Opioid and cannabinoid receptors share a common pool of GTP-binding proteins in cotransfected cells, but not in cells which endogenously coexpress the receptors.

PubWeight™: 0.90‹?›

🔗 View Article (PMID 10789829)

Published in Cell Mol Neurobiol on June 01, 2000

Authors

M Shapira1, Z Vogel, Y Sarne

Author Affiliations

1: Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Articles citing this

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol Rev (2010) 4.31

Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes. Pharmacol Rev (2010) 1.89

CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid-seeking behaviour in the rat. Br J Pharmacol (2004) 1.08

Signal transduction via cannabinoid receptors. CNS Neurol Disord Drug Targets (2009) 0.99

Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshoot. Mol Pharmacol (2010) 0.90

Expression of a G protein-coupled receptor (GPCR) leads to attenuation of signaling by other GPCRs: experimental evidence for a spontaneous GPCR constitutive inactive form. J Biol Chem (2010) 0.90

AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies. Neuropharmacology (2012) 0.89

Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells. Br J Pharmacol (2002) 0.86

CB1 receptors modulate the intake of a sweetened-fat diet in response to μ-opioid receptor stimulation of the nucleus accumbens. Pharmacol Biochem Behav (2010) 0.83

Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: can a single model explain disparate results? J Theor Biol (2008) 0.81

Molecular Pharmacology of δ-Opioid Receptors. Pharmacol Rev (2016) 0.80

A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a Predominantly Gi Coupled GPCR (C5aR) Signalling. Biosensors (Basel) (2012) 0.79

Endothelial atypical cannabinoid receptor: do we have enough evidence? Br J Pharmacol (2014) 0.76

Interacting Cannabinoid and Opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play. Front Behav Neurosci (2016) 0.75

Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex. Front Pharmacol (2016) 0.75

Articles cited by this

Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (1990) 13.60

Cloning of a delta opioid receptor by functional expression. Science (1992) 3.49

The GTP-binding protein, Go, regulates neuronal calcium channels. Nature (1987) 3.24

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol Pharmacol (1995) 2.34

Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. J Neurosci (1997) 2.25

A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions. J Biol Chem (1997) 2.20

Multiple opioid receptors: ligand selectivity profiles and binding site signatures. Mol Pharmacol (1989) 1.73

Cloning and pharmacological characterization of a rat mu opioid receptor. Neuron (1993) 1.68

Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs. Mol Pharmacol (1986) 1.66

Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2. Biochem J (1990) 1.63

Opioid receptor-coupled second messenger systems. Life Sci (1991) 1.58

mu and delta opioid receptors differentially couple to G protein subtypes in membranes of human neuroblastoma SH-SY5Y cells. Neuron (1993) 1.25

Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase. J Neurochem (1993) 1.20

Muscarinic acetylcholine receptor-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes. Eur J Biochem (1989) 1.09

Differences in G-protein activation by mu- and delta-opioid, and cannabinoid, receptors in rat striatum. Eur J Pharmacol (1996) 1.08

Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells. Mol Pharmacol (1992) 1.03

Expression of the mu-opioid receptor in CHO cells: ability of mu-opioid ligands to promote alpha-azidoanilido[32P]GTP labeling of multiple G protein alpha subunits. J Neurochem (1995) 1.02

G proteins and opioid receptor-mediated signalling. Cell Signal (1997) 1.01

Identification of cannabinoid receptors in cultures of rat cerebellar granule cells. Brain Res (1993) 1.00

Ability of delta-opioid receptors to interact with multiple G-proteins is independent of receptor density. J Biol Chem (1994) 0.95

Cholera toxin-A subunit blocks opioid excitatory effects on sensory neuron action potentials indicating mediation by Gs-linked opioid receptors. Brain Res (1990) 0.93

A human neuroblastoma cell line expresses mu and delta opioid receptor sites. J Biol Chem (1986) 0.92

Regulation of multiple effectors by the cloned delta-opioid receptor: stimulation of phospholipase C and type II adenylyl cyclase. J Neurochem (1995) 0.89

Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. J Neurochem (1998) 0.88

Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins. J Neurochem (1995) 0.88

Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes. J Neurochem (1997) 0.87

Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors. Mol Pharmacol (1993) 0.86

