PubRank

C López-Otín

Author PubWeight™ 117.06‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem 1994 3.64
2 Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem 2000 2.12
3 Deubiquitinases in cancer: new functions and therapeutic options. Oncogene 2011 2.08
4 Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann Rheum Dis 1999 2.06
5 Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol 1999 1.87
6 The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain. J Mol Biol 1996 1.82
7 Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13). Genomics 1997 1.73
8 Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium. Arthritis Rheum 1997 1.58
9 Autophagy: molecular mechanisms, physiological functions and relevance in human pathology. Cell Mol Life Sci 2004 1.57
10 Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res 1996 1.53
11 Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase. J Cell Sci 2000 1.50
12 NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome. Leukemia 2012 1.41
13 Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas. Cancer Res 2001 1.40
14 Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis. Lab Invest 1997 1.38
15 Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase. J Biol Chem 1999 1.37
16 Collagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalization. J Biol Chem 1999 1.36
17 Identification and structural and functional characterization of human enamelysin (MMP-20). Biochemistry 1997 1.35
18 Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family. Cancer Res 1994 1.30
19 Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development. J Biol Chem 2000 1.29
20 Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3. Biochem J 1998 1.29
21 Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes. Analysis of its potential role in postpartum involution of the uterus. J Biol Chem 1998 1.26
22 Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions. Cancer Res 1997 1.25
23 Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. J Biol Chem 1998 1.25
24 Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor. Am J Pathol 1998 1.24
25 A genomic view of the complexity of mammalian proteolytic systems. Biochem Soc Trans 2005 1.24
26 An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies. Clin Chim Acta 2000 1.19
27 Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell Mol Life Sci 2007 1.19
28 Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. J Biol Chem 1997 1.17
29 Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members. J Biol Chem 1999 1.17
30 Evaluation of some newer matrix metalloproteinases. Ann N Y Acad Sci 1999 1.17
31 Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity. Cancer Res 2000 1.14
32 Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors. APMIS 1999 1.14
33 Differential effects of transforming growth factor-beta on the expression of collagenase-1 and collagenase-3 in human fibroblasts. J Biol Chem 1998 1.13
34 Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta. Cell Growth Differ 1997 1.12
35 ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism. Mol Biol Cell 2000 1.12
36 Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. Cancer Res 2000 1.08
37 Zn-alpha 2-glycoprotein levels in breast cancer cytosols and correlation with clinical, histological and biochemical parameters. Eur J Cancer 1993 1.08
38 A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation. J Cell Biol 2001 1.07
39 Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. J Biol Chem 2001 1.04
40 Identification of the major protein components in breast secretions from women with benign and malignant breast diseases. Cancer Res 1992 1.02
41 Mutational analysis of the human cyclin-dependent kinase inhibitor p27kip1 in primary breast carcinomas. Hum Genet 1996 1.01
42 Sequence and evolutionary relationships of African swine fever virus thymidine kinase. Virology 1990 1.00
43 Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. J Biol Chem 1999 0.99
44 Glucocorticoids and androgens up-regulate the Zn-alpha 2-glycoprotein messenger RNA in human breast cancer cells. Breast Cancer Res Treat 1994 0.99
45 Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx. J Pathol 1998 0.99
46 Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. Cancer Res 1998 0.99
47 Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation. Am J Pathol 1998 0.98
48 A protein related to brain microtubule-associated protein MAP1B is a component of the mammalian centrosome. J Cell Sci 1994 0.97
49 Apolipoprotein D gene induction by retinoic acid is concomitant with growth arrest and cell differentiation in human breast cancer cells. J Biol Chem 1994 0.95
50 Amino acid sequence and structural properties of protein p12, an African swine fever virus attachment protein. J Virol 1992 0.95
51 Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases. J Biol Chem 1996 0.95
52 Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues. J Biol Chem 1994 0.94
53 Location of phosphorylated residues in human respiratory syncytial virus phosphoprotein. J Gen Virol 1991 0.92
54 Phosphorylation of a neuronal-specific beta-tubulin isotype. J Biol Chem 1990 0.92
55 A barley flour inhibitor of insect alpha-amylase is a major allergen associated with baker's asthma disease. FEBS Lett 1989 0.91
56 Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate. Matrix Biol 1999 0.91
57 Mapping and sequence of the gene encoding protein p17, a major African swine fever virus structural protein. Virology 1995 0.91
58 Overproduction and purification of biologically active native fungal alpha-sarcin in Escherichia coli. Gene 1994 0.90
59 The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family. Genomics 1995 0.90
60 Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog. Proc Natl Acad Sci U S A 1997 0.90
61 Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins. Genomics 1999 0.89
62 A functional link between the tumour suppressors ARF and p33ING1. Oncogene 2006 0.89
63 Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases. J Biol Chem 1994 0.89
64 Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor. J Biol Chem 1991 0.88
65 Structure and expression in E. coli of the gene coding for protein p10 of African swine fever virus. Arch Virol 1993 0.88
