Why cytoplasmic signalling proteins should be recruited to cell membranes.

PubWeight™: 2.03‹?› | Rank: Top 2%

🔗 View Article (PMID 10754559)

Published in Trends Cell Biol on May 01, 2000

Authors

B N Kholodenko1, J B Hoek, H V Westerhoff

Author Affiliations

1: Dept of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. boris.kholodenko@mail.tju.edu

Articles citing this

Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol (2006) 7.25

Cholesterol, lipid rafts, and disease. J Clin Invest (2002) 4.05

Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses. Mol Syst Biol (2007) 2.56

Subcellular targeting strategies for drug design and delivery. Nat Rev Drug Discov (2010) 2.04

Molecular mechanisms in signal transduction at the membrane. Nat Struct Mol Biol (2010) 1.86

Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. Mol Syst Biol (2009) 1.77

Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops. J Biol Chem (2006) 1.75

The extracellular regulation of bone morphogenetic protein signaling. Development (2009) 1.69

Annexins in cell membrane dynamics. Ca(2+)-regulated association of lipid microdomains. J Cell Biol (2000) 1.67

Structural basis for the recognition of c-Src by its inactivator Csk. Cell (2008) 1.66

Diffusion control of protein phosphorylation in signal transduction pathways. Biochem J (2000) 1.66

Fluorescence correlation spectroscopy studies of Peptide and protein binding to phospholipid vesicles. Biophys J (2004) 1.47

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling. Cell Commun Signal (2013) 1.36

Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation. J Cell Biol (2002) 1.27

Organism-scale modeling of early Drosophila patterning via bone morphogenetic proteins. Dev Cell (2010) 1.22

The dynamic control of signal transduction networks in cancer cells. Nat Rev Cancer (2015) 1.09

Identification of novel membrane-binding domains in multiple yeast Cdc42 effectors. Mol Biol Cell (2007) 1.07

Four-dimensional dynamics of MAPK information processing systems. Wiley Interdiscip Rev Syst Biol Med (2010) 1.06

Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly. Biochem J (2006) 1.04

Determination of the two-dimensional interaction rate constants of a cytokine receptor complex. Biophys J (2006) 1.04

Bidirectional control of the inner dynamics of focal adhesions promotes cell migration. Cell Adh Migr (2009) 1.00

Impact of receptor clustering on ligand binding. BMC Syst Biol (2011) 0.99

Mathematical model of a cell size checkpoint. PLoS Comput Biol (2010) 0.97

A unified model for signal transduction reactions in cellular membranes. Biophys J (2002) 0.96

Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction. PLoS Comput Biol (2005) 0.95

Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle. FEBS J (2009) 0.95

The BglF sensor recruits the BglG transcription regulator to the membrane and releases it on stimulation. Proc Natl Acad Sci U S A (2003) 0.94

Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification. PLoS Genet (2013) 0.94

High-throughput analysis of peptide-binding modules. Proteomics (2012) 0.93

An adaptor domain-mediated autocatalytic interfacial kinase reaction. Chemistry (2009) 0.91

Molecular dynamics simulations reveal that Tyr-317 phosphorylation reduces Shc binding affinity for phosphotyrosyl residues of epidermal growth factor receptor. Biophys J (2009) 0.89

Spatial regulation and the rate of signal transduction activation. PLoS Comput Biol (2006) 0.88

The tyrosine kinase Csk dimerizes through Its SH3 domain. PLoS One (2009) 0.88

Design principles of nuclear receptor signaling: how complex networking improves signal transduction. Mol Syst Biol (2010) 0.88

Membrane recruitment of scaffold proteins drives specific signaling. PLoS One (2007) 0.87

The role of modelling in identifying drug targets for diseases of the cell cycle. J R Soc Interface (2006) 0.87

The membrane environment can promote or suppress bistability in cell signaling networks. J Phys Chem B (2012) 0.86

Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalk. Biophys J (2008) 0.85

Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes. Proc Natl Acad Sci U S A (2012) 0.85

Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila. Nat Commun (2014) 0.84

Quantitative measurement of protein relocalization in live cells. Biophys J (2013) 0.83

Perspective: Dynamics of receptor tyrosine kinase signaling complexes. FEBS Lett (2012) 0.83

Limits to the precision of gradient sensing with spatial communication and temporal integration. Proc Natl Acad Sci U S A (2016) 0.83

