Published in Proc Natl Acad Sci U S A on April 11, 2000
Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome. Am J Hum Genet (2005) 3.26
BHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dubé syndrome: a new series of 50 families and a review of published reports. J Med Genet (2008) 2.79
A 1-Mb resolution radiation hybrid map of the canine genome. Proc Natl Acad Sci U S A (2003) 2.30
Selective sweep mapping of genes with large phenotypic effects. Genome Res (2005) 1.95
Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the domestic dog genome to all chromosomes. Genome Res (2001) 1.88
Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Genetics (2008) 1.86
An integrated 4249 marker FISH/RH map of the canine genome. BMC Genomics (2004) 1.61
Leading the way: canine models of genomics and disease. Dis Model Mech (2010) 1.47
Linkage disequilibrium mapping in domestic dog breeds narrows the progressive rod-cone degeneration interval and identifies ancestral disease-transmitting chromosome. Genomics (2006) 1.46
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci (2013) 1.06
Franklin H. Epstein Lecture. Both ends of the leash--the human links to good dogs with bad genes. N Engl J Med (2012) 1.05
Canine tricuspid valve malformation, a model of human Ebstein anomaly, maps to dog chromosome 9. J Med Genet (2003) 1.03
Insights into morphology and disease from the dog genome project. Annu Rev Cell Dev Biol (2014) 0.91
The folliculin mutation database: an online database of mutations associated with Birt-Hogg-Dubé syndrome. Hum Mutat (2009) 0.88
A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit. PLoS Genet (2013) 0.88
Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test. Mol Cancer Res (2015) 0.87
Finding cardiovascular disease genes in the dog. J Vet Cardiol (2006) 0.86
A high-resolution comparative map of canine Chromosome 5q14.3-q33 constructed utilizing the 1.5x canine genome sequence. Mamm Genome (2004) 0.82
Genome-wide linkage study of atopic dermatitis in West Highland White Terriers. BMC Genet (2011) 0.81
Second hits in the FLCN gene in a hereditary renal cancer syndrome in dogs. Mamm Genome (2008) 0.77
Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping. Dis Model Mech (2016) 0.76
Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight, muscling and back fat thickness. PLoS Genet (2017) 0.75
Leading the way: finding genes for neurologic disease in dogs using genome-wide mRNA sequencing. BMC Genet (2012) 0.75
Demographic history, selection and functional diversity of the canine genome. Nat Rev Genet (2017) 0.75
A monograph proposing the use of canine mammary tumours as a model for the study of hereditary breast cancer susceptibility genes in humans. Vet Med Sci (2017) 0.75
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science (1990) 16.68
Linkage of early-onset familial breast cancer to chromosome 17q21. Science (1990) 16.21
Polymorphic DNA region adjacent to the 5' end of the human insulin gene. Proc Natl Acad Sci U S A (1981) 12.86
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science (1994) 8.73
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell (1990) 8.30
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature (1991) 7.49
Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell (1997) 7.27
PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science (1996) 6.56
A cancer family syndrome in twenty-four kindreds. Cancer Res (1988) 6.39
Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria. J Child Neurol (1998) 5.47
Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science (1996) 5.06
Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map. Nat Genet (1994) 4.19
Evidence for a prostate cancer susceptibility locus on the X chromosome. Nat Genet (1998) 2.90
Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene. Proc Natl Acad Sci U S A (1994) 2.38
A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat Genet (1995) 2.25
Von Hippel-Lindau disease: clinical and pathological manifestations in nine families with 50 affected members. Arch Intern Med (1976) 1.97
A second-generation genetic linkage map of the domestic dog, Canis familiaris. Genetics (1999) 1.85
An integrated linkage-radiation hybrid map of the canine genome. Mamm Genome (2000) 1.84
A class of highly polymorphic tetranucleotide repeats for canine genetic mapping. Mamm Genome (1996) 1.77
