Published in J Cell Biol on June 16, 1997
Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J Cell Biol (1999) 6.01
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell (2001) 5.84
Regulation of cadherin adhesive activity. J Cell Biol (2000) 5.63
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol (1998) 4.91
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol (1997) 4.27
A novel role for p120 catenin in E-cadherin function. J Cell Biol (2002) 4.01
Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J Cell Biol (2007) 3.76
p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol (2000) 3.60
Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev Cell (2002) 3.60
Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts. Mol Biol Cell (2005) 3.43
The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest (2002) 3.23
Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42. J Cell Biol (2004) 3.06
Regulation of cell-cell adhesion by the cadherin-catenin complex. Biochem Soc Trans (2008) 2.91
Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly. Mol Biol Cell (1998) 2.71
Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling. J Cell Biol (2011) 2.67
Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton. Philos Trans R Soc Lond B Biol Sci (2000) 2.62
Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J Cell Biol (1998) 2.60
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer (2002) 2.38
Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition. J Cell Biol (2000) 2.38
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nat Cell Biol (2012) 2.23
Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells. Mol Biol Cell (2006) 2.22
DE-Cadherin is required for intercellular motility during Drosophila oogenesis. J Cell Biol (1999) 2.18
The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J Cell Biol (2002) 2.14
Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells. Mol Biol Cell (1997) 2.08
Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J Cell Biol (2004) 2.02
VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol Biol Cell (2002) 1.97
Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context. Mol Biol Cell (1999) 1.94
Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. Proc Natl Acad Sci U S A (2009) 1.91
Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase. J Cell Biol (1998) 1.85
Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton. J Cell Biol (2002) 1.84
Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion. J Cell Biol (1998) 1.84
RhoE regulates actin cytoskeleton organization and cell migration. Mol Cell Biol (1998) 1.80
Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions. Mol Biol Cell (2000) 1.79
Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes. Mol Biol Cell (2000) 1.79
Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression. J Biol Chem (2010) 1.79
Molecular bases of cell-cell junctions stability and dynamics. Cold Spring Harb Perspect Biol (2009) 1.78
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell (2000) 1.76
RAC1 regulates adherens junctions through endocytosis of E-cadherin. Mol Biol Cell (2001) 1.76
Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. Nat Cell Biol (2011) 1.75
ARF6 is required for growth factor- and rac-mediated membrane ruffling in macrophages at a stage distal to rac membrane targeting. Mol Cell Biol (1999) 1.73
Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes. Mol Cell Biol (1998) 1.69
Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation. Mol Biol Cell (2003) 1.67
RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs. Mol Biol Cell (1998) 1.66
Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. J Cell Biol (1999) 1.64
Feedback interactions between cell-cell adherens junctions and cytoskeletal dynamics in newt lung epithelial cells. Mol Biol Cell (2000) 1.58
Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis. Mol Cell Biol (2006) 1.58
Myofibroblast development is characterized by specific cell-cell adherens junctions. Mol Biol Cell (2004) 1.56
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol (2004) 1.56
Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1. Mol Cell Biol (2000) 1.55
Immediate-early signaling induced by E-cadherin engagement and adhesion. J Biol Chem (2007) 1.54
The desmosome and pemphigus. Histochem Cell Biol (2008) 1.54
Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol (2012) 1.53
Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol (2007) 1.53
Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion. J Cell Biol (2002) 1.48
Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway. Mol Cell Biol (2000) 1.47
Inhibition of Rho A activity causes pemphigus skin blistering. J Cell Biol (2006) 1.45
Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Proc Natl Acad Sci U S A (2001) 1.43
The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing. J Exp Med (1998) 1.43
Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell (2003) 1.39
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell (2011) 1.39
Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Mol Biol Cell (2004) 1.39
Critical activities of Rac1 and Cdc42Hs in skeletal myogenesis: antagonistic effects of JNK and p38 pathways. Mol Biol Cell (2000) 1.39
