Published in Trends Biochem Sci on May 01, 2000
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A (2005) 4.24
Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote. BMC Genomics (2004) 3.68
Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics (2011) 3.28
mTOR kinase structure, mechanism and regulation. Nature (2013) 2.80
Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol Mol Biol Rev (2002) 2.69
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol (2007) 2.38
A new fork for clinical application: targeting forkhead transcription factors in cancer. Clin Cancer Res (2009) 2.27
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature (2009) 1.97
AtATM is essential for meiosis and the somatic response to DNA damage in plants. Plant Cell (2003) 1.92
Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J (2009) 1.88
Common mechanisms of PIKK regulation. DNA Repair (Amst) (2009) 1.73
SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans. Mol Cell Biol (2004) 1.62
Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes. Mol Cell Biol (2002) 1.59
Functional interaction between FOXO3a and ATM regulates DNA damage response. Nat Cell Biol (2008) 1.58
The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis. Genes Dev (2001) 1.55
Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR. Genetics (2003) 1.33
Activating mutations of TOR (target of rapamycin). Genes Cells (2011) 1.31
Endoplasmic reticulum and Golgi localization sequences for mammalian target of rapamycin. Mol Biol Cell (2007) 1.28
c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem (2003) 1.24
A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway. Proc Natl Acad Sci U S A (2002) 1.23
Review series: TOR kinase complexes and cell migration. J Cell Biol (2011) 1.19
Deciphering the role of forkhead transcription factors in cancer therapy. Curr Drug Targets (2011) 1.17
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. J Biol Chem (2011) 1.16
Target of rapamycin regulates development and ribosomal RNA expression through kinase domain in Arabidopsis. Plant Physiol (2011) 1.14
Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage. Mol Biol Cell (2005) 1.11
Key factors in mTOR regulation. Cell Mol Life Sci (2009) 1.08
Target of rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei. J Biol Chem (2010) 1.05
Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time. DNA Repair (Amst) (2014) 1.03
Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity. Proc Natl Acad Sci U S A (2010) 1.03
Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes. Mol Cell Biol (2010) 1.01
Mammalian TOR signaling to the AGC kinases. Crit Rev Biochem Mol Biol (2011) 0.97
Replication checkpoint: tuning and coordination of replication forks in s phase. Genes (Basel) (2013) 0.95
Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. BMC Genomics (2010) 0.91
Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster. Genetics (2005) 0.91
The DNA damage response signaling cascade regulates proliferation of the phytopathogenic fungus Ustilago maydis in planta. Plant Cell (2011) 0.90
Structure/function analysis of the phosphatidylinositol-3-kinase domain of yeast tra1. Genetics (2007) 0.90
A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response. Mol Cell Biol (2008) 0.88
Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome. Am J Hum Genet (2012) 0.88
Insights into the domain and repeat architecture of target of rapamycin. J Struct Biol (2010) 0.87
Signaling cascades as drug targets in model and pathogenic fungi. Curr Opin Investig Drugs (2008) 0.86
Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition. Mol Biol Cell (2015) 0.85
Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining. J Nucleic Acids (2010) 0.84
Structural basis for the association of the redox-sensitive target of rapamycin FATC domain with membrane-mimetic micelles. J Biol Chem (2009) 0.84
Chemical Inhibitors and microRNAs (miRNA) Targeting the Mammalian Target of Rapamycin (mTOR) Pathway: Potential for Novel Anticancer Therapeutics. Int J Mol Sci (2013) 0.84
Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1. Curr Genet (2010) 0.84
Tor forms a dimer through an N-terminal helical solenoid with a complex topology. Nat Commun (2016) 0.83
Genome of the avirulent human-infective trypanosome--Trypanosoma rangeli. PLoS Negl Trop Dis (2014) 0.83
Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes. BMC Genet (2008) 0.83
Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase. J Biol Chem (2011) 0.82
Podospora anserina target of rapamycin. Curr Genet (2006) 0.81
Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance. Biomed Res Int (2014) 0.80
Structure of the intact ATM/Tel1 kinase. Nat Commun (2016) 0.79
ATM gene mutations in sporadic breast cancer patients from Brazil. Springerplus (2015) 0.79
Transcriptional analysis of three major putative phosphatidylinositol kinase genes in a parasitic protozoan, Giardia lamblia. J Eukaryot Microbiol (2007) 0.79
Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1. Genetics (2012) 0.79