Spatial simulations in systems biology: from molecules to cells. Int J Mol Sci (2012) 0.83

Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization. Sci Rep (2015) 0.83

A role for membrane shape and information processing in cardiac physiology. Pflugers Arch (2014) 0.83

Protein kinase C: the "masters" of calcium and lipid. Cold Spring Harb Perspect Biol (2011) 0.82

Challenges in studying phospholipid signaling. Nat Chem Biol (2010) 0.82

Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location. Sci Rep (2013) 0.82

Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics (2013) 0.81

Binding and function of phosphotyrosines of the Ephrin A2 (EphA2) receptor using synthetic sterile α motif (SAM) domains. J Biol Chem (2014) 0.80

Effects of confinement on models of intracellular macromolecular dynamics. Proc Natl Acad Sci U S A (2015) 0.79

Kinetic proofreading of ligand-FcepsilonRI interactions may persist beyond LAT phosphorylation. J Immunol (2007) 0.79

Signal transduction in neurons: effects of cellular prion protein on fyn kinase and ERK1/2 kinase. Immun Ageing (2010) 0.79

Perspective: On the importance of hydrodynamic interactions in the subcellular dynamics of macromolecules. J Chem Phys (2016) 0.79

One-way membrane trafficking of SOS in receptor-triggered Ras activation. Nat Struct Mol Biol (2016) 0.76

Cell cycle-dependent binding modes of the ran exchange factor RCC1 to chromatin. Biophys J (2013) 0.76

Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins. Methods Cell Biol (2015) 0.76

Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate. Nat Commun (2017) 0.75

Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling. J Biol Chem (2016) 0.75

Retinol as a cofactor for PKCδ-mediated impairment of insulin sensitivity in a mouse model of diet-induced obesity. FASEB J (2015) 0.75

RssAB signaling coordinates early development of surface multicellularity in Serratia marcescens. PLoS One (2011) 0.75

Functions of intrinsic disorder in transmembrane proteins. Cell Mol Life Sci (2017) 0.75

Detection of channel proximity by nanoparticle-assisted delaying of toxin binding; a combined patch-clamp and flow cytometric energy transfer study. Eur Biophys J (2005) 0.75

Application of Peak Intensity Analysis to Measurements of Protein Binding to Lipid Vesicles and Erythrocytes Using Fluorescence Correlation Spectroscopy: Dependence on Particle Size. J Membr Biol (2016) 0.75

Peripheral Membrane Associations of Matrix Metalloproteinases. Biochim Biophys Acta (2017) 0.75

Articles by these authors

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat Biotechnol (2001) 4.66

Quantification of short term signaling by the epidermal growth factor receptor. J Biol Chem (1999) 4.19

Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry. Eur J Biochem (2000) 3.33

Quantification of the contribution of various steps to the control of mitochondrial respiration. J Biol Chem (1982) 2.92

Why do protein kinase cascades have more than one level? Trends Biochem Sci (1997) 2.69

The danger of metabolic pathways with turbo design. Trends Biochem Sci (1998) 2.66

Quantification of information transfer via cellular signal transduction pathways. FEBS Lett (1997) 2.33

Role of calcium in the hormonal regulation of liver metabolism. Biochim Biophys Acta (1981) 2.01

Determination of the mitochondrial protonmotive force in isolated hepatocytes. J Biol Chem (1980) 2.00

An alternative PII protein in the regulation of glutamine synthetase in Escherichia coli. Mol Microbiol (1996) 1.97

Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J Biol Chem (1999) 1.94

Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway. FEBS Lett (2001) 1.91

How enzymes can capture and transmit free energy from an oscillating electric field. Proc Natl Acad Sci U S A (1986) 1.78

GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition. J Mol Biol (1998) 1.75

Modern theories of metabolic control and their applications (review). Biosci Rep (1984) 1.75

A minimal hypothesis for membrane-linked free-energy transduction. The role of independent, small coupling units. Biochim Biophys Acta (1984) 1.74

Diffusion control of protein phosphorylation in signal transduction pathways. Biochem J (2000) 1.66

Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes. J Biol Chem (1997) 1.59

The use of lac-type promoters in control analysis. Eur J Biochem (1993) 1.56

The macroworld versus the microworld of biochemical regulation and control. Trends Biochem Sci (1995) 1.54

Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry (1993) 1.53

Acetaldehyde mediates the synchronization of sustained glycolytic oscillations in populations of yeast cells. Eur J Biochem (1996) 1.50

