Published in J Exp Biol on April 01, 2000
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J (2001) 5.20
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci U S A (2002) 4.03
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Genes Dev (2001) 3.39
Lack of heme synthesis in a free-living eukaryote. Proc Natl Acad Sci U S A (2005) 1.95
Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am J Pathol (2003) 1.58
Phloem metabolism and function have to cope with low internal oxygen. Plant Physiol (2003) 1.53
Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis Res (2002) 1.52
Trafficking of heme and porphyrins in metazoa. Chem Rev (2009) 1.48
Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes. J Neuroinflammation (2007) 1.48
Molecular responses to hypoxia in tumor cells. Mol Cancer (2003) 1.43
Heme levels switch the function of Hap1 of Saccharomyces cerevisiae between transcriptional activator and transcriptional repressor. Mol Cell Biol (2007) 1.43
Gene induction during differentiation of human pulmonary type II cells in vitro. Am J Respir Cell Mol Biol (2006) 1.35
Oxygen-regulated isoforms of cytochrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling. Proc Natl Acad Sci U S A (2008) 1.33
Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J Biol Chem (2001) 1.26
The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers. Br J Cancer (2004) 1.26
Oxygen deficiency responsive gene expression in Chlamydomonas reinhardtii through a copper-sensing signal transduction pathway. Plant Physiol (2002) 1.19
Retracted Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion. J Biol Chem (2008) 1.15
The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. Mol Cell Biol (2002) 1.12
Upregulation of MiR-155 in nasopharyngeal carcinoma is partly driven by LMP1 and LMP2A and downregulates a negative prognostic marker JMJD1A. PLoS One (2011) 1.09
HIF-1alpha: a valid therapeutic target for tumor therapy. Cancer Res Treat (2004) 1.06
Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis. Arthritis Res Ther (2009) 1.06
Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis. Arthritis Res Ther (2005) 1.05
Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide. Cancer Res (2008) 1.02
Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus. Infect Immun (2010) 1.00
A neuroglobin-overexpressing transgenic mouse. Gene (2007) 0.99
Near infrared luminescent oxygen nanosensors with nanoparticle matrix tailored sensitivity. Anal Chem (2010) 0.99
HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. J Cell Biol (2009) 0.99
Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology. Respir Res (2002) 0.97
Antiangiogenic therapy in brain tumors. Expert Rev Neurother (2008) 0.95
JBP1 and JBP2 proteins are Fe2+/2-oxoglutarate-dependent dioxygenases regulating hydroxylation of thymidine residues in trypanosome DNA. J Biol Chem (2012) 0.93
Hypoxia in renal disease with proteinuria and/or glomerular hypertension. Am J Pathol (2004) 0.93
Retinoic acid receptor-related orphan receptor (ROR) alpha4 is the predominant isoform of the nuclear receptor RORalpha in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells. Biochem J (2002) 0.93
Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1alpha pathway. J Biol Chem (2011) 0.92
GLUT1 gene is a potential hypoxic marker in colorectal cancer patients. BMC Cancer (2009) 0.92
Variation in mitochondrial function in hypoxia-sensitive and hypoxia-tolerant human glioma cells. Br J Cancer (2002) 0.90
Atmospheric hypoxia limits selection for large body size in insects. PLoS One (2009) 0.90
The role of erythropoietin as an inhibitor of tissue ischemia. Int J Biol Sci (2008) 0.89
Double oxygen-sensing vector system for robust hypoxia/ischemia-regulated gene induction in cardiac muscle in vitro and in vivo. Mol Ther (2008) 0.89
Differential impact of EGFR-targeted therapies on hypoxia responses: implications for treatment sensitivity in triple-negative metastatic breast cancer. PLoS One (2011) 0.88
A novel heme-responsive element mediates transcriptional regulation in Caenorhabditis elegans. J Biol Chem (2010) 0.88
Mitochondria-controlled signaling mechanisms of brain protection in hypoxia. Front Neurosci (2015) 0.88
Skeletal muscle HIF-1alpha expression is dependent on muscle fiber type. J Gen Physiol (2005) 0.87
Production and upregulation of granulocyte chemotactic protein-2/CXCL6 by IL-1beta and hypoxia in small cell lung cancer. Br J Cancer (2006) 0.87
Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α. Mol Vis (2012) 0.85
Fibrinogen stimulates in vitro angiogenesis by choroidal endothelial cells via autocrine VEGF. Graefes Arch Clin Exp Ophthalmol (2004) 0.85