Independence of, and interactions between, cannabinoid and opioid signal transduction pathways in N18TG2 cells. Brain Res (1998) 0.85

Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells. Mol Pharmacol (1993) 0.83

Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells. J Biol Chem (1991) 0.83

Comparison of opiate inhibition of adenylate cyclase activity in neuroblastoma N18tG2 and neuroblastoma x glioma NG108-15 hybrid cell lines. Mol Pharmacol (1982) 0.83

Dissociation between the inhibitory and stimulatory effects of opioid peptides on cAMP formation in SK-N-SH neuroblastoma cells. Biochem Biophys Res Commun (1998) 0.82

Opioids potentiate transmitter release from SK-N-SH human neuroblastoma cells by modulating N-type calcium channels. Brain Res (1997) 0.79

Gz coupling to the rat kappa-opioid receptor. FEBS Lett (1995) 0.78

Cannabinoid receptor genes. Prog Neurobiol (1996) 0.76

An assessment of the role of opioid receptors in the response to cannabimimetic drugs. J Neurochem (1986) 0.75

Articles by these authors

(truncated to the top 100)

Acetylcholine receptors of muscle grown in vitro. Proc Natl Acad Sci U S A (1972) 3.96

Development of acetylcholine receptor clusters on cultured muscle cells. Proc Natl Acad Sci U S A (1973) 2.71

Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. J Med Chem (1997) 2.01

2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci U S A (2001) 1.86

Myasthenia gravis: a serum factor blocking acetylcholine receptors of the human neuromuscular junction. Lancet (1975) 1.84

An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur J Pharmacol (1998) 1.83

Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors. Proc Natl Acad Sci U S A (1993) 1.75

A factor from neurons increases the number of acetylcholine receptor aggregates on cultured muscle cells. Proc Natl Acad Sci U S A (1978) 1.66

Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor. EMBO J (1993) 1.56

Anandamide may mediate sleep induction. Nature (1997) 1.53

The inactivation and reactivation of Escherichia coli ribosomes. Methods Enzymol (1974) 1.45

Immunoperoxidase staining of alpha-bungarotoxin binding sites in muscle endplates shows distribution of acetylcholine receptors. Nature (1975) 1.42

Biosynthesis and axonal transport of rat neurohypophysial proteins and peptides. J Cell Biol (1977) 1.39

Localization of acetylcholine receptors during synaptogenesis in retina. Proc Natl Acad Sci U S A (1976) 1.38

Identification of synaptic acetylcholine receptor sites in retina with peroxidase-labeled alpha-bungarotoxin. Proc Natl Acad Sci U S A (1977) 1.29

Synapse and acetylcholine receptor synthesis by neurons dissociated from retina. Proc Natl Acad Sci U S A (1976) 1.26

Opiate-induced adenylyl cyclase superactivation is isozyme-specific. J Biol Chem (1997) 1.21

Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits. J Neurochem (1998) 1.21

Correlation of subjective pain experience with cerebral evoked responses to noxious thermal stimulations. Exp Brain Res (1978) 1.21

The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling. FEBS Lett (1995) 1.20

-Bungarotoxin used as a probe for acetylcholine receptors of cultured neurones. Nature (1973) 1.19

The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction. Cell (1995) 1.17

Neurophysin biosynthesis: conversion of a putative precursor during axonal transport. Science (1977) 1.16

Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma. J Biol Chem (1996) 1.16

(-)-Delta9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase. J Biol Chem (1996) 1.15

Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase. J Med Chem (1997) 1.15

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. Biochem J (2001) 1.14

Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants. J Biol Chem (1992) 1.12

Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment. J Biol Chem (1995) 1.11

On the specificity and stability of an enzyme that hydrolyzes N-substituted aminoacyl-transfer RNA's. Proc Natl Acad Sci U S A (1968) 1.10

Ras-GRF, the activator of Ras, is expressed preferentially in mature neurons of the central nervous system. Brain Res Mol Brain Res (1997) 1.10

The possible involvement of peptidyl transferase in the termination step of protein biosynthesis. Biochemistry (1969) 1.08

Ultrastructure of acetylcholine receptor clusters on cultured muscle fibers. J Cell Biol (1976) 1.03