Structure and partitioning of bacterial DNA: determined by a balance of compaction and expansion forces? FEMS Microbiol Lett (1995) 1.48

Understanding glucose transport by the bacterial phosphoenolpyruvate:glycose phosphotransferase system on the basis of kinetic measurements in vitro. J Biol Chem (2000) 1.46

Sustained oscillations in free-energy state and hexose phosphates in yeast. Yeast (1996) 1.45

FnrP and NNR of Paracoccus denitrificans are both members of the FNR family of transcriptional activators but have distinct roles in respiratory adaptation in response to oxygen limitation. Mol Microbiol (1997) 1.44

Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition. Hepatology (2000) 1.43

The signal transduction function for oxidative phosphorylation is at least second order in ADP. J Biol Chem (1996) 1.43

Glutamate oxidation in rat-liver homogenate. Biochim Biophys Acta (1969) 1.41

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore. J Biol Chem (1999) 1.40

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J Biol Chem (1993) 1.39

Mutational analysis of the nor gene cluster which encodes nitric-oxide reductase from Paracoccus denitrificans. Eur J Biochem (1996) 1.39

Nitrite and nitric oxide reduction in Paracoccus denitrificans is under the control of NNR, a regulatory protein that belongs to the FNR family of transcriptional activators. FEBS Lett (1995) 1.37

Quantifying heterogeneity: flow cytometry of bacterial cultures. Antonie Van Leeuwenhoek (1992) 1.37

Can free energy be transduced from electric noise? Proc Natl Acad Sci U S A (1987) 1.36

What controls glycolysis in bloodstream form Trypanosoma brucei? J Biol Chem (1999) 1.35

The two opposing activities of adenylyl transferase reside in distinct homologous domains, with intramolecular signal transduction. EMBO J (1997) 1.35

Compartmentation protects trypanosomes from the dangerous design of glycolysis. Proc Natl Acad Sci U S A (2000) 1.34

Control theory of regulatory cascades. J Theor Biol (1991) 1.34

The genes of the glutamine synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli. Mol Microbiol (1993) 1.32

Transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations. Biophys J (2000) 1.29

How yeast cells synchronize their glycolytic oscillations: a perturbation analytic treatment. Biophys J (2000) 1.29

Magainin 2 amide and analogues. Antimicrobial activity, membrane depolarization and susceptibility to proteolysis. FEBS Lett (1989) 1.28

Nitric oxide is a signal for NNR-mediated transcription activation in Paracoccus denitrificans. J Bacteriol (1999) 1.26

DNA supercoiling depends on the phosphorylation potential in Escherichia coli. Mol Microbiol (1996) 1.25

How do enzyme activities control metabolite concentrations? An additional theorem in the theory of metabolic control. Eur J Biochem (1984) 1.22

Autoamplification of a two-component regulatory system results in "learning" behavior. J Bacteriol (2001) 1.21

An additional PII in Escherichia coli: a new regulatory protein in the glutamine synthetase cascade. FEMS Microbiol Lett (1995) 1.20

Excess capacity of H(+)-ATPase and inverse respiratory control in Escherichia coli. EMBO J (1993) 1.20

Around the growth phase transition S. cerevisiae's make-up favours sustained oscillations of intracellular metabolites. FEBS Lett (1993) 1.19

Mitochondrial respiratory chain activity in skeletal muscle from patients with Parkinson's disease. Neurology (1993) 1.18

Increased oxidative damage to mitochondrial DNA following chronic ethanol consumption. Biochem Biophys Res Commun (1997) 1.18

Intracellular glucose concentration in derepressed yeast cells consuming glucose is high enough to reduce the glucose transport rate by 50%. J Bacteriol (1998) 1.18

A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle. Am J Physiol Cell Physiol (2000) 1.18

Ethanol-induced mobilization of calcium by activation of phosphoinositide-specific phospholipase C in intact hepatocytes. J Biol Chem (1987) 1.17

Control of glycolytic dynamics by hexose transport in Saccharomyces cerevisiae. Biophys J (2001) 1.16

Bacteriorhodopsin in liposomes. II. Experimental evidence in support of a theoretical model. Biochim Biophys Acta (1979) 1.16

Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells. Eur J Biochem (1992) 1.15

Signal processing at the Ras circuit: what shapes Ras activation patterns? Syst Biol (Stevenage) (2004) 1.13

Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure? Atherosclerosis (2000) 1.12

Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone. J Biol Chem (1994) 1.12

Thermodynamic efficiency of microbial growth is low but optimal for maximal growth rate. Proc Natl Acad Sci U S A (1983) 1.12

The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate. Eur J Biochem (1994) 1.11

Thermodynamics of growth. Non-equilibrium thermodynamics of bacterial growth. The phenomenological and the mosaic approach. Biochim Biophys Acta (1982) 1.09

Transport of glutamate in rat-liver mitochondria. Biochim Biophys Acta (1972) 1.06

Yeast cells with a specific cellular make-up and an environment that removes acetaldehyde are prone to sustained glycolytic oscillations. FEBS Lett (1994) 1.06

Implications of macromolecular crowding for signal transduction and metabolite channeling. Proc Natl Acad Sci U S A (1998) 1.06

Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition. Am J Physiol (1997) 1.05

Calcium-dependent and calcium-independent mechanisms of irreversible cell injury in cultured hepatocytes. J Biol Chem (1986) 1.04

Multiple mechanisms by which protein kinase A potentiates inositol 1,4,5-trisphosphate-induced Ca2+ mobilization in permeabilized hepatocytes. Biochem J (1993) 1.04

Energy buffering of DNA structure fails when Escherichia coli runs out of substrate. J Bacteriol (1995) 1.04

Electric potentiation, cooperativity, and synergism of magainin peptides in protein-free liposomes. Biochemistry (1993) 1.02

Potentiation by chronic ethanol treatment of the mitochondrial permeability transition. Biochem Biophys Res Commun (1999) 1.02

Chronic ethanol consumption causes alterations in the structural integrity of mitochondrial DNA in aged rats. Hepatology (1999) 1.02

Endotoxin and alcoholic liver disease: tolerance and susceptibility. Hepatology (1999) 1.02

Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function. FASEB J (2001) 1.02

The Escherichia coli signal transducers PII (GlnB) and GlnK form heterotrimers in vivo: fine tuning the nitrogen signal cascade. Proc Natl Acad Sci U S A (2000) 1.02

Control analysis of glycolytic oscillations. Biophys Chem (1996) 1.01

Branched-chain alpha-keto acid catabolism via the gene products of the bkd operon in Enterococcus faecalis: a new, secreted metabolite serving as a temporary redox sink. J Bacteriol (2000) 1.00

Control of frequency and amplitudes is shared by all enzymes in three models for yeast glycolytic oscillations. Biochim Biophys Acta (1996) 1.00

Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei. Proc Natl Acad Sci U S A (1999) 1.00

Regulation of oxidative phosphorylation: the flexible respiratory network of Paracoccus denitrificans. J Bioenerg Biomembr (1995) 1.00

Mosaic protonic coupling hypothesis for free energy transduction. FEBS Lett (1984) 0.99

Metabolic channelling and control of the flux. FEBS Lett (1993) 0.98

Activation and desensitization of phospholipase D in intact rat hepatocytes. J Biol Chem (1994) 0.97

Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein. Mol Microbiol (1999) 0.97

Metabolic design: how to engineer a living cell to desired metabolite concentrations and fluxes. Biotechnol Bioeng (1998) 0.97

Metabolic control by pump slippage and proton leakage in 'delocalized' and more localized chemiosmotic energy-coupling schemes. Biochem Soc Trans (1983) 0.96

Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control". J Bioenerg Biomembr (1999) 0.95

Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition. Am J Physiol (1995) 0.95

Control by enzymes, coenzymes and conserved moieties. A generalisation of the connectivity theorem of metabolic control analysis. Eur J Biochem (1994) 0.94

Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. Mol Biochem Parasitol (2000) 0.94

Redox interactions in cytochrome c oxidase: from the "neoclassical" toward "modern" models. Biophys J (1992) 0.94

The role of the matrix calcium level in the enhancement of mitochondrial pyruvate carboxylation by glucagon pretreatment. J Biol Chem (1992) 0.93

The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two. Eur J Biochem (1993) 0.93

Glucose and the ATP paradox in yeast. Biochem J (2000) 0.93

A critical appraisal of evidence for localized energy coupling. Kinetic studies on liposomes containing bacteriorhodopsin and ATP synthase. Biochem J (1985) 0.92

Variation of efficiency with free-energy dissipation in models of biological energy transduction. Biophys Chem (1987) 0.92