Strategies for hypoxia adaptation in fish species: a review. J Comp Physiol B (2013) 0.83
Hypoxia and oxidative stress markers in pediatric patients undergoing hemodialysis: cross section study. BMC Nephrol (2012) 0.82
Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum. J Cell Mol Med (2009) 0.82
Ameliorating effect of vitamin E on in vitro development of preimplantation buffalo embryos. J Assist Reprod Genet (2009) 0.82
Does expression of glucose transporter protein-1 relate to prognosis and angiogenesis in osteosarcoma? Clin Orthop Relat Res (2014) 0.81
Hypoxia and hypoxia mimetics decrease aquaporin 5 (AQP5) expression through both hypoxia inducible factor-1α and proteasome-mediated pathways. PLoS One (2013) 0.81
Granulocyte colony-stimulating factor activating HIF-1alpha acts synergistically with erythropoietin to promote tissue plasticity. PLoS One (2010) 0.81
Effects of seasonal and latitudinal cold on oxidative stress parameters and activation of hypoxia inducible factor (HIF-1) in zoarcid fish. J Comp Physiol B (2007) 0.81
Early sustained injections of erythropoietin improve angiogenesis and restoration of perfusion in the ischemic mouse hindlimb. J Korean Med Sci (2012) 0.81
Acute anemia elicits cognitive dysfunction and evidence of cerebral cellular hypoxia in older rats with systemic hypertension. Anesthesiology (2010) 0.80
Genomic approaches in the identification of hypoxia biomarkers in model fish species. J Exp Mar Bio Ecol (2009) 0.80
Anoxia- and hypoxia-induced expression of LDH-A* in the Amazon Oscar, Astronotus crassipinis. Genet Mol Biol (2011) 0.80
The proteome of Hypobaric Induced Hypoxic Lung: Insights from Temporal Proteomic Profiling for Biomarker Discovery. Sci Rep (2015) 0.79
The impact of high co-expression of Sp1 and HIF1α on prognosis of patients with hepatocellular cancer. Oncol Lett (2016) 0.78
Hyperglycemia-enhanced ischemic brain damage in mutant manganese SOD mice is associated with suppression of HIF-1alpha. Neurosci Lett (2009) 0.78
Expression profiling reveals novel hypoxic biomarkers in peripheral blood of adult mice exposed to chronic hypoxia. PLoS One (2012) 0.77
Toxicological Assessment of CoO and La2O3 Metal Oxide Nanoparticles in Human Small Airway Epithelial Cells. Toxicol Sci (2016) 0.77
Muscle fiber specific antioxidative system adaptation to swim training in rats: influence of intermittent hypoxia. J Sports Sci Med (2005) 0.77
Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart. J Cardiovasc Transl Res (2008) 0.77
Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1α with CREB-binding protein. Diabetes (2012) 0.77
Melatonin, mitochondria, and the cancer cell. Cell Mol Life Sci (2017) 0.75
Evaluating the Hypoxia Response of Ruffe and Flounder Gills by a Combined Proteome and Transcriptome Approach. PLoS One (2015) 0.75
Myeloid cell leukemia-1 (Mc1-1) is a candidate target gene of hypoxia-inducible factor-1 (HIF-1) in the testis. Reprod Biol Endocrinol (2012) 0.75
Effects of oxygen tension and IGF-I on HIF-1α protein expression in mouse blastocysts. J Assist Reprod Genet (2012) 0.75
The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth. Hypoxia (Auckl) (2016) 0.75
Simulation predicts IGFBP2-HIF1α interaction drives glioblastoma growth. PLoS Comput Biol (2015) 0.75
Hypoxia-Inducible Factor-1α Mediates Increased Sympathoexcitation via Glutamatergic N-Methyl-d-Aspartate Receptors in the Paraventricular Nucleus of Rats With Chronic Heart Failure. Circ Heart Fail (2016) 0.75
Selection of the in vitro culture media influences mRNA expression of Hedgehog genes, Il-6, and important genes regarding reactive oxygen species in single murine preimplantation embryos. ScientificWorldJournal (2012) 0.75
TRP channels as sensors of oxygen availability. Pflugers Arch (2013) 0.75
Effect of Hypoxia on Ldh-c Expression in Somatic Cells of Plateau Pika. Int J Environ Res Public Health (2016) 0.75
A comparison of whole-body vibration and resistance training on total work in the rotator cuff. J Athl Train (2009) 0.75
Dynamic mRNA and miRNA expression analysis in response to hypoxia and reoxygenation in the blunt snout bream (Megalobrama amblycephala). Sci Rep (2017) 0.75
Hypoxia Downregulates MAPK/ERK but Not STAT3 Signaling in ROS-Dependent and HIF-1-Independent Manners in Mouse Embryonic Stem Cells. Oxid Med Cell Longev (2017) 0.75
Cardioprotective Effect of Crocin Combined with Voluntary Exercise in Rat: Role of Mir-126 and Mir-210 in Heart Angiogenesis. Arq Bras Cardiol (2017) 0.75
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun (2017) 0.75