. Chest (1999) 1.51
NOTE ON THE ABSORPTION OF CALCIUM DURING THE MOLTING OF THE BLUE CRAB, CALLINECTES SAPIDUS. Science (1914) 1.50
The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates. Curr Opin Chem Biol (2001) 1.49
The jasmonate precursor, 12-oxo-phytodienoic acid, induces phytoalexin synthesis in Petroselinum crispum cell cultures. FEBS Lett (1992) 1.46
ADAPTATION IN THE PHOTOSENSITIVITY OF CIONA INTESTINALIS. Science (1918) 1.45
Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation. Eur J Biochem (1979) 1.35
Brain radiation lesions: MR imaging. Radiology (1986) 1.33
Atomic structure of GTP cyclohydrolase I. Structure (1995) 1.30
Evidence against specific binding of salicylic acid to plant catalase. FEBS Lett (1995) 1.29
Biosynthesis of riboflavin: cloning, sequencing, and expression of the gene coding for 3,4-dihydroxy-2-butanone 4-phosphate synthase of Escherichia coli. J Bacteriol (1992) 1.28
Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum. Eur J Biochem (2001) 1.27
Isoprenoid biosynthetic pathways as anti-infective drug targets. Biochem Soc Trans (2005) 1.26
Saccharomyces cerevisiae and Neurospora crassa contain heavy metal sequestering phytochelatin. Arch Microbiol (1992) 1.26
Active site topology and reaction mechanism of GTP cyclohydrolase I. Proc Natl Acad Sci U S A (1995) 1.24
Zinc plays a key role in human and bacterial GTP cyclohydrolase I. Proc Natl Acad Sci U S A (2000) 1.24
The diversity and evolutionary relationships of the pregnancy-associated glycoproteins, an aspartic proteinase subfamily consisting of many trophoblast-expressed genes. Proc Natl Acad Sci U S A (1997) 1.23
Biosynthesis of nucleotides, flavins, and deazaflavins in Methanobacterium thermoautotrophicum. J Biol Chem (1991) 1.20
Riboflavin synthases of Bacillus subtilis. Purification and amino acid sequence of the alpha subunit. J Biol Chem (1990) 1.19
New hydroxylated benzo[c]phenanthridine alkaloids from Eschscholtzia californica cell suspension cultures. J Nat Prod (1990) 1.17
Perineural spread of head and neck tumors: how accurate is MR imaging? AJNR Am J Neuroradiol (1998) 1.17
Biosynthesis of riboflavin. Studies on the mechanism of L-3,4-dihydroxy-2-butanone 4-phosphate synthase. J Biol Chem (1991) 1.16
Isolation and properties of hydroxycinnamate: CoA ligase from lignifying tissue of Forsythia. Eur J Biochem (1974) 1.15
Procedure for the enzymatic synthesis and isolation of cinnamoyl-CoA thiolesters using a bacterial system. Anal Biochem (1980) 1.15
Controlling on-surface polymerization by hierarchical and substrate-directed growth. Nat Chem (2012) 1.14
Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors. Eur J Biochem (1998) 1.13
Dimethylallyl pyrophosphate is not the committed precursor of isopentenyl pyrophosphate during terpenoid biosynthesis from 1-deoxyxylulose in higher plants. Proc Natl Acad Sci U S A (1999) 1.12
Reactivation of metal-requiring apoenzymes by phytochelatin-metal complexes. FEBS Lett (1991) 1.12