Correlation between the peptidyl transferase activity of the 50 s ribosomal subunit and the ability of the subunit to interact with antibiotics. J Mol Biol (1971) 1.03

Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes. J Neurochem (1998) 1.02

Laminin induces acetylcholine receptor aggregation on cultured myotubes and enhances the receptor aggregation activity of a neuronal factor. J Neurosci (1983) 1.02

A study investigating the acute dose-response effects of 13 mg and 17 mg Delta 9- tetrahydrocannabinol on cognitive-motor skills, subjective and autonomic measures in regular users of marijuana. J Psychopharmacol (2008) 1.02

How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor. Proc Natl Acad Sci U S A (1992) 1.02

Kappa-opiate agonists inhibit adenylate cyclase and produce heterologous desensitization in rat spinal cord. J Neurochem (1989) 1.01

Reconstitution of functional muscarinic receptors by co-expression of amino- and carboxyl-terminal receptor fragments. FEBS Lett (1993) 1.01

Ribosome activation and the binding of dihydrostreptomycin: effect of polynucleotides and temperature on activation. J Mol Biol (1970) 0.99

Adenylyl cyclase interaction with the D2 dopamine receptor family; differential coupling to Gi, Gz, and Gs. Cell Mol Neurobiol (1999) 0.99

Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells. J Neurosci (1994) 0.98

Acupuncture and the opioid system: implications in management of migraine. Pediatr Neurol (1997) 0.97

Expression of opioid receptors during heart ontogeny in normotensive and hypertensive rats. Circulation (1996) 0.97

Regulation of adenylyl cyclase isozymes on acute and chronic activation of inhibitory receptors. Mol Pharmacol (1998) 0.95

Differential modulation of adenylyl cyclases I and II by various G beta subunits. J Biol Chem (1998) 0.93

Sigma receptor ligands modulate contractility, Ca++ influx and beating rate in cultured cardiac myocytes. J Pharmacol Exp Ther (1994) 0.92

The adsorption of enkephalin to porous polystyrene beads: a simple assay for enkephalin hydrolysis. FEBS Lett (1977) 0.92

Kappa opiate agonists inhibit Ca2+ influx in rat spinal cord-dorsal root ganglion cocultures. Involvement of a GTP-binding protein. J Biol Chem (1989) 0.91

Embryonic brain extract induces collagen biosynthesis in cultured muscle cells: involvement in acetylcholine receptor aggregation. Proc Natl Acad Sci U S A (1982) 0.91

Role of the highly conserved Asp-Arg-Tyr motif in signal transduction of the CB2 cannabinoid receptor. FEBS Lett (2000) 0.90

Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides. Eur J Pharmacol (1995) 0.89

Inotropic action of sigma receptor ligands in isolated cardiac myocytes from adult rats. Eur J Pharmacol (1995) 0.88

Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor. J Neurochem (2000) 0.88

Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol. J Pharmacol Exp Ther (1995) 0.88

D2/D3 dopamine receptor heterodimers exhibit unique functional properties. J Biol Chem (2001) 0.87

Aplysia acetylcholine receptors: blockade by and binding of alpha-bungarotoxin. Brain Res (1974) 0.86

Effects of eserine and neostigmine on the interaction of alpha-bungarotoxin with Aplysia acetylcholine receptors. Mol Pharmacol (1976) 0.86

Characterization of a triple opioid system in the human neuroblastoma NMB cell line. Brain Res (1994) 0.86

Differential superactivation of adenylyl cyclase isozymes after chronic activation of the CB(1) cannabinoid receptor. Mol Pharmacol (2000) 0.86

Nociceptive stimulus induces release of endogenous beta-endorphin in the rat brain. Neuroscience (1998) 0.86

Independence of, and interactions between, cannabinoid and opioid signal transduction pathways in N18TG2 cells. Brain Res (1998) 0.85

Pre- and postnatal development of opiate receptor subtypes in rat spinal cord. Brain Res Dev Brain Res (1990) 0.85

Inhibition of adenylyl cyclase isoforms V and VI by various Gbetagamma subunits. FASEB J (1998) 0.85

The protection by 70 S ribosomes of N-acyl-aminoacyl-tRNA against cleavage by peptidyl-tRNA hydrolase and its use to assay ribosomal association. Eur J Biochem (1971) 0.85

