Published in Genomics on March 15, 2000
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Hypervariable 'minisatellite' regions in human DNA. Nature (1985) 31.03
A gene map of the human genome. Science (1996) 14.32
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature (1995) 13.80
A physical map of the human genome. Nature (2001) 12.39
Individual-specific 'fingerprints' of human DNA. Nature (1985) 10.38
Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles. J Exp Med (1968) 6.56
Persistence of sulphonamide resistance in Escherichia coli in the UK despite national prescribing restriction. Lancet (2001) 6.37
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature (1997) 6.06
Contigs built with fingerprints, markers, and FPC V4.7. Genome Res (2000) 5.56
Physician participation in state Medicaid programs. J Hum Resour (1978) 5.39
Chronic fatigue in adolescents. Pediatrics (1991) 5.24
Influence of socioeconomic and cultural factors on racial differences in late-stage presentation of breast cancer. JAMA (1998) 4.94
Evolutionary relationships of human populations from an analysis of nuclear DNA polymorphisms. Nature (1986) 4.84
A systematic, high-resolution linkage of the cytogenetic and physical maps of the human genome. Nat Genet (2000) 4.78
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
Codon usage can affect efficiency of translation of genes in Escherichia coli. Nucleic Acids Res (1984) 4.51
The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial. Kidney Int (2011) 4.27
Subtle chromosomal rearrangements in children with unexplained mental retardation. Lancet (1999) 4.20
A 4-Mb high-density single nucleotide polymorphism-based map around human APOE. Genomics (1998) 3.91
SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. Am J Hum Genet (2000) 3.58
The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. Cell (1995) 3.05
Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. Mol Cell (2000) 3.03
Diagnosis of alpha 1-antitrypsin deficiency by enzymatic amplification of human genomic DNA and direct sequencing of polymerase chain reaction products. Nucleic Acids Res (1988) 3.00
An SNP map of human chromosome 22. Nature (2000) 2.99
Genetic influences on F cells and other hematologic variables: a twin heritability study. Blood (2000) 2.95
Ultrastructure of the antigen-retaining reticulum of lymph node follicles as shown by high-resolution autoradiography. Nature (1965) 2.76
Rapid assessment of S. cerevisiae mating type by PCR. Trends Genet (1990) 2.75
Cloning a selected fragment from a human DNA 'fingerprint': isolation of an extremely polymorphic minisatellite. Nucleic Acids Res (1986) 2.70
The association of race/ethnicity, socioeconomic status, and physician recommendation for mammography: who gets the message about breast cancer screening? Am J Public Health (2001) 2.66
Antigens in immunity. XII. Antigen trapping in the spleen. Int Arch Allergy Appl Immunol (1966) 2.62
Development and clinical application of an innovative fluorescence in situ hybridization technique which detects submicroscopic rearrangements involving telomeres. Eur J Hum Genet (1997) 2.59
Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature (2002) 2.59
Risk of malaria in British residents returning from malarious areas. BMJ (1990) 2.56
DNA "fingerprints" and segregation analysis of multiple markers in human pedigrees. Am J Hum Genet (1986) 2.55
Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nat Genet (1998) 2.51
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. Blood (2001) 2.50
Activities of daily living in frontotemporal dementia and Alzheimer disease. Neurology (2007) 2.49
A SNP resource for human chromosome 22: extracting dense clusters of SNPs from the genomic sequence. Genome Res (2001) 2.49
The DNA sequence and biological annotation of human chromosome 1. Nature (2006) 2.42
Recombination breakpoints in the human beta-globin gene cluster. Blood (1998) 2.38
Mullerian inhibiting substance in humans: normal levels from infancy to adulthood. J Clin Endocrinol Metab (1996) 2.37
Human major histocompatibility complex contains genes for the major heat shock protein HSP70. Proc Natl Acad Sci U S A (1989) 2.34
Antigens in immunity. XIV. Electron microscopic radioautographic studies of antigen capture in the lymph node medulla. J Exp Med (1968) 2.29
Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus. Proc Natl Acad Sci U S A (1986) 2.26
Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range. Results of the Cholesterol and Recurrent Events (CARE) trial. Ann Intern Med (1998) 2.22
Molecular definition of the 22q11 deletions in velo-cardio-facial syndrome. Am J Hum Genet (1995) 2.19
CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication. Mol Cell Biol (1997) 2.17
Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors. Proc Natl Acad Sci U S A (1982) 2.16
The Abbott IMx automated benchtop immunochemistry analyzer system. Clin Chem (1988) 2.12
Planning for a good death: responding to unexpected events. BMJ (2003) 2.10
A longitudinal study of possible allergy to enzyme detergents. Clin Allergy (1985) 2.07
Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events. J Immunol (1992) 2.05
The extent of linkage disequilibrium in four populations with distinct demographic histories. Am J Hum Genet (2000) 2.03
Analgesic efficacy and potency of two oral controlled-release morphine preparations. Clin Pharmacol Ther (1993) 2.01
A comprehensive screen for TWIST mutations in patients with craniosynostosis identifies a new microdeletion syndrome of chromosome band 7p21.1. Am J Hum Genet (1998) 2.00
Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia. EMBO J (1987) 2.00
Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region. EMBO J (1989) 1.97
Optimizing blood vessel contrast in fast three-dimensional MRI. Magn Reson Med (1990) 1.97
Trends in prescribing and utilization of statins and other lipid lowering drugs across Europe 1997-2003. Br J Clin Pharmacol (2005) 1.93
Binge eating disorder: its further validation in a multisite study. Int J Eat Disord (1993) 1.89
Structure and expression of the hairless gene of mice. Proc Natl Acad Sci U S A (1994) 1.85
Computational drug repositioning: from data to therapeutics. Clin Pharmacol Ther (2013) 1.82
Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1. J Virol (1995) 1.81
AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes. Bioinformatics (2007) 1.80
Familial infantile convulsions and paroxysmal choreoathetosis: a new neurological syndrome linked to the pericentromeric region of human chromosome 16. Am J Hum Genet (1997) 1.79
DNA sequence elements located immediately upstream of the -10 hexamer in Escherichia coli promoters: a systematic study. Nucleic Acids Res (2000) 1.79
Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease. Hum Mol Genet (1993) 1.76
Low incidence of BRCA2 mutations in breast carcinoma and other cancers. Nat Genet (1996) 1.74
Detection of somatic changes in human cancer DNA by DNA fingerprint analysis. Br J Cancer (1987) 1.74
Increased prescribing trends of paediatric psychotropic medications. Arch Dis Child (2004) 1.73
Teaching of fertility regulation in medical schools. Survey in the United States and Canada, 1964. JAMA (1966) 1.71
Looking after ourselves: an individual responsibility? R Soc Health J (1982) 1.71
Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse beta-globin locus control region. Blood (1998) 1.68
Finasteride in the treatment of men with frontal male pattern hair loss. J Am Acad Dermatol (1999) 1.67
Asprin and codeine in two postpartum pain models. Clin Pharmacol Ther (1976) 1.66
The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X. Nature (2001) 1.63
Expressed sequences from conidial, mycelial, and sexual stages of Neurospora crassa. Fungal Genet Biol (1997) 1.62
Geography of HFE C282Y and H63D mutations. Genet Test (2000) 1.62
Two simple procedures for releasing chromatin from routinely fixed cells for fluorescence in situ hybridization. Cytogenet Cell Genet (1994) 1.61
Melanesians and Polynesians share a unique alpha-thalassemia mutation. Am J Hum Genet (1985) 1.58
Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approach. Nat Genet (1996) 1.57
Serum alkaline phosphatase reflects post-Fontan hemodynamics in children. Pediatr Cardiol (2008) 1.56
Rapid detection of deletions causing delta beta thalassemia and hereditary persistence of fetal hemoglobin by enzymatic amplification. Blood (1994) 1.55
Suicidal ideation among outpatients at general neurology clinics: prospective study. BMJ (2000) 1.54
Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency. Blood (2001) 1.52
The outcome of neurology outpatients with medically unexplained symptoms: a prospective cohort study. J Neurol Neurosurg Psychiatry (2003) 1.48
Presence of gene for beta globin in homozygous beta0 thalassaemia. Nature (1976) 1.48
Premature mortality in the United States: the roles of geographic area, socioeconomic status, household type, and availability of medical care. Am J Public Health (1999) 1.48
Update on transcobalamin deficiency: clinical presentation, treatment and outcome. J Inherit Metab Dis (2013) 1.47
Reducing pediatric liver transplant complications: a potential roadmap for transplant quality improvement initiatives within North America. Am J Transplant (2012) 1.46
Assessment of bacterial viability status by flow cytometry and single cell sorting. J Appl Microbiol (1998) 1.46
Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol Genomics (2001) 1.46