Published in Proc Natl Acad Sci U S A on March 14, 2000
Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A (2003) 2.24
Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2007) 1.65
DNA building blocks: keeping control of manufacture. Crit Rev Biochem Mol Biol (2011) 1.64
Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint. Nucleic Acids Res (2010) 1.52
Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage. Nucleic Acids Res (2008) 1.52
Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality. Mol Cell Biol (2000) 1.52
Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype. EMBO J (2012) 1.35
Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit. Mol Cell Biol (2008) 1.20
Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer. Proc Natl Acad Sci U S A (2001) 1.18
Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proc Natl Acad Sci U S A (2006) 1.17
The protein kinase Snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyurea. Mol Cell Biol (2004) 1.11
The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo. Biochemistry (2005) 1.10
Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins. J Biol Chem (2011) 1.03
Role of the iron mobilization and oxidative stress regulons in the genomic response of yeast to hydroxyurea. Mol Genet Genomics (2005) 1.03
Ability for anaerobic growth is not sufficient for development of the petite phenotype in Saccharomyces kluyveri. J Bacteriol (2001) 1.03
Why multiple small subunits (Y2 and Y4) for yeast ribonucleotide reductase? Toward understanding the role of Y4. Proc Natl Acad Sci U S A (2001) 1.01
Cotransport of the heterodimeric small subunit of the Saccharomyces cerevisiae ribonucleotide reductase between the nucleus and the cytoplasm. Genetics (2006) 0.99
Synergy among differentially regulated repressors of the ribonucleotide diphosphate reductase genes of Saccharomyces cerevisiae. Eukaryot Cell (2006) 0.97
Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics (2014) 0.96
Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase. Biochemistry (2006) 0.94
The intrinsically disordered RNR inhibitor Sml1 is a dynamic dimer. Biochemistry (2008) 0.93
Chlamydial ribonucleotide reductase: tyrosyl radical function in catalysis replaced by the FeIII-FeIV cluster. Proc Natl Acad Sci U S A (2006) 0.91
RNR4 mutant alleles pso3-1 and rnr4Delta block induced mutation in Saccharomyces cerevisiae. Curr Genet (2007) 0.87
dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants. Proc Natl Acad Sci U S A (2015) 0.86
Depletion of cellular iron by curcumin leads to alteration in histone acetylation and degradation of Sml1p in Saccharomyces cerevisiae. PLoS One (2013) 0.85
Examples of high-frequency EPR studies in bioinorganic chemistry. J Biol Inorg Chem (2002) 0.83
Role of arginine 293 and glutamine 288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase. J Mol Biol (2012) 0.82
Choosing the right metal: case studies of class I ribonucleotide reductases. J Biol Chem (2014) 0.79
The evolution of aerobic fermentation in Schizosaccharomyces pombe was associated with regulatory reprogramming but not nucleosome reorganization. Mol Biol Evol (2010) 0.77
Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit. Nucleic Acids Res (2014) 0.77
White spot syndrome virus protein kinase 1 defeats the host cell's iron-withholding defense mechanism by interacting with host ferritin. J Virol (2014) 0.77
Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups. Nucleic Acids Res (2014) 0.77
Checkpoint-dependent RNR induction promotes fork restart after replicative stress. Sci Rep (2015) 0.76
Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage. Mol Cell Biol (2012) 0.76
Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme. FEBS Lett (2016) 0.75
The conserved Lys-95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit M2. J Biol Chem (2013) 0.75
Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Small Subunit Localization in Response to Iron Deficiency. J Biol Chem (2016) 0.75
Cell cycle checkpoints: preventing an identity crisis. Science (1996) 13.74
Computed circular dichroism spectra for the evaluation of protein conformation. Biochemistry (1969) 10.58
A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol Cell (1998) 7.16
Reduction of ribonucleotides. Annu Rev Biochem (1979) 6.33
The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell (1998) 5.37
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev (1998) 5.20
Interactions between deoxyribonucleotide and DNA synthesis. Annu Rev Biochem (1988) 4.79
Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev (1990) 3.61
DNA damage and checkpoint pathways: molecular anatomy and interactions with repair. Cell (1998) 3.04
From RNA to DNA, why so many ribonucleotide reductases? Science (1993) 3.03
Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability. Mol Cell Biol (1987) 2.97
Iron and free radical in ribonucleotide reductase. Exchange of iron and Mössbauer spectroscopy of the protein B2 subunit of the Escherichia coli enzyme. J Biol Chem (1973) 2.59
Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae. Mol Cell Biol (1997) 2.46
Yeast Sml1, a protein inhibitor of ribonucleotide reductase. J Biol Chem (1999) 1.91
Ribonucleotide reductase from calf thymus. Purification and properties. Biochemistry (1979) 1.90
Ribonucleotide reductase from calf thymus. Separation of the enzyme into two nonidentical subunits, proteins M1 and M2. J Biol Chem (1980) 1.78
Rnr4p, a novel ribonucleotide reductase small-subunit protein. Mol Cell Biol (1997) 1.64
Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate. Mol Cell Biol (1987) 1.63
Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells. J Biol Chem (1985) 1.37
Purification and characterization of recombinant mouse and herpes simplex virus ribonucleotide reductase R2 subunit. Biochemistry (1991) 1.29
Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators. J Biol Chem (1993) 1.25
Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly. Proc Natl Acad Sci U S A (1999) 1.20
Deoxyribonucleotide biosynthesis in yeast (Saccharomyces cerevisiae). A ribonucleotide reductase system of sufficient activity for DNA synthesis. Eur J Biochem (1984) 1.11
Evidence by site-directed mutagenesis supports long-range electron transfer in mouse ribonucleotide reductase. Biochemistry (1995) 1.09
Half-site reactivity of the tyrosyl radical of ribonucleotide reductase from Escherichia coli. J Biol Chem (1987) 1.08
Identification of a free radical and oxygen dependence of ribonucleotide reductase in yeast. Free Radic Res Commun (1990) 1.06
1H NMR studies of mouse ribonucleotide reductase: the R2 protein carboxyl-terminal tail, essential for subunit interaction, is highly flexible but becomes rigid in the presence of protein R1. Biochemistry (1994) 1.00
Demonstration of normal and mutant protein M1 subunits of deoxyGTP-resistant ribonucleotide reductase from mutant mouse lymphoma cells. J Biol Chem (1981) 1.00
Ribonucleotide reductase from Saccharomyces cerevisiae. Biochem Biophys Res Commun (1970) 0.98
Purification, characterization, and localization of subunit interaction area of recombinant mouse ribonucleotide reductase R1 subunit. J Biol Chem (1994) 0.94
High field EPR studies of mouse ribonucleotide reductase indicate hydrogen bonding of the tyrosyl radical. J Biol Chem (1996) 0.94
Residues important for radical stability in ribonucleotide reductase from Escherichia coli. J Biol Chem (1995) 0.92
A nitrocellulose filter binding assay for ribonucleotide reductase. Anal Biochem (1986) 0.88
[Saccharomyces cerevisiae ADE12 gene, coding for adenylosuccinate synthetase (EC 6.3.4.4). Cloning, sequencing, expression, and superproduction]. Mol Gen Mikrobiol Virusol (1995) 0.83
Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging (2001) 8.14
Reduction of ribonucleotides. Annu Rev Biochem (1979) 6.33
NMR solution structure of the human prion protein. Proc Natl Acad Sci U S A (2000) 4.80
A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum. Science (1999) 4.75
The primary sequence of rabbit alpha-globin mRNA. Cell (1978) 3.88
Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J (1996) 3.18
The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage. EMBO J (2001) 2.80
Iron and free radical in ribonucleotide reductase. Exchange of iron and Mössbauer spectroscopy of the protein B2 subunit of the Escherichia coli enzyme. J Biol Chem (1973) 2.59
Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits. J Biol Chem (1985) 2.47
Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity. J Med Chem (1996) 2.20
Cell cycle-dependent regulation of mammalian ribonucleotide reductase. The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis. J Biol Chem (1984) 2.19
S-phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs. Biochemistry (1990) 2.07
Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy (2008) 1.97
Trigeminocardiac reflex in embolization of intracranial dural arteriovenous fistula. AJNR Am J Neuroradiol (2007) 1.91
