Opiate-induced adenylyl cyclase superactivation is isozyme-specific.

Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. Science (2013) 1.91

Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology (Berl) (2010) 1.90

Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Neurosignals (2008) 1.73

Mu-opioid receptor desensitization: is morphine different? Br J Pharmacol (2004) 1.64

Tolerance and withdrawal from prolonged opioid use in critically ill children. Pediatrics (2010) 1.46

Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization. Mol Pharmacol (2008) 1.13

Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons. Mol Pharmacol (2009) 1.09

Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal. J Biol Chem (2008) 0.97

Differential effect of membrane cholesterol removal on mu- and delta-opioid receptors: a parallel comparison of acute and chronic signaling to adenylyl cyclase. J Biol Chem (2009) 0.96

Chronic opioid potentiates presynaptic but impairs postsynaptic N-methyl-D-aspartic acid receptor activity in spinal cords: implications for opioid hyperalgesia and tolerance. J Biol Chem (2012) 0.92

Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA. Br J Pharmacol (2010) 0.82

Acute Pain Management in Opioid Dependent Patients. Rev Pain (2009) 0.82

Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment. Front Pharmacol (2014) 0.81

Identification of new Gβγ interaction sites in adenylyl cyclase 2. Cell Signal (2011) 0.81

Termination and activation of store-operated cyclic AMP production. J Cell Mol Med (2012) 0.80

Molecular Pharmacology of δ-Opioid Receptors. Pharmacol Rev (2016) 0.80

Nicotine withdrawal and kappa-opioid receptors. Psychopharmacology (Berl) (2009) 0.79

Morphine as a Potential Oxidative Stress-Causing Agent. Mini Rev Org Chem (2013) 0.79

The dopamine D(2) receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2011) 0.79

A novel noncanonical signaling pathway for the μ-opioid receptor. Mol Pharmacol (2013) 0.78

Drug-induced sensitization of adenylyl cyclase: assay streamlining and miniaturization for small molecule and siRNA screening applications. J Vis Exp (2014) 0.78

Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP. Front Integr Neurosci (2014) 0.78

Posttranslation modification of G protein-coupled receptor in relationship to biased agonism. Methods Enzymol (2013) 0.77

Activators of G-protein signaling 3: a drug addiction molecular gateway. Behav Pharmacol (2010) 0.77

Regulation of adenylate cyclase type VIII splice variants by acute and chronic Gi/o-coupled receptor activation. Biochem J (2005) 0.77

Sustained morphine treatment augments prostaglandin E2-evoked calcitonin gene-related peptide release from primary sensory neurons in a PKA-dependent manner. Eur J Pharmacol (2010) 0.76

Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine-induced adenylyl cyclase sensitization but not mitogen-activated protein kinase phosphorylation. FEBS J (2012) 0.76

Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration. JCI Insight (2017) 0.75

Gαi/o-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years later. Eur J Pharmacol (2015) 0.75

Prolonged Morphine Treatment Alters Expression and Plasma Membrane Distribution of β-Adrenergic Receptors and Some Other Components of Their Signaling System in Rat Cerebral Cortex. J Mol Neurosci (2017) 0.75

Similarity and difference in the effects of peptides TGENHR and TQVEHR on HL-60 promyelocytes and Purkinje cells of rat cerebellar vermis. Dokl Biol Sci (2004) 0.75

Acetylcholine receptors of muscle grown in vitro. Proc Natl Acad Sci U S A (1972) 3.96

Development of acetylcholine receptor clusters on cultured muscle cells. Proc Natl Acad Sci U S A (1973) 2.71

Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. J Med Chem (1997) 2.01

2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci U S A (2001) 1.86

Myasthenia gravis: a serum factor blocking acetylcholine receptors of the human neuromuscular junction. Lancet (1975) 1.84

An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur J Pharmacol (1998) 1.83

Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors. Proc Natl Acad Sci U S A (1993) 1.75

A factor from neurons increases the number of acetylcholine receptor aggregates on cultured muscle cells. Proc Natl Acad Sci U S A (1978) 1.66

Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor. EMBO J (1993) 1.56

Anandamide may mediate sleep induction. Nature (1997) 1.53

The inactivation and reactivation of Escherichia coli ribosomes. Methods Enzymol (1974) 1.45

Immunoperoxidase staining of alpha-bungarotoxin binding sites in muscle endplates shows distribution of acetylcholine receptors. Nature (1975) 1.42

Localization of acetylcholine receptors during synaptogenesis in retina. Proc Natl Acad Sci U S A (1976) 1.38

Identification of synaptic acetylcholine receptor sites in retina with peroxidase-labeled alpha-bungarotoxin. Proc Natl Acad Sci U S A (1977) 1.29

Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death. J Biol Chem (1995) 1.27

Synapse and acetylcholine receptor synthesis by neurons dissociated from retina. Proc Natl Acad Sci U S A (1976) 1.26

Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits. J Neurochem (1998) 1.21

The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling. FEBS Lett (1995) 1.20

Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase. J Neurochem (1993) 1.20

-Bungarotoxin used as a probe for acetylcholine receptors of cultured neurones. Nature (1973) 1.19

The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction. Cell (1995) 1.17

Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma. J Biol Chem (1996) 1.16

(-)-Delta9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase. J Biol Chem (1996) 1.15

Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase. J Med Chem (1997) 1.15

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. Biochem J (2001) 1.14

Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants. J Biol Chem (1992) 1.12

Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment. J Biol Chem (1995) 1.11

On the specificity and stability of an enzyme that hydrolyzes N-substituted aminoacyl-transfer RNA's. Proc Natl Acad Sci U S A (1968) 1.10

Ras-GRF, the activator of Ras, is expressed preferentially in mature neurons of the central nervous system. Brain Res Mol Brain Res (1997) 1.10

The possible involvement of peptidyl transferase in the termination step of protein biosynthesis. Biochemistry (1969) 1.08

Ultrastructure of acetylcholine receptor clusters on cultured muscle fibers. J Cell Biol (1976) 1.03

Correlation between the peptidyl transferase activity of the 50 s ribosomal subunit and the ability of the subunit to interact with antibiotics. J Mol Biol (1971) 1.03

Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes. J Neurochem (1998) 1.02

Laminin induces acetylcholine receptor aggregation on cultured myotubes and enhances the receptor aggregation activity of a neuronal factor. J Neurosci (1983) 1.02

How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor. Proc Natl Acad Sci U S A (1992) 1.02

Kappa-opiate agonists inhibit adenylate cyclase and produce heterologous desensitization in rat spinal cord. J Neurochem (1989) 1.01

Reconstitution of functional muscarinic receptors by co-expression of amino- and carboxyl-terminal receptor fragments. FEBS Lett (1993) 1.01

Ribosome activation and the binding of dihydrostreptomycin: effect of polynucleotides and temperature on activation. J Mol Biol (1970) 0.99

Adenylyl cyclase interaction with the D2 dopamine receptor family; differential coupling to Gi, Gz, and Gs. Cell Mol Neurobiol (1999) 0.99

Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells. J Neurosci (1994) 0.98

Acupuncture and the opioid system: implications in management of migraine. Pediatr Neurol (1997) 0.97

Expression of opioid receptors during heart ontogeny in normotensive and hypertensive rats. Circulation (1996) 0.97

Regulation of adenylyl cyclase isozymes on acute and chronic activation of inhibitory receptors. Mol Pharmacol (1998) 0.95

Differential modulation of adenylyl cyclases I and II by various G beta subunits. J Biol Chem (1998) 0.93

The adsorption of enkephalin to porous polystyrene beads: a simple assay for enkephalin hydrolysis. FEBS Lett (1977) 0.92

Sigma receptor ligands modulate contractility, Ca++ influx and beating rate in cultured cardiac myocytes. J Pharmacol Exp Ther (1994) 0.92

Kappa opiate agonists inhibit Ca2+ influx in rat spinal cord-dorsal root ganglion cocultures. Involvement of a GTP-binding protein. J Biol Chem (1989) 0.91

