Published in Trends Biochem Sci on March 01, 2000
A continuum of anionic charge: structures and functions of D-alanyl-teichoic acids in gram-positive bacteria. Microbiol Mol Biol Rev (2003) 5.18
Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res (2008) 4.09
The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol (2013) 3.84
Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A (2008) 3.41
The life of lipid droplets. Biochim Biophys Acta (2008) 2.75
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev (2004) 2.16
Wnt signal transduction pathways. Organogenesis (2008) 2.14
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12
Three decades of Wnts: a personal perspective on how a scientific field developed. EMBO J (2012) 1.89
Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc Natl Acad Sci U S A (2008) 1.86
Acyl-coenzyme A:cholesterol acyltransferases. Am J Physiol Endocrinol Metab (2009) 1.85
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J Biol Chem (2008) 1.75
Recent progress on acyl CoA: lysophospholipid acyltransferase research. J Lipid Res (2008) 1.71
Wnt proteins. Cold Spring Harb Perspect Biol (2012) 1.70
Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat Chem Biol (2013) 1.57
Lipid-independent secretion of a Drosophila Wnt protein. J Biol Chem (2008) 1.48
Wnt signalling and the control of cellular metabolism. Biochem J (2010) 1.42
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A (2011) 1.35
Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol. Mol Biol Cell (2007) 1.31
Murine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum. J Biol Chem (2011) 1.30
Topological orientation of acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) and identification of a putative active site histidine and the role of the n terminus in dimer/tetramer formation. J Biol Chem (2010) 1.28
Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine. J Biol Chem (2011) 1.27
A member of the sugar transporter family, Stl1p is the glycerol/H+ symporter in Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.27
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proc Natl Acad Sci U S A (2010) 1.23
GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor. Mol Biol Cell (2006) 1.22
Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions. Mol Biol Cell (2009) 1.19
Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum. Mol Biol Cell (2008) 1.16
A distinct DGAT with sn-3 acetyltransferase activity that synthesizes unusual, reduced-viscosity oils in Euonymus and transgenic seeds. Proc Natl Acad Sci U S A (2010) 1.15
Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice. J Invest Dermatol (2010) 1.15
Lipid modification of secreted signaling proteins. Cell Cycle (2006) 1.14
Lipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fat--store 'em up or burn 'em down. Genetics (2013) 1.13
Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog. PLoS One (2010) 1.11
Mutations affecting peptidoglycan acetylation in Neisseria gonorrhoeae and Neisseria meningitidis. Infect Immun (2005) 1.11
Human acyl-coenzyme A:cholesterol acyltransferase expressed in chinese hamster ovary cells: membrane topology and active site location. Mol Biol Cell (2003) 1.09
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep (2013) 1.09
DGAT1 mutation is linked to a congenital diarrheal disorder. J Clin Invest (2012) 1.07
Evolutionary view of acyl-CoA diacylglycerol acyltransferase (DGAT), a key enzyme in neutral lipid biosynthesis. BMC Evol Biol (2011) 1.05
Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1. PLoS One (2009) 1.04
A genomewide screen reveals a role of mitochondria in anaerobic uptake of sterols in yeast. Mol Biol Cell (2005) 1.03
Identification of key residues and regions important for porcupine-mediated Wnt acylation. J Biol Chem (2014) 1.02
Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). PLoS One (2012) 1.02
Precise regulation of porcupine activity is required for physiological Wnt signaling. J Biol Chem (2012) 1.02
O-acetylation of peptidoglycan in gram-negative bacteria: identification and characterization of peptidoglycan O-acetyltransferase in Neisseria gonorrhoeae. J Biol Chem (2010) 1.01
Diminished WNT -> β-catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors. Genes Dev (2014) 1.00
A single natural nucleotide mutation alters bacterial pathogen host tropism. Nat Genet (2015) 0.98
Identification of a new family of enzymes with potential O-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria. BMC Microbiol (2005) 0.97
Evidence that the algI/algJ gene cassette, required for O acetylation of Pseudomonas aeruginosa alginate, evolved by lateral gene transfer. J Bacteriol (2004) 0.97
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97
Functional and topological analysis of yeast acyl-CoA:diacylglycerol acyltransferase 2, an endoplasmic reticulum enzyme essential for triacylglycerol biosynthesis. J Biol Chem (2011) 0.96
Novel eukaryotic enzymes modifying cell-surface biopolymers. Biol Direct (2010) 0.96
