Published in Nature on September 28, 2000
An initial map of insertion and deletion (INDEL) variation in the human genome. Genome Res (2006) 11.60
SNPdetector: a software tool for sensitive and accurate SNP detection. PLoS Comput Biol (2005) 10.04
The allele frequency spectrum in genome-wide human variation data reveals signals of differential demographic history in three large world populations. Genetics (2004) 7.00
Challenges and standards in integrating surveys of structural variation. Nat Genet (2007) 6.05
Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array. Genome Res (2004) 5.59
High-throughput variation detection and genotyping using microarrays. Genome Res (2001) 5.24
The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature (2009) 4.19
Genome coverage and sequence fidelity of phi29 polymerase-based multiple strand displacement whole genome amplification. Nucleic Acids Res (2004) 3.37
Sequence variations in the public human genome data reflect a bottlenecked population history. Proc Natl Acad Sci U S A (2002) 2.70
Efficient multipoint linkage analysis through reduction of inheritance space. Am J Hum Genet (2001) 2.58
PolyScan: an automatic indel and SNP detection approach to the analysis of human resequencing data. Genome Res (2007) 2.58
A SNP resource for human chromosome 22: extracting dense clusters of SNPs from the genomic sequence. Genome Res (2001) 2.49
Small insertions and deletions (INDELs) in human genomes. Hum Mol Genet (2010) 2.25
High-throughput MALDI-TOF discovery of genomic sequence polymorphisms. Genome Res (2004) 1.92
The power to detect linkage disequilibrium with quantitative traits in selected samples. Am J Hum Genet (2001) 1.64
Minimal introns are not "junk". Genome Res (2002) 1.49
Analysis of similarity within 142 pairs of orthologous intergenic regions of Caenorhabditis elegans and Caenorhabditis briggsae. Nucleic Acids Res (2002) 1.44
Single nucleotide polymorphisms (SNPs) that map to gaps in the human SNP map. Nucleic Acids Res (2003) 1.42
Reduced variation on the chicken Z chromosome. Genetics (2004) 1.39
An interactive bovine in silico SNP database (IBISS). Mamm Genome (2004) 1.16
Brain investigation and brain conceptualization. Funct Neurol (2013) 1.03
The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes. Arthritis Res (2000) 0.93
Relationship between IFN-gamma gene polymorphism and susceptibility to intrauterine HBV infection. World J Gastroenterol (2006) 0.89
Single nucleotide polymorphism mapping using genome-wide unique sequences. Genome Res (2002) 0.89
Sequencing of the core MHC region of black grouse (Tetrao tetrix) and comparative genomics of the galliform MHC. BMC Genomics (2012) 0.89
Single nucleotide polymorphisms and disease gene mapping. Arthritis Res (2002) 0.86
Geographic stratification of linkage disequilibrium: a worldwide population study in a region of chromosome 22. Hum Genomics (2004) 0.83
Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat. PLoS One (2008) 0.82
Rapid parallel mutation scanning of gene fragments using a microelectronic protein-DNA chip format. Nucleic Acids Res (2002) 0.81
Interaction research on the antiviral molecule dufulin targeting on southern rice black streaked dwarf virus p9-1 nonstructural protein. Viruses (2015) 0.80
Genetic variation and pharmacogenomics: concepts, facts, and challenges. Dialogues Clin Neurosci (2004) 0.78
Ordered catenation of sequence-tagged sites and multiplexed SNP genotyping by sequencing. Nucleic Acids Res (2002) 0.77
Lack of association between the polymorphisms of hypoxia-inducible factor 1A (HIF1A) gene and SLE susceptibility in a Chinese population. Immunogenetics (2014) 0.76
The evolution of comparative genomics. Mol Genet Genomic Med (2014) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18
The Ensembl genome database project. Nucleic Acids Res (2002) 40.87
The DNA of Caenorhabditis elegans. Genetics (1974) 37.68
The DNA sequence of human chromosome 22. Nature (1999) 30.88
Gene-expression profiles in hereditary breast cancer. N Engl J Med (2001) 29.80
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Ensembl 2009. Nucleic Acids Res (2008) 25.38
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature (1994) 21.30
The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol (1983) 21.29
Methylmercury as a reversible denaturing agent for agarose gel electrophoresis. Anal Biochem (1976) 21.07
Ensembl 2008. Nucleic Acids Res (2007) 20.67
Ensembl 2007. Nucleic Acids Res (2006) 20.10