Linkage of a microsatellite marker to the canine copper toxicosis locus in Bedlington terriers. Am J Vet Res (1997) 1.65
A linkage map of the canine genome. Genomics (1997) 1.56
Rodent model of reproductive tract leiomyomata. Clinical and pathological features. Am J Pathol (1995) 1.52
Genetic and pathologic findings in a kindred with hereditary sarcoma, breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma. Cancer (1978) 1.49
Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK). Nat Genet (1994) 1.36
Linkage analysis and comparative mapping of canine progressive rod-cone degeneration (prcd) establishes potential locus homology with retinitis pigmentosa (RP17) in humans. Proc Natl Acad Sci U S A (1998) 1.33
A whole-genome radiation hybrid map of the dog genome. Genomics (1998) 1.32
Centrosema mosaic: a plant virus disease transmitted by both aphids and plant bugs. Nature (1961) 1.27
Construction and optimization of a dog whole-genome radiation hybrid panel. Mamm Genome (1999) 1.23
Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10. Proc Natl Acad Sci U S A (1993) 1.14
A novel retinal degeneration locus identified by linkage and comparative mapping of canine early retinal degeneration. Genomics (1999) 1.13
Hereditary multifocal renal cystadenocarcinomas and nodular dermatofibrosis in the German shepherd dog: macroscopic and histopathologic changes. Vet Pathol (1985) 1.12
Semper fidelis: what man's best friend can teach us about human biology and disease. Am J Hum Genet (1997) 1.07
The occurrence of tumors in domestic animals. Natl Cancer Inst Monogr (1980) 1.06
The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene. Biochem Biophys Res Commun (1994) 0.99
Naturally occurring cancer in pet dogs: important models for developing improved cancer therapy for humans. Mol Med Today (1997) 0.99
Genetic markers linked to neuronal ceroid lipofuscinosis in English setter dogs. Anim Genet (1998) 0.96
A novel renal cell carcinoma susceptibility gene maps on chromosome 10 in the Eker rat. Jpn J Cancer Res (1993) 0.96
Bilateral nephrogenic carcinomas in Lindau-Von Hippel disease. J Urol (1961) 0.95
Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5. Genomics (1997) 0.94
Toward a dog radiation hybrid map. J Hered (1999) 0.92
Anchoring of canine linkage groups with chromosome-specific markers. Mamm Genome (1999) 0.90
Punctate palmoplantar keratoderma and malignancy in a four-generation family. Br J Dermatol (1996) 0.89
Multiple hypernephromas of the kidney in association with Lindau's disease. N Engl J Med (1951) 0.88
Diagnosis and management of tuberous sclerosis complex. Semin Pediatr Neurol (1998) 0.84
The highly polymorphic canine microsatellite ZuBeCa6 is localized on canine chromosome 5q12-q13. Anim Genet (1998) 0.80
Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility. Toxicol Lett (1995) 0.78
Genetics of kidney tumours. Forum (Genova) (1999) 0.77
Computed tomography of hereditary multifocal renal cystadenocarcinomas in German shepherd dogs. Vet Radiol Ultrasound (1997) 0.77
Hereditary multifocal renal cystadenocarcinomas and nodular dermatofibrosis in 51 German shepherd dogs. J Small Anim Pract (1997) 0.77
Chromosomal assignment of seven genes on canine chromosomes by fluorescence in situ hybridization. Mamm Genome (1996) 0.77
Five new linkage groups in the canine linkage map. Anim Genet (1999) 0.77
Renal angiomyolipoma associated with neurofibromatosis and primary carcinoid of mesentery. Urology (1993) 0.77
Identification and analysis of the dog keratin 9 (KRT9) gene. Anim Genet (1998) 0.76
BRCA1 mutations in a population-based sample of young women with breast cancer. N Engl J Med (1996) 3.83
Patterns of differentiation and hybridization in North American wolflike canids, revealed by analysis of microsatellite loci. Mol Biol Evol (1994) 2.28
Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res (1997) 2.18
Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am J Hum Genet (1999) 2.12
Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the domestic dog genome to all chromosomes. Genome Res (2001) 1.88
A second-generation genetic linkage map of the domestic dog, Canis familiaris. Genetics (1999) 1.85
Molecular genetics of the most endangered canid: the Ethiopian wolf Canis simensis. Mol Ecol (1994) 1.85
An integrated linkage-radiation hybrid map of the canine genome. Mamm Genome (2000) 1.84
A class of highly polymorphic tetranucleotide repeats for canine genetic mapping. Mamm Genome (1996) 1.77