Evidence for mu-, delta-, and kappa-opioid receptors in a human neuroblastoma cell line. Life Sci (1993) 0.85

Delta9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress. Neuroscience (2005) 0.85

Distinct components of morphine effects on cardiac myocytes are mediated by the kappa and delta opioid receptors. J Mol Cell Cardiol (1997) 0.84

Desensitization to gamma-aminobutyric acid in crustacean muscle fibres. J Physiol (1976) 0.84

The specific resistance of N-substituted initiator methionyl-+RNA to enzymatic hydrolysis. Biochem Biophys Res Commun (1968) 0.84

Pharmacological basis for functional selectivity of partial muscarinic receptor agonists. Eur J Pharmacol (1996) 0.84

Multiple effects of opiates on intracellular calcium level and on calcium uptake in three neuronal cell lines. Brain Res (1995) 0.84

Hippocampal interneurons co-express transcripts encoding the alpha7 nicotinic receptor subunit and the cannabinoid receptor 1. Neuroscience (2008) 0.83

Protection of enkephalins from enzymatic degradation utilizing selective metal-chelating inhibitors. Eur J Pharmacol (1983) 0.83

Inhibition of enkephalin-degrading enzymes from rat brain and of thermolysin by amino acid hydroxamates. Life Sci (1981) 0.83

Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells. Mol Pharmacol (1993) 0.83

Localization of alpha-bungarotoxin binding sites in synapses of the developing chick retina. Brain Res (1980) 0.83

Dynorphins modulate DNA synthesis in fetal brain cell aggregates. J Neurochem (1995) 0.82

Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death. Cell Death Dis (2013) 0.82

Beta-endorphin is a potent inhibitor of thymidine incorporation into DNA via mu- and kappa-opioid receptors in fetal rat brain cell aggregates in culture. J Neurochem (1993) 0.82

Immunoperoxidase localization of alpha bungarotoxin: a new approach to myasthenia gravis. Ann N Y Acad Sci (1976) 0.82

Morphine-related metabolites differentially activate adenylyl cyclase isozymes after acute and chronic administration. FEBS Lett (2000) 0.82

The effect of puromycin on the biological activity of Leu-enkephalin. FEBS Lett (1979) 0.81

Cannabinoids inhibit agonist-stimulated formation of inositol phosphates in rat hippocampal cultures. Eur J Pharmacol (1993) 0.81

Cortical potentials evoked by innocuous tactile and noxious thermal stimulation in the rat: differences in localization and latency. Behav Neural Biol (1982) 0.81

Identification of distinct binding site subunits of mu and delta opioid receptors. Biochemistry (1986) 0.81

kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments. FEBS Lett (1995) 0.81

Long-term opiate exposure leads to increase in synapsin I in rat spinal cord-dorsal root ganglion cocultures. J Neurochem (1993) 0.81

Modulation of thymidine incorporation by kappa-opioid ligands in rat spinal cord-dorsal root ganglion co-cultures. Brain Res (1993) 0.81

Subcellular fractionation studies related to the processing of neurosecretory proteins in Aplysia neurons. J Neurochem (1977) 0.80

Humoral-endorphin blood levels in autistic, schizophrenic and healthy subjects. Psychopharmacology (Berl) (1984) 0.80

A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA. Glia (1994) 0.80

Increased expression of synapsin I mRNA in defined areas of the rat central nervous system following chronic morphine treatment. Brain Res Mol Brain Res (1995) 0.80

M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update. Ann N Y Acad Sci (1996) 0.79

Acute and chronic activation of the mu-opioid receptor with the endogenous ligand endomorphin differentially regulates adenylyl cyclase isozymes. Neuropharmacology (2000) 0.79

Nonopioid effect of morphine on electrically evoked acetylcholine release from Torpedo electromotor neurons. J Neurochem (1992) 0.79

Opioids potentiate transmitter release from SK-N-SH human neuroblastoma cells by modulating N-type calcium channels. Brain Res (1997) 0.79

Protection of Escherichia coli ribosomes against streptomycin by purified initiation factors. Eur J Biochem (1972) 0.79

Ascorbate-like factor from embryonic brain. Role in collagen formation, basement membrane deposition, and acetylcholine receptor aggregation by muscle cells. Ann N Y Acad Sci (1987) 0.79