Published in J Biol Chem on May 19, 2000
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol (2005) 4.53
Functional analysis of the RING-type ubiquitin ligase family of Arabidopsis. Plant Physiol (2005) 3.01
Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail. Proc Natl Acad Sci U S A (2008) 1.92
CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Proc Natl Acad Sci U S A (2002) 1.89
Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. J Virol (2005) 1.42
ROC1/RBX1 E3 ubiquitin ligase silencing suppresses tumor cell growth via sequential induction of G2-M arrest, apoptosis, and senescence. Cancer Res (2009) 1.27
Proximity-induced activation of human Cdc34 through heterologous dimerization. Proc Natl Acad Sci U S A (2005) 1.19
Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains. Mol Cell Biol (2007) 1.15
The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. Br J Cancer (2003) 1.14
Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer Targets. Genes Cancer (2010) 1.09
RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. J Biol Chem (2010) 0.99
COPing with hypoxia. Semin Cell Dev Biol (2005) 0.96
Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells. Cell Death Differ (2012) 0.95
Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping. PLoS One (2008) 0.90
Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases. Cell Res (2013) 0.87
Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization. Clin Cancer Res (2013) 0.81
Control of rapsyn stability by the CUL-3-containing E3 ligase complex. J Biol Chem (2009) 0.80
SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. Oncotarget (2014) 0.80
OsCUL3a Negatively Regulates Cell Death and Immunity by Degrading OsNPR1 in Rice. Plant Cell (2017) 0.77
Induction of cell senescence by targeting to Cullin-RING Ligases (CRLs) for effective cancer therapy. Int J Biochem Mol Biol (2012) 0.75
Identification of ubiquitin ligases required for skeletal muscle atrophy. Science (2001) 12.98
Saturated molecular map of the rice genome based on an interspecific backcross population. Genetics (1994) 6.22
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Seasonal and spatial variability of bacterial and archaeal assemblages in the coastal waters near Anvers Island, Antarctica. Appl Environ Microbiol (1998) 4.85
The GA5 locus of Arabidopsis thaliana encodes a multifunctional gibberellin 20-oxidase: molecular cloning and functional expression. Proc Natl Acad Sci U S A (1995) 4.80
Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease. Gut (1989) 4.59
Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell (1988) 4.47
Regulation of JNK signaling by GSTp. EMBO J (1999) 4.06
Visual acuity and quality of life in patients with cataract in Doumen County, China. Ophthalmology (1999) 3.82
Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med (1992) 3.77
A novel europium(III)-based MRI contrast agent. J Am Chem Soc (2001) 3.71
Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. Mol Cell (1999) 3.58
Complications of cholecystectomy: risks of the laparoscopic approach and protective effects of operative cholangiography: a population-based study. Ann Surg (1999) 3.45
"Fluorescent timer": protein that changes color with time. Science (2000) 3.42
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc Natl Acad Sci U S A (1994) 3.03
Phenotypic analysis of genes encoding yeast zinc cluster proteins. Nucleic Acids Res (2001) 2.87
Variation in breast cancer surgery in Ontario. CMAJ (1994) 2.70
Studies on the activator 1 protein complex, an accessory factor for proliferating cell nuclear antigen-dependent DNA polymerase delta. J Biol Chem (1991) 2.70
Phyllosilicates on Mars and implications for early martian climate. Nature (2005) 2.66
Synthesis of DNA by DNA polymerase epsilon in vitro. J Biol Chem (1991) 2.60
Immediate and late clinical outcomes of carotid artery stenting in patients with symptomatic and asymptomatic carotid artery stenosis: a 5-year prospective analysis. Circulation (2001) 2.60
Prospective evaluation of patients refused admission to an intensive care unit: triage, futility and outcome. Intensive Care Med (2001) 2.59
Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization. J Biol Chem (2000) 2.53
Tumor therapy with targeted atomic nanogenerators. Science (2001) 2.48
The fall and rise of carotid endarterectomy in the United States and Canada. N Engl J Med (1998) 2.48
What influences medical students' choice of surgical careers. Surgery (2000) 2.47
Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children. Aliment Pharmacol Ther (2014) 2.37
MicroRNA dysregulation in gastric cancer: a new player enters the game. Oncogene (2010) 2.23
A survey of blindness and cataract surgery in Doumen County, China. Ophthalmology (1999) 2.15
Retracted SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53. Cell (2000) 2.12
Measurement of de novo hepatic lipogenesis in humans using stable isotopes. J Clin Invest (1991) 2.11
Clamp loading, unloading and intrinsic stability of the PCNA, beta and gp45 sliding clamps of human, E. coli and T4 replicases. Genes Cells (1996) 2.09
HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. Oncogene (1999) 2.05
The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. J Mol Biol (2001) 2.05
Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor. Mol Cell (2000) 2.02
Interleukin 2 receptor expression by macrophages in inflammatory bowel disease. Clin Exp Immunol (1988) 1.95
Measuring Friedreich ataxia: Interrater reliability of a neurologic rating scale. Neurology (2005) 1.79
Donor-specific HLA antibodies in a cohort comparing everolimus with cyclosporine after kidney transplantation. Am J Transplant (2012) 1.78
MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene (2012) 1.74
Childhood sexual abuse and sexual transmission risk behaviour among HIV-positive men who have sex with men. AIDS Care (2003) 1.73
Cerebellar leukoencephalopathy: most likely histiocytosis-related. Neurology (2008) 1.73
1H and (17)O NMR detection of a lanthanide-bound water molecule at ambient temperatures in pure water as solvent. Inorg Chem (2001) 1.70
The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo. Genetics (1995) 1.70
The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation. Mol Cell Biol (2000) 1.67
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67
Close vaginal margins as a prognostic factor after radical hysterectomy. Gynecol Oncol (1998) 1.65
Chromosomal mapping of human creatine kinase (brain type) using human-rodent somatic cell hybrids. Cytogenet Cell Genet (1980) 1.63
Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants. J Biol Chem (1999) 1.62
Interleukin-1-induced anorexia in the rat. Influence of prostaglandins. J Clin Invest (1989) 1.61
Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites. Cell (1987) 1.57
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
Estimation of renal cell carcinoma treatment effects from disease progression modeling. Clin Pharmacol Ther (2012) 1.55
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol (2001) 1.54
Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells. Proc Natl Acad Sci U S A (1992) 1.53
BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Brain Res Mol Brain Res (1998) 1.53
Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients. Ann Oncol (2005) 1.51
Conformation-dependent phosphorylation of p53. Proc Natl Acad Sci U S A (1997) 1.49
Celecoxib reduces microvessel density in patients treated with nasopharyngeal carcinoma and induces changes in gene expression. Ann Oncol (2006) 1.48
Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1. Proc Natl Acad Sci U S A (1997) 1.47
Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol. Cell (2001) 1.45
Serum amylase as a measure of salivary gland radiation damage. Hyperamylasaemia following fractionated exposure to 4 MV X rays delivered in high pressure oxygen, and effects of certain steroids on this response. Br J Radiol (1969) 1.45
Osteopontin levels are elevated in patients with asthma. J Int Med Res (2011) 1.45
Meta-analysis: effect of preoperative infliximab use on early postoperative complications in patients with ulcerative colitis undergoing abdominal surgery. Aliment Pharmacol Ther (2012) 1.45
Impaired immune responses and altered peptide repertoire in tapasin-deficient mice. Nat Immunol (2000) 1.44
Homeotic transformation of cervical vertebrae in Hoxa-4 mutant mice. Proc Natl Acad Sci U S A (1994) 1.43
Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro. J Biol Chem (1997) 1.43
EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway. Oncogene (2011) 1.42
Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen. Proc Natl Acad Sci U S A (1998) 1.41
Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer. Br J Cancer (2009) 1.41
Randomized trial of high-dose chemotherapy with autologous bone marrow support as adjuvant therapy for high-risk, multi-node-positive malignant melanoma. J Natl Cancer Inst (1993) 1.40
The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity. Cancer Epidemiol Biomarkers Prev (1997) 1.38
Haemophagocytosis in bone marrow aspirate--a review of the clinical course of 10 cases. Acta Haematol (1995) 1.37
In situ spatial patterns of soil bacterial populations, mapped at multiple scales, in an arable soil. Microb Ecol (2002) 1.36
Gender recognition from speech. Part II: Fine analysis. J Acoust Soc Am (1991) 1.35
The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination. Mol Cell (1999) 1.35
Introgression of a quantitative trait locus for yield from Glycine soja into commercial soybean cultivars. Theor Appl Genet (2002) 1.34
p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol Cell Biol (1997) 1.31
Short-term intraindividual variability in hemostasis factors. The ARIC Study. Atherosclerosis Risk in Communities Intraindividual Variability Study. Ann Epidemiol (1992) 1.30
Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. Proc Natl Acad Sci U S A (1996) 1.29
Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells. Proc Natl Acad Sci U S A (1992) 1.29
Systematically missing confounders in individual participant data meta-analysis of observational cohort studies. Stat Med (2009) 1.27
Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1. Hum Mol Genet (2000) 1.27
Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax. J Exp Clin Cancer Res (2007) 1.27
Influence of chronic angiotensin-converting enzyme inhibition on anesthetic induction. Anesthesiology (1994) 1.26
The carcinogenicity of environmental tobacco smoke. Carcinogenesis (1997) 1.26
Inhibition by brefeldin A of protein secretion from the apical cell surface of Madin-Darby canine kidney cells. J Biol Chem (1991) 1.25
Thrombotic risk factors in Chinese Budd-Chiari syndrome patients. An observational study with a systematic review of the literature. Thromb Haemost (2013) 1.25
Increased de novo hepatic lipogenesis in human immunodeficiency virus infection. J Clin Endocrinol Metab (1993) 1.24
Regulation of starch accumulation by granule-associated plant 14-3-3 proteins. Proc Natl Acad Sci U S A (2001) 1.24
L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro. J Immunol (1996) 1.24
Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7 TeV. Phys Rev Lett (2012) 1.23
Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies. Mol Cell Biol (2000) 1.20