Frequency of BRCA1/BRCA2 mutations in a population-based sample of young breast carcinoma cases. Cancer (2000) 1.75
Histocompatibility testing of dog families with highly polymorphic microsatellite markers. Transplantation (1996) 1.72
Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25. Am J Hum Genet (1997) 1.68
Double-blind, placebo-controlled trial of the pain-relieving effects of the implantation of gold beads into dogs with hip dysplasia. Vet Rec (2006) 1.63
A linkage map of the canine genome. Genomics (1997) 1.56
Local domains of supercoiling activate a eukaryotic promoter in vivo. Nature (1993) 1.45
Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer. Br J Cancer (2007) 1.38
SNPs in ecological and conservation studies: a test in the Scandinavian wolf population. Mol Ecol (2005) 1.36
Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history. Cancer (2001) 1.33
Linkage analysis and comparative mapping of canine progressive rod-cone degeneration (prcd) establishes potential locus homology with retinitis pigmentosa (RP17) in humans. Proc Natl Acad Sci U S A (1998) 1.33
Analysis of chromosome 1q42.2-43 in 152 families with high risk of prostate cancer. Am J Hum Genet (1999) 1.30
Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library. Genomics (1999) 1.30
Germ-line BRCA1 mutations in selected men with prostate cancer. Am J Hum Genet (1996) 1.26
Human, canine and murine BRCA1 genes: sequence comparison among species. Hum Mol Genet (1996) 1.23
Understanding the genetics of autoimmune disease: two loci that regulate late onset Addison's disease in Portuguese Water Dogs. Int J Immunogenet (2006) 1.21
Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes. Br J Cancer (2003) 1.19
Genetic diversity and fitness in black-footed ferrets before and during a bottleneck. J Hered (2002) 1.18
A novel retinal degeneration locus identified by linkage and comparative mapping of canine early retinal degeneration. Genomics (1999) 1.13
Hereditary multifocal renal cystadenocarcinomas and nodular dermatofibrosis in the German shepherd dog: macroscopic and histopathologic changes. Vet Pathol (1985) 1.12
Origin, genetic diversity, and genome structure of the domestic dog. Bioessays (1999) 1.11
Familial prostate cancer. Epidemiol Rev (2001) 1.08
Polymorphic microsatellite DNA loci identified in the African elephant (Loxodonta africana). Mol Ecol (2000) 1.06
A genomic scan of families with prostate cancer identifies multiple regions of interest. Am J Hum Genet (2000) 1.05
Polymorphism analysis of four canine MHC class I genes. Tissue Antigens (1998) 0.98
Mutation detection by mismatch binding protein, MutS, in amplified DNA: application to the cystic fibrosis gene. Proc Natl Acad Sci U S A (1994) 0.97
Genetic markers linked to neuronal ceroid lipofuscinosis in English setter dogs. Anim Genet (1998) 0.96
Microsatellite markers for American mink (Mustela vison) and ermine (Mustela erminea). Mol Ecol (1999) 0.96
Isolation and characterization of microsatellites from the canine genome. Anim Genet (1993) 0.95
Eighteen canine microsatellites. Anim Genet (1995) 0.94
Estimated frequency of the canine hyperuricosuria mutation in different dog breeds. J Vet Intern Med (2010) 0.94
Association of dopamine- and serotonin-related genes with canine aggression. Genes Brain Behav (2010) 0.93
Characterization of a minimal screening set of 172 microsatellite markers for genome-wide screens of the canine genome. J Biochem Biophys Methods (2001) 0.92
A canine cancer-gene microarray for CGH analysis of tumors. Cytogenet Genome Res (2003) 0.91
Anchoring of canine linkage groups with chromosome-specific markers. Mamm Genome (1999) 0.90
Canine homolog of the T-box transcription factor T; failure of the protein to bind to its DNA target leads to a short-tail phenotype. Mamm Genome (2001) 0.90
Inflammatory response to therapeutic gold bead implantation in canine hip joint osteoarthritis. Vet Pathol (2010) 0.90
Calculation of urinary enzyme excretion, with renal structure and function in dogs with pyometra. Res Vet Sci (2001) 0.90
Variability of canine microsatellites within and between different dog breeds. Mamm Genome (1997) 0.90
Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis. Prostate Cancer Prostatic Dis (2008) 0.90
Pharmacokinetic aspects of measurement of glomerular filtration rate in the dog: a review. J Vet Intern Med (1999) 0.90
