Published in Nat Genet on April 01, 2000
Experimental determination and system level analysis of essential genes in Escherichia coli MG1655. J Bacteriol (2003) 7.32
Reverse engineering gene networks using singular value decomposition and robust regression. Proc Natl Acad Sci U S A (2002) 5.29
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46
Waddington's canalization revisited: developmental stability and evolution. Proc Natl Acad Sci U S A (2002) 4.01
Degeneracy and complexity in biological systems. Proc Natl Acad Sci U S A (2001) 3.81
Combining biological networks to predict genetic interactions. Proc Natl Acad Sci U S A (2004) 3.18
Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast. Genome Biol (2005) 2.68
Metabolic functions of duplicate genes in Saccharomyces cerevisiae. Genome Res (2005) 2.68
Redundancy, antiredundancy, and the robustness of genomes. Proc Natl Acad Sci U S A (2002) 2.42
Plasticity of genetic interactions in metabolic networks of yeast. Proc Natl Acad Sci U S A (2007) 2.40
Functional overlap and regulatory links shape genetic interactions between signaling pathways. Cell (2010) 2.29
Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans. J Clin Invest (2008) 2.08
Robustness--it's not where you think it is. Nat Genet (2000) 2.06
The new mutation theory of phenotypic evolution. Proc Natl Acad Sci U S A (2007) 1.97
Functional analysis of gene duplications in Saccharomyces cerevisiae. Genetics (2006) 1.96
Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans. Proc Biol Sci (2004) 1.94
Buffering of crucial functions by paleologous duplicated genes may contribute cyclicality to angiosperm genome duplication. Proc Natl Acad Sci U S A (2006) 1.87
Influence of metabolic network structure and function on enzyme evolution. Genome Biol (2006) 1.79
Decoupled evolution of coding region and mRNA expression patterns after gene duplication: implications for the neutralist-selectionist debate. Proc Natl Acad Sci U S A (2000) 1.77
Evolution of complex modular biological networks. PLoS Comput Biol (2008) 1.76
The evolution of recombination in a heterogeneous environment. Genetics (2000) 1.72
Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. Mol Syst Biol (2007) 1.67
Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background. Aging Cell (2003) 1.64
The regulatory utilization of genetic redundancy through responsive backup circuits. Proc Natl Acad Sci U S A (2006) 1.61
fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Genes Dev (2002) 1.60
Hsp90 selectively modulates phenotype in vertebrate development. PLoS Genet (2007) 1.60
Direct evolution of genetic robustness in microRNA. Proc Natl Acad Sci U S A (2006) 1.59
Molecular evolution in large genetic networks: does connectivity equal constraint? J Mol Evol (2004) 1.55
Contribution of individual random mutations to genotype-by-environment interactions in Escherichia coli. Proc Natl Acad Sci U S A (2001) 1.54
Evolution of robustness to noise and mutation in gene expression dynamics. PLoS One (2007) 1.51
Hap4p overexpression in glucose-grown Saccharomyces cerevisiae induces cells to enter a novel metabolic state. Genome Biol (2002) 1.49
Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster. Genetics (2005) 1.45
In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays. Nat Methods (2010) 1.34
Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions. Genome Biol (2005) 1.33
Speciation genetics: current status and evolving approaches. Philos Trans R Soc Lond B Biol Sci (2010) 1.28
Widespread correlations between dominance and homozygous effects of mutations: implications for theories of dominance. Genetics (2005) 1.28
The regulatory code for transcriptional response diversity and its relation to genome structural properties in A. thaliana. PLoS Genet (2006) 1.28
Multiple formaldehyde oxidation/detoxification pathways in Burkholderia fungorum LB400. J Bacteriol (2004) 1.25
GenomeHistory: a software tool and its application to fully sequenced genomes. Nucleic Acids Res (2002) 1.25
Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biol (2010) 1.24
Expression profiles reveal parallel evolution of epistatic interactions involving the CRP regulon in Escherichia coli. PLoS Genet (2008) 1.23
Systems-biology approaches for predicting genomic evolution. Nat Rev Genet (2011) 1.23
Small-scale copy number variation and large-scale changes in gene expression. Proc Natl Acad Sci U S A (2008) 1.20
Protein networks, pleiotropy and the evolution of senescence. Proc Biol Sci (2004) 1.20
Variable selection for large p small n regression models with incomplete data: mapping QTL with epistases. BMC Bioinformatics (2008) 1.18
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO J (2000) 1.18
Evolution of complexity in signaling pathways. Proc Natl Acad Sci U S A (2006) 1.14
A network perspective on metabolism and aging. Integr Comp Biol (2010) 1.10
Population genetic models of duplicated genes. Genetica (2009) 1.09
Information processing in the transcriptional regulatory network of yeast: functional robustness. BMC Syst Biol (2009) 1.08
Substitution as a mechanism for genetic robustness: the duplicated deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae. PLoS Genet (2007) 1.08