The atm-1 gene is required for genome stability in Caenorhabditis elegans. Mol Genet Genomics (2012) 0.79
A mutation in yeast Tel1p that causes differential effects on the DNA damage checkpoint and telomere maintenance. Curr Genet (2005) 0.78
Prospects for the Use of ATR Inhibitors to Treat Cancer. Pharmaceuticals (Basel) (2010) 0.77
A novel apoptosis correlated molecule: expression and characterization of protein Latcripin-1 from Lentinula edodes C(91-3). Int J Mol Sci (2012) 0.77
Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity. PLoS Genet (2015) 0.77
Structure of the human dimeric ATM kinase. Cell Cycle (2016) 0.77
The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function. G3 (Bethesda) (2013) 0.77
Tra1 as a screening target for transcriptional activation domain discovery. Bioorg Med Chem Lett (2009) 0.77
NMR- and circular dichroism-monitored lipid binding studies suggest a general role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK). J Biol Chem (2013) 0.76
Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting. Membranes (Basel) (2015) 0.76
Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase. PLoS One (2014) 0.76
Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1. BMC Genet (2012) 0.76
Organization of the MASP2 locus and its expression profile in mouse and rat. Mamm Genome (2004) 0.76
Ectopic expression of Arabidopsis Target of Rapamycin (AtTOR) improves water-use efficiency and yield potential in rice. Sci Rep (2017) 0.76
Functions and regulation of the MRX complex at DNA double-strand breaks. Microb Cell (2016) 0.75
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol (2001) 66.87
The Pfam protein families database. Nucleic Acids Res (2000) 42.28
Automatic clustering of orthologs and in-paralogs from pairwise species comparisons. J Mol Biol (2001) 16.47
Volume changes in protein evolution. J Mol Biol (1994) 12.07
Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins. Nucleic Acids Res (1999) 11.64
NIFAS: visual analysis of domain evolution in proteins. Bioinformatics (2001) 3.60
Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J Mol Biol (1997) 2.03
Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling. J Biol Chem (1999) 1.45
Widespread eukaryotic sequences, highly similar to bacterial DNA polymerase I, looking for functions. Curr Biol (1997) 1.45
A comparison of sequence and structure protein domain families as a basis for structural genomics. Bioinformatics (1999) 1.25
The imprint of somatic hypermutation on the repertoire of human germline V genes. J Mol Biol (1996) 1.21
Substitution of two variant residues in the protein tyrosine phosphatase-like PTP35/IA-2 sequence reconstitutes catalytic activity. Biochem Biophys Res Commun (1996) 1.14
MEDUSA: large scale automatic selection and visual assessment of PCR primer pairs. Bioinformatics (2001) 0.95
Basic fibroblast growth factor in Dupuytren's contracture. Am J Pathol (1992) 0.94
Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation. J Biol Chem (1998) 0.93
Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase. Eur J Biochem (2000) 0.91
Thermodynamics of the high-affinity interaction of TCF4 with beta-catenin. J Mol Biol (2001) 0.90
Characterization of a biologically active extracellular domain of fibroblast growth factor receptor 1 expressed in Escherichia coli. Eur J Biochem (1992) 0.85
Biochemical bases of the interaction of human basic fibroblast growth factor with glycosaminoglycans. New insights from trypsin digestion studies. Eur J Biochem (1993) 0.85
Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding. Biochemistry (2000) 0.80
Structure-function relationship of basic fibroblast growth factor: site-directed mutagenesis of a putative heparin-binding and receptor-binding region. Biochem Biophys Res Commun (1992) 0.79
Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes. J Immunol (2000) 0.79
Subcellular localization and biological activity of M(r) 18,000 basic fibroblast growth factor: site-directed mutagenesis of a putative nuclear translocation sequence. Growth Factors (1993) 0.78
Biochemical characterization of the molecular interaction between recombinant basic fibroblast growth factor and a recombinant soluble fibroblast growth factor receptor. Biochem J (1993) 0.77
Comparison of the human germline and rearranged VH repertoire reveals complementarity between germline variability and somatic mutation. Ann N Y Acad Sci (1995) 0.76
The NH2-terminal extension of high molecular weight forms of basic fibroblast growth factor (bFGF) is not essential for the binding of bFGF to nuclear chromatin in transfected NIH 3T3 cells. Growth Factors (1993) 0.76
METASIM: object-oriented modelling of cell regulation. Comput Appl Biosci (1992) 0.75
Expression of PTP35, the murine homologue of the protein tyrosine phosphatase-related sequence IA-2, is regulated during cell growth and stimulated by mitogens in 3T3 fibroblasts. Biochem Biophys Res Commun (1995) 0.75
Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity. Eur J Biochem (1999) 0.75