Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.

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Published in Curr Biol on March 23, 2000

Authors

A L Rozelle1, L M Machesky, M Yamamoto, M H Driessens, R H Insall, M G Roth, K Luby-Phelps, G Marriott, A Hall, H L Yin

Author Affiliations

1: Departments of Physiology and Biochemistry, University of Texas Southwestern Medical Center, Dallas 75390, USA.

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure (1999) 3.04

The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C. Science (1990) 3.02

Dynamic fatty acylation of p21N-ras. EMBO J (1987) 2.99

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Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells. J Cell Biol (1995) 2.90

Attendance of general practitioners at child protection case conferences. BMJ (1991) 2.90

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Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblasts. J Cell Biol (1989) 2.75

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Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J Cell Biol (2001) 2.74

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Ca2+ control of actin gelation. Interaction of gelsolin with actin filaments and regulation of actin gelation. J Biol Chem (1980) 2.73

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Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin. Am J Respir Crit Care Med (1998) 2.69

Negative control for the initiation of meiosis in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1985) 2.69

Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome. J Pediatr (1975) 2.66

Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons. Neuron (1988) 2.66

The oral examination: a study of academic and non-academic factors. Med Educ (1993) 2.65

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Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles. J Cell Biol (1996) 2.60

Mutations in the cytoplasmic domain of the influenza virus hemagglutinin affect different stages of intracellular transport. J Cell Biol (1985) 2.60

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