The diverse roles of Rac signaling in tumorigenesis. Cell Cycle (2011) 1.38
Infection of primary human bronchial epithelial cells by Haemophilus influenzae: macropinocytosis as a mechanism of airway epithelial cell entry. Infect Immun (1999) 1.36
Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med (2007) 1.36
The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression. Cell Adh Migr (2012) 1.34
Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility. Mol Biol Cell (2004) 1.33
TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis. Genes Dev (2007) 1.32
The IL-1 receptor and Rho directly associate to drive cell activation in inflammation. J Clin Invest (1999) 1.30
Rab5 induces Rac-independent lamellipodia formation and cell migration. Mol Biol Cell (1999) 1.28
The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts. Mol Biol Cell (2000) 1.26
H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes. J Cell Biol (1999) 1.26
The tumor-suppressor function of E-cadherin. Am J Hum Genet (1998) 1.25
Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells. Mol Biol Cell (1998) 1.25
From mechanical force to RhoA activation. Biochemistry (2012) 1.23
Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration. J Thromb Haemost (2008) 1.23
Cellular interaction of integrin alpha3beta1 with laminin 5 promotes gap junctional communication. J Cell Biol (1998) 1.22
A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens. Mol Biol Cell (2012) 1.22
Cadherins in collective cell migration of mesenchymal cells. Curr Opin Cell Biol (2012) 1.22
Regulation of Cdc42-mediated morphological effects: a novel function for p53. EMBO J (2002) 1.21
Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG. J Cell Biol (2004) 1.20
Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scattering. Mol Cell Biol (2001) 1.18
Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases. Cold Spring Harb Perspect Biol (2009) 1.17
Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells. Infect Immun (1998) 1.17
Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1. J Cell Biochem (2009) 1.14
Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B. Mol Biol Cell (2010) 1.14
Epithelial cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa. Mol Biol Cell (2003) 1.14
Inactivation of nuclear Wnt-beta-catenin signaling limits blastocyst competency for implantation. Development (2008) 1.14
Deregulated activation of matriptase in breast cancer cells. Clin Exp Metastasis (2002) 1.12
The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium. Int Rev Cell Mol Biol (2011) 1.12
VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx. J Cell Biol (2012) 1.11
A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells. Neural Dev (2008) 1.10
Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epithelia. J Cell Biol (2009) 1.10
The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility. Mol Biol Cell (2006) 1.10
Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes. Am J Pathol (2009) 1.09
Follicular thyroid tumors with the PAX8-PPARgamma1 rearrangement display characteristic genetic alterations. Am J Pathol (2005) 1.09
Escherichia coli cytotoxic necrotizing factor 1 effaces microvilli and decreases transmigration of polymorphonuclear leukocytes in intestinal T84 epithelial cell monolayers. Infect Immun (1998) 1.09
Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin. Mol Biol Cell (2011) 1.08
Ajuba is required for Rac activation and maintenance of E-cadherin adhesion. J Cell Biol (2011) 1.08
The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol Cell Biol (2010) 1.08
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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell (1992) 28.36
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell (1995) 24.99
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88
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A repeating amino acid motif shared by proteins with diverse cellular roles. Cell (1994) 4.56
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BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients. Br J Cancer (2011) 1.86
Dictyostelium RasG is required for normal motility and cytokinesis, but not growth. J Cell Biol (1997) 1.86
The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators. Curr Biol (2000) 1.86
Rac mediates growth factor-induced arachidonic acid release. Cell (1995) 1.83
Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction. Mol Biol Cell (1999) 1.76
RAC1 regulates adherens junctions through endocytosis of E-cadherin. Mol Biol Cell (2001) 1.76
A novel role for RhoGDI as an inhibitor of GAP proteins. EMBO J (1993) 1.74
Structural requirements and thermodynamics of the interaction of proline peptides with profilin. Biochemistry (1996) 1.72
A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J (1998) 1.72
Regulation and function of the Rho subfamily of small GTPases. Curr Opin Genet Dev (1994) 1.71
Evidence for an association between hookworm infection and cognitive function in Indonesian school children. Trop Med Int Health (1999) 1.71
p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. J Biol Chem (1995) 1.70
Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin. J Cell Biol (2001) 1.68
Hepatitis B vaccination policy in drug treatment services. BMJ (1995) 1.68