Roles of N-glycosylation and lipidation in Wg secretion and signaling. Dev Biol (2012) 0.96
Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Mol Biol Cell (2009) 0.96
Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae. J Biol Chem (2011) 0.95
Revised mechanism of D-alanine incorporation into cell wall polymers in Gram-positive bacteria. Microbiology (2013) 0.94
Differential palmit(e)oylation of Wnt1 on C93 and S224 residues has overlapping and distinct consequences. PLoS One (2011) 0.94
Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. Blood (2007) 0.93
Lipid-modified morphogens: functions of fats. Curr Opin Genet Dev (2009) 0.93
Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein. J Biol Chem (2014) 0.92
Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. Elife (2015) 0.92
Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence. Plant Physiol (2009) 0.91
Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase. J Biol Chem (2013) 0.91
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies. Lab Invest (2015) 0.91
Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine. Curr Med Chem (2015) 0.89
Hepatitis C virus entry is impaired by claudin-1 downregulation in diacylglycerol acyltransferase-1-deficient cells. J Virol (2014) 0.89
The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids. J Lipid Res (2008) 0.88
cat-ELCCA: a robust method to monitor the fatty acid acyltransferase activity of ghrelin O-acyltransferase (GOAT). Angew Chem Int Ed Engl (2010) 0.88
A permease encoded by STL1 is required for active glycerol uptake by Candida albicans. Microbiology (2009) 0.88
Function and localization of the Arabidopsis thaliana diacylglycerol acyltransferase DGAT2 expressed in yeast. PLoS One (2014) 0.87
Fatty acylation of Wnt proteins. Nat Chem Biol (2016) 0.87
Characterization of human lysophospholipid acyltransferase 3. J Lipid Res (2009) 0.86
Updating the Wnt pathways. Biosci Rep (2014) 0.86
Bacillus anthracis acetyltransferases PatA1 and PatA2 modify the secondary cell wall polysaccharide and affect the assembly of S-layer proteins. J Bacteriol (2012) 0.86
Membrane topology of hedgehog acyltransferase. J Biol Chem (2014) 0.86
Characterization of a second sterol-esterifying enzyme in Toxoplasma highlights the importance of cholesterol storage pathways for the parasite. Mol Microbiol (2013) 0.85
Biosynthesis of phytosterol esters: identification of a sterol o-acyltransferase in Arabidopsis. Plant Physiol (2007) 0.84
Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling. J Lipid Res (2015) 0.83
The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells. Differentiation (2008) 0.83
Ghrelin O-acyltransferase assays and inhibition. Methods Enzymol (2012) 0.83
The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. Fly (Austin) (2010) 0.83
Purification of recombinant acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) from H293 cells and binding studies between the enzyme and substrates using difference intrinsic fluorescence spectroscopy. Biochemistry (2010) 0.83
Identification of the WNT1 residues required for palmitoylation by Porcupine. FEBS Lett (2014) 0.83
N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects. Proteomics (2015) 0.82
Fatty acylation of proteins: The long and the short of it. Prog Lipid Res (2016) 0.81
Soybean oil biosynthesis: role of diacylglycerol acyltransferases. Funct Integr Genomics (2013) 0.81
Subcellular localization and functional expression of the glycerol uptake protein 1 (GUP1) of Saccharomyces cerevisiae tagged with green fluorescent protein. Biochem J (2005) 0.81
Palmitoylation of Hedgehog proteins. Vitam Horm (2012) 0.81
DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signaling. Cell Mol Life Sci (2015) 0.80
The role of the Wnt signaling pathway in cancer stem cells: prospects for drug development. Res Rep Biochem (2014) 0.80
Palmitoylation and depalmitoylation defects. J Inherit Metab Dis (2014) 0.80
Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer. Oncol Lett (2013) 0.79
Changes in Subcellular Distribution of n-Octanoyl or n-Decanoyl Ghrelin in Ghrelin-Producing Cells. Front Endocrinol (Lausanne) (2013) 0.79
Programmed cell death in Saccharomyces cerevisiae is hampered by the deletion of GUP1 gene. BMC Microbiol (2012) 0.79
Characterization of a lysophospholipid acyltransferase involved in membrane remodeling in Candida albicans. Biochim Biophys Acta (2014) 0.79
The Secreted Signaling Protein Wnt3 Is Associated with Membrane Domains In Vivo: A SPIM-FCS Study. Biophys J (2016) 0.78
Monoacylglycerol and diacylglycerol acyltransferases and the synthesis of neutral glycerides in Manduca sexta. Insect Biochem Mol Biol (2014) 0.78
Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage. Neurobiol Aging (2015) 0.78
Enzymatic characterization of a human acyltransferase activity. PLoS One (2009) 0.78
Mechanistic analysis of ghrelin-O-acyltransferase using substrate analogs. Bioorg Chem (2015) 0.78
Porcupine is not required for the production of the majority of Wnts from primary human astrocytes and CD8+ T cells. PLoS One (2014) 0.78