Embryonic brain extract induces collagen biosynthesis in cultured muscle cells: involvement in acetylcholine receptor aggregation. Proc Natl Acad Sci U S A (1982) 0.91

Opioid and cannabinoid receptors share a common pool of GTP-binding proteins in cotransfected cells, but not in cells which endogenously coexpress the receptors. Cell Mol Neurobiol (2000) 0.90

Role of the highly conserved Asp-Arg-Tyr motif in signal transduction of the CB2 cannabinoid receptor. FEBS Lett (2000) 0.90

Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides. Eur J Pharmacol (1995) 0.89

Inotropic action of sigma receptor ligands in isolated cardiac myocytes from adult rats. Eur J Pharmacol (1995) 0.88

Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor. J Neurochem (2000) 0.88

Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol. J Pharmacol Exp Ther (1995) 0.88

D2/D3 dopamine receptor heterodimers exhibit unique functional properties. J Biol Chem (2001) 0.87

Effects of eserine and neostigmine on the interaction of alpha-bungarotoxin with Aplysia acetylcholine receptors. Mol Pharmacol (1976) 0.86

Differential superactivation of adenylyl cyclase isozymes after chronic activation of the CB(1) cannabinoid receptor. Mol Pharmacol (2000) 0.86

Uncomplicated general anesthesia in the elderly results in cognitive decline: does cognitive decline predict morbidity and mortality? Med Hypotheses (2006) 0.86

Nociceptive stimulus induces release of endogenous beta-endorphin in the rat brain. Neuroscience (1998) 0.86

Patient safety begins with proper planning: a quantitative method to improve hospital design. Qual Saf Health Care (2010) 0.86

Aplysia acetylcholine receptors: blockade by and binding of alpha-bungarotoxin. Brain Res (1974) 0.86

Inhibition of adenylyl cyclase isoforms V and VI by various Gbetagamma subunits. FASEB J (1998) 0.85

Delta9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress. Neuroscience (2005) 0.85

Pre- and postnatal development of opiate receptor subtypes in rat spinal cord. Brain Res Dev Brain Res (1990) 0.85

The protection by 70 S ribosomes of N-acyl-aminoacyl-tRNA against cleavage by peptidyl-tRNA hydrolase and its use to assay ribosomal association. Eur J Biochem (1971) 0.85

Distinct components of morphine effects on cardiac myocytes are mediated by the kappa and delta opioid receptors. J Mol Cell Cardiol (1997) 0.84

The specific resistance of N-substituted initiator methionyl-+RNA to enzymatic hydrolysis. Biochem Biophys Res Commun (1968) 0.84

In vivo dynamic light scattering microscopy of tumour blood vessels. J Microsc (2007) 0.84

Pharmacological basis for functional selectivity of partial muscarinic receptor agonists. Eur J Pharmacol (1996) 0.84

Expression of preproenkephalin A gene and presence of Met-enkephalin in dorsal root ganglia of the adult rat. J Neurochem (1994) 0.84

Inhibition of enkephalin-degrading enzymes from rat brain and of thermolysin by amino acid hydroxamates. Life Sci (1981) 0.83

Hippocampal interneurons co-express transcripts encoding the alpha7 nicotinic receptor subunit and the cannabinoid receptor 1. Neuroscience (2008) 0.83

Protection of enkephalins from enzymatic degradation utilizing selective metal-chelating inhibitors. Eur J Pharmacol (1983) 0.83

Localization of alpha-bungarotoxin binding sites in synapses of the developing chick retina. Brain Res (1980) 0.83

Dynorphins modulate DNA synthesis in fetal brain cell aggregates. J Neurochem (1995) 0.82

Morphine-related metabolites differentially activate adenylyl cyclase isozymes after acute and chronic administration. FEBS Lett (2000) 0.82

Immunoperoxidase localization of alpha bungarotoxin: a new approach to myasthenia gravis. Ann N Y Acad Sci (1976) 0.82

Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death. Cell Death Dis (2013) 0.82

Beta-endorphin is a potent inhibitor of thymidine incorporation into DNA via mu- and kappa-opioid receptors in fetal rat brain cell aggregates in culture. J Neurochem (1993) 0.82