Etiology of acetonemia in Norwegian cattle. 1. Effect of ketogenic silage, season, energy level, and genetic factors. J Dairy Sci (1992) 0.90
Genetic linkage analysis of prostate cancer families to Xq27-28. Hum Hered (2001) 0.89
Meiotic linkage mapping of 52 genes onto the canine map does not identify significant levels of microrearrangement. Mamm Genome (2001) 0.89
Breed differences in the proportional morbidity of testicular tumours and distribution of histopathologic types in a population-based canine cancer registry. Vet Comp Oncol (2010) 0.89
Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D). Gene (1999) 0.89
Comparison of MultiMap and TSP/CONCORDE for constructing radiation hybrid maps. J Hered (2003) 0.87
Identification of genetic variation in 11 candidate genes of canine mammary tumour. Vet Comp Oncol (2011) 0.87
Fine mapping of canine XLPRA establishes homology of the human and canine RP3 intervals. Invest Ophthalmol Vis Sci (2001) 0.86
Fine mapping a locus controlling leg morphology in the domestic dog. Cold Spring Harb Symp Quant Biol (2009) 0.86
Building comparative maps using 1.5x sequence coverage: human chromosome 1p and the canine genome. Cold Spring Harb Symp Quant Biol (2003) 0.86
Establishing appropriate genome-wide significance levels for canine linkage analyses. J Hered (2003) 0.85
Identification and characterization of a highly polymorphic microsatellite marker within the canine MHC class I region. Mamm Genome (1995) 0.85
Toward a framework linkage map of the canine genome. J Hered (1999) 0.85
Linkage analysis of 150 high-risk prostate cancer families at 1q24-25. Genet Epidemiol (2000) 0.85
The Psychosis Project: outcome and cost-effectiveness of a psychoeducational treatment programme for schizophrenic adolescents. Acta Psychiatr Scand (1994) 0.84
Late-onset progressive retinal atrophy in the Gordon and Irish Setter breeds is associated with a frameshift mutation in C2orf71. Anim Genet (2012) 0.84
A longitudinal study on growth and growth variables in dogs of four large breeds raised in domestic environments. J Anim Sci (2007) 0.84
The relationship between some plasma clearance methods for estimation of glomerular filtration rate in dogs with pyometra. J Vet Intern Med (1999) 0.83
A population-based case-control study of canine mammary tumours and clinical use of medroxyprogesterone acetate. APMIS (1997) 0.82
A study of inherited short tail and taillessness in Pembroke Welsh corgi. J Small Anim Pract (2007) 0.82
Factors that affect depth perception in stereoscopic displays. Hum Factors (1992) 0.82
Stratification, blinding and placebo effect in a randomized, double blind placebo-controlled clinical trial of gold bead implantation in dogs with hip dysplasia. Acta Vet Scand (2005) 0.82
Adult-onset alcohol consumption induces osteopenia in female rats. Alcohol Clin Exp Res (2001) 0.82
Clinical characteristics of prostate cancer in an analysis of linkage to four putative susceptibility loci. Clin Cancer Res (2001) 0.81
[Dogs and health. A review of documented connections]. Tidsskr Nor Laegeforen (1997) 0.81
Risk factors affecting metaphyseal irregularities in the radius and ulna of growing Newfoundland dogs. J Anim Sci (2007) 0.80
A population study of a mutation allele associated with cone-rod dystrophy in the standard wire-haired dachshund. Anim Genet (2009) 0.80
[Registration of canine cancer]. Tidsskr Nor Laegeforen (1995) 0.80
Construction of a panel of canine-rodent hybrid cell lines for use in partitioning of the canine genome. Genomics (1997) 0.79
Germline mutations in the p73 gene do not predispose to familial prostate-brain cancer. Prostate (2001) 0.79
Temporal integration differences between crossed and uncrossed stereoscopic mechanisms. Percept Psychophys (1995) 0.79
DNA sequence and physical mapping of the canine transglutaminase 1 gene. Cytogenet Cell Genet (2001) 0.79
Three polymorphic canine microsatellites. Anim Genet (1994) 0.79
Identification, characterization, and physical mapping of 14 polymorphic simple sequence repeat markers on human chromosome 21. Genomics (1994) 0.78
Intestinal lymphangiectasia in the Lundehund. Scanning electron microscopy of intestinal mucosa. Acta Pathol Microbiol Immunol Scand A (1984) 0.78
Renal microcystic tubular lesions in two 1Year-old dogs - an early sign of hereditary renal cystadenocarcinoma? J Comp Pathol (2000) 0.78
Polymorphic repeats in the androgen receptor gene in high-risk sibships. Prostate (2001) 0.78