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol (1977) 19.51
The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature (2000) 17.14
The Catalogue of Somatic Mutations in Cancer (COSMIC). Curr Protoc Hum Genet (2008) 16.09
Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet (1996) 15.73
Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature (2000) 15.53
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature (2001) 15.44
Ensembl 2005. Nucleic Acids Res (2005) 15.13
Efficient initiation of HCV RNA replication in cell culture. Science (2000) 15.12
Genome sequence of Yersinia pestis, the causative agent of plague. Nature (2001) 14.36
A gene map of the human genome. Science (1996) 14.32
Flavivirus genome organization, expression, and replication. Annu Rev Microbiol (1990) 14.20
Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56
A physical map of 30,000 human genes. Science (1998) 12.43
A physical map of the human genome. Nature (2001) 12.39
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy (2008) 12.35
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer (2004) 12.35
Ensembl 2002: accommodating comparative genomics. Nucleic Acids Res (2003) 12.26
Massive gene decay in the leprosy bacillus. Nature (2001) 11.98
Ensembl 2004. Nucleic Acids Res (2004) 11.88
Ensembl 2006. Nucleic Acids Res (2006) 11.66
Expression profiling using cDNA microarrays. Nat Genet (1999) 11.58
Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature (1999) 10.97
Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature (2001) 10.96
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem (1999) 10.14
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature (2000) 9.86
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86
Transposition of R factor genes to bacteriophage lambda. Proc Natl Acad Sci U S A (1975) 9.28
Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc Natl Acad Sci U S A (2006) 9.26
Degenerate oligonucleotide-primed PCR: general amplification of target DNA by a single degenerate primer. Genomics (1992) 9.06
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95
Data management and analysis for gene expression arrays. Nat Genet (1998) 8.60
Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science (1985) 8.54
Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol (1993) 8.47
Plasmid-determined resistance to antimicrobial agents. Annu Rev Microbiol (1978) 8.35
Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Res (2001) 8.34
Ratio-based decisions and the quantitative analysis of cDNA microarray images. J Biomed Opt (1997) 8.32
A mechanism for RNA splicing. Proc Natl Acad Sci U S A (1980) 7.76
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science (2001) 7.66
Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science (1997) 7.53
The DNA sequence and comparative analysis of human chromosome 20. Nature (2002) 7.40
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol (1999) 7.16
The neural circuit for touch sensitivity in Caenorhabditis elegans. J Neurosci (1985) 7.13
Mechanisms of antibiotic resistance in bacteria. Annu Rev Biochem (1973) 7.08
The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90
Complete nucleotide sequence of the genomic RNA of Sindbis virus. Virology (1984) 6.60
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene (2007) 6.55
Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J Virol (1993) 6.36
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science (1997) 6.23
Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature (1991) 6.17
Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins. Proc Natl Acad Sci U S A (1981) 6.08
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science (1999) 5.95
Microarray based comparative genomic hybridisation (array-CGH) detects submicroscopic chromosomal deletions and duplications in patients with learning disability/mental retardation and dysmorphic features. J Med Genet (2004) 5.76
Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res (2000) 5.74
The problems of drug-resistant pathogenic bacteria. R factors: biochemical mechanisms of resistance to aminoglycoside antibiotics. Ann N Y Acad Sci (1971) 5.52
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A (2001) 5.48
CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature (1997) 5.45
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J (1998) 5.34
Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo. J Virol (2000) 5.26
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc Natl Acad Sci U S A (1973) 5.20