Yeast Sml1, a protein inhibitor of ribonucleotide reductase. J Biol Chem (1999) 1.91
Ribonucleotide reductase from calf thymus. Purification and properties. Biochemistry (1979) 1.90
Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks. J Biol Chem (2000) 1.87
Ribonucleoside diphosphate reductase. Purification of the two subunits, proteins B1 and B2. Eur J Biochem (1969) 1.84
Numerical selection of optimal tumor imaging agents with application to engineered antibodies. Cancer Biother Radiopharm (2001) 1.81
Quality of life and seeking help in women with urinary incontinence. Acta Obstet Gynecol Scand (2001) 1.81
Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reductase. Mol Cell Biol (1986) 1.81
The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse. Exp Cell Res (1988) 1.80
Physicochemical characterization of ribonucleoside diphosphate reductase from Escherichia coli. J Biol Chem (1973) 1.79
Ribonucleotide reductase from calf thymus. Separation of the enzyme into two nonidentical subunits, proteins M1 and M2. J Biol Chem (1980) 1.78
The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site. Nat Struct Biol (2000) 1.77
Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. J Biol Chem (2001) 1.77
Allosteric regulation of calf thymus ribonucleoside diphosphate reductase. Biochemistry (1979) 1.76
Phenotype of patients with peroxisomal disorders subdivided into sixteen complementation groups. J Pediatr (1995) 1.73
Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. J Biol Chem (2001) 1.69
Retracted The LIS1-related protein NUDF of Aspergillus nidulans and its interaction partner NUDE bind directly to specific subunits of dynein and dynactin and to alpha- and gamma-tubulin. J Biol Chem (2001) 1.67
Rnr4p, a novel ribonucleotide reductase small-subunit protein. Mol Cell Biol (1997) 1.64
Molecular cloning and characterization of Pals, proteins associated with mLin-7. J Biol Chem (2000) 1.64
Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science (1992) 1.56
Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer. Curr Opin Cell Biol (2000) 1.53
Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality. Mol Cell Biol (2000) 1.52
Ribonucleoside diphosphate reductase (Escherichia coli). Methods Enzymol (1978) 1.49
Familial clustering of symptoms and disruptive behaviors in multiplex families with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry (2000) 1.48
Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation. Cancer Res (1988) 1.47
Resonance assignment and structure determination for RNA. Methods Enzymol (2001) 1.46
Effect of malnutrition at the time of diagnosis on the survival of children treated for cancer in El Salvador and Northern Brazil. J Pediatr Hematol Oncol (2000) 1.44
Modeling and prediction of human behavior. Neural Comput (1999) 1.44
Crystal structure of a dUTPase. Nature (1992) 1.41
The T cell response to major grass allergens is regulated and includes IL-10 production in atopic but not in non-atopic subjects. Int Arch Allergy Immunol (2010) 1.40
Invasive in vivo measurement of rear-, mid- and forefoot motion during walking. Gait Posture (2007) 1.37
Exploration of requirements for peptide binding to HLA DRB1*0101 and DRB1*0401. J Immunol (1994) 1.37
Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells. J Biol Chem (1985) 1.37
Inactivation of ribonucleotide reductase by nitric oxide. Biochem Biophys Res Commun (1991) 1.32
Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells. Proc Natl Acad Sci U S A (1981) 1.31
Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4) with attention deficit hyperactivity disorder (ADHD). Mol Psychiatry (2000) 1.30
Metabolic fate of oxidized guanine ribonucleotides in mammalian cells. Biochemistry (1999) 1.30
Localization of ribonucleotide reductase in mammalian cells. EMBO J (1984) 1.30
Allosteric regulation of Trypanosoma brucei ribonucleotide reductase studied in vitro and in vivo. J Biol Chem (1998) 1.30
Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells. J Biol Chem (1990) 1.30
Purification and characterization of recombinant mouse and herpes simplex virus ribonucleotide reductase R2 subunit. Biochemistry (1991) 1.29
Foot kinematics during walking measured using bone and surface mounted markers. J Biomech (2007) 1.28
Characterization of the free radical of mammalian ribonucleotide reductase. J Biol Chem (1982) 1.28
Quality of care. Development of a patient-centred questionnaire based on a grounded theory model. Scand J Caring Sci (1994) 1.27
Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: possible regulation mechanism. Biochem Biophys Res Commun (1983) 1.27
Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis. Dev Dyn (2001) 1.26
Tissue distribution and disposition of daunomycin (NCS-82151) in mice: fluorometric and isotopic methods. Cancer Chemother Rep (1970) 1.26
Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators. J Biol Chem (1993) 1.25
Amphetamine addiction and pregnancy. II. Pregnancy, delivery and the neonatal period. Socio-medical aspects. Acta Obstet Gynecol Scand (1981) 1.24
Expression and function of angiopoietin-1 in breast cancer. Br J Cancer (2000) 1.24
Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase. J Biol Chem (2000) 1.24
Thioredoxin reductase. Characterization of a homogenous preparation from Escherichia coli B. J Biol Chem (1967) 1.24
Nucleotide sequences from the rabbit beta globin gene inserted into Escherichia coli plasmids. Science (1977) 1.21
Glutathione-dependent hydrogen donor system for calf thymus ribonucleoside-diphosphate reductase. Proc Natl Acad Sci U S A (1979) 1.21
Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies. Leukemia (2013) 1.20
Structural proteins of adenoviruses. IX. Molecular weight and subunit composition of adenovirus type 2 fiber. Virology (1973) 1.20
Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness. Proc Natl Acad Sci U S A (2001) 1.19
Correlation of amplification and overexpression of the c-myc oncogene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses. Br J Cancer (2004) 1.19
Reaction mechanism of ribonucleoside diphosphate reductase from Escherichia coli. Oxidation-reduction-active disulfides in the B1 subunit. J Biol Chem (1974) 1.19
Shear stress and the endothelium. Kidney Int Suppl (1998) 1.19
Nucleotide sequence of a portion of the Autographa californica nuclear polyhedrosis virus genome containing the EcoRI site-rich region (hr5) and an open reading frame just 5' of the p10 gene. J Gen Virol (1986) 1.18
Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. J Biol Chem (1999) 1.18
Simultaneous HLA Class I and Class II antibodies screening with flow cytometry. Hum Immunol (1998) 1.18
The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2. J Mol Biol (1996) 1.17
Elevated expression of M1 and M2 components and drug-induced posttranscriptional modulation of ribonucleotide reductase in a hydroxyurea-resistant mouse cell line. Biochemistry (1987) 1.17
Spectrum and iron content of protein B2 from ribonucleoside diphosphate reductase. Eur J Biochem (1969) 1.17
Simultaneous multiple-wavelength cw lasing in laser-diode-pumped composite rods of Nd:YAG and Nd:YLF. Appl Opt (1999) 1.16
Cell and process design for targeting of recombinant protein into the culture medium of Escherichia coli. Appl Microbiol Biotechnol (2002) 1.16
'Satisfaction with care': associations with health-related quality of life and psychosocial function among Swedish patients with endocrine gastrointestinal tumours. Eur J Cancer Care (Engl) (2002) 1.16
Magnetic interaction between the tyrosyl free radical and the antiferromagnetically coupled iron center in ribonucleotide reductase. Biochemistry (1987) 1.14
Physical activity level and its association with metabolic syndrome among an employed population in China. Obes Rev (2008) 1.14
Quality of care from a patient perspective--a grounded theory study. Scand J Caring Sci (1993) 1.13
2'-Deoxy-2'-azidocytidine, a new inhibitor of DNA replication in mammalian cells. Eur J Biochem (1977) 1.12
Induction of a new ribonucleotide reductase after infection of mouse L cells with pseudorabies virus. J Virol (1982) 1.11
Enzymatic synthesis of deoxyribonucleotides, 8. The effects of ATP and dATP in the CDP reductase system from E. coli. Proc Natl Acad Sci U S A (1965) 1.10
Evidence by site-directed mutagenesis supports long-range electron transfer in mouse ribonucleotide reductase. Biochemistry (1995) 1.09
An S-phase specific release from a transcriptional block regulates the expression of mouse ribonucleotide reductase R2 subunit. EMBO J (1992) 1.09
A polymorphic L1 retroposon insertion in the centromere of the human Y chromosome. Hum Mol Genet (2000) 1.08
The influence of amphetamine addiction on pregnancy and the newborn infant. Acta Paediatr Scand (1978) 1.07
Reduction and loss of the iron center in the reaction of the small subunit of mouse ribonucleotide reductase with hydroxyurea. Biochemistry (1993) 1.06