Similarly strong purifying selection acts on human disease genes of all evolutionary ages. Genome Biol Evol (2009) 1.07
Lessons from model organisms: phenotypic robustness and missing heritability in complex disease. PLoS Genet (2012) 1.06
Role of duplicate genes in robustness against deleterious human mutations. PLoS Genet (2008) 1.06
A framework for evolutionary systems biology. BMC Syst Biol (2009) 1.05
Mutator suppression and escape from replication error-induced extinction in yeast. PLoS Genet (2011) 1.05
'Glocal' robustness analysis and model discrimination for circadian oscillators. PLoS Comput Biol (2009) 1.05
Genetics and geometry of canalization and developmental stability in Drosophila subobscura. BMC Evol Biol (2005) 1.03
Eukaryotic genes of archaebacterial origin are more important than the more numerous eubacterial genes, irrespective of function. Proc Natl Acad Sci U S A (2010) 1.03
Synergistic fitness interactions and a high frequency of beneficial changes among mutations accumulated under relaxed selection in Saccharomyces cerevisiae. Genetics (2008) 1.01
The cellular robustness by genetic redundancy in budding yeast. PLoS Genet (2010) 1.00
Evolutionary models for formation of network motifs and modularity in the Saccharomyces transcription factor network. PLoS Comput Biol (2007) 1.00
Decoupling Environment-Dependent and Independent Genetic Robustness across Bacterial Species. PLoS Comput Biol (2010) 0.99
Transcriptional compensation for gene loss plays a minor role in maintaining genetic robustness in Saccharomyces cerevisiae. Genetics (2005) 0.98
How selection affects phenotypic fluctuation. Mol Syst Biol (2009) 0.98
Molecular networks in drug discovery. Crit Rev Biomed Eng (2010) 0.98
A critical view of metabolic network adaptations. HFSP J (2008) 0.98
Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana. Mol Biol Evol (2010) 0.97
The degree of redundancy in metabolic genes is linked to mode of metabolism. Biophys J (2007) 0.96
Epigenetic epistatic interactions constrain the evolution of gene expression. Mol Syst Biol (2013) 0.96
DNA replication error-induced extinction of diploid yeast. Genetics (2014) 0.95
Evolution under fluctuating environments explains observed robustness in metabolic networks. PLoS Comput Biol (2010) 0.95
Genetics, individuality, and medicine in the 21st century. Am J Hum Genet (2004) 0.94
Systematic identification of novel, essential host genes affecting bromovirus RNA replication. PLoS One (2011) 0.90
Protein interaction networks in plants. Planta (2006) 0.89
Extensive phenotypic variation in early flowering mutants of Arabidopsis. Plant Physiol (2004) 0.89
Proportionality between variances in gene expression induced by noise and mutation: consequence of evolutionary robustness. BMC Evol Biol (2011) 0.89
Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation. BMC Genomics (2008) 0.89
Genetic robustness and functional evolution of gene duplicates. Nucleic Acids Res (2013) 0.86
Phenotypic and transcriptional plasticity directed by a yeast mitogen-activated protein kinase network. Genetics (2003) 0.86
Tissue culture-induced heritable genomic variation in rice, and their phenotypic implications. PLoS One (2014) 0.86
Preservation of genetic and regulatory robustness in ancient gene duplicates of Saccharomyces cerevisiae. Genome Res (2014) 0.86
GPCR genes are preferentially retained after whole genome duplication. PLoS One (2008) 0.85
Dissection of genetic pathways in C. elegans. Methods Cell Biol (2011) 0.84
Mutational robustness of gene regulatory networks. PLoS One (2012) 0.84
Transcriptional reprogramming and backup between duplicate genes: is it a genomewide phenomenon? Genetics (2005) 0.84
Protein complexity, gene duplicability and gene dispensability in the yeast genome. Gene (2006) 0.84
Parasites lead to evolution of robustness against gene loss in host signaling networks. Mol Syst Biol (2008) 0.82
A network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidis. Mol Microbiol (2012) 0.80
Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns. Neuropharmacology (2015) 0.79
Widespread divergence of the CEACAM/PSG genes in vertebrates and humans suggests sensitivity to selection. PLoS One (2013) 0.79
Mechanisms of mutational robustness in transcriptional regulation. Front Genet (2015) 0.79
The evolution of developmental patterning under genetic duplication constraints. J R Soc Interface (2008) 0.79
Enzyme isoforms may increase phenotypic robustness. Evolution (2008) 0.78
The Phenotypic Plasticity of Duplicated Genes in Saccharomyces cerevisiae and the Origin of Adaptations. G3 (Bethesda) (2016) 0.77
Quasi-species evolution in subdivided populations favours maximally deleterious mutations. Proc Biol Sci (2007) 0.77
Congruent evolution of fitness and genetic robustness in vesicular stomatitis virus. J Virol (2013) 0.77
Yeast Interspecies Comparative Proteomics Reveals Divergence in Expression Profiles and Provides Insights into Proteome Resource Allocation and Evolutionary Roles of Gene Duplication. Mol Cell Proteomics (2015) 0.76
Robustness and Specificity in Signal Transduction via Physiologic Protein Interaction Networks. Clin Exp Pharmacol (2012) 0.76
Growth condition dependency is the major cause of non-responsiveness upon genetic perturbation. PLoS One (2017) 0.75