66 A gene homologous to topoisomerase II in African swine fever virus. Virology 1992 0.87
67 Expression of collagenase-3 in the rat ovary during the ovulatory process. J Endocrinol 1996 0.87
68 The primary structure of the cytotoxin restrictocin. Eur J Biochem 1984 0.87
69 Hormonal regulation of the human pepsinogen C gene in breast cancer cells. Identification of a cis-acting element mediating its induction by androgens, glucocorticoids, and progesterone. J Biol Chem 1996 0.87
70 Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease. Biochem J 1990 0.86
71 Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues. FEBS Lett 1991 0.86
72 A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level. Hum Genet 1993 0.86
73 The amino acid sequence of Ole e I, the major allergen from olive tree (Olea europaea) pollen. Eur J Biochem 1993 0.85
74 Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-gamma is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1. Oncogene 2000 0.85
75 Expression of pepsinogen C in human breast tumours and correlation with clinicopathologic parameters. Br J Cancer 1993 0.85
76 Prostate specific antigen--a new constituent of breast cyst fluid. Breast Cancer Res Treat 1996 0.84
77 Pepsinogen C is a new prognostic marker in primary breast cancer. J Clin Oncol 1995 0.84
78 Rye inhibitors of animal alpha-amylases show different specificities, aggregative properties and IgE-binding capacities than their homologues from wheat and barley. Eur J Biochem 1994 0.84
79 Beta-turns as structural motifs for the proteolytic processing of seed proteins. FEBS Lett 1990 0.84
80 Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes. Genomics 1993 0.84
81 Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO). Genomics 1998 0.83
82 Expression and prognostic significance of apolipoprotein D in breast cancer. Am J Pathol 1994 0.83
83 Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3. Genomics 1996 0.83
84 Isolation and characterization of a pepsin C zymogen produced by human breast tissues. J Biol Chem 1992 0.83
85 Human cystatin D. cDNA cloning, characterization of the Escherichia coli expressed inhibitor, and identification of the native protein in saliva. J Biol Chem 1993 0.82
86 Thiol-disulfide exchange of ribonuclease inhibitor bound to ribonuclease A. Evidence of active inhibitor-bound ribonuclease. J Biol Chem 1995 0.82
87 Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia. Leukemia 2012 0.82
88 Detection, isolation and complete amino acid sequence of an aeroallergenic protein from rapeseed flour. Clin Exp Allergy 1997 0.81
89 Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis. Leukemia 2013 0.81
90 Structural analysis of the small chain of the 2S albumin, napin nIII, from rapeseed. Chemical and spectroscopic evidence of an intramolecular bond formation. Biochim Biophys Acta 1991 0.81
91 Cholesterol and apolipoprotein D in gross cystic disease of the breast. Clin Chem 1992 0.80
92 Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis. Leukemia 2015 0.80
93 Factors affecting protein composition of breast secretions from nonlactating women. Breast Cancer Res Treat 1992 0.80
94 Wheat flour peroxidase is a prominent allergen associated with baker's asthma. Clin Exp Allergy 1997 0.80
95 Relationship between serum prolactin levels and protein composition of breast secretions in nonlactating women. J Clin Endocrinol Metab 1994 0.79
96 Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase. J Biol Chem 1997 0.79
97 Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds. J Biol Chem 1995 0.79
98 The PLEES proteins: a family of structurally related enzymes widely distributed from bacteria to humans. Biochem J 1997 0.79
99 Alternative splicing gives rise to two novel long isoforms of Zn-alpha 2-glycoprotein, a member of the immunoglobulin superfamily. Gene 1996 0.79
100 Mapping of the human Zn-alpha 2-glycoprotein gene (AZGP1) to chromosome 7q22 by in situ hybridization. Cytogenet Cell Genet 1994 0.78
101 Conformational studies of the human complex-forming glycoprotein, heterogeneous in charge: protein HC. Biochemistry 1984 0.78
102 Growth inhibition of human breast cancer cells by 1,25-dihydroxyvitamin D3 is accompanied by induction of apolipoprotein D expression. Cancer Res 1997 0.78
103 Immunofluorometric assay of pepsinogen C and preliminary clinical applications. Clin Chem 1997 0.78
104 Retinoic acid-induced expression of apolipoprotein D and concomitant growth arrest in human breast cancer cells are mediated through a retinoic acid receptor RARalpha-dependent signaling pathway. J Biol Chem 1996 0.78
105 GCDFP-70 protein in cyst fluid identified as albumin and used to classify cysts in women with breast gross cystic disease. Clin Chem 1991 0.77
106 Human glandular kallikrein in breast milk, amniotic fluid, and breast cyst fluid. Clin Chem 1999 0.77
107 Isolation and characterization of an olive allergen-like protein from lilac pollen. Sequence analysis of three cDNA encoding protein isoforms. Eur J Biochem 1994 0.76
108 Inhibitory effects of human cystatin C on plum pox potyvirus proteases. Plant Mol Biol 1993 0.76
109 High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus. Gene 1993 0.76
110 Cloning and expression analysis of the cDNA encoding rat Zn-alpha 2-glycoprotein. Gene 1994 0.76
111 Quantification and molecular analysis of cathepsin D in breast cyst fluids. Eur J Cancer 1992 0.76
112 Isolation of three allergenic fractions of the major allergen from Olea europea pollen and N-terminal amino acid sequence. Biochem Biophys Res Commun 1990 0.76
113 Tau-related protein present in paired helical filaments has a decreased tubulin binding capacity as compared with microtubule-associated protein tau. Biochim Biophys Acta 1991 0.75
114 Prostate-specific membrane antigen in breast carcinoma. Lancet 1997 0.75
115 Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus. Virus Res 1993 0.75
116 A general method to cleave a known DNA sequence at any site. Biotechniques 1991 0.75
117 Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization. Cytogenet Cell Genet 1993 0.75
118 Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24. Genomics 1998 0.75
119 Strategies for cloning new MMPs and TIMPs. Methods Mol Biol 2001 0.75